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Adult Combined Hepatocellular Carcinoma and Cholangiocarcinoma

MedGen UID:
859699
Concept ID:
C3900105
Neoplastic Process

Definition

A combined hepatocellular carcinoma and cholangiocarcinoma that occurs during adulthood. [from NCI]

Term Hierarchy

CClinical test,  RResearch test,  OOMIM,  GGeneReviews,  VClinVar  
  • CROGVAdult Combined Hepatocellular Carcinoma and Cholangiocarcinoma

Professional guidelines

PubMed

Köhler B, Bes M, Chan HL, Esteban JI, Piratvisuth T, Sukeepaisarnjaroen W, Tanwandee T, Thongsawat S, Mang A, Morgenstern D, Swiatek-de Lange M, Dayyani F
Int J Biol Markers 2024 Jun;39(2):107-117. Epub 2024 Mar 28 doi: 10.1177/03936155241235185. PMID: 38549363
Granata V, Grassi R, Fusco R, Setola SV, Belli A, Ottaiano A, Nasti G, La Porta M, Danti G, Cappabianca S, Cutolo C, Petrillo A, Izzo F
Radiol Med 2021 Dec;126(12):1584-1600. Epub 2021 Nov 29 doi: 10.1007/s11547-021-01428-7. PMID: 34843029
Schizas D, Mastoraki A, Routsi E, Papapanou M, Tsapralis D, Vassiliu P, Toutouzas K, Felekouras E
Hepatobiliary Pancreat Dis Int 2020 Dec;19(6):515-523. Epub 2020 Jul 24 doi: 10.1016/j.hbpd.2020.07.004. PMID: 32753331

Recent clinical studies

Etiology

Gong W, Zhang S, Tian X, Chen W, He Y, Chen L, Ding T, Ren P, Shi L, Wu Q, Sun Y, Chen L, Guo H
Hepatol Int 2024 Aug;18(4):1310-1325. Epub 2024 May 20 doi: 10.1007/s12072-024-10694-2. PMID: 38767772Free PMC Article
Gigante E, Bouattour M, Bedoya JU, Regnault H, Ziol M, Assenat E, Paradis V, Calderaro J, Ganne-Carrié N, Bouhier-Leporrier K, Amaddeo G, Nault JC
United European Gastroenterol J 2024 May;12(4):429-439. Epub 2023 Dec 7 doi: 10.1002/ueg2.12503. PMID: 38059651Free PMC Article
Patil N, Sahai P, Rastogi A, Sharma N, Shasthry SM, Mukund A, Laroia ST, Kumar G, Pamecha V, Sarin SK
Indian J Pathol Microbiol 2023 Oct-Dec;66(4):744-750. doi: 10.4103/ijpm.ijpm_357_22. PMID: 38084526
Shi L, Shen W, Davis MI, Kong K, Vu P, Saha SK, Adil R, Kreuzer J, Egan R, Lee TD, Greninger P, Shrimp JH, Zhao W, Wei TY, Zhou M, Eccleston J, Sussman J, Manocha U, Weerasekara V, Kondo H, Vijay V, Wu MJ, Kearney SE, Ho J, McClanaghan J, Murchie E, Crowther GS, Patnaik S, Boxer MB, Shen M, Ting DT, Kim WY, Stanger BZ, Deshpande V, Ferrone CR, Benes CH, Haas W, Hall MD, Bardeesy N
Nat Cancer 2023 Mar;4(3):365-381. Epub 2023 Mar 13 doi: 10.1038/s43018-023-00523-0. PMID: 36914816Free PMC Article
Zhou YM, Sui CJ, Zhang XF, Li B, Yang JM
BMC Gastroenterol 2017 Feb 10;17(1):25. doi: 10.1186/s12876-017-0584-y. PMID: 28183290Free PMC Article

Diagnosis

Gigante E, Bouattour M, Bedoya JU, Regnault H, Ziol M, Assenat E, Paradis V, Calderaro J, Ganne-Carrié N, Bouhier-Leporrier K, Amaddeo G, Nault JC
United European Gastroenterol J 2024 May;12(4):429-439. Epub 2023 Dec 7 doi: 10.1002/ueg2.12503. PMID: 38059651Free PMC Article
Patil N, Sahai P, Rastogi A, Sharma N, Shasthry SM, Mukund A, Laroia ST, Kumar G, Pamecha V, Sarin SK
Indian J Pathol Microbiol 2023 Oct-Dec;66(4):744-750. doi: 10.4103/ijpm.ijpm_357_22. PMID: 38084526
Matsukuma KE, Yeh MM
Ann Diagn Pathol 2019 Feb;38:126-137. Epub 2018 Oct 12 doi: 10.1016/j.anndiagpath.2018.10.005. PMID: 30597357
Singh S, Chakraborty S, Bonthu N, Radio S, Hussain SM, Sasson A
Dig Dis Sci 2013 Jul;58(7):2114-23. Epub 2013 Feb 9 doi: 10.1007/s10620-013-2585-1. PMID: 23397471
Noh SJ, Lee HK, Yu HC, Moon WS
Clin Mol Hepatol 2012 Dec;18(4):416-9. Epub 2012 Dec 21 doi: 10.3350/cmh.2012.18.4.416. PMID: 23323259Free PMC Article

Therapy

Gigante E, Bouattour M, Bedoya JU, Regnault H, Ziol M, Assenat E, Paradis V, Calderaro J, Ganne-Carrié N, Bouhier-Leporrier K, Amaddeo G, Nault JC
United European Gastroenterol J 2024 May;12(4):429-439. Epub 2023 Dec 7 doi: 10.1002/ueg2.12503. PMID: 38059651Free PMC Article
Jang YJ, Kim EJ, Kim HD, Kim KP, Ryu MH, Park SR, Choi WM, Lee D, Choi J, Shim JH, Kim KM, Lim YS, Lee HC, Ryoo BY, Yoo C
J Cancer Res Clin Oncol 2023 Aug;149(10):7547-7555. Epub 2023 Mar 27 doi: 10.1007/s00432-023-04704-3. PMID: 36971796
Mole DJ, Fallowfield JA, Sherif AE, Kendall T, Semple S, Kelly M, Ridgway G, Connell JJ, McGonigle J, Banerjee R, Brady JM, Zheng X, Hughes M, Neyton L, McClintock J, Tucker G, Nailon H, Patel D, Wackett A, Steven M, Welsh F, Rees M; HepaT1ca Study Group
PLoS One 2020;15(12):e0238568. Epub 2020 Dec 2 doi: 10.1371/journal.pone.0238568. PMID: 33264327Free PMC Article
Chan LS, Sze DY, Poultsides GA, Louie JD, Abdelrazek Mohammed MA, Wang DS
Cardiovasc Intervent Radiol 2017 Sep;40(9):1383-1391. Epub 2017 Apr 21 doi: 10.1007/s00270-017-1648-7. PMID: 28432387
Noh SJ, Lee HK, Yu HC, Moon WS
Clin Mol Hepatol 2012 Dec;18(4):416-9. Epub 2012 Dec 21 doi: 10.3350/cmh.2012.18.4.416. PMID: 23323259Free PMC Article

Prognosis

Li Y, He D, Lu ZJ, Gu XF, Liu XY, Chen M, Tu YX, Zhou Y, Owen G, Zhang X, Jiang D
BMC Cancer 2024 Oct 7;24(1):1232. doi: 10.1186/s12885-024-12970-8. PMID: 39375615Free PMC Article
Gong W, Zhang S, Tian X, Chen W, He Y, Chen L, Ding T, Ren P, Shi L, Wu Q, Sun Y, Chen L, Guo H
Hepatol Int 2024 Aug;18(4):1310-1325. Epub 2024 May 20 doi: 10.1007/s12072-024-10694-2. PMID: 38767772Free PMC Article
Laohawetwanit T, Lerttanatum N, Wanpiyarat N, Manasilp N, Chaiparnich S
Ann Diagn Pathol 2021 Aug;53:151770. Epub 2021 Jun 16 doi: 10.1016/j.anndiagpath.2021.151770. PMID: 34147845
Zhou YM, Sui CJ, Zhang XF, Li B, Yang JM
BMC Gastroenterol 2017 Feb 10;17(1):25. doi: 10.1186/s12876-017-0584-y. PMID: 28183290Free PMC Article
Khaw YL, Nolan N, Heaslip I, McCormick PA, Sheahan K
J Clin Oncol 2011 Jul 20;29(21):e630-3. Epub 2011 May 23 doi: 10.1200/JCO.2011.35.2757. PMID: 21606429

Clinical prediction guides

Chun SJ, Jung YJ, Choi Y, Yi NJ, Lee KW, Suh KS, Lee KB, Kang HC, Chie EK, Kim KS
Cancer Res Treat 2025 Jan;57(1):229-239. Epub 2024 Jul 3 doi: 10.4143/crt.2024.176. PMID: 38965925Free PMC Article
Gong W, Zhang S, Tian X, Chen W, He Y, Chen L, Ding T, Ren P, Shi L, Wu Q, Sun Y, Chen L, Guo H
Hepatol Int 2024 Aug;18(4):1310-1325. Epub 2024 May 20 doi: 10.1007/s12072-024-10694-2. PMID: 38767772Free PMC Article
Patil N, Sahai P, Rastogi A, Sharma N, Shasthry SM, Mukund A, Laroia ST, Kumar G, Pamecha V, Sarin SK
Indian J Pathol Microbiol 2023 Oct-Dec;66(4):744-750. doi: 10.4103/ijpm.ijpm_357_22. PMID: 38084526
Sasaki M, Sato Y, Nakanuma Y
Histopathology 2022 Apr;80(5):859-868. Epub 2022 Mar 3 doi: 10.1111/his.14622. PMID: 35076959
Chan LS, Sze DY, Poultsides GA, Louie JD, Abdelrazek Mohammed MA, Wang DS
Cardiovasc Intervent Radiol 2017 Sep;40(9):1383-1391. Epub 2017 Apr 21 doi: 10.1007/s00270-017-1648-7. PMID: 28432387

Recent systematic reviews

Schizas D, Mastoraki A, Routsi E, Papapanou M, Tsapralis D, Vassiliu P, Toutouzas K, Felekouras E
Hepatobiliary Pancreat Dis Int 2020 Dec;19(6):515-523. Epub 2020 Jul 24 doi: 10.1016/j.hbpd.2020.07.004. PMID: 32753331
Laohawetwanit T, Klaikaew N
Pathol Int 2020 Sep;70(9):661-670. Epub 2020 Jul 7 doi: 10.1111/pin.12983. PMID: 32638458
Li DB, Si XY, Wang SJ, Zhou YM
Hepatobiliary Pancreat Dis Int 2019 Feb;18(1):12-18. Epub 2018 Oct 25 doi: 10.1016/j.hbpd.2018.10.001. PMID: 30442549
Zhou Y, Wu L, Xu D, Wan T, Si X
HPB (Oxford) 2017 Sep;19(9):768-774. Epub 2017 Jun 20 doi: 10.1016/j.hpb.2017.05.008. PMID: 28645571

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