Esophageal Neuroendocrine Tumor G1

MedGen UID:: 232157
•Concept ID:: C1333444
•: Neoplastic Process

Synonym:

Esophageal NET G1

Definition

A rare, well differentiated, low grade neoplasm with neuroendocrine differentiation that arises from the esophagus. The mitotic count is less than 2 per 10 HPF and/or the Ki67 index is equal to or less than 2 percent. The majority of cases have a polypoid appearance, are small lesions, and found incidentally. [from NCI]

Term Hierarchy

GTR
MeSH

CClinical test, RResearch test, OOMIM, GGeneReviews, VClinVar

CROGVEsophageal Neuroendocrine Tumor G1

Neoplasm
- Epithelial neoplasm
  - Carcinoma
    - Adenocarcinoma
      - Carcinoid tumor
        Digestive System Neuroendocrine Tumor G1
        Esophageal Neuroendocrine Tumor G1

Recent clinical studies

Etiology

Safety and efficacy of the FLOT regimen in the Polish population - an analysis of the prospective trial.

Marcisz-Grzanka K, Winiarek M, Pałucki J, Wieszczy P, Olesiński T, Jóźwiak M, Samsel R, Sułkowska U, Kolasińska-Ćwikła A, Wyrwicz LS
Neoplasma 2022 Dec;69(6):1445-1450. Epub 2022 Nov 11 doi: 10.4149/neo_2022_220720N734. PMID: 36353936

Nationwide registry for patients with neuroendocrine neoplasm of pancreas, gastrointestinal tract, lungs, bronchi, or thymus in Japan.

Masui T, Ito T, Komoto I, Kojima S, Kasai Y, Tanabe M, Hara K, Hirano S, Okusaka T, Ichikawa Y, Kinugasa Y, Kokudo N, Kudo A, Sakurai A, Sugihara K, Date H, Haruma K, Hijioka S, Hirata K, Yamano H, Sakamine M, Kikuchi T, Fukushima M, Imamura M, Uemoto S
Int J Clin Oncol 2022 May;27(5):840-849. Epub 2022 Feb 18 doi: 10.1007/s10147-022-02130-y. PMID: 35178624 Free PMC Article

Digestive Neuroendocrine Tumor Distribution and Characteristics According to the 2010 WHO Classification: a Single Institution Experience in Lebanon.

Kourie HR, Ghorra C, Rassy M, Kesserouani C, Kattan J
Asian Pac J Cancer Prev 2016;17(5):2679-81. PMID: 27268650

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Diagnosis

Nationwide registry for patients with neuroendocrine neoplasm of pancreas, gastrointestinal tract, lungs, bronchi, or thymus in Japan.

A Case of Pedunculated Esophageal Neuroendocrine Tumor G1.

Aoki H, Omori Y, Katanuma A
Clin Gastroenterol Hepatol 2022 Apr;20(4):e651-e652. Epub 2021 Mar 1 doi: 10.1016/j.cgh.2021.02.039. PMID: 33662595

Digestive Neuroendocrine Tumor Distribution and Characteristics According to the 2010 WHO Classification: a Single Institution Experience in Lebanon.

Kourie HR, Ghorra C, Rassy M, Kesserouani C, Kattan J
Asian Pac J Cancer Prev 2016;17(5):2679-81. PMID: 27268650

Endoscopic submucosal dissection for foregut neuroendocrine tumors: an initial study.

Li QL, Zhang YQ, Chen WF, Xu MD, Zhong YS, Ma LL, Qin WZ, Hu JW, Cai MY, Yao LQ, Zhou PH
World J Gastroenterol 2012 Oct 28;18(40):5799-806. doi: 10.3748/wjg.v18.i40.5799. PMID: 23155323 Free PMC Article

Use of the succinate dehydrogenase inhibition test in assessing the heat sensitivity of tumor cells.

Kohnoe S, Maehara Y, Takahashi I, Yoshida M, Emi Y, Kusumoto T, Sugimachi K
Oncology 1993 Nov-Dec;50(6):500-4. doi: 10.1159/000227236. PMID: 8233294

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Therapy

Safety and efficacy of the FLOT regimen in the Polish population - an analysis of the prospective trial.

Digestive Neuroendocrine Tumor Distribution and Characteristics According to the 2010 WHO Classification: a Single Institution Experience in Lebanon.

Kourie HR, Ghorra C, Rassy M, Kesserouani C, Kattan J
Asian Pac J Cancer Prev 2016;17(5):2679-81. PMID: 27268650

The immunomodulator PSK induces in vitro cytotoxic activity in tumour cell lines via arrest of cell cycle and induction of apoptosis.

Jiménez-Medina E, Berruguilla E, Romero I, Algarra I, Collado A, Garrido F, Garcia-Lora A
BMC Cancer 2008 Mar 24;8:78. doi: 10.1186/1471-2407-8-78. PMID: 18366723 Free PMC Article

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