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Unresectable Neuroendocrine Tumor G1

MedGen UID:
1667976
•Concept ID:
C4727011
•
Neoplastic Process

Definition

Neuroendocrine tumor grade 1 that is not amenable to surgical resection. [from NCI]

Term Hierarchy

CClinical test,  RResearch test,  OOMIM,  GGeneReviews,  VClinVar  
  • CROGVUnresectable Neuroendocrine Tumor G1

Professional guidelines

PubMed

The Role of Liver Transplantation in the Treatment of Liver Metastases from Neuroendocrine Tumors.
Citterio D, Coppa J, Sposito C, Busset MDD, Virdis M, Pezzoli I, Mazzaferro V
Curr Treat Options Oncol 2023 Nov;24(11):1651-1665. Epub 2023 Oct 26 doi: 10.1007/s11864-023-01124-w. PMID: 37882889Free PMC Article
Liver Resection for Neuroendocrine Tumor Liver Metastases Within Milan Criteria for Liver Transplantation.
Ruzzenente A, Bagante F, Bertuzzo F, Aldrighetti L, Campagnaro T, Ercolani G, Conci S, Giuliante F, Dore A, Ferrero A, Torzilli G, Grazi GL, Ratti F, Cucchetti A, De Rose AM, Russolillo N, Cimino M, Perri P, Guglielmi A, Iacono C
J Gastrointest Surg 2019 Jan;23(1):93-100. Epub 2018 Sep 21 doi: 10.1007/s11605-018-3973-9. PMID: 30242647
Pancreatic neuroendocrine tumors: Nosography, management and treatment.
Orditura M, Petrillo A, Ventriglia J, Diana A, Laterza MM, Fabozzi A, Savastano B, Franzese E, Conzo G, Santini L, Ciardiello F, De Vita F
Int J Surg 2016 Apr;28 Suppl 1:S156-62. Epub 2015 Dec 18 doi: 10.1016/j.ijsu.2015.12.052. PMID: 26708853

Recent clinical studies

Etiology

Real-world effectiveness of systemic anticancer therapy for advanced melanoma in the west of Scotland from 2010 to 2018.
Clarke J, Bennie M, Kurdi A, Pan J, Mueller T, Crearie C, Baillie K, Laskey J, Waterston A
Future Oncol 2023 Feb;19(6):451-461. Epub 2023 Apr 11 doi: 10.2217/fon-2022-0959. PMID: 37039001
Combined nivolumab and ipilimumab with or without stereotactic body radiation therapy for advanced Merkel cell carcinoma: a randomised, open label, phase 2 trial.
Kim S, Wuthrick E, Blakaj D, Eroglu Z, Verschraegen C, Thapa R, Mills M, Dibs K, Liveringhouse C, Russell J, Caudell JJ, Tarhini A, Markowitz J, Kendra K, Wu R, Chen DT, Berglund A, Michael L, Aoki M, Wang MH, Hamaidi I, Cheng P, de la Iglesia J, Slebos RJ, Chung CH, Knepper TC, Moran-Segura CM, Nguyen JV, Perez BA, Rose T, Harrison L, Messina JL, Sondak VK, Tsai KY, Khushalani NI, Brohl AS
Lancet 2022 Sep 24;400(10357):1008-1019. Epub 2022 Sep 12 doi: 10.1016/S0140-6736(22)01659-2. PMID: 36108657Free PMC Article
Impact of tumor grade on pancreatic neuroendocrine tumors.
Shyr BS, Shyr BU, Chen SC, Shyr YM, Wang SE
Asian J Surg 2022 Dec;45(12):2659-2663. Epub 2022 Mar 1 doi: 10.1016/j.asjsur.2022.01.094. PMID: 35246343
Long-Term Outcomes With Nivolumab Plus Ipilimumab or Nivolumab Alone Versus Ipilimumab in Patients With Advanced Melanoma.
Wolchok JD, Chiarion-Sileni V, Gonzalez R, Grob JJ, Rutkowski P, Lao CD, Cowey CL, Schadendorf D, Wagstaff J, Dummer R, Ferrucci PF, Smylie M, Butler MO, Hill A, Márquez-Rodas I, Haanen JBAG, Guidoboni M, Maio M, Schöffski P, Carlino MS, Lebbé C, McArthur G, Ascierto PA, Daniels GA, Long GV, Bas T, Ritchings C, Larkin J, Hodi FS
J Clin Oncol 2022 Jan 10;40(2):127-137. Epub 2021 Nov 24 doi: 10.1200/JCO.21.02229. PMID: 34818112Free PMC Article
Pancreatic neuroendocrine tumors.
Perri G, Prakash LR, Katz MHG
Curr Opin Gastroenterol 2019 Sep;35(5):468-477. doi: 10.1097/MOG.0000000000000571. PMID: 31306159

Diagnosis

Ampullary Neuroendocrine Neoplasm: Clinicopathological Characteristics and Novel Endoscopic Entity.
Matsumoto K, Fujimori N, Hata Y, Minoda Y, Murakami M, Teramatsu K, Takamatsu Y, Takeno A, Oono T, Ihara E, Nakata K, Nakamura M, Yamamoto T, Koga Y, Oda Y, Ito T, Ogawa Y
Dig Dis 2023;41(2):316-324. Epub 2022 May 19 doi: 10.1159/000525013. PMID: 35588707
CDK4 and TERT amplification in head and neck mucosal melanoma.
Lyu J, Miao Y, Yu F, Chang C, Guo W, Zhu H
J Oral Pathol Med 2021 Nov;50(10):971-978. Epub 2021 Apr 12 doi: 10.1111/jop.13180. PMID: 33797827
Pancreatic neuroendocrine tumors.
Perri G, Prakash LR, Katz MHG
Curr Opin Gastroenterol 2019 Sep;35(5):468-477. doi: 10.1097/MOG.0000000000000571. PMID: 31306159
Resection of the Primary Tumor Followed by Peptide Receptor Radionuclide Therapy as Upfront Strategy for the Treatment of G1-G2 Pancreatic Neuroendocrine Tumors with Unresectable Liver Metastases.
Bertani E, Fazio N, Radice D, Zardini C, Grana C, Bodei L, Funicelli L, Ferrari C, Spada F, Partelli S, Falconi M
Ann Surg Oncol 2016 Dec;23(Suppl 5):981-989. Epub 2016 Sep 9 doi: 10.1245/s10434-016-5550-3. PMID: 27613553
Pancreatic neuroendocrine tumors: Nosography, management and treatment.
Orditura M, Petrillo A, Ventriglia J, Diana A, Laterza MM, Fabozzi A, Savastano B, Franzese E, Conzo G, Santini L, Ciardiello F, De Vita F
Int J Surg 2016 Apr;28 Suppl 1:S156-62. Epub 2015 Dec 18 doi: 10.1016/j.ijsu.2015.12.052. PMID: 26708853

Therapy

Cryoablation and post-progression immune checkpoint inhibition in metastatic melanoma: a phase II trial.
Mooradian MJ, Fintelmann FJ, LaSalle TJ, Simon J, Graur A, Muzikansky A, Mino-Kenudson M, Shalhout S, Kaufman HL, Jenkins RW, Lawrence D, Lawless A, Sharova T, Uppot RN, Fang J, Blaum EM, Gonye ALK, Gushterova I, Boland GM, Azzoli C, Hacohen N, Sade-Feldman M, Sullivan RJ
Nat Commun 2024 Aug 27;15(1):7357. doi: 10.1038/s41467-024-51722-x. PMID: 39191779Free PMC Article
Transplant oncology: multivisceral transplantation for neuroendocrine tumor and liver metastasis.
Nagai S
Curr Opin Organ Transplant 2023 Jun 1;28(3):222-227. Epub 2023 Apr 10 doi: 10.1097/MOT.0000000000001063. PMID: 37040627
Combined nivolumab and ipilimumab with or without stereotactic body radiation therapy for advanced Merkel cell carcinoma: a randomised, open label, phase 2 trial.
Kim S, Wuthrick E, Blakaj D, Eroglu Z, Verschraegen C, Thapa R, Mills M, Dibs K, Liveringhouse C, Russell J, Caudell JJ, Tarhini A, Markowitz J, Kendra K, Wu R, Chen DT, Berglund A, Michael L, Aoki M, Wang MH, Hamaidi I, Cheng P, de la Iglesia J, Slebos RJ, Chung CH, Knepper TC, Moran-Segura CM, Nguyen JV, Perez BA, Rose T, Harrison L, Messina JL, Sondak VK, Tsai KY, Khushalani NI, Brohl AS
Lancet 2022 Sep 24;400(10357):1008-1019. Epub 2022 Sep 12 doi: 10.1016/S0140-6736(22)01659-2. PMID: 36108657Free PMC Article
Neoadjuvant immunotherapy of locoregionally advanced solid tumors.
Tarhini AA, Eads JR, Moore KN, Tatard-Leitman V, Wright J, Forde PM, Ferris RL
J Immunother Cancer 2022 Aug;10(8) doi: 10.1136/jitc-2022-005036. PMID: 35973745Free PMC Article
Long-Term Outcomes With Nivolumab Plus Ipilimumab or Nivolumab Alone Versus Ipilimumab in Patients With Advanced Melanoma.
Wolchok JD, Chiarion-Sileni V, Gonzalez R, Grob JJ, Rutkowski P, Lao CD, Cowey CL, Schadendorf D, Wagstaff J, Dummer R, Ferrucci PF, Smylie M, Butler MO, Hill A, Márquez-Rodas I, Haanen JBAG, Guidoboni M, Maio M, Schöffski P, Carlino MS, Lebbé C, McArthur G, Ascierto PA, Daniels GA, Long GV, Bas T, Ritchings C, Larkin J, Hodi FS
J Clin Oncol 2022 Jan 10;40(2):127-137. Epub 2021 Nov 24 doi: 10.1200/JCO.21.02229. PMID: 34818112Free PMC Article

Prognosis

The Role of Liver Transplantation in the Treatment of Liver Metastases from Neuroendocrine Tumors.
Citterio D, Coppa J, Sposito C, Busset MDD, Virdis M, Pezzoli I, Mazzaferro V
Curr Treat Options Oncol 2023 Nov;24(11):1651-1665. Epub 2023 Oct 26 doi: 10.1007/s11864-023-01124-w. PMID: 37882889Free PMC Article
Real-world effectiveness of systemic anticancer therapy for advanced melanoma in the west of Scotland from 2010 to 2018.
Clarke J, Bennie M, Kurdi A, Pan J, Mueller T, Crearie C, Baillie K, Laskey J, Waterston A
Future Oncol 2023 Feb;19(6):451-461. Epub 2023 Apr 11 doi: 10.2217/fon-2022-0959. PMID: 37039001
Ampullary Neuroendocrine Neoplasm: Clinicopathological Characteristics and Novel Endoscopic Entity.
Matsumoto K, Fujimori N, Hata Y, Minoda Y, Murakami M, Teramatsu K, Takamatsu Y, Takeno A, Oono T, Ihara E, Nakata K, Nakamura M, Yamamoto T, Koga Y, Oda Y, Ito T, Ogawa Y
Dig Dis 2023;41(2):316-324. Epub 2022 May 19 doi: 10.1159/000525013. PMID: 35588707
Impact of tumor grade on pancreatic neuroendocrine tumors.
Shyr BS, Shyr BU, Chen SC, Shyr YM, Wang SE
Asian J Surg 2022 Dec;45(12):2659-2663. Epub 2022 Mar 1 doi: 10.1016/j.asjsur.2022.01.094. PMID: 35246343
Pancreatic neuroendocrine tumors.
Perri G, Prakash LR, Katz MHG
Curr Opin Gastroenterol 2019 Sep;35(5):468-477. doi: 10.1097/MOG.0000000000000571. PMID: 31306159

Clinical prediction guides

Liver Transplant for Patients With Neuroendocrine Tumor: A Report of 2 Exceptional Cases and Literature Review.
Moradi A, Lamsehchi N, Khaki S, Nasiri-Toosi M, Jafarian A
Exp Clin Transplant 2023 Jul;21(7):578-585. doi: 10.6002/ect.2023.0110. PMID: 37584538
Combined nivolumab and ipilimumab with or without stereotactic body radiation therapy for advanced Merkel cell carcinoma: a randomised, open label, phase 2 trial.
Kim S, Wuthrick E, Blakaj D, Eroglu Z, Verschraegen C, Thapa R, Mills M, Dibs K, Liveringhouse C, Russell J, Caudell JJ, Tarhini A, Markowitz J, Kendra K, Wu R, Chen DT, Berglund A, Michael L, Aoki M, Wang MH, Hamaidi I, Cheng P, de la Iglesia J, Slebos RJ, Chung CH, Knepper TC, Moran-Segura CM, Nguyen JV, Perez BA, Rose T, Harrison L, Messina JL, Sondak VK, Tsai KY, Khushalani NI, Brohl AS
Lancet 2022 Sep 24;400(10357):1008-1019. Epub 2022 Sep 12 doi: 10.1016/S0140-6736(22)01659-2. PMID: 36108657Free PMC Article
Impact of tumor grade on pancreatic neuroendocrine tumors.
Shyr BS, Shyr BU, Chen SC, Shyr YM, Wang SE
Asian J Surg 2022 Dec;45(12):2659-2663. Epub 2022 Mar 1 doi: 10.1016/j.asjsur.2022.01.094. PMID: 35246343
Long-Term Outcomes With Nivolumab Plus Ipilimumab or Nivolumab Alone Versus Ipilimumab in Patients With Advanced Melanoma.
Wolchok JD, Chiarion-Sileni V, Gonzalez R, Grob JJ, Rutkowski P, Lao CD, Cowey CL, Schadendorf D, Wagstaff J, Dummer R, Ferrucci PF, Smylie M, Butler MO, Hill A, Márquez-Rodas I, Haanen JBAG, Guidoboni M, Maio M, Schöffski P, Carlino MS, Lebbé C, McArthur G, Ascierto PA, Daniels GA, Long GV, Bas T, Ritchings C, Larkin J, Hodi FS
J Clin Oncol 2022 Jan 10;40(2):127-137. Epub 2021 Nov 24 doi: 10.1200/JCO.21.02229. PMID: 34818112Free PMC Article
Pancreatic neuroendocrine tumors.
Perri G, Prakash LR, Katz MHG
Curr Opin Gastroenterol 2019 Sep;35(5):468-477. doi: 10.1097/MOG.0000000000000571. PMID: 31306159

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