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Nonmucinous bronchioloalveolar adenocarcinoma

MedGen UID:
266089
•Concept ID:
C1266034
•
Neoplastic Process
Synonyms: Bronchiolo-alveolar carcinoma, Clara cell; Bronchiolo-alveolar carcinoma, non-mucinous; Bronchiolo-alveolar carcinoma, type II pneumocyte; Minimally Invasive Lung Non-Mucinous Adenocarcinoma; Non-Mucinous Minimally Invasive Lung Adenocarcinoma; nonmucinous bronchioloalveolar adenocarcinoma
SNOMED CT: Bronchiolo-alveolar carcinoma, type II pneumocyte (128659000); Bronchiolo-alveolar carcinoma, Clara cell (128659000); Bronchiolo-alveolar carcinoma, non-mucinous (128659000)
 
Monarch Initiative: MONDO:0000895

Definition

A morphologic variant of minimally invasive lung adenocarcinoma characterized by the presence of Clara cells and/or type II cells. [from NCI]

Term Hierarchy

CClinical test,  RResearch test,  OOMIM,  GGeneReviews,  VClinVar  
  • CROGVNonmucinous bronchioloalveolar adenocarcinoma

Professional guidelines

PubMed

Genotype-phenotype correlation in Chinese patients with pulmonary mixed type adenocarcinoma: Relationship between histologic subtypes, TITF-1/SP-A expressions and EGFR mutations.
Jie-Liu, Li XY, Zhao YQ, Liu RQ, Zhang JB, Ma J, Chen LJ, Hu XF
Pathol Res Pract 2014 Mar;210(3):176-81. Epub 2013 Dec 5 doi: 10.1016/j.prp.2013.11.013. PMID: 24370340
Small peripheral glandular lesions detected by screening CT for lung cancer. A diagnostic dilemma for the pathologist.
Vazquez MF, Flieder DB
Radiol Clin North Am 2000 May;38(3):579-89. doi: 10.1016/s0033-8389(05)70186-x. PMID: 10855263

Recent clinical studies

Etiology

Postoperative survival of pulmonary invasive mucinous adenocarcinoma versus non-mucinous invasive adenocarcinoma.
Cui D, Xie S, Liu Q
BMC Pulm Med 2023 Jan 9;23(1):9. doi: 10.1186/s12890-023-02305-x. PMID: 36624430Free PMC Article
Erlotinib versus carboplatin and paclitaxel in advanced lepidic adenocarcinoma: IFCT-0504.
Cadranel J, Gervais R, Merle P, Moro-Sibilot D, Westeel V, Bigay-Game L, Quoix E, Friard S, Barlesi F, Lethrosne C, Moreau L, Monnet I, Salaun M, Oliviero G, Souquet PJ, Antoine M, Langlais A, Morin F, Wislez M, Zalcman G; Intergroupe Francophone de Cancérologie Thoracique (IFCT)
Eur Respir J 2015 Nov;46(5):1440-50. Epub 2015 Sep 17 doi: 10.1183/13993003.02358-2014. PMID: 26381515
Expression of CLDN1 and CLDN10 in lung adenocarcinoma in situ and invasive lepidic predominant adenocarcinoma.
Zhang Z, Wang A, Sun B, Zhan Z, Chen K, Wang C
J Cardiothorac Surg 2013 Apr 16;8:95. doi: 10.1186/1749-8090-8-95. PMID: 23591077Free PMC Article
Clinicopathological features of lung adenocarcinoma with KRAS mutations.
Kakegawa S, Shimizu K, Sugano M, Miyamae Y, Kaira K, Araki T, Nakano T, Kamiyoshihara M, Kawashima O, Takeyoshi I
Cancer 2011 Sep 15;117(18):4257-66. Epub 2011 Mar 8 doi: 10.1002/cncr.26010. PMID: 21387273
Tgf-beta signaling pathway in lung adenocarcinoma invasion.
Toonkel RL, Borczuk AC, Powell CA
J Thorac Oncol 2010 Feb;5(2):153-7. doi: 10.1097/JTO.0b013e3181c8cc0c. PMID: 20101143Free PMC Article

Diagnosis

International association for the study of lung cancer/american thoracic society/european respiratory society international multidisciplinary classification of lung adenocarcinoma.
Travis WD, Brambilla E, Noguchi M, Nicholson AG, Geisinger KR, Yatabe Y, Beer DG, Powell CA, Riely GJ, Van Schil PE, Garg K, Austin JH, Asamura H, Rusch VW, Hirsch FR, Scagliotti G, Mitsudomi T, Huber RM, Ishikawa Y, Jett J, Sanchez-Cespedes M, Sculier JP, Takahashi T, Tsuboi M, Vansteenkiste J, Wistuba I, Yang PC, Aberle D, Brambilla C, Flieder D, Franklin W, Gazdar A, Gould M, Hasleton P, Henderson D, Johnson B, Johnson D, Kerr K, Kuriyama K, Lee JS, Miller VA, Petersen I, Roggli V, Rosell R, Saijo N, Thunnissen E, Tsao M, Yankelewitz D
J Thorac Oncol 2011 Feb;6(2):244-85. doi: 10.1097/JTO.0b013e318206a221. PMID: 21252716Free PMC Article
Bronchioloalveolar carcinoma: the case for two diseases.
Garfield DH, Cadranel J, West HL
Clin Lung Cancer 2008 Jan;9(1):24-9. doi: 10.3816/CLC.2008.n.004. PMID: 18282354
Distinctive evaluation of nonmucinous and mucinous subtypes of bronchioloalveolar carcinomas in EGFR and K-ras gene-mutation analyses for Japanese lung adenocarcinomas: confirmation of the correlations with histologic subtypes and gene mutations.
Sakuma Y, Matsukuma S, Yoshihara M, Nakamura Y, Noda K, Nakayama H, Kameda Y, Tsuchiya E, Miyagi Y
Am J Clin Pathol 2007 Jul;128(1):100-8. doi: 10.1309/WVXFGAFLAUX48DU6. PMID: 17580276
Bronchioloalveolar carcinoma: clinical, histopathologic, and radiologic findings.
Lee KS, Kim Y, Han J, Ko EJ, Park CK, Primack SL
Radiographics 1997 Nov-Dec;17(6):1345-57. doi: 10.1148/radiographics.17.6.9397450. PMID: 9397450
Neoplastic mimics of pneumonia.
Casey KR
Semin Respir Infect 1995 Sep;10(3):131-42. PMID: 7481127

Therapy

Erlotinib versus carboplatin and paclitaxel in advanced lepidic adenocarcinoma: IFCT-0504.
Cadranel J, Gervais R, Merle P, Moro-Sibilot D, Westeel V, Bigay-Game L, Quoix E, Friard S, Barlesi F, Lethrosne C, Moreau L, Monnet I, Salaun M, Oliviero G, Souquet PJ, Antoine M, Langlais A, Morin F, Wislez M, Zalcman G; Intergroupe Francophone de Cancérologie Thoracique (IFCT)
Eur Respir J 2015 Nov;46(5):1440-50. Epub 2015 Sep 17 doi: 10.1183/13993003.02358-2014. PMID: 26381515
Frequency of EGFR and KRAS mutations in Japanese patients with lung adenocarcinoma with features of the mucinous subtype of bronchioloalveolar carcinoma.
Hata A, Katakami N, Fujita S, Kaji R, Imai Y, Takahashi Y, Nishimura T, Tomii K, Ishihara K
J Thorac Oncol 2010 Aug;5(8):1197-200. doi: 10.1097/JTO.0b013e3181e2a2bc. PMID: 20661086
Non-mucinous and mucinous subtypes of adenocarcinoma with bronchioloalveolar carcinoma features differ by biomarker expression and in the response to gefitinib.
Wislez M, Antoine M, Baudrin L, Poulot V, Neuville A, Pradere M, Longchampt E, Isaac-Sibille S, Lebitasy MP, Cadranel J
Lung Cancer 2010 May;68(2):185-91. Epub 2009 Jul 5 doi: 10.1016/j.lungcan.2009.05.021. PMID: 19581016
EGFR and K-ras mutations along the spectrum of pulmonary epithelial tumors of the lung and elaboration of a combined clinicopathologic and molecular scoring system to predict clinical responsiveness to EGFR inhibitors.
Sartori G, Cavazza A, Sgambato A, Marchioni A, Barbieri F, Longo L, Bavieri M, Murer B, Meschiari E, Tamberi S, Cadioli A, Luppi F, Migaldi M, Rossi G
Am J Clin Pathol 2009 Apr;131(4):478-89. doi: 10.1309/AJCPH0TRMPXVZW2F. PMID: 19289583
Bronchoalveolar carcinoma: clinical, radiologic, and pathologic factors and survival.
Okubo K, Mark EJ, Flieder D, Wain JC, Wright CD, Moncure AC, Grillo HC, Mathisen DJ
J Thorac Cardiovasc Surg 1999 Oct;118(4):702-9. doi: 10.1016/S0022-5223(99)70016-4. PMID: 10504637

Prognosis

Radiologic implications of the 2011 classification of adenocarcinoma of the lung.
Austin JH, Garg K, Aberle D, Yankelevitz D, Kuriyama K, Lee HJ, Brambilla E, Travis WD
Radiology 2013 Jan;266(1):62-71. Epub 2012 Oct 15 doi: 10.1148/radiol.12120240. PMID: 23070271
International association for the study of lung cancer/american thoracic society/european respiratory society international multidisciplinary classification of lung adenocarcinoma.
Travis WD, Brambilla E, Noguchi M, Nicholson AG, Geisinger KR, Yatabe Y, Beer DG, Powell CA, Riely GJ, Van Schil PE, Garg K, Austin JH, Asamura H, Rusch VW, Hirsch FR, Scagliotti G, Mitsudomi T, Huber RM, Ishikawa Y, Jett J, Sanchez-Cespedes M, Sculier JP, Takahashi T, Tsuboi M, Vansteenkiste J, Wistuba I, Yang PC, Aberle D, Brambilla C, Flieder D, Franklin W, Gazdar A, Gould M, Hasleton P, Henderson D, Johnson B, Johnson D, Kerr K, Kuriyama K, Lee JS, Miller VA, Petersen I, Roggli V, Rosell R, Saijo N, Thunnissen E, Tsao M, Yankelewitz D
J Thorac Oncol 2011 Feb;6(2):244-85. doi: 10.1097/JTO.0b013e318206a221. PMID: 21252716Free PMC Article
Bronchioloalveolar carcinoma: the case for two diseases.
Garfield DH, Cadranel J, West HL
Clin Lung Cancer 2008 Jan;9(1):24-9. doi: 10.3816/CLC.2008.n.004. PMID: 18282354
Distinctive evaluation of nonmucinous and mucinous subtypes of bronchioloalveolar carcinomas in EGFR and K-ras gene-mutation analyses for Japanese lung adenocarcinomas: confirmation of the correlations with histologic subtypes and gene mutations.
Sakuma Y, Matsukuma S, Yoshihara M, Nakamura Y, Noda K, Nakayama H, Kameda Y, Tsuchiya E, Miyagi Y
Am J Clin Pathol 2007 Jul;128(1):100-8. doi: 10.1309/WVXFGAFLAUX48DU6. PMID: 17580276
Bronchioloalveolar carcinoma: clinical, histopathologic, and radiologic findings.
Lee KS, Kim Y, Han J, Ko EJ, Park CK, Primack SL
Radiographics 1997 Nov-Dec;17(6):1345-57. doi: 10.1148/radiographics.17.6.9397450. PMID: 9397450

Clinical prediction guides

Postoperative survival of pulmonary invasive mucinous adenocarcinoma versus non-mucinous invasive adenocarcinoma.
Cui D, Xie S, Liu Q
BMC Pulm Med 2023 Jan 9;23(1):9. doi: 10.1186/s12890-023-02305-x. PMID: 36624430Free PMC Article
International association for the study of lung cancer/american thoracic society/european respiratory society international multidisciplinary classification of lung adenocarcinoma.
Travis WD, Brambilla E, Noguchi M, Nicholson AG, Geisinger KR, Yatabe Y, Beer DG, Powell CA, Riely GJ, Van Schil PE, Garg K, Austin JH, Asamura H, Rusch VW, Hirsch FR, Scagliotti G, Mitsudomi T, Huber RM, Ishikawa Y, Jett J, Sanchez-Cespedes M, Sculier JP, Takahashi T, Tsuboi M, Vansteenkiste J, Wistuba I, Yang PC, Aberle D, Brambilla C, Flieder D, Franklin W, Gazdar A, Gould M, Hasleton P, Henderson D, Johnson B, Johnson D, Kerr K, Kuriyama K, Lee JS, Miller VA, Petersen I, Roggli V, Rosell R, Saijo N, Thunnissen E, Tsao M, Yankelewitz D
J Thorac Oncol 2011 Feb;6(2):244-85. doi: 10.1097/JTO.0b013e318206a221. PMID: 21252716Free PMC Article
Distinctive evaluation of nonmucinous and mucinous subtypes of bronchioloalveolar carcinomas in EGFR and K-ras gene-mutation analyses for Japanese lung adenocarcinomas: confirmation of the correlations with histologic subtypes and gene mutations.
Sakuma Y, Matsukuma S, Yoshihara M, Nakamura Y, Noda K, Nakayama H, Kameda Y, Tsuchiya E, Miyagi Y
Am J Clin Pathol 2007 Jul;128(1):100-8. doi: 10.1309/WVXFGAFLAUX48DU6. PMID: 17580276
Bronchoalveolar carcinoma: clinical, radiologic, and pathologic factors and survival.
Okubo K, Mark EJ, Flieder D, Wain JC, Wright CD, Moncure AC, Grillo HC, Mathisen DJ
J Thorac Cardiovasc Surg 1999 Oct;118(4):702-9. doi: 10.1016/S0022-5223(99)70016-4. PMID: 10504637
Bronchioloalveolar carcinomas. Cell types, patterns of growth, and prognostic correlates.
Clayton F
Cancer 1986 Apr 15;57(8):1555-64. doi: 10.1002/1097-0142(19860415)57:8<1555::aid-cncr2820570820>3.0.co;2-n. PMID: 3004694

Recent systematic reviews

International association for the study of lung cancer/american thoracic society/european respiratory society international multidisciplinary classification of lung adenocarcinoma.
Travis WD, Brambilla E, Noguchi M, Nicholson AG, Geisinger KR, Yatabe Y, Beer DG, Powell CA, Riely GJ, Van Schil PE, Garg K, Austin JH, Asamura H, Rusch VW, Hirsch FR, Scagliotti G, Mitsudomi T, Huber RM, Ishikawa Y, Jett J, Sanchez-Cespedes M, Sculier JP, Takahashi T, Tsuboi M, Vansteenkiste J, Wistuba I, Yang PC, Aberle D, Brambilla C, Flieder D, Franklin W, Gazdar A, Gould M, Hasleton P, Henderson D, Johnson B, Johnson D, Kerr K, Kuriyama K, Lee JS, Miller VA, Petersen I, Roggli V, Rosell R, Saijo N, Thunnissen E, Tsao M, Yankelewitz D
J Thorac Oncol 2011 Feb;6(2):244-85. doi: 10.1097/JTO.0b013e318206a221. PMID: 21252716Free PMC Article

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