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Nasopharyngeal Low Grade Papillary Adenocarcinoma

MedGen UID:
354457
•Concept ID:
C1711278
•
Neoplastic Process
Synonyms: Low Grade Nasopharyngeal Papillary Adenocarcinoma; Low-Grade Nasopharyngeal Papillary Adenocarcinoma; Nasopharyngeal Low-Grade Papillary Adenocarcinoma; Nasopharyngeal Papillary Adenocarcinoma

Definition

A low-grade exophytic adenocarcinoma with papillary growth that arises from the epithelium of the nasopharynx. If it is completely removed, the prognosis is excellent. [from NCI]

Term Hierarchy

CClinical test,  RResearch test,  OOMIM,  GGeneReviews,  VClinVar  
  • CROGVNasopharyngeal Low Grade Papillary Adenocarcinoma

Recent clinical studies

Etiology

Low-grade Nasopharyngeal Papillary Adenocarcinoma: A Clinicopathologic Series of 35 Cases.
Jin Z, Ye M, Sheng Y, Sun J, Zhang J, Chen Y, Lin L, Bai Q, Hu C
Am J Surg Pathol 2025 Jan 1;49(1):35-44. Epub 2024 Oct 17 doi: 10.1097/PAS.0000000000002321. PMID: 39450942
Nasopharyngeal adenocarcinomas: a clinicopathologic study of 44 cases including immunohistochemical features of 18 papillary phenotypes.
Pineda-Daboin K, Neto A, Ochoa-Perez V, Luna MA
Ann Diagn Pathol 2006 Aug;10(4):215-21. doi: 10.1016/j.anndiagpath.2005.11.002. PMID: 16844563
Polymorphous low-grade adenocarcinoma of the nasopharynx. Case report and review of the literature.
Lengyel E, Somogyi A, Gõdény M, Szerdahelyi A, Németh G
Strahlenther Onkol 2000 Jan;176(1):40-2. doi: 10.1007/pl00002304. PMID: 10650835
Nasopharyngeal papillary adenocarcinoma. A clinicopathologic study of a low-grade carcinoma.
Wenig BM, Hyams VJ, Heffner DK
Am J Surg Pathol 1988 Dec;12(12):946-53. PMID: 2462370

Diagnosis

Low-grade Nasopharyngeal Papillary Adenocarcinoma: A Clinicopathologic Series of 35 Cases.
Jin Z, Ye M, Sheng Y, Sun J, Zhang J, Chen Y, Lin L, Bai Q, Hu C
Am J Surg Pathol 2025 Jan 1;49(1):35-44. Epub 2024 Oct 17 doi: 10.1097/PAS.0000000000002321. PMID: 39450942
Low-Grade Nasopharyngeal Papillary Adenocarcinoma.
Wang L, Min Q, Jiang J, Shao Y, Cao Y, Yan D
J Coll Physicians Surg Pak 2019 Nov;29(11):1114-1115. doi: 10.29271/jcpsp.2019.11.1114. PMID: 31659975
Thyroid-Like Low-Grade Nasopharyngeal Papillary Adenocarcinoma.
Huang F, Xiang X, Hong B, Min J, Li J
Am J Clin Pathol 2019 Oct 7;152(5):582-589. doi: 10.1093/ajcp/aqz082. PMID: 31287861
Thyroid-Like Low-Grade Nasopharyngeal Papillary Adenocarcinoma.
Baumann KB, Betz SJ
Head Neck Pathol 2019 Dec;13(4):661-663. Epub 2018 Jul 11 doi: 10.1007/s12105-018-0947-x. PMID: 29995295Free PMC Article
Low-grade papillary adenocarcinoma of nasopharynx with expression of thyroid transcription factor-1: Case report and review of literature.
Rajeswari B, Sukumaran Nair RK, Parukuttyamma K, Mathews A
Indian J Pathol Microbiol 2016 Oct-Dec;59(4):518-520. doi: 10.4103/0377-4929.191809. PMID: 27721286

Therapy

Endoscopic Low-Temperature Plasma Radiofrequency Ablation for Primary Thyroid-Like Low-Grade Nasopharyngeal Papillary Adenocarcinoma.
Zhong QY, Sun Q, Liu ZH
Ear Nose Throat J 2021 Aug;100(7):563-564. Epub 2019 Oct 17 doi: 10.1177/0145561319880976. PMID: 31619076

Prognosis

Immunohistochemical characteristics of thyroid-like low-grade nasopharyngeal papillary adenocarcinoma: A case report and review.
Guo H, Zhang Z, Huang C, Qiu J, Qu X
Medicine (Baltimore) 2023 Jan 27;102(4):e32655. doi: 10.1097/MD.0000000000032655. PMID: 36705380Free PMC Article
Genetic profile identification and clinicopathologic characteristics analysis of the thyroid-like low-grade nasopharyngeal papillary adenocarcinoma.
Wang T, Liu X, Yu W, Gao L, Deng W, He Q, Liao F, Chu L
Pathol Res Pract 2022 Aug;236:153980. Epub 2022 Jun 16 doi: 10.1016/j.prp.2022.153980. PMID: 35759937
Thyroid-Like Low-Grade Nasopharyngeal Papillary Adenocarcinoma.
Baumann KB, Betz SJ
Head Neck Pathol 2019 Dec;13(4):661-663. Epub 2018 Jul 11 doi: 10.1007/s12105-018-0947-x. PMID: 29995295Free PMC Article
Primary thyroid-like low-grade nasopharyngeal papillary adenocarcinoma: A case report and literature review.
Zhang WL, Ma S, Havrilla L, Cai L, Yu CQ, Shen S, Xu HT, Wang L, Yu JH, Lin XY, Wang E, Yang LH
Medicine (Baltimore) 2017 Nov;96(47):e8851. doi: 10.1097/MD.0000000000008851. PMID: 29381996Free PMC Article
Low-grade papillary adenocarcinoma of nasopharynx with expression of thyroid transcription factor-1: Case report and review of literature.
Rajeswari B, Sukumaran Nair RK, Parukuttyamma K, Mathews A
Indian J Pathol Microbiol 2016 Oct-Dec;59(4):518-520. doi: 10.4103/0377-4929.191809. PMID: 27721286

Clinical prediction guides

The rare combination of low-grade thyroid-like nasopharyngeal papillary adenocarcinoma and squamous cell carcinoma: a case report and literature review.
Toyran T, Inceman M, Erdogan K, Kücükosmanoglu A, Ekici NY, Ugu AH
Pol J Pathol 2022;73(4):359-363. doi: 10.5114/pjp.2022.125569. PMID: 36946273
Clinicopathologic Characteristics of Thyroid-like Low-grade Nasopharyngeal Papillary Adenocarcinoma: A Case Report.
Li L, Zhou F, Lin F, Han C
Appl Immunohistochem Mol Morphol 2019 Sep;27(8):e81-e84. doi: 10.1097/PAI.0000000000000545. PMID: 29494399
Thyroid-like low-grade nasopharyngeal papillary adenocarcinoma with squamous differentiation: a novel histological finding.
Oide T, Kadosono O, Matsushima J, Wu D, Nagashima H, Saigusa H, Masunaga A, Nakatani Y, Hiroshima K
Hum Pathol 2017 Dec;70:43-48. Epub 2017 Jun 7 doi: 10.1016/j.humpath.2017.05.020. PMID: 28601658
Thyroid-like low-grade nasopharyngeal papillary adenocarcinoma: case report and literature review.
Oishi N, Kondo T, Nakazawa T, Mochizuki K, Kasai K, Inoue T, Yamamoto T, Watanabe H, Hatsushika K, Masuyama K, Katoh R
Pathol Res Pract 2014 Dec;210(12):1142-5. Epub 2014 May 9 doi: 10.1016/j.prp.2014.04.020. PMID: 24893893
Thyroid-like low-grade nasopharyngeal papillary adenocarcinoma: report of two cases.
Ohe C, Sakaida N, Tadokoro C, Fukui H, Asako M, Tomoda K, Uemura Y
Pathol Int 2010 Feb;60(2):107-11. doi: 10.1111/j.1440-1827.2009.02480.x. PMID: 20398195

Recent systematic reviews

Radiological features of thyroid-like low-grade nasopharyngeal papillary adenocarcinoma: case series and systematic review.
Baba A, Matsushima S, Kessoku H, Omura K, Kurokawa R, Fukasawa N, Takeshita Y, Yamauchi H, Ogino N, Kayama R, Uchihara K, Yoshimatsu L, Ojiri H
Neuroradiology 2024 Feb;66(2):249-259. Epub 2023 Dec 16 doi: 10.1007/s00234-023-03254-2. PMID: 38103083

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