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Proximal Gastric Adenocarcinoma

MedGen UID:
1718863
•Concept ID:
C5237322
•
Neoplastic Process

Definition

A gastric adenocarcinoma that arises from the proximal part of the stomach. [from NCI]

Term Hierarchy

CClinical test,  RResearch test,  OOMIM,  GGeneReviews,  VClinVar  
  • CROGVProximal Gastric Adenocarcinoma

Professional guidelines

PubMed

Updated European guidelines for clinical management of familial adenomatous polyposis (FAP), MUTYH-associated polyposis (MAP), gastric adenocarcinoma, proximal polyposis of the stomach (GAPPS) and other rare adenomatous polyposis syndromes: a joint EHTG-ESCP revision.
Zaffaroni G, Mannucci A, Koskenvuo L, de Lacy B, Maffioli A, Bisseling T, Half E, Cavestro GM, Valle L, Ryan N, Aretz S, Brown K, Buttitta F, Carneiro F, Claber O, Blanco-Colino R, Collard M, Crosbie E, Cunha M, Doulias T, Fleming C, Heinrich H, Hüneburg R, Metras J, Nagtegaal I, Negoi I, Nielsen M, Pellino G, Ricciardiello L, Sagir A, Sánchez-Guillén L, Seppälä TT, Siersema P, Striebeck B, Sampson JR, Latchford A, Parc Y, Burn J, Möslein G
Br J Surg 2024 May 3;111(5) doi: 10.1093/bjs/znae070. PMID: 38722804Free PMC Article

Recent clinical studies

Etiology

Hypergastrinemia and mortality in gastric adenocarcinoma: a population-based cohort study, the HUNT study.
Ness-Jensen E, Bringeland EA, Mjønes P, Lagergren J, Grønbech JE, Waldum H, Fossmark R
Scand J Gastroenterol 2022 May;57(5):558-565. Epub 2022 Jan 22 doi: 10.1080/00365521.2022.2026462. PMID: 35068320
Hypergastrinemia is associated with an increased risk of gastric adenocarcinoma with proximal location: A prospective population-based nested case-control study.
Ness-Jensen E, Bringeland EA, Mattsson F, Mjønes P, Lagergren J, Grønbech JE, Waldum HL, Fossmark R
Int J Cancer 2021 Apr 15;148(8):1879-1886. Epub 2020 Nov 2 doi: 10.1002/ijc.33354. PMID: 33091962Free PMC Article
Oesophageal and proximal gastric adenocarcinomas are rare after detection of Helicobacter pylori infection.
Kumar S, Metz DC, Ginsberg GG, Kaplan DE, Goldberg DS
Aliment Pharmacol Ther 2020 Apr;51(8):781-788. Epub 2020 Mar 4 doi: 10.1111/apt.15677. PMID: 32133681Free PMC Article
Mediastinal lymph node dissection and distal esophagectomy is not essential in early esophagogastric junction adenocarcinoma.
Lee IS, Ahn JY, Yook JH, Kim BS
World J Surg Oncol 2017 Jan 18;15(1):28. doi: 10.1186/s12957-016-1088-x. PMID: 28100248Free PMC Article
Total gastrectomy is not necessary for proximal gastric cancer.
Harrison LE, Karpeh MS, Brennan MF
Surgery 1998 Feb;123(2):127-30. PMID: 9481396

Diagnosis

Hypergastrinemia and mortality in gastric adenocarcinoma: a population-based cohort study, the HUNT study.
Ness-Jensen E, Bringeland EA, Mjønes P, Lagergren J, Grønbech JE, Waldum H, Fossmark R
Scand J Gastroenterol 2022 May;57(5):558-565. Epub 2022 Jan 22 doi: 10.1080/00365521.2022.2026462. PMID: 35068320
Two updates on oesophagogastric junction adenocarcinoma from the fifth WHO classification: Alteration of definition and emphasis on HER2 test.
Li Y, Li J, Li J
Histol Histopathol 2021 Mar;36(3):339-346. Epub 2020 Dec 30 doi: 10.14670/HH-18-296. PMID: 33377175
Hypergastrinemia is associated with an increased risk of gastric adenocarcinoma with proximal location: A prospective population-based nested case-control study.
Ness-Jensen E, Bringeland EA, Mattsson F, Mjønes P, Lagergren J, Grønbech JE, Waldum HL, Fossmark R
Int J Cancer 2021 Apr 15;148(8):1879-1886. Epub 2020 Nov 2 doi: 10.1002/ijc.33354. PMID: 33091962Free PMC Article
Oesophageal and proximal gastric adenocarcinomas are rare after detection of Helicobacter pylori infection.
Kumar S, Metz DC, Ginsberg GG, Kaplan DE, Goldberg DS
Aliment Pharmacol Ther 2020 Apr;51(8):781-788. Epub 2020 Mar 4 doi: 10.1111/apt.15677. PMID: 32133681Free PMC Article
Mediastinal lymph node dissection and distal esophagectomy is not essential in early esophagogastric junction adenocarcinoma.
Lee IS, Ahn JY, Yook JH, Kim BS
World J Surg Oncol 2017 Jan 18;15(1):28. doi: 10.1186/s12957-016-1088-x. PMID: 28100248Free PMC Article

Therapy

Laparoscopic D2 total gastrectomy and en-mass splenectomy and distal pancreatectomy for locally advanced proximal gastric cancer.
Toh BC, Rao J
Surg Endosc 2018 Apr;32(4):2156. Epub 2017 Aug 25 doi: 10.1007/s00464-017-5801-9. PMID: 28842726
Randomized Controlled Trial to Evaluate Splenectomy in Total Gastrectomy for Proximal Gastric Carcinoma.
Sano T, Sasako M, Mizusawa J, Yamamoto S, Katai H, Yoshikawa T, Nashimoto A, Ito S, Kaji M, Imamura H, Fukushima N, Fujitani K; Stomach Cancer Study Group of the Japan Clinical Oncology Group
Ann Surg 2017 Feb;265(2):277-283. doi: 10.1097/SLA.0000000000001814. PMID: 27280511

Prognosis

Hypergastrinemia is associated with an increased risk of gastric adenocarcinoma with proximal location: A prospective population-based nested case-control study.
Ness-Jensen E, Bringeland EA, Mattsson F, Mjønes P, Lagergren J, Grønbech JE, Waldum HL, Fossmark R
Int J Cancer 2021 Apr 15;148(8):1879-1886. Epub 2020 Nov 2 doi: 10.1002/ijc.33354. PMID: 33091962Free PMC Article
Oesophageal and proximal gastric adenocarcinomas are rare after detection of Helicobacter pylori infection.
Kumar S, Metz DC, Ginsberg GG, Kaplan DE, Goldberg DS
Aliment Pharmacol Ther 2020 Apr;51(8):781-788. Epub 2020 Mar 4 doi: 10.1111/apt.15677. PMID: 32133681Free PMC Article
Mediastinal lymph node dissection and distal esophagectomy is not essential in early esophagogastric junction adenocarcinoma.
Lee IS, Ahn JY, Yook JH, Kim BS
World J Surg Oncol 2017 Jan 18;15(1):28. doi: 10.1186/s12957-016-1088-x. PMID: 28100248Free PMC Article
The importance of the proximal resection margin distance for proximal gastric adenocarcinoma: A multi-institutional study of the US Gastric Cancer Collaborative.
Postlewait LM, Squires MH 3rd, Kooby DA, Poultsides GA, Weber SM, Bloomston M, Fields RC, Pawlik TM, Votanopoulos KI, Schmidt CR, Ejaz A, Acher AW, Worhunsky DJ, Saunders N, Swords D, Jin LX, Cho CS, Winslow ER, Cardona K, Staley CA, Maithel SK
J Surg Oncol 2015 Aug;112(2):203-7. Epub 2015 Aug 14 doi: 10.1002/jso.23971. PMID: 26272801
Total gastrectomy is not necessary for proximal gastric cancer.
Harrison LE, Karpeh MS, Brennan MF
Surgery 1998 Feb;123(2):127-30. PMID: 9481396

Clinical prediction guides

Two updates on oesophagogastric junction adenocarcinoma from the fifth WHO classification: Alteration of definition and emphasis on HER2 test.
Li Y, Li J, Li J
Histol Histopathol 2021 Mar;36(3):339-346. Epub 2020 Dec 30 doi: 10.14670/HH-18-296. PMID: 33377175
Mediastinal lymph node dissection and distal esophagectomy is not essential in early esophagogastric junction adenocarcinoma.
Lee IS, Ahn JY, Yook JH, Kim BS
World J Surg Oncol 2017 Jan 18;15(1):28. doi: 10.1186/s12957-016-1088-x. PMID: 28100248Free PMC Article
Allelotype analysis of adenocarcinoma of the gastric cardia.
Gleeson CM, Sloan JM, McGuigan JA, Ritchie AJ, Weber JL, Russell SE
Br J Cancer 1997;76(11):1455-65. doi: 10.1038/bjc.1997.578. PMID: 9400942Free PMC Article
Proximal compared with distal adenocarcinoma of the stomach: differences and consequences. German Gastric Cancer TNM Study Group.
Rohde H, Bauer P, Stützer H, Heitmann K, Gebbensleben B
Br J Surg 1991 Oct;78(10):1242-8. doi: 10.1002/bjs.1800781031. PMID: 1958996

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