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Ovarian Mixed Cell Adenocarcinoma

MedGen UID:
1792063
Concept ID:
C5555622
Neoplastic Process
Synonym: Ovarian Mixed Carcinoma

Definition

An adenocarcinoma that arises from the ovary and is characterized by the presence of two or more adenocarcinoma components, most often endometrioid and clear cell. [from NCI]

Term Hierarchy

CClinical test,  RResearch test,  OOMIM,  GGeneReviews,  VClinVar  
  • CROGVOvarian Mixed Cell Adenocarcinoma

Professional guidelines

PubMed

Wang X, Wang S, Yao S, Shi W, Ma K
J Ovarian Res 2022 Sep 16;15(1):104. doi: 10.1186/s13048-022-01037-6. PMID: 36114551Free PMC Article
Karami S, Daughtery SE, Schwartz K, Davis FG, Ruterbusch JJ, Wacholder S, Graubard BI, Berndt SI, Hofmann JN, Purdue MP, Moore LE, Colt JS
Int J Cancer 2016 Aug 1;139(3):584-92. Epub 2016 Apr 9 doi: 10.1002/ijc.30108. PMID: 27009534Free PMC Article
Friedlander ML, Russell K, Millis S, Gatalica Z, Bender R, Voss A
Int J Gynecol Cancer 2016 May;26(4):648-54. doi: 10.1097/IGC.0000000000000677. PMID: 26937756Free PMC Article

Recent clinical studies

Etiology

Tubridy EA, Eiva MA, Liu F, Omran DK, Gysler S, Brown EG, Roy AG, Zeng Y, Oh J, Cao Q, Gitto SB, Powell DJ Jr
Gynecol Oncol 2024 May;184:74-82. Epub 2024 Jan 29 doi: 10.1016/j.ygyno.2024.01.029. PMID: 38290413Free PMC Article
Berek JS, Matias-Guiu X, Creutzberg C, Fotopoulou C, Gaffney D, Kehoe S, Lindemann K, Mutch D, Concin N; Endometrial Cancer Staging Subcommittee, FIGO Women's Cancer Committee
J Gynecol Oncol 2023 Sep;34(5):e85. Epub 2023 Aug 8 doi: 10.3802/jgo.2023.34.e85. PMID: 37593813Free PMC Article
Berek JS, Matias-Guiu X, Creutzberg C, Fotopoulou C, Gaffney D, Kehoe S, Lindemann K, Mutch D, Concin N; Endometrial Cancer Staging Subcommittee, FIGO Women's Cancer Committee
Int J Gynaecol Obstet 2023 Aug;162(2):383-394. Epub 2023 Jun 20 doi: 10.1002/ijgo.14923. PMID: 37337978
Zhou L, Yao L, Dai L, Zhu H, Ye X, Wang S, Cheng H, Ma R, Liu H, Cui H, Chang X
J Ovarian Res 2021 May 4;14(1):63. doi: 10.1186/s13048-021-00804-1. PMID: 33941230Free PMC Article
Devouassoux-Shisheboran M, Genestie C
Chin J Cancer 2015 Jan;34(1):50-5. doi: 10.5732/cjc.014.10273. PMID: 25556618Free PMC Article

Diagnosis

Mandelker D, Marra A, Zheng-Lin B, Selenica P, Blanco-Heredia J, Zhu Y, Gazzo A, Wong D, Yelskaya Z, Rai V, Somar J, Ostafi S, Mehta N, Yang C, Li Y, Brown DN, da Silva EM, Pei X, Linkov I, Terraf P, Misyura M, Ceyhan-Birsoy O, Ladanyi M, Berger M, Pareja F, Stadler Z, Offit K, Riaz N, Park W, Chou J, Capanu M, Koehler M, Rosen E, O'Reilly EM, Reis-Filho JS
J Clin Oncol 2023 Nov 20;41(33):5151-5162. Epub 2023 Aug 22 doi: 10.1200/JCO.23.00561. PMID: 37607324Free PMC Article
Wang X, Wang S, Yao S, Shi W, Ma K
J Ovarian Res 2022 Sep 16;15(1):104. doi: 10.1186/s13048-022-01037-6. PMID: 36114551Free PMC Article
Zhou L, Yao L, Dai L, Zhu H, Ye X, Wang S, Cheng H, Ma R, Liu H, Cui H, Chang X
J Ovarian Res 2021 May 4;14(1):63. doi: 10.1186/s13048-021-00804-1. PMID: 33941230Free PMC Article
Matias-Guiu X, Stewart CJR
Pathology 2018 Feb;50(2):190-204. Epub 2017 Dec 11 doi: 10.1016/j.pathol.2017.10.006. PMID: 29241974
Corakçi A, Ozeren S, Ozkan S, Gürbüz Y, Ustün H, Yücesoy I
Arch Gynecol Obstet 2005 Feb;271(2):176-7. Epub 2004 Feb 28 doi: 10.1007/s00404-004-0604-3. PMID: 14991382

Therapy

Wang X, Wang S, Yao S, Shi W, Ma K
J Ovarian Res 2022 Sep 16;15(1):104. doi: 10.1186/s13048-022-01037-6. PMID: 36114551Free PMC Article
Karami S, Daughtery SE, Schwartz K, Davis FG, Ruterbusch JJ, Wacholder S, Graubard BI, Berndt SI, Hofmann JN, Purdue MP, Moore LE, Colt JS
Int J Cancer 2016 Aug 1;139(3):584-92. Epub 2016 Apr 9 doi: 10.1002/ijc.30108. PMID: 27009534Free PMC Article
Tsujioka H, Hamada H, Miyakawa T, Hachisuga T, Kawarabayashi T
Gynecol Oncol 2003 Jun;89(3):540-2. doi: 10.1016/s0090-8258(03)00139-2. PMID: 12798727
Nishida T, Oda T, Sugiyama T, Kataoka A, Honda S, Yakushiji M
Eur J Obstet Gynecol Reprod Biol 1998 May;78(1):95-7. doi: 10.1016/s0301-2115(98)00013-x. PMID: 9605457
Viteri A, Vernace SJ, Schaffner F
Gastroenterology 1976 Dec;71(6):1075-8. PMID: 791743

Prognosis

Berek JS, Matias-Guiu X, Creutzberg C, Fotopoulou C, Gaffney D, Kehoe S, Lindemann K, Mutch D, Concin N; Endometrial Cancer Staging Subcommittee, FIGO Women's Cancer Committee
J Gynecol Oncol 2023 Sep;34(5):e85. Epub 2023 Aug 8 doi: 10.3802/jgo.2023.34.e85. PMID: 37593813Free PMC Article
Berek JS, Matias-Guiu X, Creutzberg C, Fotopoulou C, Gaffney D, Kehoe S, Lindemann K, Mutch D, Concin N; Endometrial Cancer Staging Subcommittee, FIGO Women's Cancer Committee
Int J Gynaecol Obstet 2023 Aug;162(2):383-394. Epub 2023 Jun 20 doi: 10.1002/ijgo.14923. PMID: 37337978
Wang X, Wang S, Yao S, Shi W, Ma K
J Ovarian Res 2022 Sep 16;15(1):104. doi: 10.1186/s13048-022-01037-6. PMID: 36114551Free PMC Article
Matias-Guiu X, Stewart CJR
Pathology 2018 Feb;50(2):190-204. Epub 2017 Dec 11 doi: 10.1016/j.pathol.2017.10.006. PMID: 29241974
McPherson AW, Roth A, Ha G, Chauve C, Steif A, de Souza CPE, Eirew P, Bouchard-Côté A, Aparicio S, Sahinalp SC, Shah SP
Genome Biol 2017 Jul 27;18(1):140. doi: 10.1186/s13059-017-1267-2. PMID: 28750660Free PMC Article

Clinical prediction guides

Tubridy EA, Eiva MA, Liu F, Omran DK, Gysler S, Brown EG, Roy AG, Zeng Y, Oh J, Cao Q, Gitto SB, Powell DJ Jr
Gynecol Oncol 2024 May;184:74-82. Epub 2024 Jan 29 doi: 10.1016/j.ygyno.2024.01.029. PMID: 38290413Free PMC Article
Euscher ED, Marques-Piubelli ML, Ramalingam P, Wistuba I, Lawson BC, Frumovitz M, Malpica A
Am J Surg Pathol 2023 Jun 1;47(6):635-648. Epub 2023 Apr 6 doi: 10.1097/PAS.0000000000002039. PMID: 37026792
Mirkovic J, Olkhov-Mitsel E, Amemiya Y, Al-Hussaini M, Nofech-Mozes S, Djordjevic B, Kupets R, Seth A, McCluggage WG
Histopathology 2023 Jun;82(7):978-990. Epub 2023 Mar 31 doi: 10.1111/his.14892. PMID: 36860193
Matias-Guiu X, Stewart CJR
Pathology 2018 Feb;50(2):190-204. Epub 2017 Dec 11 doi: 10.1016/j.pathol.2017.10.006. PMID: 29241974
McPherson AW, Roth A, Ha G, Chauve C, Steif A, de Souza CPE, Eirew P, Bouchard-Côté A, Aparicio S, Sahinalp SC, Shah SP
Genome Biol 2017 Jul 27;18(1):140. doi: 10.1186/s13059-017-1267-2. PMID: 28750660Free PMC Article

Recent systematic reviews

Wang X, Wang S, Yao S, Shi W, Ma K
J Ovarian Res 2022 Sep 16;15(1):104. doi: 10.1186/s13048-022-01037-6. PMID: 36114551Free PMC Article
Helder-Woolderink JM, Blok EA, Vasen HF, Hollema H, Mourits MJ, De Bock GH
Eur J Cancer 2016 Mar;55:65-73. Epub 2016 Jan 13 doi: 10.1016/j.ejca.2015.12.005. PMID: 26773421

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