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Metastatic HER2-Negative Breast Carcinoma

MedGen UID:
1709546
Concept ID:
C5239111
Neoplastic Process
Synonyms: Metastatic HER2 Negative Breast Adenocarcinoma; Metastatic HER2 Negative Breast Carcinoma

Definition

A HER2-negative breast adenocarcinoma that has spread to another anatomic site. [from NCI]

Term Hierarchy

CClinical test,  RResearch test,  OOMIM,  GGeneReviews,  VClinVar  
  • CROGVMetastatic HER2-Negative Breast Carcinoma

Professional guidelines

PubMed

Wekking D, Lambertini M, Dessì M, Denaro N, Bardanzellu F, Garrone O, Scartozzi M, Solinas C
Semin Oncol 2023 Dec;50(6):131-139. Epub 2024 Jan 13 doi: 10.1053/j.seminoncol.2024.01.002. PMID: 38245458
Schlam I, Giordano A, Tolaney SM
Expert Opin Drug Saf 2023 Jul-Dec;22(12):1149-1156. Epub 2023 Dec 18 doi: 10.1080/14740338.2023.2288147. PMID: 37994878
Cortesi L, Rugo HS, Jackisch C
Target Oncol 2021 May;16(3):255-282. Epub 2021 Mar 12 doi: 10.1007/s11523-021-00796-4. PMID: 33710534Free PMC Article

Recent clinical studies

Etiology

Bardia A, Jhaveri K, Kalinsky K, Pernas S, Tsurutani J, Xu B, Hamilton E, Im SA, Nowecki Z, Sohn J, Laurentiis M, Jañez NM, Adamo B, Lee KS, Jung KH, Rubovszky G, Tseng LM, Lu YS, Yuan Y, Maxwell MJ, Haddad V, Khan SS, Rugo HS, Pistilli B
Future Oncol 2024 Mar;20(8):423-436. Epub 2023 Jun 30 doi: 10.2217/fon-2023-0188. PMID: 37387213
Fox S, Speirs V, Shaaban AM
Virchows Arch 2022 Jan;480(1):85-93. Epub 2021 Aug 30 doi: 10.1007/s00428-021-03190-7. PMID: 34458944
Hortobagyi GN, Stemmer SM, Burris HA, Yap YS, Sonke GS, Paluch-Shimon S, Campone M, Petrakova K, Blackwell KL, Winer EP, Janni W, Verma S, Conte P, Arteaga CL, Cameron DA, Mondal S, Su F, Miller M, Elmeliegy M, Germa C, O'Shaughnessy J
Ann Oncol 2018 Jul 1;29(7):1541-1547. doi: 10.1093/annonc/mdy155. PMID: 29718092
Robson M, Im SA, Senkus E, Xu B, Domchek SM, Masuda N, Delaloge S, Li W, Tung N, Armstrong A, Wu W, Goessl C, Runswick S, Conte P
N Engl J Med 2017 Aug 10;377(6):523-533. Epub 2017 Jun 4 doi: 10.1056/NEJMoa1706450. PMID: 28578601
Masuda N, Lee SJ, Ohtani S, Im YH, Lee ES, Yokota I, Kuroi K, Im SA, Park BW, Kim SB, Yanagita Y, Ohno S, Takao S, Aogi K, Iwata H, Jeong J, Kim A, Park KH, Sasano H, Ohashi Y, Toi M
N Engl J Med 2017 Jun 1;376(22):2147-2159. doi: 10.1056/NEJMoa1612645. PMID: 28564564

Diagnosis

Shirley M
Drugs 2024 Mar;84(3):337-346. doi: 10.1007/s40265-024-01998-6. PMID: 38388873
Venetis K, Pepe F, Pescia C, Cursano G, Criscitiello C, Frascarelli C, Mane E, Russo G, Taurelli Salimbeni B, Troncone G, Guerini Rocco E, Curigliano G, Fusco N, Malapelle U
Cancer Treat Rev 2023 Dec;121:102642. Epub 2023 Oct 13 doi: 10.1016/j.ctrv.2023.102642. PMID: 37864956
Najjar S, Allison KH
Virchows Arch 2022 Jan;480(1):163-176. Epub 2022 Jan 14 doi: 10.1007/s00428-022-03267-x. PMID: 35029776
Fox S, Speirs V, Shaaban AM
Virchows Arch 2022 Jan;480(1):85-93. Epub 2021 Aug 30 doi: 10.1007/s00428-021-03190-7. PMID: 34458944
Cristofanilli M, Turner NC, Bondarenko I, Ro J, Im SA, Masuda N, Colleoni M, DeMichele A, Loi S, Verma S, Iwata H, Harbeck N, Zhang K, Theall KP, Jiang Y, Bartlett CH, Koehler M, Slamon D
Lancet Oncol 2016 Apr;17(4):425-439. Epub 2016 Mar 3 doi: 10.1016/S1470-2045(15)00613-0. PMID: 26947331

Therapy

Bardia A, Jhaveri K, Kalinsky K, Pernas S, Tsurutani J, Xu B, Hamilton E, Im SA, Nowecki Z, Sohn J, Laurentiis M, Jañez NM, Adamo B, Lee KS, Jung KH, Rubovszky G, Tseng LM, Lu YS, Yuan Y, Maxwell MJ, Haddad V, Khan SS, Rugo HS, Pistilli B
Future Oncol 2024 Mar;20(8):423-436. Epub 2023 Jun 30 doi: 10.2217/fon-2023-0188. PMID: 37387213
Schmid P, Adams S, Rugo HS, Schneeweiss A, Barrios CH, Iwata H, Diéras V, Hegg R, Im SA, Shaw Wright G, Henschel V, Molinero L, Chui SY, Funke R, Husain A, Winer EP, Loi S, Emens LA; IMpassion130 Trial Investigators
N Engl J Med 2018 Nov 29;379(22):2108-2121. Epub 2018 Oct 20 doi: 10.1056/NEJMoa1809615. PMID: 30345906
Robson M, Im SA, Senkus E, Xu B, Domchek SM, Masuda N, Delaloge S, Li W, Tung N, Armstrong A, Wu W, Goessl C, Runswick S, Conte P
N Engl J Med 2017 Aug 10;377(6):523-533. Epub 2017 Jun 4 doi: 10.1056/NEJMoa1706450. PMID: 28578601
Masuda N, Lee SJ, Ohtani S, Im YH, Lee ES, Yokota I, Kuroi K, Im SA, Park BW, Kim SB, Yanagita Y, Ohno S, Takao S, Aogi K, Iwata H, Jeong J, Kim A, Park KH, Sasano H, Ohashi Y, Toi M
N Engl J Med 2017 Jun 1;376(22):2147-2159. doi: 10.1056/NEJMoa1612645. PMID: 28564564
Prat A, Pineda E, Adamo B, Galván P, Fernández A, Gaba L, Díez M, Viladot M, Arance A, Muñoz M
Breast 2015 Nov;24 Suppl 2:S26-35. Epub 2015 Aug 5 doi: 10.1016/j.breast.2015.07.008. PMID: 26253814

Prognosis

Bardia A, Jhaveri K, Kalinsky K, Pernas S, Tsurutani J, Xu B, Hamilton E, Im SA, Nowecki Z, Sohn J, Laurentiis M, Jañez NM, Adamo B, Lee KS, Jung KH, Rubovszky G, Tseng LM, Lu YS, Yuan Y, Maxwell MJ, Haddad V, Khan SS, Rugo HS, Pistilli B
Future Oncol 2024 Mar;20(8):423-436. Epub 2023 Jun 30 doi: 10.2217/fon-2023-0188. PMID: 37387213
Fox S, Speirs V, Shaaban AM
Virchows Arch 2022 Jan;480(1):85-93. Epub 2021 Aug 30 doi: 10.1007/s00428-021-03190-7. PMID: 34458944
Goetz MP, Toi M, Campone M, Sohn J, Paluch-Shimon S, Huober J, Park IH, Trédan O, Chen SC, Manso L, Freedman OC, Garnica Jaliffe G, Forrester T, Frenzel M, Barriga S, Smith IC, Bourayou N, Di Leo A
J Clin Oncol 2017 Nov 10;35(32):3638-3646. Epub 2017 Oct 2 doi: 10.1200/JCO.2017.75.6155. PMID: 28968163
Masuda N, Lee SJ, Ohtani S, Im YH, Lee ES, Yokota I, Kuroi K, Im SA, Park BW, Kim SB, Yanagita Y, Ohno S, Takao S, Aogi K, Iwata H, Jeong J, Kim A, Park KH, Sasano H, Ohashi Y, Toi M
N Engl J Med 2017 Jun 1;376(22):2147-2159. doi: 10.1056/NEJMoa1612645. PMID: 28564564
Tolaney SM, Barry WT, Dang CT, Yardley DA, Moy B, Marcom PK, Albain KS, Rugo HS, Ellis M, Shapira I, Wolff AC, Carey LA, Overmoyer BA, Partridge AH, Guo H, Hudis CA, Krop IE, Burstein HJ, Winer EP
N Engl J Med 2015 Jan 8;372(2):134-41. doi: 10.1056/NEJMoa1406281. PMID: 25564897Free PMC Article

Clinical prediction guides

Najjar S, Allison KH
Virchows Arch 2022 Jan;480(1):163-176. Epub 2022 Jan 14 doi: 10.1007/s00428-022-03267-x. PMID: 35029776
Kalinsky K, Barlow WE, Gralow JR, Meric-Bernstam F, Albain KS, Hayes DF, Lin NU, Perez EA, Goldstein LJ, Chia SKL, Dhesy-Thind S, Rastogi P, Alba E, Delaloge S, Martin M, Kelly CM, Ruiz-Borrego M, Gil-Gil M, Arce-Salinas CH, Brain EGC, Lee ES, Pierga JY, Bermejo B, Ramos-Vazquez M, Jung KH, Ferrero JM, Schott AF, Shak S, Sharma P, Lew DL, Miao J, Tripathy D, Pusztai L, Hortobagyi GN
N Engl J Med 2021 Dec 16;385(25):2336-2347. Epub 2021 Dec 1 doi: 10.1056/NEJMoa2108873. PMID: 34914339Free PMC Article
Ellis H, Ma CX
Curr Oncol Rep 2019 Dec 11;21(12):110. doi: 10.1007/s11912-019-0846-7. PMID: 31828441
Hortobagyi GN, Stemmer SM, Burris HA, Yap YS, Sonke GS, Paluch-Shimon S, Campone M, Petrakova K, Blackwell KL, Winer EP, Janni W, Verma S, Conte P, Arteaga CL, Cameron DA, Mondal S, Su F, Miller M, Elmeliegy M, Germa C, O'Shaughnessy J
Ann Oncol 2018 Jul 1;29(7):1541-1547. doi: 10.1093/annonc/mdy155. PMID: 29718092
Prat A, Pineda E, Adamo B, Galván P, Fernández A, Gaba L, Díez M, Viladot M, Arance A, Muñoz M
Breast 2015 Nov;24 Suppl 2:S26-35. Epub 2015 Aug 5 doi: 10.1016/j.breast.2015.07.008. PMID: 26253814

Recent systematic reviews

Wang T, Shen G, Li J, Huo X, Wang M, Liu Z, Zhao F, Ren D, Zhao J
Curr Cancer Drug Targets 2023;23(9):718-730. doi: 10.2174/1568009623666230407101128. PMID: 37026492
Burstein HJ, Somerfield MR, Barton DL, Dorris A, Fallowfield LJ, Jain D, Johnston SRD, Korde LA, Litton JK, Macrae ER, Peterson LL, Vikas P, Yung RL, Rugo HS
J Clin Oncol 2021 Dec 10;39(35):3959-3977. Epub 2021 Jul 29 doi: 10.1200/JCO.21.01392. PMID: 34324367Free PMC Article
Harbeck N, Bartlett M, Spurden D, Hooper B, Zhan L, Rosta E, Cameron C, Mitra D, Zhou A
Future Oncol 2021 Jun;17(16):2107-2122. Epub 2021 Mar 5 doi: 10.2217/fon-2020-1264. PMID: 33663223
Giuliano M, Schettini F, Rognoni C, Milani M, Jerusalem G, Bachelot T, De Laurentiis M, Thomas G, De Placido P, Arpino G, De Placido S, Cristofanilli M, Giordano A, Puglisi F, Pistilli B, Prat A, Del Mastro L, Venturini S, Generali D
Lancet Oncol 2019 Oct;20(10):1360-1369. Epub 2019 Sep 4 doi: 10.1016/S1470-2045(19)30420-6. PMID: 31494037
Redfern A, Burslem K, Woodward N, Beith J, McCarthy N, De Boer R, Bell R
Asia Pac J Clin Oncol 2016 Mar;12 Suppl 1:19-31. doi: 10.1111/ajco.12492. PMID: 27001209

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