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Esophageal Intramucosal Adenocarcinoma

MedGen UID:
1698382
•Concept ID:
C5206186
•
Neoplastic Process

Definition

Adenocarcinoma that arises from the esophagus and is confined entirely to the mucosa. [from NCI]

Term Hierarchy

CClinical test,  RResearch test,  OOMIM,  GGeneReviews,  VClinVar  
  • CROGVEsophageal Intramucosal Adenocarcinoma

Professional guidelines

PubMed

Impact of bariatric surgery on surveillance and treatment outcomes of Barrett's esophagus: A stage-matched cohort study.
Jaruvongvanich V, Osman K, Matar R, Baroud S, Hanada Y, Chesta FNU, Maselli DB, Mahmoud T, Wang KK, Abu Dayyeh BK
Surg Obes Relat Dis 2021 Aug;17(8):1457-1464. Epub 2021 Apr 28 doi: 10.1016/j.soard.2021.04.018. PMID: 34083137
AGA Clinical Practice Update on Endoscopic Treatment of Barrett's Esophagus With Dysplasia and/or Early Cancer: Expert Review.
Sharma P, Shaheen NJ, Katzka D, Bergman JJGHM
Gastroenterology 2020 Feb;158(3):760-769. Epub 2019 Nov 12 doi: 10.1053/j.gastro.2019.09.051. PMID: 31730766
Endoscopic Treatment of High-Grade Dysplasia and Intramucosal Esophageal Adenocarcinoma.
Reed CC, Shaheen NJ
J Laparoendosc Adv Surg Tech A 2016 Oct;26(10):768-772. Epub 2016 Aug 19 doi: 10.1089/lap.2016.29012.ccr. PMID: 27541732Free PMC Article

Recent clinical studies

Etiology

AGA Clinical Practice Update on Endoscopic Treatment of Barrett's Esophagus With Dysplasia and/or Early Cancer: Expert Review.
Sharma P, Shaheen NJ, Katzka D, Bergman JJGHM
Gastroenterology 2020 Feb;158(3):760-769. Epub 2019 Nov 12 doi: 10.1053/j.gastro.2019.09.051. PMID: 31730766
Barrett Esophagus and Intramucosal Esophageal Adenocarcinoma.
Rajendra S, Sharma P
Hematol Oncol Clin North Am 2017 Jun;31(3):409-426. Epub 2017 Mar 22 doi: 10.1016/j.hoc.2017.01.003. PMID: 28501084
Post-ablation surveillance in Barrett's esophagus: A review of the literature.
Stier MW, Konda VJ, Hart J, Waxman I
World J Gastroenterol 2016 May 7;22(17):4297-306. doi: 10.3748/wjg.v22.i17.4297. PMID: 27158198Free PMC Article
Esophageal resection for high-grade dysplasia and intramucosal carcinoma: When and how?
Konda VJ, Ferguson MK
World J Gastroenterol 2010 Aug 14;16(30):3786-92. doi: 10.3748/wjg.v16.i30.3786. PMID: 20698041Free PMC Article
New options for the therapy of Barrett's high-grade dysplasia and intramucosal adenocarcinoma: endoscopic mucosal resection and ablation versus vagal-sparing esophagectomy.
DeMeester SR
Ann Thorac Surg 2008 Feb;85(2):S747-50. doi: 10.1016/j.athoracsur.2007.10.102. PMID: 18222209

Diagnosis

Management of Dysplastic Barrett's Esophagus and Early Esophageal Adenocarcinoma.
Cotton CC, Eluri S, Shaheen NJ
Gastroenterol Clin North Am 2022 Sep;51(3):485-500. Epub 2022 Aug 30 doi: 10.1016/j.gtc.2022.06.004. PMID: 36153106Free PMC Article
AGA Clinical Practice Update on Endoscopic Treatment of Barrett's Esophagus With Dysplasia and/or Early Cancer: Expert Review.
Sharma P, Shaheen NJ, Katzka D, Bergman JJGHM
Gastroenterology 2020 Feb;158(3):760-769. Epub 2019 Nov 12 doi: 10.1053/j.gastro.2019.09.051. PMID: 31730766
Barrett Esophagus and Intramucosal Esophageal Adenocarcinoma.
Rajendra S, Sharma P
Hematol Oncol Clin North Am 2017 Jun;31(3):409-426. Epub 2017 Mar 22 doi: 10.1016/j.hoc.2017.01.003. PMID: 28501084
Intramucosal esophageal cancer and high-grade dysplasia: which treatment frame the debate.
Oelschlager BK
J Gastrointest Surg 2009 Jul;13(7):1169-71. Epub 2009 Mar 26 doi: 10.1007/s11605-009-0864-0. PMID: 19322615
New options for the therapy of Barrett's high-grade dysplasia and intramucosal adenocarcinoma: endoscopic mucosal resection and ablation versus vagal-sparing esophagectomy.
DeMeester SR
Ann Thorac Surg 2008 Feb;85(2):S747-50. doi: 10.1016/j.athoracsur.2007.10.102. PMID: 18222209

Therapy

Management of Dysplastic Barrett's Esophagus and Early Esophageal Adenocarcinoma.
Cotton CC, Eluri S, Shaheen NJ
Gastroenterol Clin North Am 2022 Sep;51(3):485-500. Epub 2022 Aug 30 doi: 10.1016/j.gtc.2022.06.004. PMID: 36153106Free PMC Article
Barrett's esophagus, towards improved clinical practice.
Martínez-Domínguez SJ, Lanas Á, Domper-Arnal MJ
Med Clin (Barc) 2022 Jul 22;159(2):92-100. Epub 2022 May 21 doi: 10.1016/j.medcli.2022.02.012. PMID: 35606193
EMR/ESD: Techniques, Complications, and Evidence.
Ahmed Y, Othman M
Curr Gastroenterol Rep 2020 Jun 15;22(8):39. doi: 10.1007/s11894-020-00777-z. PMID: 32542462
AGA Clinical Practice Update on Endoscopic Treatment of Barrett's Esophagus With Dysplasia and/or Early Cancer: Expert Review.
Sharma P, Shaheen NJ, Katzka D, Bergman JJGHM
Gastroenterology 2020 Feb;158(3):760-769. Epub 2019 Nov 12 doi: 10.1053/j.gastro.2019.09.051. PMID: 31730766
Management of Early-Stage Adenocarcinoma of the Esophagus: Endoscopic Mucosal Resection and Endoscopic Submucosal Dissection.
Seewald S, Ang TL, Pouw RE, Bannwart F, Bergman JJ
Dig Dis Sci 2018 Aug;63(8):2146-2154. doi: 10.1007/s10620-018-5158-5. PMID: 29934725

Prognosis

Genetic and Epigenetic Alterations in Barrett's Esophagus and Esophageal Adenocarcinoma.
Kaz AM, Grady WM, Stachler MD, Bass AJ
Gastroenterol Clin North Am 2015 Jun;44(2):473-89. Epub 2015 Apr 1 doi: 10.1016/j.gtc.2015.02.015. PMID: 26021206Free PMC Article
Screening for Barrett's Esophagus.
di Pietro M, Chan D, Fitzgerald RC, Wang KK
Gastroenterology 2015 May;148(5):912-23. Epub 2015 Feb 17 doi: 10.1053/j.gastro.2015.02.012. PMID: 25701083Free PMC Article
SSAT controversies intramucosal esophageal cancer and high-grade dysplasia: which treatment? Surgical therapy: improved outcomes and piece of mind.
Peters JH
J Gastrointest Surg 2009 Jul;13(7):1179-81. Epub 2009 Mar 18 doi: 10.1007/s11605-009-0863-1. PMID: 19294473
Total endoscopic resection of Barrett esophagus.
Seewald S, Ang TL, Gotoda T, Soehendra N
Endoscopy 2008 Dec;40(12):1016-20. Epub 2008 Dec 8 doi: 10.1055/s-0028-1103401. PMID: 19065485
New options for the therapy of Barrett's high-grade dysplasia and intramucosal adenocarcinoma: endoscopic mucosal resection and ablation versus vagal-sparing esophagectomy.
DeMeester SR
Ann Thorac Surg 2008 Feb;85(2):S747-50. doi: 10.1016/j.athoracsur.2007.10.102. PMID: 18222209

Clinical prediction guides

Endoscopic eradication therapy for Barrett's oesophagus: state of the art.
Kolb JM, Wani S
Curr Opin Gastroenterol 2020 Jul;36(4):351-358. doi: 10.1097/MOG.0000000000000650. PMID: 32487852Free PMC Article
Barrett's Esophagus: A Comprehensive and Contemporary Review for Pathologists.
Naini BV, Souza RF, Odze RD
Am J Surg Pathol 2016 May;40(5):e45-66. doi: 10.1097/PAS.0000000000000598. PMID: 26813745Free PMC Article
Screening for Barrett's Esophagus.
di Pietro M, Chan D, Fitzgerald RC, Wang KK
Gastroenterology 2015 May;148(5):912-23. Epub 2015 Feb 17 doi: 10.1053/j.gastro.2015.02.012. PMID: 25701083Free PMC Article
Lymphovascular invasion and nodal metastasis in intramucosal adenocarcinoma of the esophagus and esophagogastric junction.
Li ZG, Zhu H, Shi H, Xie H, Goldblum JR, Thota PN, Liu X
J Dig Dis 2015 Apr;16(4):197-204. doi: 10.1111/1751-2980.12230. PMID: 25620066
Is endoscopic surveillance for non-dysplastic Barrett's esophagus cost-effective? Review of economic evaluations.
Hirst NG, Gordon LG, Whiteman DC, Watson DI, Barendregt JJ
J Gastroenterol Hepatol 2011 Feb;26(2):247-54. doi: 10.1111/j.1440-1746.2010.06506.x. PMID: 21261712

Recent systematic reviews

Efficacy of Cryotherapy as a Primary Endoscopic Ablation Modality for Dysplastic Barrett's Esophagus and Early Esophageal Neoplasia: A Systematic Review and Meta-Analysis.
Tariq R, Enslin S, Hayat M, Kaul V
Cancer Control 2020 Jan-Dec;27(1):1073274820976668. doi: 10.1177/1073274820976668. PMID: 33297725Free PMC Article
Efficacy and safety outcomes of multimodal endoscopic eradication therapy in Barrett's esophagus-related neoplasia: a systematic review and pooled analysis.
Desai M, Saligram S, Gupta N, Vennalaganti P, Bansal A, Choudhary A, Vennelaganti S, He J, Titi M, Maselli R, Qumseya B, Olyaee M, Waxman I, Repici A, Hassan C, Sharma P
Gastrointest Endosc 2017 Mar;85(3):482-495.e4. Epub 2016 Sep 23 doi: 10.1016/j.gie.2016.09.022. PMID: 27670227
Endoscopic eradication therapy for mucosal neoplasia in Barrett's esophagus.
Dunbar KB
Curr Opin Gastroenterol 2013 Jul;29(4):446-53. doi: 10.1097/MOG.0b013e3283622848. PMID: 23703368
Efficacy and durability of radiofrequency ablation for Barrett's Esophagus: systematic review and meta-analysis.
Orman ES, Li N, Shaheen NJ
Clin Gastroenterol Hepatol 2013 Oct;11(10):1245-55. Epub 2013 May 2 doi: 10.1016/j.cgh.2013.03.039. PMID: 23644385Free PMC Article
Is endoscopic surveillance for non-dysplastic Barrett's esophagus cost-effective? Review of economic evaluations.
Hirst NG, Gordon LG, Whiteman DC, Watson DI, Barendregt JJ
J Gastroenterol Hepatol 2011 Feb;26(2):247-54. doi: 10.1111/j.1440-1746.2010.06506.x. PMID: 21261712

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