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Digestive System Neuroendocrine Carcinoma

MedGen UID:
459354
Concept ID:
C2987128
Neoplastic Process
Synonyms: Gastrointestinal NEC; Gastrointestinal NEC G3; Gastrointestinal Neuroendocrine Carcinoma; Gastrointestinal System Neuroendocrine Carcinoma

Definition

A high grade poorly differentiated carcinoma arising from the digestive system. It is composed of small or large neoplastic cells that express immunohistochemical evidence of neuroendocrine differentiation. There is marked nuclear atypia, necrosis, and more than 20 mitoses per 10 HPF. [from NCI]

Term Hierarchy

CClinical test,  RResearch test,  OOMIM,  GGeneReviews,  VClinVar  
  • CROGVDigestive System Neuroendocrine Carcinoma

Professional guidelines

PubMed

Xu G, Wang Y, Zhang H, She X, Yang J
Future Oncol 2021 Mar;17(9):1069-1081. Epub 2020 Nov 2 doi: 10.2217/fon-2020-0703. PMID: 33136448
Gonzalez RS
Surg Pathol Clin 2020 Sep;13(3):377-397. doi: 10.1016/j.path.2020.04.002. PMID: 32773190
Parbhu SK, Adler DG
Hosp Pract (1995) 2016 Aug;44(3):109-19. Epub 2016 Jul 18 doi: 10.1080/21548331.2016.1210474. PMID: 27404266

Recent clinical studies

Etiology

Köhler F, Matthes N, Rosenfeldt M, Kunzmann V, Germer CT, Wiegering A
Dtsch Arztebl Int 2023 Aug 7;120(31-32):519-525. doi: 10.3238/arztebl.m2023.0136. PMID: 37282595Free PMC Article
Konukiewitz B, Jesinghaus M, Kasajima A, Klöppel G
Virchows Arch 2022 Feb;480(2):247-257. Epub 2021 Oct 13 doi: 10.1007/s00428-021-03211-5. PMID: 34647171Free PMC Article
Volante M, Grillo F, Massa F, Maletta F, Mastracci L, Campora M, Ferro J, Vanoli A, Papotti M
Pathologica 2021 Feb;113(1):19-27. doi: 10.32074/1591-951X-230. PMID: 33686307Free PMC Article
Mastracci L, Rindi G, Grillo F, Solcia E, Campora M, Fassan M, Parente P, Vanoli A, La Rosa S
Pathologica 2021 Feb;113(1):5-11. doi: 10.32074/1591-951X-229. PMID: 33686305Free PMC Article
Waldum HL, Fossmark R
Int J Mol Sci 2018 Dec 18;19(12) doi: 10.3390/ijms19124109. PMID: 30567376Free PMC Article

Diagnosis

Konukiewitz B, Jesinghaus M, Kasajima A, Klöppel G
Virchows Arch 2022 Feb;480(2):247-257. Epub 2021 Oct 13 doi: 10.1007/s00428-021-03211-5. PMID: 34647171Free PMC Article
Volante M, Grillo F, Massa F, Maletta F, Mastracci L, Campora M, Ferro J, Vanoli A, Papotti M
Pathologica 2021 Feb;113(1):19-27. doi: 10.32074/1591-951X-230. PMID: 33686307Free PMC Article
Mastracci L, Rindi G, Grillo F, Solcia E, Campora M, Fassan M, Parente P, Vanoli A, La Rosa S
Pathologica 2021 Feb;113(1):5-11. doi: 10.32074/1591-951X-229. PMID: 33686305Free PMC Article
Dhillon J, Betancourt M
Monogr Clin Cytol 2020;26:74-91. Epub 2020 Sep 28 doi: 10.1159/000455736. PMID: 32987385
Gonzalez RS
Surg Pathol Clin 2020 Sep;13(3):377-397. doi: 10.1016/j.path.2020.04.002. PMID: 32773190

Therapy

Simon TG, Wilechansky RM, Stoyanova S, Grossman A, Dichtel LE, Lauer GM, Miller KK, Hoshida Y, Corey KE, Loomba R, Chung RT, Chan AT
JAMA 2024 Mar 19;331(11):920-929. doi: 10.1001/jama.2024.1215. PMID: 38502074Free PMC Article
Pan WX, Zhang XM, Hao SL, Han W
World J Gastroenterol 2023 Jul 14;29(26):4174-4185. doi: 10.3748/wjg.v29.i26.4174. PMID: 37475845Free PMC Article
Köhler F, Matthes N, Rosenfeldt M, Kunzmann V, Germer CT, Wiegering A
Dtsch Arztebl Int 2023 Aug 7;120(31-32):519-525. doi: 10.3238/arztebl.m2023.0136. PMID: 37282595Free PMC Article
Morizane C, Machida N, Honma Y, Okusaka T, Boku N, Kato K, Nomura S, Hiraoka N, Sekine S, Taniguchi H, Okano N, Yamaguchi K, Sato T, Ikeda M, Mizuno N, Ozaka M, Kataoka T, Ueno M, Kitagawa Y, Terashima M, Furuse J; Japan Clinical Oncology Group (JCOG)
JAMA Oncol 2022 Oct 1;8(10):1447-1455. doi: 10.1001/jamaoncol.2022.3395. PMID: 35980649Free PMC Article
Rindi G, Wiedenmann B
Nat Rev Endocrinol 2011 Aug 2;8(1):54-64. doi: 10.1038/nrendo.2011.120. PMID: 21808296

Prognosis

Sok C, Ajay PS, Tsagkalidis V, Kooby DA, Shah MM
Ann Surg Oncol 2024 Mar;31(3):1509-1518. Epub 2023 Dec 7 doi: 10.1245/s10434-023-14712-9. PMID: 38062290Free PMC Article
Mathiesen JS, Effraimidis G, Rossing M, Rasmussen ÅK, Hoejberg L, Bastholt L, Godballe C, Oturai P, Feldt-Rasmussen U
Semin Cancer Biol 2022 Feb;79:163-179. Epub 2021 Apr 1 doi: 10.1016/j.semcancer.2021.03.035. PMID: 33812987
Volante M, Grillo F, Massa F, Maletta F, Mastracci L, Campora M, Ferro J, Vanoli A, Papotti M
Pathologica 2021 Feb;113(1):19-27. doi: 10.32074/1591-951X-230. PMID: 33686307Free PMC Article
Mastracci L, Rindi G, Grillo F, Solcia E, Campora M, Fassan M, Parente P, Vanoli A, La Rosa S
Pathologica 2021 Feb;113(1):5-11. doi: 10.32074/1591-951X-229. PMID: 33686305Free PMC Article
Waldum HL, Fossmark R
Int J Mol Sci 2018 Dec 18;19(12) doi: 10.3390/ijms19124109. PMID: 30567376Free PMC Article

Clinical prediction guides

Padilla J, Osman NM, Bissig-Choisat B, Grimm SL, Qin X, Major AM, Yang L, Lopez-Terrada D, Coarfa C, Li F, Bissig KD, Moore DD, Fu L
J Hepatol 2024 Feb;80(2):282-292. Epub 2023 Oct 27 doi: 10.1016/j.jhep.2023.10.018. PMID: 37890720Free PMC Article
Mastracci L, Rindi G, Grillo F, Solcia E, Campora M, Fassan M, Parente P, Vanoli A, La Rosa S
Pathologica 2021 Feb;113(1):5-11. doi: 10.32074/1591-951X-229. PMID: 33686305Free PMC Article
Washington MK, Goldberg RM, Chang GJ, Limburg P, Lam AK, Salto-Tellez M, Arends MJ, Nagtegaal ID, Klimstra DS, Rugge M, Schirmacher P, Lazar AJ, Odze RD, Carneiro F, Fukayama M, Cree IA; WHO Classification of Tumours Editorial Board
Int J Cancer 2021 Mar 1;148(5):1040-1050. Epub 2020 Nov 19 doi: 10.1002/ijc.33210. PMID: 32674220
Yan J, Yu S, Jia C, Li M, Chen J
Biochim Biophys Acta Rev Cancer 2020 Aug;1874(1):188367. Epub 2020 Apr 25 doi: 10.1016/j.bbcan.2020.188367. PMID: 32339609
Roncati L, Gasparri P, Gallo G, Bernardelli G, Zanelli G, Manenti A
Adv Exp Med Biol 2020;1226:87-95. doi: 10.1007/978-3-030-36214-0_7. PMID: 32030678

Recent systematic reviews

Kmiotek E, Lakda S, Borakati A, Ogunbiyi O, Mandair D, Caplin M, Toumpanakis C, Mirnezami R
Curr Oncol 2023 Oct 18;30(10):9192-9204. doi: 10.3390/curroncol30100664. PMID: 37887564Free PMC Article
Ziogas IA, Rallis KS, Tasoudis PT, Moris D, Schulick RD, Del Chiaro M
Eur J Surg Oncol 2023 Apr;49(4):682-687. Epub 2023 Jan 9 doi: 10.1016/j.ejso.2023.01.005. PMID: 36646615
Manuel-Vazquez A, Ramia JM, Latorre-Fragua R, Valle-Rubio A, Arteaga-Peralta V, Ramiro-Pérez C, de la Plaza-Llamas R
Pancreas 2018 May/Jun;47(5):551-555. doi: 10.1097/MPA.0000000000001048. PMID: 29683974
Ravaioli M, Ercolani G, Neri F, Cescon M, Stacchini G, Del Gaudio M, Cucchetti A, Pinna AD
World J Gastroenterol 2014 May 14;20(18):5345-52. doi: 10.3748/wjg.v20.i18.5345. PMID: 24833864Free PMC Article
Gioacchini FM, Postacchini V, Simonetti O, Offidani A, Magliulo G, Re M
Eur Arch Otorhinolaryngol 2013 Aug;270(8):2191-9. Epub 2012 Nov 29 doi: 10.1007/s00405-012-2283-1. PMID: 23192664

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