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Endometrial endometrioid adenocarcinoma with spindled epithelial cells

MedGen UID:
234979
•Concept ID:
C1336913
•
Neoplastic Process
Synonyms: Endometrial Endometrioid Adenocarcinoma with Spindled Epithelial Cells; endometrial endometrioid adenocarcinoma with spindled epithelial cells; Sarcomatoid Uterine Corpus Endometrioid Adenocarcinoma; sarcomatoid uterine corpus endometrioid adenocarcinoma
 
Monarch Initiative: MONDO:0004220

Definition

A primary endometrioid adenocarcinoma of the endometrium characterized by the presence of spindled malignant epithelial cells. [from NCI]

Term Hierarchy

CClinical test,  RResearch test,  OOMIM,  GGeneReviews,  VClinVar  
  • CROGVEndometrial endometrioid adenocarcinoma with spindled epithelial cells

Professional guidelines

PubMed

The value of SOX2 in the differential diagnosis of SMARCA4 (BRG1)-deficient uterine neoplasms.
Zheng L, Zhang L, Wang XI, Katz G, Tandon N, Zhao B, Lucci J, Ding J, Zhang S
Hum Pathol 2022 Jun;124:45-55. Epub 2022 Mar 22 doi: 10.1016/j.humpath.2022.03.009. PMID: 35331811

Recent clinical studies

Diagnosis

Low grade endometrial endometrioid adenocarcinoma: A review and update with emphasis on morphologic variants, mimics, immunohistochemical and molecular features.
Lucas E, Carrick KS
Semin Diagn Pathol 2022 May;39(3):159-175. Epub 2022 Feb 11 doi: 10.1053/j.semdp.2022.02.002. PMID: 35397943
The value of SOX2 in the differential diagnosis of SMARCA4 (BRG1)-deficient uterine neoplasms.
Zheng L, Zhang L, Wang XI, Katz G, Tandon N, Zhao B, Lucci J, Ding J, Zhang S
Hum Pathol 2022 Jun;124:45-55. Epub 2022 Mar 22 doi: 10.1016/j.humpath.2022.03.009. PMID: 35331811
Corded and Hyalinized and Spindled Endometrioid Endometrial Carcinoma: A Clinicopathologic and Molecular Analysis of 9 Tumors Based on the TCGA Classifier.
Safdar NS, Thompson EF, Gilks CB, Isacson C, Bennett JA, Clarke B, Young RH, Oliva E
Am J Surg Pathol 2021 Aug 1;45(8):1038-1046. doi: 10.1097/PAS.0000000000001737. PMID: 34115671
Pathologic and molecular features of uterine carcinosarcomas.
Lopez-Garcia MA, Palacios J
Semin Diagn Pathol 2010 Nov;27(4):274-86. doi: 10.1053/j.semdp.2010.09.005. PMID: 21309261
Endometrioid carcinoma of the uterine corpus: a review of its pathology with emphasis on recent advances and problematic aspects.
Clement PB, Young RH
Adv Anat Pathol 2002 May;9(3):145-84. doi: 10.1097/00125480-200205000-00001. PMID: 11981113

Prognosis

The value of SOX2 in the differential diagnosis of SMARCA4 (BRG1)-deficient uterine neoplasms.
Zheng L, Zhang L, Wang XI, Katz G, Tandon N, Zhao B, Lucci J, Ding J, Zhang S
Hum Pathol 2022 Jun;124:45-55. Epub 2022 Mar 22 doi: 10.1016/j.humpath.2022.03.009. PMID: 35331811
Pathologic and molecular features of uterine carcinosarcomas.
Lopez-Garcia MA, Palacios J
Semin Diagn Pathol 2010 Nov;27(4):274-86. doi: 10.1053/j.semdp.2010.09.005. PMID: 21309261
Endometrioid carcinomas of the uterine corpus with sex cord-like formations, hyalinization, and other unusual morphologic features: a report of 31 cases of a neoplasm that may be confused with carcinosarcoma and other uterine neoplasms.
Murray SK, Clement PB, Young RH
Am J Surg Pathol 2005 Feb;29(2):157-66. doi: 10.1097/01.pas.0000149704.89463.05. PMID: 15644772
Endometrioid carcinoma of the ovary with a prominent spindle-cell component, a source of diagnostic confusion. A report of 14 cases.
Tornos C, Silva EG, Ordonez NG, Gershenson DM, Young RH, Scully RE
Am J Surg Pathol 1995 Dec;19(12):1343-53. doi: 10.1097/00000478-199512000-00001. PMID: 7503356

Clinical prediction guides

Pathologic and molecular features of uterine carcinosarcomas.
Lopez-Garcia MA, Palacios J
Semin Diagn Pathol 2010 Nov;27(4):274-86. doi: 10.1053/j.semdp.2010.09.005. PMID: 21309261

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