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Anus adenocarcinoma

MedGen UID:
233976
•Concept ID:
C1332257
•
Neoplastic Process
Synonyms: Adenocarcinoma of anus; Adenocarcinoma of Anus; adenocarcinoma of anus; Adenocarcinoma of the Anus; adenocarcinoma of the anus; Anal Adenocarcinoma; anal adenocarcinoma; anus adenocarcinoma
SNOMED CT: Adenocarcinoma of anus (423607006)
 
Monarch Initiative: MONDO:0002652

Definition

An adenocarcinoma arising in the anal canal epithelium, including the mucosal surface, the anal glands, and the lining of fistulous tracts. The prognosis is related to the stage at diagnosis. [from NCI]

Professional guidelines

PubMed

Rectal cancer lexicon 2023 revised and updated consensus statement from the Society of Abdominal Radiology Colorectal and Anal Cancer Disease-Focused Panel.
Lee S, Kassam Z, Baheti AD, Hope TA, Chang KJ, Korngold EK, Taggart MW, Horvat N
Abdom Radiol (NY) 2023 Sep;48(9):2792-2806. Epub 2023 May 5 doi: 10.1007/s00261-023-03893-2. PMID: 37145311Free PMC Article
The diagnosis and management of extramammary Paget's disease.
Ito T, Kaku-Ito Y, Furue M
Expert Rev Anticancer Ther 2018 Jun;18(6):543-553. Epub 2018 Mar 27 doi: 10.1080/14737140.2018.1457955. PMID: 29575944
Pruritus ani: diagnosis and treatment.
Nasseri YY, Osborne MC
Gastroenterol Clin North Am 2013 Dec;42(4):801-13. Epub 2013 Nov 7 doi: 10.1016/j.gtc.2013.09.002. PMID: 24280401

Recent clinical studies

Etiology

Inguinal lymph node metastases from rectal adenocarcinoma: a systematic review.
Wyatt J, Powell SG, Ahmed S, Arthur J, Altaf K, Ahmed S, Javed MA
Tech Coloproctol 2023 Nov;27(11):969-978. Epub 2023 May 26 doi: 10.1007/s10151-023-02826-x. PMID: 37233960Free PMC Article
Cystic lesions of the retrorectal space.
Brown IS, Sokolova A, Rosty C, Graham RP
Histopathology 2023 Jan;82(2):232-241. Epub 2022 Aug 24 doi: 10.1111/his.14769. PMID: 35962741
An update on anal neoplasia.
Fléjou JF
Histopathology 2015 Jan;66(1):147-60. doi: 10.1111/his.12574. PMID: 25283345
Uncommon anal neoplasms.
Billingsley KG, Stern LE, Lowy AM, Kahlenberg MS, Thomas CR Jr
Surg Oncol Clin N Am 2004 Apr;13(2):375-88. doi: 10.1016/j.soc.2003.12.002. PMID: 15137963
Extramammary Paget's disease.
Mehta NJ, Torno R, Sorra T
South Med J 2000 Jul;93(7):713-5. PMID: 10923963

Diagnosis

Uncommon Anal Cancers.
Cruz-Ramos PA, Nguyen S, Hayman AV
Surg Oncol Clin N Am 2025 Jan;34(1):103-113. Epub 2024 Aug 17 doi: 10.1016/j.soc.2024.07.006. PMID: 39547762
Anal and Perianal Preneoplastic Lesions.
Loughrey MB, Shepherd NA
Gastroenterol Clin North Am 2024 Mar;53(1):201-220. Epub 2023 Oct 16 doi: 10.1016/j.gtc.2023.09.007. PMID: 38280748
Cystic lesions of the retrorectal space.
Brown IS, Sokolova A, Rosty C, Graham RP
Histopathology 2023 Jan;82(2):232-241. Epub 2022 Aug 24 doi: 10.1111/his.14769. PMID: 35962741
Anal cancer: current standards in care and recent changes in practice.
Shridhar R, Shibata D, Chan E, Thomas CR
CA Cancer J Clin 2015 Mar;65(2):139-62. Epub 2015 Jan 12 doi: 10.3322/caac.21259. PMID: 25582527
Anal neoplasms.
Garrett K, Kalady MF
Surg Clin North Am 2010 Feb;90(1):147-61, Table of Contents. doi: 10.1016/j.suc.2009.09.008. PMID: 20109639

Therapy

Photodynamic therapy with topical photosensitizers in mucosal and semimucosal areas: Review from a dermatologic perspective.
Grandi V, Sessa M, Pisano L, Rossi R, Galvan A, Gattai R, Mori M, Tiradritti L, Bacci S, Zuccati G, Cappugi P, Pimpinelli N
Photodiagnosis Photodyn Ther 2018 Sep;23:119-131. Epub 2018 Apr 15 doi: 10.1016/j.pdpdt.2018.04.005. PMID: 29669264
Oxaliplatin-induced posterior reversible encephalopathy syndrome (PRES).
Janjua TK, Hassan M, Afridi HK, Zahid NA
BMJ Case Rep 2017 Oct 4;2017 doi: 10.1136/bcr-2017-221571. PMID: 28978604Free PMC Article
Oncologic issues and kidney transplantation: a review of frequency, mortality, and screening.
Asch WS, Bia MJ
Adv Chronic Kidney Dis 2014 Jan;21(1):106-13. doi: 10.1053/j.ackd.2013.07.003. PMID: 24359993
Anal cancer: current and future methodology.
Eng C
Cancer Invest 2006 Aug-Sep;24(5):535-44. doi: 10.1080/07357900600815208. PMID: 16939964
Uncommon anal neoplasms.
Billingsley KG, Stern LE, Lowy AM, Kahlenberg MS, Thomas CR Jr
Surg Oncol Clin N Am 2004 Apr;13(2):375-88. doi: 10.1016/j.soc.2003.12.002. PMID: 15137963

Prognosis

Beyond squamous cell carcinoma: MRI appearance of uncommon anal neoplasms and mimickers.
El Homsi M, Golia Pernicka JS, Lall C, Nougaret S, Paspulati RM, Pickhardt PJ, Sheedy SP, Petkovska I
Abdom Radiol (NY) 2023 Sep;48(9):2898-2912. Epub 2023 Apr 7 doi: 10.1007/s00261-023-03891-4. PMID: 37027015Free PMC Article
Extramammary Paget disease.
St Claire K, Hoover A, Ashack K, Khachemoune A
Dermatol Online J 2019 Apr 15;25(4) PMID: 31046904
Low rectal cancer: classification and standardization of surgery.
Rullier E, Denost Q, Vendrely V, Rullier A, Laurent C
Dis Colon Rectum 2013 May;56(5):560-7. doi: 10.1097/DCR.0b013e31827c4a8c. PMID: 23575394
Anal neoplasms.
Garrett K, Kalady MF
Surg Clin North Am 2010 Feb;90(1):147-61, Table of Contents. doi: 10.1016/j.suc.2009.09.008. PMID: 20109639
Extramammary Paget's disease.
Mehta NJ, Torno R, Sorra T
South Med J 2000 Jul;93(7):713-5. PMID: 10923963

Clinical prediction guides

Importance of investigating high-risk human papillomavirus in lymph node metastasis of esophageal adenocarcinoma.
Sharma P, Gautam SD, Rajendra S
World J Gastroenterol 2020 Jun 7;26(21):2729-2739. doi: 10.3748/wjg.v26.i21.2729. PMID: 32550750Free PMC Article
Extramammary Paget disease.
St Claire K, Hoover A, Ashack K, Khachemoune A
Dermatol Online J 2019 Apr 15;25(4) PMID: 31046904
How to deal with rectal lesions more than 15 cm from the anal verge through transanal endoscopic microsurgery.
Serra-Aracil X, Gràcia R, Mora-López L, Serra-Pla S, Pallisera-Lloveras A, Labró M, Navarro-Soto S
Am J Surg 2019 Jan;217(1):53-58. Epub 2018 Apr 22 doi: 10.1016/j.amjsurg.2018.04.014. PMID: 29709273
Pathology of Anal Cancer.
Hoff PM, Coudry R, Moniz CM
Surg Oncol Clin N Am 2017 Jan;26(1):57-71. doi: 10.1016/j.soc.2016.07.013. PMID: 27889037
Low rectal cancer: classification and standardization of surgery.
Rullier E, Denost Q, Vendrely V, Rullier A, Laurent C
Dis Colon Rectum 2013 May;56(5):560-7. doi: 10.1097/DCR.0b013e31827c4a8c. PMID: 23575394

Recent systematic reviews

Recommended guidelines for screening for underlying malignancy in extramammary Paget's disease based on anatomic subtype.
Kibbi N, Owen JL, Worley B, Alam M; Extramammary Paget's Disease Guideline Study Group
J Am Acad Dermatol 2025 Feb;92(2):261-268. Epub 2024 Oct 12 doi: 10.1016/j.jaad.2024.07.1531. PMID: 39401611
Perianal Mucinous Adenocarcinoma: A Case Report and a Systematic Review of the Literature.
Gkegkes ID, Milionis V, Goutas N, Mantzoros I, Bourtzinakou AA, Stamatiadis AP
J Gastrointest Cancer 2024 Oct 18;56(1):6. doi: 10.1007/s12029-024-01116-5. PMID: 39422801
Inguinal lymph node metastases from rectal adenocarcinoma: a systematic review.
Wyatt J, Powell SG, Ahmed S, Arthur J, Altaf K, Ahmed S, Javed MA
Tech Coloproctol 2023 Nov;27(11):969-978. Epub 2023 May 26 doi: 10.1007/s10151-023-02826-x. PMID: 37233960Free PMC Article
High dose rate brachytherapy in the management of anal cancer: A review.
Ali ZS, Solomon E, Mann P, Wong S, Chan KKW, Taggar AS
Radiother Oncol 2022 Jun;171:43-52. Epub 2022 Apr 4 doi: 10.1016/j.radonc.2022.03.019. PMID: 35381275
A systematic review of transanal minimally invasive surgery (TAMIS) from 2010 to 2013.
Martin-Perez B, Andrade-Ribeiro GD, Hunter L, Atallah S
Tech Coloproctol 2014 Sep;18(9):775-88. Epub 2014 May 7 doi: 10.1007/s10151-014-1148-6. PMID: 24848524

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