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Endometrial Low Grade Endometrioid Adenocarcinoma

MedGen UID:: 1792870
•Concept ID:: C5556429
•: Neoplastic Process

Synonyms:

Endometrial Low-Grade Endometrioid Adenocarcinoma; Low Grade Endometrial Endometrioid Adenocarcinoma; Low Grade Endometrial Endometrioid Carcinoma; Low-Grade Endometrial Endometrioid Adenocarcinoma; Low-Grade Endometrial Endometrioid Carcinoma

Definition

Endometrial endometrioid adenocarcinoma exhibiting 50% or less solid non-glandular, non-squamous growth. [from NCI]

Term Hierarchy

GTR
MeSH

CClinical test, RResearch test, OOMIM, GGeneReviews, VClinVar

CROGVEndometrial Low Grade Endometrioid Adenocarcinoma

Neoplasm
- Epithelial neoplasm
  - Carcinoma
    - Adenocarcinoma
      - Endometrioid adenocarcinoma
        Endometrial endometrioid adenocarcinoma
        Endometrial Low Grade Endometrioid Adenocarcinoma
        FIGO Grade 1 Endometrial Endometrioid Adenocarcinoma
        FIGO Grade 2 Endometrial Endometrioid Adenocarcinoma

Professional guidelines

PubMed

The clinical features and management of Lynch syndrome-associated ovarian cancer.

Ran X, Jing H, Li Z
J Obstet Gynaecol Res 2022 Jul;48(7):1538-1545. Epub 2022 Apr 27 doi: 10.1111/jog.15273. PMID: 35478369

Role of the pathologist in assessing response to treatment of ovarian and endometrial cancers.

Williams AT, Ganesan R
Histopathology 2020 Jan;76(1):93-101. doi: 10.1111/his.13994. PMID: 31846531

Problems in the differential diagnosis of endometrial hyperplasia and carcinoma.

Silverberg SG
Mod Pathol 2000 Mar;13(3):309-27. doi: 10.1038/modpathol.3880053. PMID: 10757341

See all (31)

Recent clinical studies

Etiology

Clinical Behavior and Molecular Landscape of Stage I p53-Abnormal Low-Grade Endometrioid Endometrial Carcinomas.

Jamieson A, Vermij L, Kramer CJH, Jobsen JJ, Jürgemlienk-Schulz I, Lutgens L, Mens JW, Haverkort MAD, Slot A, Nout RA, Oosting J, Carlson J, Howitt BE, Ip PPC, Lax SF, McCluggage WG, Singh N, McAlpine JN, Creutzberg CL, Horeweg N, Gilks CB, Bosse T
Clin Cancer Res 2023 Dec 1;29(23):4949-4957. doi: 10.1158/1078-0432.CCR-23-1397. PMID: 37773079 Free PMC Article

FIGO staging of endometrial cancer: 2023.

Berek JS, Matias-Guiu X, Creutzberg C, Fotopoulou C, Gaffney D, Kehoe S, Lindemann K, Mutch D, Concin N; Endometrial Cancer Staging Subcommittee, FIGO Women's Cancer Committee
J Gynecol Oncol 2023 Sep;34(5):e85. Epub 2023 Aug 8 doi: 10.3802/jgo.2023.34.e85. PMID: 37593813 Free PMC Article

FIGO staging of endometrial cancer: 2023.

Berek JS, Matias-Guiu X, Creutzberg C, Fotopoulou C, Gaffney D, Kehoe S, Lindemann K, Mutch D, Concin N; Endometrial Cancer Staging Subcommittee, FIGO Women's Cancer Committee
Int J Gynaecol Obstet 2023 Aug;162(2):383-394. Epub 2023 Jun 20 doi: 10.1002/ijgo.14923. PMID: 37337978

The Many Uses of p53 Immunohistochemistry in Gynecological Pathology: Proceedings of the ISGyP Companion Society Session at the 2020 USCAP Annual9 Meeting.

Köbel M, Kang EY
Int J Gynecol Pathol 2021 Jan;40(1):32-40. doi: 10.1097/PGP.0000000000000725. PMID: 33290354

Recurrent endometrial cancer.

Del Carmen MG, Boruta DM 2nd, Schorge JO
Clin Obstet Gynecol 2011 Jun;54(2):266-77. doi: 10.1097/GRF.0b013e318218c6d1. PMID: 21508696

See all (450)

Diagnosis

Clinical Behavior and Molecular Landscape of Stage I p53-Abnormal Low-Grade Endometrioid Endometrial Carcinomas.

Endometrial Carcinoma Diagnosis: Use of FIGO Grading and Genomic Subcategories in Clinical Practice: Recommendations of the International Society of Gynecological Pathologists.

Soslow RA, Tornos C, Park KJ, Malpica A, Matias-Guiu X, Oliva E, Parkash V, Carlson J, McCluggage WG, Gilks CB
Int J Gynecol Pathol 2019 Jan;38 Suppl 1(Iss 1 Suppl 1):S64-S74. doi: 10.1097/PGP.0000000000000518. PMID: 30550484 Free PMC Article

High-grade Endometrial Carcinomas: Morphologic and Immunohistochemical Features, Diagnostic Challenges and Recommendations.

Murali R, Davidson B, Fadare O, Carlson JA, Crum CP, Gilks CB, Irving JA, Malpica A, Matias-Guiu X, McCluggage WG, Mittal K, Oliva E, Parkash V, Rutgers JKL, Staats PN, Stewart CJR, Tornos C, Soslow RA
Int J Gynecol Pathol 2019 Jan;38 Suppl 1(Iss 1 Suppl 1):S40-S63. doi: 10.1097/PGP.0000000000000491. PMID: 30550483 Free PMC Article

Molecular Genetics of Endometrial Carcinoma.

Bell DW, Ellenson LH
Annu Rev Pathol 2019 Jan 24;14:339-367. Epub 2018 Oct 17 doi: 10.1146/annurev-pathol-020117-043609. PMID: 30332563

Recurrent endometrial cancer.

Del Carmen MG, Boruta DM 2nd, Schorge JO
Clin Obstet Gynecol 2011 Jun;54(2):266-77. doi: 10.1097/GRF.0b013e318218c6d1. PMID: 21508696

See all (366)

Therapy

Role of the pathologist in assessing response to treatment of ovarian and endometrial cancers.

Williams AT, Ganesan R
Histopathology 2020 Jan;76(1):93-101. doi: 10.1111/his.13994. PMID: 31846531

Chemotherapy for Endometrial Cancer in Adjuvant and Advanced Disease Settings.

Bestvina CM, Fleming GF
Oncologist 2016 Oct;21(10):1250-1259. Epub 2016 Jul 13 doi: 10.1634/theoncologist.2016-0062. PMID: 27412393 Free PMC Article

The Therapeutic Challenge of Targeting HER2 in Endometrial Cancer.

Diver EJ, Foster R, Rueda BR, Growdon WB
Oncologist 2015 Sep;20(9):1058-68. Epub 2015 Jun 22 doi: 10.1634/theoncologist.2015-0149. PMID: 26099744 Free PMC Article

Histopathology of endometrial hyperplasia and endometrial carcinoma: an update.

Horn LC, Meinel A, Handzel R, Einenkel J
Ann Diagn Pathol 2007 Aug;11(4):297-311. doi: 10.1016/j.anndiagpath.2007.05.002. PMID: 17630117

Pathology and physiopathology of adenomyosis.

Bergeron C, Amant F, Ferenczy A
Best Pract Res Clin Obstet Gynaecol 2006 Aug;20(4):511-21. Epub 2006 Mar 24 doi: 10.1016/j.bpobgyn.2006.01.016. PMID: 16563870

See all (83)

Prognosis

FIGO staging of endometrial cancer: 2023.

Berek JS, Matias-Guiu X, Creutzberg C, Fotopoulou C, Gaffney D, Kehoe S, Lindemann K, Mutch D, Concin N; Endometrial Cancer Staging Subcommittee, FIGO Women's Cancer Committee
Int J Gynaecol Obstet 2023 Aug;162(2):383-394. Epub 2023 Jun 20 doi: 10.1002/ijgo.14923. PMID: 37337978

The Many Uses of p53 Immunohistochemistry in Gynecological Pathology: Proceedings of the ISGyP Companion Society Session at the 2020 USCAP Annual9 Meeting.

Köbel M, Kang EY
Int J Gynecol Pathol 2021 Jan;40(1):32-40. doi: 10.1097/PGP.0000000000000725. PMID: 33290354

Endometrial Carcinoma Diagnosis: Use of FIGO Grading and Genomic Subcategories in Clinical Practice: Recommendations of the International Society of Gynecological Pathologists.

Molecular Genetics of Endometrial Carcinoma.

Bell DW, Ellenson LH
Annu Rev Pathol 2019 Jan 24;14:339-367. Epub 2018 Oct 17 doi: 10.1146/annurev-pathol-020117-043609. PMID: 30332563

See all (435)

Clinical prediction guides

Clinical Behavior and Molecular Landscape of Stage I p53-Abnormal Low-Grade Endometrioid Endometrial Carcinomas.

High-grade endometrial carcinomas: Morphologic spectrum and molecular classification.

Zhang C, Zheng W
Semin Diagn Pathol 2022 May;39(3):176-186. Epub 2021 Nov 20 doi: 10.1053/j.semdp.2021.11.002. PMID: 34852949

Atypical Endometrial Hyperplasia, Low-grade: "Much ADO About Nothing".

D'Angelo E, Espinosa I, Cipriani V, Szafranska J, Barbareschi M, Prat J
Am J Surg Pathol 2021 Jul 1;45(7):988-996. doi: 10.1097/PAS.0000000000001705. PMID: 34105519

The Many Uses of p53 Immunohistochemistry in Gynecological Pathology: Proceedings of the ISGyP Companion Society Session at the 2020 USCAP Annual9 Meeting.

Köbel M, Kang EY
Int J Gynecol Pathol 2021 Jan;40(1):32-40. doi: 10.1097/PGP.0000000000000725. PMID: 33290354

Molecular Genetics of Endometrial Carcinoma.

Bell DW, Ellenson LH
Annu Rev Pathol 2019 Jan 24;14:339-367. Epub 2018 Oct 17 doi: 10.1146/annurev-pathol-020117-043609. PMID: 30332563

See all (295)

Recent systematic reviews

Prognosis of polymerase epsilon (POLE) mutation in high-grade endometrioid endometrial cancer: Systematic review and meta-analysis.

Casanova J, Duarte GS, da Costa AG, Catarino A, Nave M, Antunes T, Serra SS, Dias SS, Abu-Rustum N, Lima J
Gynecol Oncol 2024 Mar;182:99-107. Epub 2024 Jan 22 doi: 10.1016/j.ygyno.2024.01.018. PMID: 38262245 Free PMC Article

Transvaginal ultrasound versus magnetic resonance imaging for preoperative assessment of myometrial infiltration in patients with low-grade endometrioid endometrial cancer: A systematic review and head-to-head meta-analysis.

Tameish S, Florez N, Vidal JRP, Chen H, Vara J, Alcázar JL
J Clin Ultrasound 2023 Sep;51(7):1188-1197. Epub 2023 Jun 15 doi: 10.1002/jcu.23508. PMID: 37318272

Fertility-Sparing Approach in Patients with Endometrioid Endometrial Cancer Grade 2 Stage IA (FIGO): A Qualitative Systematic Review.

Giampaolino P, Cafasso V, Boccia D, Ascione M, Mercorio A, Viciglione F, Palumbo M, Serafino P, Buonfantino C, De Angelis MC, Verrazzo P, Grasso G, Gullo G, Bifulco G, Della Corte L
Biomed Res Int 2022;2022:4070368. Epub 2022 Sep 27 doi: 10.1155/2022/4070368. PMID: 36203482 Free PMC Article

TCGA molecular subgroups and FIGO grade in endometrial endometrioid carcinoma.

Travaglino A, Raffone A, Mollo A, Borrelli G, Alfano P, Zannoni GF, Insabato L, Zullo F
Arch Gynecol Obstet 2020 May;301(5):1117-1125. Epub 2020 Apr 6 doi: 10.1007/s00404-020-05531-4. PMID: 32253551

Endometrial cancer after endometrial ablation: systematic review of medical literature.

AlHilli MM, Hopkins MR, Famuyide AO
J Minim Invasive Gynecol 2011 May-Jun;18(3):393-400. doi: 10.1016/j.jmig.2011.02.004. PMID: 21545966

See all (8)

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Endometrial Low Grade Endometrioid Adenocarcinoma

Definition

Term Hierarchy

Professional guidelines

PubMed

Recent clinical studies

Etiology

Diagnosis

Therapy

Prognosis

Clinical prediction guides

Recent systematic reviews

Supplemental Content

Table of contents

Practice guidelines

Related information

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