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Nonmucinous bronchioloalveolar adenocarcinoma

MedGen UID:
266089
Concept ID:
C1266034
Neoplastic Process
Synonyms: Bronchiolo-alveolar carcinoma, Clara cell; Bronchiolo-alveolar carcinoma, non-mucinous; Bronchiolo-alveolar carcinoma, type II pneumocyte; Minimally Invasive Lung Non-Mucinous Adenocarcinoma; Non-Mucinous Minimally Invasive Lung Adenocarcinoma; nonmucinous bronchioloalveolar adenocarcinoma
SNOMED CT: Bronchiolo-alveolar carcinoma, type II pneumocyte (128659000); Bronchiolo-alveolar carcinoma, Clara cell (128659000); Bronchiolo-alveolar carcinoma, non-mucinous (128659000)
 
Monarch Initiative: MONDO:0000895

Definition

A morphologic variant of minimally invasive lung adenocarcinoma characterized by the presence of Clara cells and/or type II cells. [from NCI]

Term Hierarchy

CClinical test,  RResearch test,  OOMIM,  GGeneReviews,  VClinVar  
  • CROGVNonmucinous bronchioloalveolar adenocarcinoma

Professional guidelines

PubMed

Jie-Liu, Li XY, Zhao YQ, Liu RQ, Zhang JB, Ma J, Chen LJ, Hu XF
Pathol Res Pract 2014 Mar;210(3):176-81. Epub 2013 Dec 5 doi: 10.1016/j.prp.2013.11.013. PMID: 24370340
Vazquez MF, Flieder DB
Radiol Clin North Am 2000 May;38(3):579-89. doi: 10.1016/s0033-8389(05)70186-x. PMID: 10855263

Recent clinical studies

Etiology

Cui D, Xie S, Liu Q
BMC Pulm Med 2023 Jan 9;23(1):9. doi: 10.1186/s12890-023-02305-x. PMID: 36624430Free PMC Article
Cadranel J, Gervais R, Merle P, Moro-Sibilot D, Westeel V, Bigay-Game L, Quoix E, Friard S, Barlesi F, Lethrosne C, Moreau L, Monnet I, Salaun M, Oliviero G, Souquet PJ, Antoine M, Langlais A, Morin F, Wislez M, Zalcman G; Intergroupe Francophone de Cancérologie Thoracique (IFCT)
Eur Respir J 2015 Nov;46(5):1440-50. Epub 2015 Sep 17 doi: 10.1183/13993003.02358-2014. PMID: 26381515
Zhang Z, Wang A, Sun B, Zhan Z, Chen K, Wang C
J Cardiothorac Surg 2013 Apr 16;8:95. doi: 10.1186/1749-8090-8-95. PMID: 23591077Free PMC Article
Kakegawa S, Shimizu K, Sugano M, Miyamae Y, Kaira K, Araki T, Nakano T, Kamiyoshihara M, Kawashima O, Takeyoshi I
Cancer 2011 Sep 15;117(18):4257-66. Epub 2011 Mar 8 doi: 10.1002/cncr.26010. PMID: 21387273
Toonkel RL, Borczuk AC, Powell CA
J Thorac Oncol 2010 Feb;5(2):153-7. doi: 10.1097/JTO.0b013e3181c8cc0c. PMID: 20101143Free PMC Article

Diagnosis

Mir E, Sareen R, Kulshreshtha R, Shah A
Pneumonol Alergol Pol 2015;83(3):208-11. doi: 10.5603/PiAP.2015.0033. PMID: 26050981
Yamamoto M, Takeuchi K, Shimoji M, Maniwa T, Isaka M, Nakagawa K, Ohde Y, Kondo H, Nakajima T
Cancer Sci 2012 Feb;103(2):390-2. doi: 10.1111/j.1349-7006.2011.02136.x. PMID: 22296236
Travis WD, Brambilla E, Noguchi M, Nicholson AG, Geisinger KR, Yatabe Y, Beer DG, Powell CA, Riely GJ, Van Schil PE, Garg K, Austin JH, Asamura H, Rusch VW, Hirsch FR, Scagliotti G, Mitsudomi T, Huber RM, Ishikawa Y, Jett J, Sanchez-Cespedes M, Sculier JP, Takahashi T, Tsuboi M, Vansteenkiste J, Wistuba I, Yang PC, Aberle D, Brambilla C, Flieder D, Franklin W, Gazdar A, Gould M, Hasleton P, Henderson D, Johnson B, Johnson D, Kerr K, Kuriyama K, Lee JS, Miller VA, Petersen I, Roggli V, Rosell R, Saijo N, Thunnissen E, Tsao M, Yankelewitz D
J Thorac Oncol 2011 Feb;6(2):244-85. doi: 10.1097/JTO.0b013e318206a221. PMID: 21252716Free PMC Article
Lee KS, Kim Y, Han J, Ko EJ, Park CK, Primack SL
Radiographics 1997 Nov-Dec;17(6):1345-57. doi: 10.1148/radiographics.17.6.9397450. PMID: 9397450
Casey KR
Semin Respir Infect 1995 Sep;10(3):131-42. PMID: 7481127

Therapy

Cadranel J, Gervais R, Merle P, Moro-Sibilot D, Westeel V, Bigay-Game L, Quoix E, Friard S, Barlesi F, Lethrosne C, Moreau L, Monnet I, Salaun M, Oliviero G, Souquet PJ, Antoine M, Langlais A, Morin F, Wislez M, Zalcman G; Intergroupe Francophone de Cancérologie Thoracique (IFCT)
Eur Respir J 2015 Nov;46(5):1440-50. Epub 2015 Sep 17 doi: 10.1183/13993003.02358-2014. PMID: 26381515
Whitson BA, Groth SS, Andrade RS, Mitiek MO, Maddaus MA, D'Cunha J
J Thorac Cardiovasc Surg 2012 Mar;143(3):591-600.e1. Epub 2011 Dec 15 doi: 10.1016/j.jtcvs.2011.10.088. PMID: 22177098
Hata A, Katakami N, Fujita S, Kaji R, Imai Y, Takahashi Y, Nishimura T, Tomii K, Ishihara K
J Thorac Oncol 2010 Aug;5(8):1197-200. doi: 10.1097/JTO.0b013e3181e2a2bc. PMID: 20661086
Sartori G, Cavazza A, Sgambato A, Marchioni A, Barbieri F, Longo L, Bavieri M, Murer B, Meschiari E, Tamberi S, Cadioli A, Luppi F, Migaldi M, Rossi G
Am J Clin Pathol 2009 Apr;131(4):478-89. doi: 10.1309/AJCPH0TRMPXVZW2F. PMID: 19289583
Okubo K, Mark EJ, Flieder D, Wain JC, Wright CD, Moncure AC, Grillo HC, Mathisen DJ
J Thorac Cardiovasc Surg 1999 Oct;118(4):702-9. doi: 10.1016/S0022-5223(99)70016-4. PMID: 10504637

Prognosis

Cui D, Xie S, Liu Q
BMC Pulm Med 2023 Jan 9;23(1):9. doi: 10.1186/s12890-023-02305-x. PMID: 36624430Free PMC Article
Mir E, Sareen R, Kulshreshtha R, Shah A
Pneumonol Alergol Pol 2015;83(3):208-11. doi: 10.5603/PiAP.2015.0033. PMID: 26050981
Austin JH, Garg K, Aberle D, Yankelevitz D, Kuriyama K, Lee HJ, Brambilla E, Travis WD
Radiology 2013 Jan;266(1):62-71. Epub 2012 Oct 15 doi: 10.1148/radiol.12120240. PMID: 23070271
Travis WD, Brambilla E, Noguchi M, Nicholson AG, Geisinger KR, Yatabe Y, Beer DG, Powell CA, Riely GJ, Van Schil PE, Garg K, Austin JH, Asamura H, Rusch VW, Hirsch FR, Scagliotti G, Mitsudomi T, Huber RM, Ishikawa Y, Jett J, Sanchez-Cespedes M, Sculier JP, Takahashi T, Tsuboi M, Vansteenkiste J, Wistuba I, Yang PC, Aberle D, Brambilla C, Flieder D, Franklin W, Gazdar A, Gould M, Hasleton P, Henderson D, Johnson B, Johnson D, Kerr K, Kuriyama K, Lee JS, Miller VA, Petersen I, Roggli V, Rosell R, Saijo N, Thunnissen E, Tsao M, Yankelewitz D
J Thorac Oncol 2011 Feb;6(2):244-85. doi: 10.1097/JTO.0b013e318206a221. PMID: 21252716Free PMC Article
Casey KR
Semin Respir Infect 1995 Sep;10(3):131-42. PMID: 7481127

Clinical prediction guides

Cui D, Xie S, Liu Q
BMC Pulm Med 2023 Jan 9;23(1):9. doi: 10.1186/s12890-023-02305-x. PMID: 36624430Free PMC Article
Travis WD, Brambilla E, Noguchi M, Nicholson AG, Geisinger KR, Yatabe Y, Beer DG, Powell CA, Riely GJ, Van Schil PE, Garg K, Austin JH, Asamura H, Rusch VW, Hirsch FR, Scagliotti G, Mitsudomi T, Huber RM, Ishikawa Y, Jett J, Sanchez-Cespedes M, Sculier JP, Takahashi T, Tsuboi M, Vansteenkiste J, Wistuba I, Yang PC, Aberle D, Brambilla C, Flieder D, Franklin W, Gazdar A, Gould M, Hasleton P, Henderson D, Johnson B, Johnson D, Kerr K, Kuriyama K, Lee JS, Miller VA, Petersen I, Roggli V, Rosell R, Saijo N, Thunnissen E, Tsao M, Yankelewitz D
J Thorac Oncol 2011 Feb;6(2):244-85. doi: 10.1097/JTO.0b013e318206a221. PMID: 21252716Free PMC Article
Maezawa N, Tsuta K, Shibuki Y, Yamazaki S, Maeshima AM, Watanabe S, Matsuno Y
Cancer 2006 Dec 25;108(6):488-93. doi: 10.1002/cncr.22287. PMID: 17096436
Nakanishi K, Matsuo H, Kanai Y, Endou H, Hiroi S, Tominaga S, Mukai M, Ikeda E, Ozeki Y, Aida S, Kawai T
Virchows Arch 2006 Feb;448(2):142-50. Epub 2005 Sep 21 doi: 10.1007/s00428-005-0063-7. PMID: 16175382
Okubo K, Mark EJ, Flieder D, Wain JC, Wright CD, Moncure AC, Grillo HC, Mathisen DJ
J Thorac Cardiovasc Surg 1999 Oct;118(4):702-9. doi: 10.1016/S0022-5223(99)70016-4. PMID: 10504637

Recent systematic reviews

Travis WD, Brambilla E, Noguchi M, Nicholson AG, Geisinger KR, Yatabe Y, Beer DG, Powell CA, Riely GJ, Van Schil PE, Garg K, Austin JH, Asamura H, Rusch VW, Hirsch FR, Scagliotti G, Mitsudomi T, Huber RM, Ishikawa Y, Jett J, Sanchez-Cespedes M, Sculier JP, Takahashi T, Tsuboi M, Vansteenkiste J, Wistuba I, Yang PC, Aberle D, Brambilla C, Flieder D, Franklin W, Gazdar A, Gould M, Hasleton P, Henderson D, Johnson B, Johnson D, Kerr K, Kuriyama K, Lee JS, Miller VA, Petersen I, Roggli V, Rosell R, Saijo N, Thunnissen E, Tsao M, Yankelewitz D
J Thorac Oncol 2011 Feb;6(2):244-85. doi: 10.1097/JTO.0b013e318206a221. PMID: 21252716Free PMC Article

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