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Pancreatic small cell neuroendocrine carcinoma

MedGen UID:
459466
Concept ID:
C2987240
Neoplastic Process
Synonyms: endocrine pancreas small cell carcinoma; Pancreatic Small Cell Carcinoma; Pancreatic Small Cell NEC; pancreatic small cell NEC; Pancreatic Small Cell NEC G3; pancreatic small cell NEC G3; Pancreatic Small Cell Neuroendocrine Carcinoma; pancreatic small cell neuroendocrine carcinoma; small cell carcinoma of endocrine pancreas
 
Monarch Initiative: MONDO:0006348

Definition

An aggressive, high-grade and poorly differentiated carcinoma with neuroendocrine differentiation that arises from the pancreas. It is characterized by the presence of malignant small cells. [from NCI]

Term Hierarchy

CClinical test,  RResearch test,  OOMIM,  GGeneReviews,  VClinVar  
  • CROGVPancreatic small cell neuroendocrine carcinoma

Professional guidelines

PubMed

Harris PE, Zhernosekov K
Front Endocrinol (Lausanne) 2022;13:941832. Epub 2022 Oct 31 doi: 10.3389/fendo.2022.941832. PMID: 36387893Free PMC Article
Buscail L, Bournet B, Cordelier P
Nat Rev Gastroenterol Hepatol 2020 Mar;17(3):153-168. Epub 2020 Jan 31 doi: 10.1038/s41575-019-0245-4. PMID: 32005945
Ciardiello F, Tortora G
N Engl J Med 2008 Mar 13;358(11):1160-74. doi: 10.1056/NEJMra0707704. PMID: 18337605

Curated

NCCN Clinical Practice Guidelines in Oncology (NCCN Guidelines®), Neuroendocrine and Adrenal Tumors, 2023

Recent clinical studies

Etiology

Kawasaki K, Rekhtman N, Quintanal-Villalonga Á, Rudin CM
Nat Rev Clin Oncol 2023 Jan;20(1):16-32. Epub 2022 Oct 28 doi: 10.1038/s41571-022-00696-0. PMID: 36307533
Mastracci L, Rindi G, Grillo F, Solcia E, Campora M, Fassan M, Parente P, Vanoli A, La Rosa S
Pathologica 2021 Feb;113(1):5-11. doi: 10.32074/1591-951X-229. PMID: 33686305Free PMC Article
Rüschoff J, Nagelmeier I, Jasani B, Stoss O
Pathologe 2021 Nov;42(Suppl 1):62-68. Epub 2020 Dec 21 doi: 10.1007/s00292-020-00878-6. PMID: 33346874
Aggarwal R, Huang J, Alumkal JJ, Zhang L, Feng FY, Thomas GV, Weinstein AS, Friedl V, Zhang C, Witte ON, Lloyd P, Gleave M, Evans CP, Youngren J, Beer TM, Rettig M, Wong CK, True L, Foye A, Playdle D, Ryan CJ, Lara P, Chi KN, Uzunangelov V, Sokolov A, Newton Y, Beltran H, Demichelis F, Rubin MA, Stuart JM, Small EJ
J Clin Oncol 2018 Aug 20;36(24):2492-2503. Epub 2018 Jul 9 doi: 10.1200/JCO.2017.77.6880. PMID: 29985747Free PMC Article
Sorbye H, Strosberg J, Baudin E, Klimstra DS, Yao JC
Cancer 2014 Sep 15;120(18):2814-23. Epub 2014 Apr 25 doi: 10.1002/cncr.28721. PMID: 24771552

Diagnosis

Mastracci L, Rindi G, Grillo F, Solcia E, Campora M, Fassan M, Parente P, Vanoli A, La Rosa S
Pathologica 2021 Feb;113(1):5-11. doi: 10.32074/1591-951X-229. PMID: 33686305Free PMC Article
El Rassy E, Tabchi S, Kourie HR, Assi T, Chebib R, Farhat F, Kattan J
Clin Res Hepatol Gastroenterol 2016 Jun;40(3):276-280. Epub 2015 Nov 11 doi: 10.1016/j.clinre.2015.09.010. PMID: 26566245
Sorbye H, Strosberg J, Baudin E, Klimstra DS, Yao JC
Cancer 2014 Sep 15;120(18):2814-23. Epub 2014 Apr 25 doi: 10.1002/cncr.28721. PMID: 24771552
Chan JK
Int J Surg Pathol 2014 Feb;22(1):12-32. Epub 2014 Jan 9 doi: 10.1177/1066896913517939. PMID: 24406626
Pepe G, Moncayo R, Bombardieri E, Chiti A
Eur J Nucl Med Mol Imaging 2012 Feb;39 Suppl 1:S41-51. doi: 10.1007/s00259-011-2019-2. PMID: 22388628

Therapy

Singhal A, Li BT, O'Reilly EM
Nat Med 2024 Apr;30(4):969-983. Epub 2024 Apr 18 doi: 10.1038/s41591-024-02903-0. PMID: 38637634
Wei D, Wang L, Zuo X, Maitra A, Bresalier RS
Clin Cancer Res 2024 Feb 16;30(4):655-662. doi: 10.1158/1078-0432.CCR-23-2098. PMID: 37831007Free PMC Article
Goodwin CM, Waters AM, Klomp JE, Javaid S, Bryant KL, Stalnecker CA, Drizyte-Miller K, Papke B, Yang R, Amparo AM, Ozkan-Dagliyan I, Baldelli E, Calvert V, Pierobon M, Sorrentino JA, Beelen AP, Bublitz N, Lüthen M, Wood KC, Petricoin EF, Sers C, McRee AJ, Cox AD, Der CJ
Cancer Res 2023 Jan 4;83(1):141-157. doi: 10.1158/0008-5472.CAN-22-0391. PMID: 36346366Free PMC Article
Pandit B, Royzen M
Genes (Basel) 2022 Mar 5;13(3) doi: 10.3390/genes13030466. PMID: 35328020Free PMC Article
Brahmer JR, Tykodi SS, Chow LQ, Hwu WJ, Topalian SL, Hwu P, Drake CG, Camacho LH, Kauh J, Odunsi K, Pitot HC, Hamid O, Bhatia S, Martins R, Eaton K, Chen S, Salay TM, Alaparthy S, Grosso JF, Korman AJ, Parker SM, Agrawal S, Goldberg SM, Pardoll DM, Gupta A, Wigginton JM
N Engl J Med 2012 Jun 28;366(26):2455-65. Epub 2012 Jun 2 doi: 10.1056/NEJMoa1200694. PMID: 22658128Free PMC Article

Prognosis

Mastracci L, Rindi G, Grillo F, Solcia E, Campora M, Fassan M, Parente P, Vanoli A, La Rosa S
Pathologica 2021 Feb;113(1):5-11. doi: 10.32074/1591-951X-229. PMID: 33686305Free PMC Article
Elosua-Bayes M, Nieto P, Mereu E, Gut I, Heyn H
Nucleic Acids Res 2021 May 21;49(9):e50. doi: 10.1093/nar/gkab043. PMID: 33544846Free PMC Article
Steins M, Thomas M, Geißler M
Recent Results Cancer Res 2018;211:1-17. doi: 10.1007/978-3-319-91442-8_1. PMID: 30069756
Sorbye H, Strosberg J, Baudin E, Klimstra DS, Yao JC
Cancer 2014 Sep 15;120(18):2814-23. Epub 2014 Apr 25 doi: 10.1002/cncr.28721. PMID: 24771552
Steins M, Thomas M, Geissler M
Recent Results Cancer Res 2010;184:21-31. doi: 10.1007/978-3-642-01222-8_2. PMID: 20072828

Clinical prediction guides

Mastracci L, Rindi G, Grillo F, Solcia E, Campora M, Fassan M, Parente P, Vanoli A, La Rosa S
Pathologica 2021 Feb;113(1):5-11. doi: 10.32074/1591-951X-229. PMID: 33686305Free PMC Article
Naito T, Mitsunaga S, Miura S, Tatematsu N, Inano T, Mouri T, Tsuji T, Higashiguchi T, Inui A, Okayama T, Yamaguchi T, Morikawa A, Mori N, Takahashi T, Strasser F, Omae K, Mori K, Takayama K
J Cachexia Sarcopenia Muscle 2019 Feb;10(1):73-83. Epub 2018 Oct 18 doi: 10.1002/jcsm.12351. PMID: 30334618Free PMC Article
Steins M, Thomas M, Geißler M
Recent Results Cancer Res 2018;211:1-17. doi: 10.1007/978-3-319-91442-8_1. PMID: 30069756
Gao H, Korn JM, Ferretti S, Monahan JE, Wang Y, Singh M, Zhang C, Schnell C, Yang G, Zhang Y, Balbin OA, Barbe S, Cai H, Casey F, Chatterjee S, Chiang DY, Chuai S, Cogan SM, Collins SD, Dammassa E, Ebel N, Embry M, Green J, Kauffmann A, Kowal C, Leary RJ, Lehar J, Liang Y, Loo A, Lorenzana E, Robert McDonald E 3rd, McLaughlin ME, Merkin J, Meyer R, Naylor TL, Patawaran M, Reddy A, Röelli C, Ruddy DA, Salangsang F, Santacroce F, Singh AP, Tang Y, Tinetto W, Tobler S, Velazquez R, Venkatesan K, Von Arx F, Wang HQ, Wang Z, Wiesmann M, Wyss D, Xu F, Bitter H, Atadja P, Lees E, Hofmann F, Li E, Keen N, Cozens R, Jensen MR, Pryer NK, Williams JA, Sellers WR
Nat Med 2015 Nov;21(11):1318-25. Epub 2015 Oct 19 doi: 10.1038/nm.3954. PMID: 26479923
Chan JK
Int J Surg Pathol 2014 Feb;22(1):12-32. Epub 2014 Jan 9 doi: 10.1177/1066896913517939. PMID: 24406626

Recent systematic reviews

Bellefkih FZ, Benchakroun N, Lalya I, Amaoui B, El Kacemi H, Acharki A, El Hfid M, El Mazghi A, Chekrine T, Bouchbika Z, Jouhadi H, Sahraoui S, Tawfiq N, Michalet M
Cancer Radiother 2023 Sep;27(6-7):622-637. Epub 2023 Jul 25 doi: 10.1016/j.canrad.2023.06.010. PMID: 37500390
Rodger FE, Brennan PT, Nair R, Holroyd DJ
Surg Oncol 2022 Sep;44:101819. Epub 2022 Jul 20 doi: 10.1016/j.suronc.2022.101819. PMID: 35940030
Gadducci A, Carinelli S, Aletti G
Gynecol Oncol 2017 Mar;144(3):637-646. Epub 2017 Jan 3 doi: 10.1016/j.ygyno.2016.12.003. PMID: 28057354
Servato JP, da Silva SJ, de Faria PR, Cardoso SV, Loyola AM
Int J Oral Maxillofac Surg 2013 Jan;42(1):89-98. Epub 2012 Nov 3 doi: 10.1016/j.ijom.2012.10.004. PMID: 23131461
Isidori AM, Lenzi A
Arq Bras Endocrinol Metabol 2007 Nov;51(8):1217-25. doi: 10.1590/s0004-27302007000800007. PMID: 18209859

Supplemental Content

Table of contents

    Clinical resources

    Practice guidelines

    • PubMed
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      See practice and clinical guidelines in NCBI Bookshelf. The search results may include broader topics and may not capture all published guidelines. See the FAQ for details.

    Curated

    • NCCN, 2023
      NCCN Clinical Practice Guidelines in Oncology (NCCN Guidelines®), Neuroendocrine and Adrenal Tumors, 2023

    Consumer resources

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