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Metastatic Thyroid Gland Medullary Carcinoma

MedGen UID:
1687138
•Concept ID:
C5206759
•
Neoplastic Process

Definition

A thyroid gland medullary carcinoma that has spread from the original site of growth to another anatomic site. [from NCI]

Term Hierarchy

CClinical test,  RResearch test,  OOMIM,  GGeneReviews,  VClinVar  
  • CROGVMetastatic Thyroid Gland Medullary Carcinoma

Professional guidelines

PubMed

Advances in the management of MEN2: from improved surgical and medical treatment to novel kinase inhibitors.
Wells SA Jr
Endocr Relat Cancer 2018 Feb;25(2):T1-T13. Epub 2017 Nov 15 doi: 10.1530/ERC-17-0325. PMID: 29142004Free PMC Article
Genetics, diagnosis, and management of medullary thyroid carcinoma and pheochromocytoma/paraganglioma.
Moraitis AG, Martucci VL, Pacak K
Endocr Pract 2014 Feb;20(2):176-87. doi: 10.4158/EP13268.RA. PMID: 24449662
Incretin-based therapies in the treatment of type 2 diabetes--more than meets the eye?
Labuzek K, Kozłowski M, Szkudłapski D, Sikorska P, Kozłowska M, Okopień B
Eur J Intern Med 2013 Apr;24(3):207-12. Epub 2013 Jan 31 doi: 10.1016/j.ejim.2013.01.009. PMID: 23375875

Recent clinical studies

Etiology

Update on C-Cell Neuroendocrine Neoplasm: Prognostic and Predictive Histopathologic and Molecular Features of Medullary Thyroid Carcinoma.
Jung CK, Agarwal S, Hang JF, Lim DJ, Bychkov A, Mete O
Endocr Pathol 2023 Mar;34(1):1-22. Epub 2023 Mar 8 doi: 10.1007/s12022-023-09753-5. PMID: 36890425
Overview of the 2022 WHO Classification of Thyroid Neoplasms.
Baloch ZW, Asa SL, Barletta JA, Ghossein RA, Juhlin CC, Jung CK, LiVolsi VA, Papotti MG, Sobrinho-Simões M, Tallini G, Mete O
Endocr Pathol 2022 Mar;33(1):27-63. Epub 2022 Mar 14 doi: 10.1007/s12022-022-09707-3. PMID: 35288841
Peptide receptor radionuclide therapy in patients with medullary thyroid carcinoma: predictors and pitfalls.
Beukhof CM, Brabander T, van Nederveen FH, van Velthuysen MF, de Rijke YB, Hofland LJ, Franssen GJH, Fröberg LAC, Kam BLR, Visser WE, de Herder WW, Peeters RP
BMC Cancer 2019 Apr 5;19(1):325. doi: 10.1186/s12885-019-5540-5. PMID: 30953466Free PMC Article
Genetics, diagnosis, and management of medullary thyroid carcinoma and pheochromocytoma/paraganglioma.
Moraitis AG, Martucci VL, Pacak K
Endocr Pract 2014 Feb;20(2):176-87. doi: 10.4158/EP13268.RA. PMID: 24449662
Small cell tumors of the thyroid gland: a review.
Eloy C, Cameselle-Teijeiro JM, Rousseau E, Sobrinho-Simões M
Int J Surg Pathol 2014 May;22(3):197-201. Epub 2013 Nov 25 doi: 10.1177/1066896913510029. PMID: 24275884

Diagnosis

Overview of the 2022 WHO Classification of Thyroid Neoplasms.
Baloch ZW, Asa SL, Barletta JA, Ghossein RA, Juhlin CC, Jung CK, LiVolsi VA, Papotti MG, Sobrinho-Simões M, Tallini G, Mete O
Endocr Pathol 2022 Mar;33(1):27-63. Epub 2022 Mar 14 doi: 10.1007/s12022-022-09707-3. PMID: 35288841
Diagnosis and pathologic characteristics of medullary thyroid carcinoma-review of current guidelines.
Thomas CM, Asa SL, Ezzat S, Sawka AM, Goldstein D
Curr Oncol 2019 Oct;26(5):338-344. Epub 2019 Oct 1 doi: 10.3747/co.26.5539. PMID: 31708652Free PMC Article
Role of ultrasonography in thyroid disease.
Sheth S
Otolaryngol Clin North Am 2010 Apr;43(2):239-55, vii. doi: 10.1016/j.otc.2010.02.001. PMID: 20510712
Tumors of the thyroid gland: histologic and cytologic features--part 2.
Muro-Cacho CA, Ku NN
Cancer Control 2000 Jul-Aug;7(4):377-85. doi: 10.1177/107327480000700413. PMID: 10895133
Amyloid goitre.
James PD
J Clin Pathol 1972 Aug;25(8):683-8. doi: 10.1136/jcp.25.8.683. PMID: 5076803Free PMC Article

Therapy

LIBRETTO-531: a phase III study of selpercatinib in multikinase inhibitor-naïve RET-mutant medullary thyroid cancer.
Wirth LJ, Brose MS, Elisei R, Capdevila J, Hoff AO, Hu MI, Tahara M, Robinson B, Gao M, Xia M, Maeda P, Sherman E
Future Oncol 2022 Sep;18(28):3143-3150. Epub 2022 Aug 15 doi: 10.2217/fon-2022-0657. PMID: 35969032Free PMC Article
New drugs for medullary thyroid cancer: new promises?
Spitzweg C, Morris JC, Bible KC
Endocr Relat Cancer 2016 Jun;23(6):R287-97. Epub 2016 May 16 doi: 10.1530/ERC-16-0104. PMID: 27185870
Thyroid carcinoma in children, adolescents and adults, both spontaneous and after childhood radiation exposure.
Ho WL, Zacharin MR
Eur J Pediatr 2016 May;175(5):677-83. Epub 2016 Jan 25 doi: 10.1007/s00431-016-2692-z. PMID: 26805408
Incretin-based therapies in the treatment of type 2 diabetes--more than meets the eye?
Labuzek K, Kozłowski M, Szkudłapski D, Sikorska P, Kozłowska M, Okopień B
Eur J Intern Med 2013 Apr;24(3):207-12. Epub 2013 Jan 31 doi: 10.1016/j.ejim.2013.01.009. PMID: 23375875
Targeted therapy for endocrine cancer: the medullary thyroid carcinoma paradigm.
Ye L, Santarpia L, Gagel RF
Endocr Pract 2009 Sep-Oct;15(6):597-604. doi: 10.4158/EP09148.RAR. PMID: 19546050

Prognosis

Update on C-Cell Neuroendocrine Neoplasm: Prognostic and Predictive Histopathologic and Molecular Features of Medullary Thyroid Carcinoma.
Jung CK, Agarwal S, Hang JF, Lim DJ, Bychkov A, Mete O
Endocr Pathol 2023 Mar;34(1):1-22. Epub 2023 Mar 8 doi: 10.1007/s12022-023-09753-5. PMID: 36890425
Overview of the 2022 WHO Classification of Thyroid Neoplasms.
Baloch ZW, Asa SL, Barletta JA, Ghossein RA, Juhlin CC, Jung CK, LiVolsi VA, Papotti MG, Sobrinho-Simões M, Tallini G, Mete O
Endocr Pathol 2022 Mar;33(1):27-63. Epub 2022 Mar 14 doi: 10.1007/s12022-022-09707-3. PMID: 35288841
Association between age and disease specific mortality in medullary thyroid cancer.
Sahli ZT, Canner JK, Zeiger MA, Mathur A
Am J Surg 2021 Feb;221(2):478-484. Epub 2020 Sep 26 doi: 10.1016/j.amjsurg.2020.09.025. PMID: 33010878Free PMC Article
Peptide receptor radionuclide therapy in patients with medullary thyroid carcinoma: predictors and pitfalls.
Beukhof CM, Brabander T, van Nederveen FH, van Velthuysen MF, de Rijke YB, Hofland LJ, Franssen GJH, Fröberg LAC, Kam BLR, Visser WE, de Herder WW, Peeters RP
BMC Cancer 2019 Apr 5;19(1):325. doi: 10.1186/s12885-019-5540-5. PMID: 30953466Free PMC Article
Medullary thyroid carcinoma.
Brauckhoff M, Lorenz K, Ukkat J, Brauckhoff K, Gimm O, Dralle H
Scand J Surg 2004;93(4):249-60. doi: 10.1177/145749690409300402. PMID: 15658665

Clinical prediction guides

Update on C-Cell Neuroendocrine Neoplasm: Prognostic and Predictive Histopathologic and Molecular Features of Medullary Thyroid Carcinoma.
Jung CK, Agarwal S, Hang JF, Lim DJ, Bychkov A, Mete O
Endocr Pathol 2023 Mar;34(1):1-22. Epub 2023 Mar 8 doi: 10.1007/s12022-023-09753-5. PMID: 36890425
Association between age and disease specific mortality in medullary thyroid cancer.
Sahli ZT, Canner JK, Zeiger MA, Mathur A
Am J Surg 2021 Feb;221(2):478-484. Epub 2020 Sep 26 doi: 10.1016/j.amjsurg.2020.09.025. PMID: 33010878Free PMC Article
Peptide receptor radionuclide therapy in patients with medullary thyroid carcinoma: predictors and pitfalls.
Beukhof CM, Brabander T, van Nederveen FH, van Velthuysen MF, de Rijke YB, Hofland LJ, Franssen GJH, Fröberg LAC, Kam BLR, Visser WE, de Herder WW, Peeters RP
BMC Cancer 2019 Apr 5;19(1):325. doi: 10.1186/s12885-019-5540-5. PMID: 30953466Free PMC Article
New drugs for medullary thyroid cancer: new promises?
Spitzweg C, Morris JC, Bible KC
Endocr Relat Cancer 2016 Jun;23(6):R287-97. Epub 2016 May 16 doi: 10.1530/ERC-16-0104. PMID: 27185870
Thyroid carcinoma in children, adolescents and adults, both spontaneous and after childhood radiation exposure.
Ho WL, Zacharin MR
Eur J Pediatr 2016 May;175(5):677-83. Epub 2016 Jan 25 doi: 10.1007/s00431-016-2692-z. PMID: 26805408

Recent systematic reviews

Medullary Thyroid Cancer with Ectopic Cushing's Syndrome: A Case Report and Systematic Review of Detailed Cases from the Literature.
Corsello A, Ramunno V, Locantore P, Pacini G, Rossi ED, Torino F, Pontecorvi A, De Crea C, Paragliola RM, Raffaelli M, Corsello SM
Thyroid 2022 Nov;32(11):1281-1298. Epub 2022 Jul 12 doi: 10.1089/thy.2021.0696. PMID: 35833793
Cabozantinib and vandetanib for unresectable locally advanced or metastatic medullary thyroid cancer: a systematic review and economic model.
Tappenden P, Carroll C, Hamilton J, Kaltenthaler E, Wong R, Wadsley J, Moss L, Balasubramanian S
Health Technol Assess 2019 Feb;23(8):1-144. doi: 10.3310/hta23080. PMID: 30821231Free PMC Article

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