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Encapsulated Breast Papillary Carcinoma

MedGen UID:
1788984
•Concept ID:
C5444182
•
Neoplastic Process

Definition

Breast carcinoma characterized by the presence of fine fibrovascular stalks covered by neoplastic epithelial cells of low or intermediate nuclear grade, typically present within a cystic space and surrounded by a fibrous capsule. There are usually no myoepithelial cells along the papillae or at the periphery of the lesion. (WHO 2019) [from NCI]

Term Hierarchy

CClinical test,  RResearch test,  OOMIM,  GGeneReviews,  VClinVar  
  • CROGVEncapsulated Breast Papillary Carcinoma

Professional guidelines

PubMed

Papillary Breast Tumors: Continuing Controversies and Commentary on WHO's 2019 Criteria and Classification.
Patel A, Hoda RS, Hoda SA
Int J Surg Pathol 2022 Apr;30(2):124-137. Epub 2021 Aug 5 doi: 10.1177/10668969211035843. PMID: 34351218
Papillary carcinoma of the breast: diagnostic agreement and management implications.
Rakha EA, Ahmed MA, Ellis IO
Histopathology 2016 Nov;69(5):862-870. Epub 2016 Aug 1 doi: 10.1111/his.13009. PMID: 27270947
Papillary lesions of the breast: selected diagnostic and management issues.
Collins LC, Schnitt SJ
Histopathology 2008 Jan;52(1):20-9. doi: 10.1111/j.1365-2559.2007.02898.x. PMID: 18171414

Recent clinical studies

Etiology

Encapsulated papillary carcinoma of the breast: An institutional case series and literature review.
Tan HJ, Tan PH, Leong LCH, Tan VKM, Tan BKT, Lim SZ, Preetha M, Wong CY, Yong WS, Sim Y
Cancer Med 2023 May;12(10):11408-11416. Epub 2023 Mar 31 doi: 10.1002/cam4.5855. PMID: 36999966Free PMC Article
Papillary lesions of the breast - review and practical issues.
Ni Y, Tse GM
Semin Diagn Pathol 2022 Sep;39(5):344-354. Epub 2022 Jun 11 doi: 10.1053/j.semdp.2022.06.001. PMID: 35718581
Papillary lesions of the breast.
Kulka J, Madaras L, Floris G, Lax SF
Virchows Arch 2022 Jan;480(1):65-84. Epub 2021 Nov 3 doi: 10.1007/s00428-021-03182-7. PMID: 34734332Free PMC Article
Molecular analysis of encapsulated papillary carcinoma of the breast with and without invasion.
Schwartz CJ, Boroujeni AM, Khodadadi-Jamayran A, Heguy A, Snuderl M, Jour G, Cotzia P, Darvishian F
Hum Pathol 2021 May;111:67-74. Epub 2021 Mar 3 doi: 10.1016/j.humpath.2021.02.005. PMID: 33667422
High-grade encapsulated papillary carcinoma of the breast: an under-recognized entity.
Rakha EA, Varga Z, Elsheik S, Ellis IO
Histopathology 2015 Apr;66(5):740-6. Epub 2014 Dec 22 doi: 10.1111/his.12591. PMID: 25382726

Diagnosis

Papillary lesions of the breast.
Kulka J, Madaras L, Floris G, Lax SF
Virchows Arch 2022 Jan;480(1):65-84. Epub 2021 Nov 3 doi: 10.1007/s00428-021-03182-7. PMID: 34734332Free PMC Article
Apocrine lesions of the breast.
Quinn CM, D'Arcy C, Wells C
Virchows Arch 2022 Jan;480(1):177-189. Epub 2021 Sep 18 doi: 10.1007/s00428-021-03185-4. PMID: 34537861Free PMC Article
Papillary neoplasms of the breast-reviewing the spectrum.
Tay TKY, Tan PH
Mod Pathol 2021 Jun;34(6):1044-1061. Epub 2021 Jan 18 doi: 10.1038/s41379-020-00732-3. PMID: 33462367
Papillary and neuroendocrine breast lesions: the WHO stance.
Tan PH, Schnitt SJ, van de Vijver MJ, Ellis IO, Lakhani SR
Histopathology 2015 May;66(6):761-70. Epub 2015 Jan 23 doi: 10.1111/his.12463. PMID: 24845113
Encapsulated papillary carcinoma of the breast: An overview.
George K, Anna Z, Evanthia K, Vassilios K
J Cancer Res Ther 2013 Oct-Dec;9(4):564-70. doi: 10.4103/0973-1482.126448. PMID: 24518697

Therapy

Literature review and case report of bilateral intracystic papillary carcinoma associated with an invasive ductal carcinoma in a male breast.
Avau F, Chintinne M, Baudry S, Buxant F
Breast Dis 2022;41(1):5-13. doi: 10.3233/BD-210001. PMID: 34219706
The 21-gene recurrence score in special histologic subtypes of breast cancer with favorable prognosis.
Turashvili G, Brogi E, Morrow M, Hudis C, Dickler M, Norton L, Wen HY
Breast Cancer Res Treat 2017 Aug;165(1):65-76. Epub 2017 Jun 3 doi: 10.1007/s10549-017-4326-1. PMID: 28577081Free PMC Article

Prognosis

Encapsulated papillary carcinoma of the breast: An institutional case series and literature review.
Tan HJ, Tan PH, Leong LCH, Tan VKM, Tan BKT, Lim SZ, Preetha M, Wong CY, Yong WS, Sim Y
Cancer Med 2023 May;12(10):11408-11416. Epub 2023 Mar 31 doi: 10.1002/cam4.5855. PMID: 36999966Free PMC Article
Papillary neoplasms of the breast-reviewing the spectrum.
Tay TKY, Tan PH
Mod Pathol 2021 Jun;34(6):1044-1061. Epub 2021 Jan 18 doi: 10.1038/s41379-020-00732-3. PMID: 33462367
Encapsulated papillary carcinoma (EPC) of breast: A clinical, pathological and immunohistochemical analysis of eight cases.
Tariq N, Mamoon N, Usman M, Ali Z, Nazir I
J Pak Med Assoc 2016 Nov;66(11):1490-1493. PMID: 27812076
Encapsulated papillary carcinoma, apocrine type, of the breast.
Kuroda N, Fujishima N, Hayes MM, Moritani S, Ichihara S
Malays J Pathol 2014 Aug;36(2):139-43. PMID: 25194537
Encapsulated papillary carcinoma of the breast: An overview.
George K, Anna Z, Evanthia K, Vassilios K
J Cancer Res Ther 2013 Oct-Dec;9(4):564-70. doi: 10.4103/0973-1482.126448. PMID: 24518697

Clinical prediction guides

Papillary lesions of the breast.
Kulka J, Madaras L, Floris G, Lax SF
Virchows Arch 2022 Jan;480(1):65-84. Epub 2021 Nov 3 doi: 10.1007/s00428-021-03182-7. PMID: 34734332Free PMC Article
Solid Papillary Carcinoma and Encapsulated Papillary Carcinoma of the Breast: Clinical-Pathologic Features and Basement Membrane Studies of 50 Cases.
Morgan S, Dodington D, Wu JM, Turashvili G
Pathobiology 2021;88(5):359-373. Epub 2021 Jul 15 doi: 10.1159/000517189. PMID: 34265775
Encapsulated papillary carcinoma of breast; a clinicopathological study of 25 cases and literature review with emphasis on high grade variant.
Tariq MU, Idress R, Qureshi MB, Kayani N
Ann Diagn Pathol 2020 Dec;49:151613. Epub 2020 Aug 28 doi: 10.1016/j.anndiagpath.2020.151613. PMID: 32911448
Papillary carcinoma of the breast: diagnostic agreement and management implications.
Rakha EA, Ahmed MA, Ellis IO
Histopathology 2016 Nov;69(5):862-870. Epub 2016 Aug 1 doi: 10.1111/his.13009. PMID: 27270947
Breast lesions of uncertain malignant nature and limited metastatic potential: proposals to improve their recognition and clinical management.
Rakha EA, Badve S, Eusebi V, Reis-Filho JS, Fox SB, Dabbs DJ, Decker T, Hodi Z, Ichihara S, Lee AH, Palacios J, Richardson AL, Vincent-Salomon A, Schmitt FC, Tan PH, Tse GM, Ellis IO
Histopathology 2016 Jan;68(1):45-56. doi: 10.1111/his.12861. PMID: 26348644Free PMC Article

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