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Unresectable Colon Adenocarcinoma

MedGen UID:
1705920
Concept ID:
C5206341
Neoplastic Process

Definition

A colon adenocarcinoma that is not amenable to surgical resection. [from NCI]

Term Hierarchy

CClinical test,  RResearch test,  OOMIM,  GGeneReviews,  VClinVar  
  • CROGVUnresectable Colon Adenocarcinoma

Professional guidelines

PubMed

Krishnan T, Wang F, Karapetis C, Roy A, Price T
Expert Rev Anticancer Ther 2023 Jun;23(6):617-623. Epub 2023 May 3 doi: 10.1080/14737140.2023.2208353. PMID: 37127538
Morris VK, Kennedy EB, Baxter NN, Benson AB 3rd, Cercek A, Cho M, Ciombor KK, Cremolini C, Davis A, Deming DA, Fakih MG, Gholami S, Hong TS, Jaiyesimi I, Klute K, Lieu C, Sanoff H, Strickler JH, White S, Willis JA, Eng C
J Clin Oncol 2023 Jan 20;41(3):678-700. Epub 2022 Oct 17 doi: 10.1200/JCO.22.01690. PMID: 36252154Free PMC Article
Bonetti A, Giuliani J, Muggia F
Anticancer Res 2014 Jan;34(1):423-34. PMID: 24403498

Recent clinical studies

Etiology

Moreau M, Alouani E, Flecchia C, Falcoz A, Gallois C, Auclin E, André T, Cohen R, Hollebecque A, Turpin A, Pernot S, Masson T, Di Fiore F, Dutherge M, Mazard T, Hautefeuille V, Van Laethem JL, De la Fouchardière C, Perkins G, Ben-Abdelghani M, Sclafani F, Aparicio T, Kim S, Vernerey D, Taieb J, Guimbaud R, Tougeron D
Eur J Cancer 2024 May;202:114033. Epub 2024 Mar 21 doi: 10.1016/j.ejca.2024.114033. PMID: 38537314
Rahbari NN, Biondo S, Frago R, Feißt M, Kreisler E, Rossion I, Serrano M, Jäger D, Lehmann M, Sommer F, Dignass A, Bolling C, Vogel I, Bork U, Büchler MW, Folprecht G, Kieser M, Lordick F, Weitz J; SYNCHRONOUS and CCRe-IV Trial Groups
J Clin Oncol 2024 May 1;42(13):1531-1541. Epub 2024 Feb 27 doi: 10.1200/JCO.23.01540. PMID: 38412408
Strickler JH, Cercek A, Siena S, André T, Ng K, Van Cutsem E, Wu C, Paulson AS, Hubbard JM, Coveler AL, Fountzilas C, Kardosh A, Kasi PM, Lenz HJ, Ciombor KK, Elez E, Bajor DL, Cremolini C, Sanchez F, Stecher M, Feng W, Bekaii-Saab TS; MOUNTAINEER investigators
Lancet Oncol 2023 May;24(5):496-508. doi: 10.1016/S1470-2045(23)00150-X. PMID: 37142372
Antoniotti C, Rossini D, Pietrantonio F, Catteau A, Salvatore L, Lonardi S, Boquet I, Tamberi S, Marmorino F, Moretto R, Ambrosini M, Tamburini E, Tortora G, Passardi A, Bergamo F, Kassambara A, Sbarrato T, Morano F, Ritorto G, Borelli B, Boccaccino A, Conca V, Giordano M, Ugolini C, Fieschi J, Papadopulos A, Massoué C, Aprile G, Antonuzzo L, Gelsomino F, Martinelli E, Pella N, Masi G, Fontanini G, Boni L, Galon J, Cremolini C; GONO Foundation Investigators
Lancet Oncol 2022 Jul;23(7):876-887. Epub 2022 May 27 doi: 10.1016/S1470-2045(22)00274-1. PMID: 35636444
Zhang X, Wu T, Cai X, Dong J, Xia C, Zhou Y, Ding R, Yang R, Tan J, Zhang L, Zhang Y, Wang Y, Dong C, Li Y
Front Immunol 2022;13:795972. Epub 2022 Mar 17 doi: 10.3389/fimmu.2022.795972. PMID: 35371084Free PMC Article

Diagnosis

Rahbari NN, Biondo S, Frago R, Feißt M, Kreisler E, Rossion I, Serrano M, Jäger D, Lehmann M, Sommer F, Dignass A, Bolling C, Vogel I, Bork U, Büchler MW, Folprecht G, Kieser M, Lordick F, Weitz J; SYNCHRONOUS and CCRe-IV Trial Groups
J Clin Oncol 2024 May 1;42(13):1531-1541. Epub 2024 Feb 27 doi: 10.1200/JCO.23.01540. PMID: 38412408
Kiss I
Klin Onkol 2023 Winter;37(6):473-476. doi: 10.48095/ccko2023473. PMID: 38158237
Miller ED, Hitchcock KE, Romesser PB
J Gastrointest Cancer 2023 Dec;54(4):1116-1127. Epub 2023 Jan 18 doi: 10.1007/s12029-022-00900-5. PMID: 36652155Free PMC Article
Zhang X, Wu T, Cai X, Dong J, Xia C, Zhou Y, Ding R, Yang R, Tan J, Zhang L, Zhang Y, Wang Y, Dong C, Li Y
Front Immunol 2022;13:795972. Epub 2022 Mar 17 doi: 10.3389/fimmu.2022.795972. PMID: 35371084Free PMC Article
Tanaka T, Kaneko M, Nozawa H, Emoto S, Murono K, Otani K, Sasaki K, Nishikawa T, Kiyomatsu T, Hata K, Morikawa T, Kawai K, Watanabe T
Neuroendocrinology 2017;105(4):426-434. Epub 2017 Jun 23 doi: 10.1159/000478743. PMID: 28641295

Therapy

Le DT, Diaz LA Jr, Kim TW, Van Cutsem E, Geva R, Jäger D, Hara H, Burge M, O'Neil BH, Kavan P, Yoshino T, Guimbaud R, Taniguchi H, Élez E, Al-Batran SE, Boland PM, Cui Y, Leconte P, Marinello P, André T
Eur J Cancer 2023 Jun;186:185-195. Epub 2023 Feb 24 doi: 10.1016/j.ejca.2023.02.016. PMID: 37141828
Watanabe J, Muro K, Shitara K, Yamazaki K, Shiozawa M, Ohori H, Takashima A, Yokota M, Makiyama A, Akazawa N, Ojima H, Yuasa Y, Miwa K, Yasui H, Oki E, Sato T, Naitoh T, Komatsu Y, Kato T, Hihara M, Soeda J, Misumi T, Yamamoto K, Akagi K, Ochiai A, Uetake H, Tsuchihara K, Yoshino T
JAMA 2023 Apr 18;329(15):1271-1282. doi: 10.1001/jama.2023.4428. PMID: 37071094Free PMC Article
Morris VK, Kennedy EB, Baxter NN, Benson AB 3rd, Cercek A, Cho M, Ciombor KK, Cremolini C, Davis A, Deming DA, Fakih MG, Gholami S, Hong TS, Jaiyesimi I, Klute K, Lieu C, Sanoff H, Strickler JH, White S, Willis JA, Eng C
J Clin Oncol 2023 Jan 20;41(3):678-700. Epub 2022 Oct 17 doi: 10.1200/JCO.22.01690. PMID: 36252154Free PMC Article
Antoniotti C, Rossini D, Pietrantonio F, Catteau A, Salvatore L, Lonardi S, Boquet I, Tamberi S, Marmorino F, Moretto R, Ambrosini M, Tamburini E, Tortora G, Passardi A, Bergamo F, Kassambara A, Sbarrato T, Morano F, Ritorto G, Borelli B, Boccaccino A, Conca V, Giordano M, Ugolini C, Fieschi J, Papadopulos A, Massoué C, Aprile G, Antonuzzo L, Gelsomino F, Martinelli E, Pella N, Masi G, Fontanini G, Boni L, Galon J, Cremolini C; GONO Foundation Investigators
Lancet Oncol 2022 Jul;23(7):876-887. Epub 2022 May 27 doi: 10.1016/S1470-2045(22)00274-1. PMID: 35636444
Zhang X, Wu T, Cai X, Dong J, Xia C, Zhou Y, Ding R, Yang R, Tan J, Zhang L, Zhang Y, Wang Y, Dong C, Li Y
Front Immunol 2022;13:795972. Epub 2022 Mar 17 doi: 10.3389/fimmu.2022.795972. PMID: 35371084Free PMC Article

Prognosis

Moreau M, Alouani E, Flecchia C, Falcoz A, Gallois C, Auclin E, André T, Cohen R, Hollebecque A, Turpin A, Pernot S, Masson T, Di Fiore F, Dutherge M, Mazard T, Hautefeuille V, Van Laethem JL, De la Fouchardière C, Perkins G, Ben-Abdelghani M, Sclafani F, Aparicio T, Kim S, Vernerey D, Taieb J, Guimbaud R, Tougeron D
Eur J Cancer 2024 May;202:114033. Epub 2024 Mar 21 doi: 10.1016/j.ejca.2024.114033. PMID: 38537314
Rahbari NN, Biondo S, Frago R, Feißt M, Kreisler E, Rossion I, Serrano M, Jäger D, Lehmann M, Sommer F, Dignass A, Bolling C, Vogel I, Bork U, Büchler MW, Folprecht G, Kieser M, Lordick F, Weitz J; SYNCHRONOUS and CCRe-IV Trial Groups
J Clin Oncol 2024 May 1;42(13):1531-1541. Epub 2024 Feb 27 doi: 10.1200/JCO.23.01540. PMID: 38412408
Lonardi S, Rasola C, Lobefaro R, Rossini D, Formica V, Scartozzi M, Frassineti GL, Boscolo G, Cinieri S, Di Donato S, Pella N, Bergamo F, Raimondi A, Arnoldi E, Antonuzzo L, Granetto C, Zustovich F, Ronzoni M, Leo S, Morano F, Loupakis F, Buggin F, Zagonel V, Fassan M, Cremolini C, Boni L, Pietrantonio F; GONO Foundation Investigators
J Clin Oncol 2023 Dec 1;41(34):5263-5273. Epub 2023 Aug 3 doi: 10.1200/JCO.23.00506. PMID: 37535876
Le DT, Diaz LA Jr, Kim TW, Van Cutsem E, Geva R, Jäger D, Hara H, Burge M, O'Neil BH, Kavan P, Yoshino T, Guimbaud R, Taniguchi H, Élez E, Al-Batran SE, Boland PM, Cui Y, Leconte P, Marinello P, André T
Eur J Cancer 2023 Jun;186:185-195. Epub 2023 Feb 24 doi: 10.1016/j.ejca.2023.02.016. PMID: 37141828
Zhang X, Wu T, Cai X, Dong J, Xia C, Zhou Y, Ding R, Yang R, Tan J, Zhang L, Zhang Y, Wang Y, Dong C, Li Y
Front Immunol 2022;13:795972. Epub 2022 Mar 17 doi: 10.3389/fimmu.2022.795972. PMID: 35371084Free PMC Article

Clinical prediction guides

Moreau M, Alouani E, Flecchia C, Falcoz A, Gallois C, Auclin E, André T, Cohen R, Hollebecque A, Turpin A, Pernot S, Masson T, Di Fiore F, Dutherge M, Mazard T, Hautefeuille V, Van Laethem JL, De la Fouchardière C, Perkins G, Ben-Abdelghani M, Sclafani F, Aparicio T, Kim S, Vernerey D, Taieb J, Guimbaud R, Tougeron D
Eur J Cancer 2024 May;202:114033. Epub 2024 Mar 21 doi: 10.1016/j.ejca.2024.114033. PMID: 38537314
Lenz HJ, Parikh A, Spigel DR, Cohn AL, Yoshino T, Kochenderfer M, Elez E, Shao SH, Deming D, Holdridge R, Larson T, Chen E, Mahipal A, Ucar A, Cullen D, Baskin-Bey E, Kang T, Hammell AB, Yao J, Tabernero J
J Immunother Cancer 2024 Mar 13;12(3) doi: 10.1136/jitc-2023-008409. PMID: 38485190Free PMC Article
Lonardi S, Rasola C, Lobefaro R, Rossini D, Formica V, Scartozzi M, Frassineti GL, Boscolo G, Cinieri S, Di Donato S, Pella N, Bergamo F, Raimondi A, Arnoldi E, Antonuzzo L, Granetto C, Zustovich F, Ronzoni M, Leo S, Morano F, Loupakis F, Buggin F, Zagonel V, Fassan M, Cremolini C, Boni L, Pietrantonio F; GONO Foundation Investigators
J Clin Oncol 2023 Dec 1;41(34):5263-5273. Epub 2023 Aug 3 doi: 10.1200/JCO.23.00506. PMID: 37535876
Le DT, Diaz LA Jr, Kim TW, Van Cutsem E, Geva R, Jäger D, Hara H, Burge M, O'Neil BH, Kavan P, Yoshino T, Guimbaud R, Taniguchi H, Élez E, Al-Batran SE, Boland PM, Cui Y, Leconte P, Marinello P, André T
Eur J Cancer 2023 Jun;186:185-195. Epub 2023 Feb 24 doi: 10.1016/j.ejca.2023.02.016. PMID: 37141828
Janssens K, Vanhoutte G, Lybaert W, Demey W, Decaestecker J, Hendrickx K, Rezaei Kalantari H, Zwaenepoel K, Pauwels P, Fransen E, Op de Beeck K, Van Camp G, Rolfo C, Peeters M
Clin Cancer Res 2023 May 1;29(9):1741-1750. doi: 10.1158/1078-0432.CCR-22-1500. PMID: 36716292

Recent systematic reviews

Zhang C, Cao C, Liu L, Lv Y, Li J, Lu J, Wang S, Du B, Yang X
Expert Rev Anticancer Ther 2023 Jan;23(1):107-115. Epub 2022 Nov 25 doi: 10.1080/14737140.2023.2149497. PMID: 36397266
Morris VK, Kennedy EB, Baxter NN, Benson AB 3rd, Cercek A, Cho M, Ciombor KK, Cremolini C, Davis A, Deming DA, Fakih MG, Gholami S, Hong TS, Jaiyesimi I, Klute K, Lieu C, Sanoff H, Strickler JH, White S, Willis JA, Eng C
J Clin Oncol 2023 Jan 20;41(3):678-700. Epub 2022 Oct 17 doi: 10.1200/JCO.22.01690. PMID: 36252154Free PMC Article
Chrabaszcz S, Rajeev R, Witmer HDD, Dhiman A, Klooster B, Gamblin TC, Banerjee A, Johnston FM, Turaga KK
Am J Clin Oncol 2022 Aug 1;45(8):366-372. Epub 2022 Jul 15 doi: 10.1097/COC.0000000000000921. PMID: 35838247
Tsilimigras DI, Ntanasis-Stathopoulos I, Bagante F, Moris D, Cloyd J, Spartalis E, Pawlik TM
Surg Oncol 2018 Jun;27(2):280-288. Epub 2018 May 8 doi: 10.1016/j.suronc.2018.05.012. PMID: 29937183

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