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Neuroendocrine Carcinoma of Unknown Primary

MedGen UID:
1720013
Concept ID:
C5235863
Neoplastic Process

Definition

A neuroendocrine carcinoma that has metastasized from an unknown primary site. [from NCI]

Term Hierarchy

CClinical test,  RResearch test,  OOMIM,  GGeneReviews,  VClinVar  
  • CROGVNeuroendocrine Carcinoma of Unknown Primary

Professional guidelines

PubMed

Fennig S, Landman Y, Brenner R, Billan S, Fenig E
Cancer Med 2022 Mar;11(6):1484-1489. Epub 2022 Feb 6 doi: 10.1002/cam4.4562. PMID: 35128847Free PMC Article
Bochtler T, Löffler H, Krämer A
Semin Diagn Pathol 2018 May;35(3):199-206. Epub 2017 Nov 26 doi: 10.1053/j.semdp.2017.11.013. PMID: 29203116
Ghosh L, Dahut W, Kakar S, Posadas EM, Torres CG, Cancel-Santiago R, Ghosh BC
Curr Probl Surg 2005 Jan;42(1):12-66. doi: 10.1067/j.cpsurg.2004.10.002. PMID: 15711508

Recent clinical studies

Etiology

Simon TG, Wilechansky RM, Stoyanova S, Grossman A, Dichtel LE, Lauer GM, Miller KK, Hoshida Y, Corey KE, Loomba R, Chung RT, Chan AT
JAMA 2024 Mar 19;331(11):920-929. doi: 10.1001/jama.2024.1215. PMID: 38502074Free PMC Article
Okumura T, Noguchi T, Sekiguchi N, Kobayashi T, Kanda S, Ida K, Minagawa T, Tokumaru S, Umemura T, Koizumi T
Chemotherapy 2023;68(2):87-94. Epub 2022 Nov 3 doi: 10.1159/000527377. PMID: 36327945
Hui JYC, Prathibha S, White M, Praska CE, LaRocca CJ, Ankeny J, Domingo-Musibay E, Fiessinger L, Jensen EH, Tuttle TM, Marmor S
J Am Acad Dermatol 2023 Feb;88(2):465-467. Epub 2022 Jun 14 doi: 10.1016/j.jaad.2022.06.015. PMID: 35714787
Broida SE, Chen XT, Baum CL, Brewer JD, Block MS, Jakub JW, Pockaj BA, Foote RL, Markovic SN, Hieken TJ, Houdek MT
J Surg Oncol 2022 Nov;126(6):1080-1086. Epub 2022 Jul 9 doi: 10.1002/jso.27010. PMID: 35809230
Bochtler T, Löffler H, Krämer A
Semin Diagn Pathol 2018 May;35(3):199-206. Epub 2017 Nov 26 doi: 10.1053/j.semdp.2017.11.013. PMID: 29203116

Diagnosis

Rindi G, Mete O, Uccella S, Basturk O, La Rosa S, Brosens LAA, Ezzat S, de Herder WW, Klimstra DS, Papotti M, Asa SL
Endocr Pathol 2022 Mar;33(1):115-154. Epub 2022 Mar 16 doi: 10.1007/s12022-022-09708-2. PMID: 35294740
Ambrosini V, Kunikowska J, Baudin E, Bodei L, Bouvier C, Capdevila J, Cremonesi M, de Herder WW, Dromain C, Falconi M, Fani M, Fanti S, Hicks RJ, Kabasakal L, Kaltsas G, Lewington V, Minozzi S, Cinquini M, Öberg K, Oyen WJG, O'Toole D, Pavel M, Ruszniewski P, Scarpa A, Strosberg J, Sundin A, Taïeb D, Virgolini I, Wild D, Herrmann K, Yao J
Eur J Cancer 2021 Mar;146:56-73. Epub 2021 Feb 12 doi: 10.1016/j.ejca.2021.01.008. PMID: 33588146Free PMC Article
Bellizzi AM
Hum Pathol 2020 Feb;96:8-33. Epub 2019 Dec 17 doi: 10.1016/j.humpath.2019.12.002. PMID: 31857137Free PMC Article
Stelow EB, Yaziji H
Semin Diagn Pathol 2018 Mar;35(2):143-152. Epub 2017 Nov 23 doi: 10.1053/j.semdp.2017.11.012. PMID: 29224972
Ghosh L, Dahut W, Kakar S, Posadas EM, Torres CG, Cancel-Santiago R, Ghosh BC
Curr Probl Surg 2005 Jan;42(1):12-66. doi: 10.1067/j.cpsurg.2004.10.002. PMID: 15711508

Therapy

Simon TG, Wilechansky RM, Stoyanova S, Grossman A, Dichtel LE, Lauer GM, Miller KK, Hoshida Y, Corey KE, Loomba R, Chung RT, Chan AT
JAMA 2024 Mar 19;331(11):920-929. doi: 10.1001/jama.2024.1215. PMID: 38502074Free PMC Article
Rowell NP
Br J Radiol 2023 Aug;96(1148):20220660. Epub 2023 Jun 29 doi: 10.1259/bjr.20220660. PMID: 37335288Free PMC Article
Walter T, Lievre A, Coriat R, Malka D, Elhajbi F, Di Fiore F, Hentic O, Smith D, Hautefeuille V, Roquin G, Perrier M, Dahan L, Granger V, Sobhani I, Mineur L, Niccoli P, Assenat E, Scoazec JY, Le Malicot K, Lepage C, Lombard-Bohas C
Lancet Oncol 2023 Mar;24(3):297-306. Epub 2023 Feb 2 doi: 10.1016/S1470-2045(23)00001-3. PMID: 36739879
Hadoux J, Walter T, Kanaan C, Hescot S, Hautefeuille V, Perrier M, Tauveron I, Laboureau S, Do Cao C, Petorin C, Blanchet O, Faron M, Leteurtre E, Rousselet MC, Joubert Zakeyh J, Marchal A, Chatelain D, Beaulaton C, Hervieu V, Lombard-Bohas C, Ducreux M, Scoazec JY, Baudin E; Groupe d’Etude des Tumeurs Endocrines (GTE); ENDOCAN-RENATEN network
Endocr Relat Cancer 2022 Oct 1;29(10):569-580. Epub 2022 Aug 17 doi: 10.1530/ERC-22-0102. PMID: 35920609
Ambrosini V, Kunikowska J, Baudin E, Bodei L, Bouvier C, Capdevila J, Cremonesi M, de Herder WW, Dromain C, Falconi M, Fani M, Fanti S, Hicks RJ, Kabasakal L, Kaltsas G, Lewington V, Minozzi S, Cinquini M, Öberg K, Oyen WJG, O'Toole D, Pavel M, Ruszniewski P, Scarpa A, Strosberg J, Sundin A, Taïeb D, Virgolini I, Wild D, Herrmann K, Yao J
Eur J Cancer 2021 Mar;146:56-73. Epub 2021 Feb 12 doi: 10.1016/j.ejca.2021.01.008. PMID: 33588146Free PMC Article

Prognosis

Simon TG, Wilechansky RM, Stoyanova S, Grossman A, Dichtel LE, Lauer GM, Miller KK, Hoshida Y, Corey KE, Loomba R, Chung RT, Chan AT
JAMA 2024 Mar 19;331(11):920-929. doi: 10.1001/jama.2024.1215. PMID: 38502074Free PMC Article
Fennig S, Landman Y, Brenner R, Billan S, Fenig E
Cancer Med 2022 Mar;11(6):1484-1489. Epub 2022 Feb 6 doi: 10.1002/cam4.4562. PMID: 35128847Free PMC Article
Bellizzi AM
Hum Pathol 2020 Feb;96:8-33. Epub 2019 Dec 17 doi: 10.1016/j.humpath.2019.12.002. PMID: 31857137Free PMC Article
Stelow EB, Yaziji H
Semin Diagn Pathol 2018 Mar;35(2):143-152. Epub 2017 Nov 23 doi: 10.1053/j.semdp.2017.11.012. PMID: 29224972
Ghosh L, Dahut W, Kakar S, Posadas EM, Torres CG, Cancel-Santiago R, Ghosh BC
Curr Probl Surg 2005 Jan;42(1):12-66. doi: 10.1067/j.cpsurg.2004.10.002. PMID: 15711508

Clinical prediction guides

Ren M, Cai X, Jia L, Bai Q, Zhu X, Hu X, Wang Q, Luo Z, Zhou X
BMC Cancer 2023 Dec 1;23(1):1175. doi: 10.1186/s12885-023-11563-1. PMID: 38041048Free PMC Article
Ogawa T, Donizy P, Wu CL, Cornejo KM, Ryś J, Hoang MP
Am J Dermatopathol 2020 Sep;42(9):629-640. doi: 10.1097/DAD.0000000000001548. PMID: 32833736
Bellizzi AM
Hum Pathol 2020 Feb;96:8-33. Epub 2019 Dec 17 doi: 10.1016/j.humpath.2019.12.002. PMID: 31857137Free PMC Article
Stelow EB, Yaziji H
Semin Diagn Pathol 2018 Mar;35(2):143-152. Epub 2017 Nov 23 doi: 10.1053/j.semdp.2017.11.012. PMID: 29224972
Bochtler T, Löffler H, Krämer A
Semin Diagn Pathol 2018 May;35(3):199-206. Epub 2017 Nov 26 doi: 10.1053/j.semdp.2017.11.013. PMID: 29203116

Recent systematic reviews

Ostojewska J, Wieczorek I, Pachciński O, Zdziennicki W, Burdan F
Folia Med Cracov 2023 Apr 30;63(1):19-37. doi: 10.24425/fmc.2023.145427. PMID: 37406274
Rowell NP
Br J Radiol 2023 Aug;96(1148):20220660. Epub 2023 Jun 29 doi: 10.1259/bjr.20220660. PMID: 37335288Free PMC Article
Shinogi T, Nagase K, Inoue T, Sato K, Onita A, Takamori A, Narisawa Y
J Dermatol 2021 Jul;48(7):1027-1034. Epub 2021 Apr 13 doi: 10.1111/1346-8138.15875. PMID: 33847013
Girardi DM, Silva ACB, Rêgo JFM, Coudry RA, Riechelmann RP
Cancer Treat Rev 2017 May;56:28-35. Epub 2017 Apr 17 doi: 10.1016/j.ctrv.2017.04.002. PMID: 28456055
Stoyianni A, Pentheroudakis G, Pavlidis N
Cancer Treat Rev 2011 Aug;37(5):358-65. Epub 2011 Apr 9 doi: 10.1016/j.ctrv.2011.03.002. PMID: 21481536

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