Full Report

Format

Full Report
Summary (Text)
Summary (XML)

Send to:

Choose Destination

File
Clipboard
Collections

Aggressive Non-Hodgkin Lymphoma

MedGen UID:: 272299
•Concept ID:: C1332225
•: Neoplastic Process

Synonym:

Aggressive Non-Hodgkin's Lymphoma

Definition

A non-Hodgkin lymphoma with an aggressive clinical course. Representative examples include Burkitt lymphoma, mantle cell lymphoma, and angioimmunoblastic T-cell lymphoma. [from NCI]

Term Hierarchy

GTR
MeSH

CClinical test, RResearch test, OOMIM, GGeneReviews, VClinVar

CROGVAggressive Non-Hodgkin Lymphoma

Hematopoietic and Lymphatic System Disorder
- Hematologic disorder
  - Hematologic neoplasm
    - Lymphoma
      - Non-Hodgkin lymphoma
        Non-Hodgkin Lymphoma by Clinical Course
        Aggressive Non-Hodgkin Lymphoma
        Aggressive Adult Non-Hodgkin Lymphoma
        Adult Burkitt Lymphoma
        Ann Arbor Stage I Adult Burkitt Lymphoma
        Ann Arbor Stage II Adult Burkitt Lymphoma
        Ann Arbor Stage III Adult Burkitt Lymphoma
        Ann Arbor Stage IV Adult Burkitt Lymphoma
        Recurrent Adult Burkitt Lymphoma
        Adult Grade III Lymphomatoid Granulomatosis
        Recurrent Adult Grade III Lymphomatoid Granulomatosis
        Adult Lymphoblastic Lymphoma
        Adult B Lymphoblastic Lymphoma
        Adult T Lymphoblastic Lymphoma
        Ann Arbor Stage I Adult Lymphoblastic Lymphoma
        Ann Arbor Stage II Adult Lymphoblastic Lymphoma
        Ann Arbor Stage III Adult Lymphoblastic Lymphoma
        Ann Arbor Stage IV Adult Lymphoblastic Lymphoma
        Recurrent Adult Lymphoblastic Lymphoma
        Adult Nasal Type Extranodal NK/T-Cell Lymphoma
        Ann Arbor Stage I Aggressive Adult Non-Hodgkin Lymphoma
        Ann Arbor Stage I Adult T-Cell Leukemia/Lymphoma
        Ann Arbor Stage II Aggressive Adult Non-Hodgkin Lymphoma
        Ann Arbor Stage II Adult T-Cell Leukemia/Lymphoma
        Ann Arbor Stage II Contiguous Adult Aggressive Non-Hodgkin Lymphoma
        Ann Arbor Stage II Non-Contiguous Aggressive Adult Non-Hodgkin Lymphoma
        Ann Arbor Stage III Aggressive Adult Non-Hodgkin Lymphoma
        Ann Arbor Stage III Adult T-Cell Leukemia/Lymphoma
        Ann Arbor Stage IV Aggressive Adult Non-Hodgkin Lymphoma
        Ann Arbor Stage IV Adult T-Cell Leukemia/Lymphoma
        Leukemia-Lymphoma, Adult T-Cell
        Acute Adult T-Cell Leukemia/Lymphoma
        Adult T-Cell Leukemia/Lymphoma by Ann Arbor Stage
        Chronic Adult T-Cell Leukemia/Lymphoma
        Cutaneous Adult T-Cell Leukemia/Lymphoma
        Hodgkin-Like Adult T-Cell Leukemia/Lymphoma
        Lymphomatous Adult T-Cell Leukemia/Lymphoma
        Recurrent Adult T-Cell Leukemia/Lymphoma
        Refractory Adult T-Cell Leukemia/Lymphoma
        Smoldering Adult T-Cell Leukemia/Lymphoma
        Recurrent Aggressive Adult Non-Hodgkin Lymphoma
        Aggressive B-cell non-Hodgkin lymphoma
        AIDS-Related Diffuse Large B-cell Lymphoma
        AIDS-Related Diffuse Large B-Cell Lymphoma Arising in HHV8-Positive Multicentric Castleman Disease
        AIDS-Related Immunoblastic Lymphoma
        AIDS-Related Plasmablastic Lymphoma
        AIDS-Related Primary Effusion Lymphoma
        B Lymphoblastic Lymphoma
        B Lymphoblastic Lymphoma by Ann Arbor Stage
        Childhood B Lymphoblastic Lymphoma
        Recurrent B Lymphoblastic Lymphoma
        Refractory B Lymphoblastic Lymphoma
        Splenic B Lymphoblastic Lymphoma
        B-cell prolymphocytic leukemia
        Recurrent B-Cell Prolymphocytic Leukemia
        Refractory B-Cell Prolymphocytic Leukemia
        Splenic Manifestation of B-Cell Prolymphocytic Leukemia
        Burkitt lymphoma
        Atypical Burkitt/Burkitt-Like Lymphoma
        Breast Burkitt Lymphoma
        Burkitt Lymphoma by Ann Arbor Stage
        Burkitt Lymphoma with Plasmacytoid Differentiation
        Childhood Burkitt Lymphoma
        Classical Burkitt Lymphoma
        Colorectal Burkitt Lymphoma
        Cutaneous Burkitt Lymphoma
        EBV-Related Burkitt Lymphoma
        Gastric Burkitt Lymphoma
        Immunodeficiency-Related Burkitt Lymphoma
        Recurrent Burkitt Lymphoma
        Refractory Burkitt Lymphoma
        Small intestinal Burkitt lymphoma
        Splenic Burkitt Lymphoma
        Sporadic Burkitt Lymphoma
        Diffuse large B-cell lymphoma activated B-cell type
        Recurrent Diffuse Large B-Cell Lymphoma Activated B-Cell Type
        Refractory Diffuse Large B-Cell Lymphoma Activated B-Cell Type
        Diffuse Large B-Cell Lymphoma Post-Transplant Lymphoproliferative Disorder
        Anaplastic Lymphoma Post-Transplant Lymphoproliferative Disorder
        Centroblastic Lymphoma Post-Transplant Lymphoproliferative Disorder
        Immunoblastic Lymphoma Post-Transplant Lymphoproliferative Disorder
        Diffuse Large B-Cell Lymphoma Unclassifiable
        Grade III lymphomatoid granulomatosis
        Childhood Grade III Lymphomatoid Granulomatosis
        Recurrent Grade III Lymphomatoid Granulomatosis
        High grade B-cell lymphoma with MYC and/ or BCL2 and/or BCL6 rearrangement
        High Grade B-Cell Lymphoma with MYC and BCL2 or BCL6 Rearrangements
        High Grade B-Cell Lymphoma with MYC, BCL2, and BCL6 Rearrangements
        Large B-Cell Lymphoma with 11q Aberration
        Malignant lymphoma, centroblastic type, follicular
        Ann Arbor Stage I Grade 3 Follicular Lymphoma
        Ann Arbor Stage II Grade 3 Follicular Lymphoma
        Ann Arbor Stage III Grade 3 Follicular Lymphoma
        Ann Arbor Stage IV Grade 3 Follicular Lymphoma
        Grade 3 Cutaneous Follicular Lymphoma
        Grade 3a Follicular Lymphoma
        Grade 3b Follicular Lymphoma
        Recurrent Grade 3 Follicular Lymphoma
        Refractory Grade 3 Follicular Lymphoma
        Stage I Centroblastic Follicular Lymphoma
        Stage II Centroblastic Follicular Lymphoma
        Mantle cell lymphoma
        Blastoid Variant Mantle Cell Lymphoma
        Colorectal Mantle Cell Lymphoma
        Cutaneous Mantle Cell Lymphoma
        Gastric mantle cell lymphoma
        Mantle Cell Lymphoma by Ann Arbor Stage
        Parotid Gland Mantle Cell Lymphoma
        Pleomorphic Variant Mantle Cell Lymphoma
        Prostate Mantle Cell Lymphoma
        Recurrent Mantle Cell Lymphoma
        Refractory Mantle Cell Lymphoma
        Small Intestinal Mantle Cell Lymphoma
        Splenic mantle cell lymphoma
        Plasmablastic lymphoma
        Plasmablastic Lymphoma of Mucosa Site
        Primary Cutaneous Plasmablastic Lymphoma
        Recurrent Plasmablastic Lymphoma
        Refractory Plasmablastic Lymphoma
        Primary cutaneous diffuse large B-cell lymphoma, Leg type
        Recurrent Primary Cutaneous Diffuse Large B-Cell Lymphoma, Leg Type
        Refractory Primary Cutaneous Diffuse Large B-Cell Lymphoma, Leg Type
        Primary effusion lymphoma
        Body Cavity Primary Effusion Lymphoma
        Extracavitary Primary Effusion Lymphoma
        Recurrent Primary Effusion Lymphoma
        Refractory Primary Effusion Lymphoma
        Recurrent Aggressive B-Cell Non-Hodgkin Lymphoma
        Refractory Aggressive B-Cell Non-Hodgkin Lymphoma
        Aggressive T-Cell Non-Hodgkin Lymphoma
        ALK-negative anaplastic large cell lymphoma
        Breast implant-associated anaplastic large cell lymphoma
        Central Nervous System Anaplastic Large Cell Lymphoma, ALK-Negative
        Systemic Anaplastic Large Cell Lymphoma, ALK-Negative
        Angioimmunoblastic T-cell lymphoma
        Cutaneous Follicular Helper T-Cell Lymphoma, Angioimmunoblastic-Type
        Follicular Helper T-Cell Lymphoma, Angioimmunoblastic-Type by Ann Arbor Stage
        Recurrent Follicular Helper T-Cell Lymphoma, Angioimmunoblastic-Type
        Refractory Follicular Helper T-Cell Lymphoma, Angioimmunoblastic-Type
        Extranodal nasal NK/T cell lymphoma
        Childhood Nasal Type Extranodal NK/T-Cell Lymphoma
        Cutaneous Nasal Type Extranodal NK/T-Cell Lymphoma
        Nasal Type NK/T-Cell Lymphoma by Ann Arbor Stage
        Recurrent Nasal Type Extranodal NK/T-Cell Lymphoma
        Refractory Nasal Type Extranodal NK/T-Cell Lymphoma
        Sinonasal Extranodal NK/T-Cell Lymphoma
        Testicular Nasal Type Extranodal NK/T-Cell Lymphoma
        Hepatosplenic T-cell lymphoma
        Recurrent Hepatosplenic T-Cell Lymphoma
        Refractory Hepatosplenic T-Cell Lymphoma
        Intestinal T-Cell Lymphoma
        Enteropathy-associated T-cell lymphoma
        Intestinal T-Cell Lymphoma, Not Otherwise Specified
        Monomorphic epitheliotropic intestinal T-cell lymphoma
        Peripheral T-cell lymphoma
        Lymphoepithelioid Variant Peripheral T-Cell Lymphoma, Not Otherwise Specified
        Primary Nodal EBV-Positive T-Cell/NK-Cell Lymphoma
        Recurrent Peripheral T-Cell Lymphoma, Not Otherwise Specified
        Refractory Peripheral T-Cell Lymphoma, Not Otherwise Specified
        Primary cutaneous aggressive epidermotropic CD8+ T-cell lymphoma
        Primary cutaneous gamma-delta t-cell lymphoma
        Recurrent Aggressive T-Cell Non-Hodgkin Lymphoma
        Recurrent Breast Implant-Associated Anaplastic Large Cell Lymphoma
        Recurrent Enteropathy-Associated T-Cell Lymphoma
        Recurrent Monomorphic Epitheliotropic Intestinal T-cell Lymphoma
        Refractory Aggressive T-Cell Non-Hodgkin Lymphoma
        Refractory Breast Implant-Associated Anaplastic Large Cell Lymphoma
        Refractory Enteropathy-Associated T-Cell Lymphoma
        Refractory Monomorphic Epitheliotropic Intestinal T-cell Lymphoma
        Refractory T Lymphoblastic Lymphoma
        T-lymphoblastic lymphoma
        Mediastinal T Lymphoblastic Lymphoma
        Splenic T Lymphoblastic Lymphoma
        T-cell childhood lymphoblastic lymphoma
        Recurrent Aggressive Non-Hodgkin Lymphoma
        Refractory Aggressive Non-Hodgkin Lymphoma

Professional guidelines

PubMed

Burkitt Lymphoma - Subtypes, Pathogenesis, and Treatment Strategies.

Noy A
Clin Lymphoma Myeloma Leuk 2020 Sep;20 Suppl 1:S37-S38. doi: 10.1016/S2152-2650(20)30455-9. PMID: 32862862

Diffuse large B-cell lymphoma: 2019 update on diagnosis, risk stratification, and treatment.

Liu Y, Barta SK
Am J Hematol 2019 May;94(5):604-616. doi: 10.1002/ajh.25460. PMID: 30859597

Modern management of lymphocyte-predominant Hodgkin lymphoma.

Xing KH, Savage KJ
Br J Haematol 2013 May;161(3):316-29. Epub 2013 Feb 8 doi: 10.1111/bjh.12244. PMID: 23398605

See all (45)

Recent clinical studies

Etiology

Lymphoblastic Lymphoma: a Concise Review.

Intermesoli T, Weber A, Leoncin M, Frison L, Skert C, Bassan R
Curr Oncol Rep 2022 Jan;24(1):1-12. Epub 2022 Jan 20 doi: 10.1007/s11912-021-01168-x. PMID: 35059993

HIV-associated Burkitt lymphoma.

Atallah-Yunes SA, Murphy DJ, Noy A
Lancet Haematol 2020 Aug;7(8):e594-e600. doi: 10.1016/S2352-3026(20)30126-5. PMID: 32735838

Diffuse large B-cell lymphoma: 2019 update on diagnosis, risk stratification, and treatment.

Liu Y, Barta SK
Am J Hematol 2019 May;94(5):604-616. doi: 10.1002/ajh.25460. PMID: 30859597

The response to lymphodepletion impacts PFS in patients with aggressive non-Hodgkin lymphoma treated with CD19 CAR T cells.

Hirayama AV, Gauthier J, Hay KA, Voutsinas JM, Wu Q, Gooley T, Li D, Cherian S, Chen X, Pender BS, Hawkins RM, Vakil A, Steinmetz RN, Acharya UH, Cassaday RD, Chapuis AG, Dhawale TM, Hendrie PC, Kiem HP, Lynch RC, Ramos J, Shadman M, Till BG, Riddell SR, Maloney DG, Turtle CJ
Blood 2019 Apr 25;133(17):1876-1887. Epub 2019 Feb 19 doi: 10.1182/blood-2018-11-887067. PMID: 30782611 Free PMC Article

Pretransplant FDG-PET in aggressive non-Hodgkin lymphoma: systematic review and meta-analysis.

Adams HJ, Kwee TC
Eur J Haematol 2017 Apr;98(4):337-347. Epub 2017 Jan 23 doi: 10.1111/ejh.12837. PMID: 27943422

See all (201)

Diagnosis

The influence of immunodeficiency, disease features, and patient characteristics on survival in plasmablastic lymphoma.

Di Ciaccio PR, Polizzotto MN, Cwynarski K, Gerrie AS, Burton C, Bower M, Kuruvilla J, Montoto S, McKay P, Fox CP, Milliken S, Jiamsakul A, Osborne W, Collins GP, Manos K, Linton KM, Iyengar S, Kassam S, Limei MP, Kliman D, Wong Doo N, Watson AM, Fedele P, Yannakou CK, Hunt S, Ku M, Sehn LH, Smith A, Renshaw H, Maxwell A, Liu Q, Dhairyawan R, Ferguson G, Pickard K, Painter D, Thakrar N, Song KW, Hamad N
Blood 2024 Jan 11;143(2):152-165. doi: 10.1182/blood.2023021348. PMID: 37832030

Lymphoblastic Lymphoma: a Concise Review.

Intermesoli T, Weber A, Leoncin M, Frison L, Skert C, Bassan R
Curr Oncol Rep 2022 Jan;24(1):1-12. Epub 2022 Jan 20 doi: 10.1007/s11912-021-01168-x. PMID: 35059993

Diffuse large B-cell lymphoma: 2019 update on diagnosis, risk stratification, and treatment.

Liu Y, Barta SK
Am J Hematol 2019 May;94(5):604-616. doi: 10.1002/ajh.25460. PMID: 30859597

Pretransplant FDG-PET in aggressive non-Hodgkin lymphoma: systematic review and meta-analysis.

Adams HJ, Kwee TC
Eur J Haematol 2017 Apr;98(4):337-347. Epub 2017 Jan 23 doi: 10.1111/ejh.12837. PMID: 27943422

Nodular lymphocyte-predominant Hodgkin lymphoma.

Savage KJ, Mottok A, Fanale M
Semin Hematol 2016 Jul;53(3):190-202. Epub 2016 May 13 doi: 10.1053/j.seminhematol.2016.05.009. PMID: 27496311

See all (157)

Therapy

An open-label, single-arm phase 2 trial of valemetostat for relapsed or refractory adult T-cell leukemia/lymphoma.

Izutsu K, Makita S, Nosaka K, Yoshimitsu M, Utsunomiya A, Kusumoto S, Morishima S, Tsukasaki K, Kawamata T, Ono T, Rai S, Katsuya H, Ishikawa J, Yamada H, Kato K, Tachibana M, Kakurai Y, Adachi N, Tobinai K, Yonekura K, Ishitsuka K
Blood 2023 Mar 9;141(10):1159-1168. doi: 10.1182/blood.2022016862. PMID: 36150143 Free PMC Article

Nivolumab Combined With Brentuximab Vedotin for Relapsed/Refractory Primary Mediastinal Large B-Cell Lymphoma: Efficacy and Safety From the Phase II CheckMate 436 Study.

Zinzani PL, Santoro A, Gritti G, Brice P, Barr PM, Kuruvilla J, Cunningham D, Kline J, Johnson NA, Mehta-Shah N, Manley T, Francis S, Sharma M, Moskowitz AJ
J Clin Oncol 2019 Nov 20;37(33):3081-3089. Epub 2019 Aug 9 doi: 10.1200/JCO.19.01492. PMID: 31398081 Free PMC Article

The response to lymphodepletion impacts PFS in patients with aggressive non-Hodgkin lymphoma treated with CD19 CAR T cells.

Pretransplant FDG-PET in aggressive non-Hodgkin lymphoma: systematic review and meta-analysis.

Adams HJ, Kwee TC
Eur J Haematol 2017 Apr;98(4):337-347. Epub 2017 Jan 23 doi: 10.1111/ejh.12837. PMID: 27943422

Transformed follicular non-Hodgkin lymphoma.

Casulo C, Burack WR, Friedberg JW
Blood 2015 Jan 1;125(1):40-7. Epub 2014 Dec 11 doi: 10.1182/blood-2014-04-516815. PMID: 25499449

See all (220)

Prognosis

An open-label, single-arm phase 2 trial of valemetostat for relapsed or refractory adult T-cell leukemia/lymphoma.

Lymphoblastic Lymphoma: a Concise Review.

Intermesoli T, Weber A, Leoncin M, Frison L, Skert C, Bassan R
Curr Oncol Rep 2022 Jan;24(1):1-12. Epub 2022 Jan 20 doi: 10.1007/s11912-021-01168-x. PMID: 35059993

HIV-associated Burkitt lymphoma.

Atallah-Yunes SA, Murphy DJ, Noy A
Lancet Haematol 2020 Aug;7(8):e594-e600. doi: 10.1016/S2352-3026(20)30126-5. PMID: 32735838

Diffuse large B-cell lymphoma: 2019 update on diagnosis, risk stratification, and treatment.

Liu Y, Barta SK
Am J Hematol 2019 May;94(5):604-616. doi: 10.1002/ajh.25460. PMID: 30859597

Transformed follicular non-Hodgkin lymphoma.

Casulo C, Burack WR, Friedberg JW
Blood 2015 Jan 1;125(1):40-7. Epub 2014 Dec 11 doi: 10.1182/blood-2014-04-516815. PMID: 25499449

See all (199)

Clinical prediction guides

Lymphoblastic Lymphoma: a Concise Review.

Intermesoli T, Weber A, Leoncin M, Frison L, Skert C, Bassan R
Curr Oncol Rep 2022 Jan;24(1):1-12. Epub 2022 Jan 20 doi: 10.1007/s11912-021-01168-x. PMID: 35059993

Modified EPOCH for high-risk non-Hodgkin lymphoma in sub-Saharan Africa.

Zuze T, Ellis GK, Kasonkanji E, Kaimila B, Nyasosela R, Nyirenda R, Tomoka T, Mulenga M, Chikasema M, Tewete B, Mtangwanika A, Chiyoyola S, Chimzimu F, Kampani C, Mhango W, Nicholas S, Randall C, Montgomery ND, Fedoriw G, Westmoreland KD, Painschab MS, Gopal S
Cancer Med 2020 Jan;9(1):77-83. Epub 2019 Nov 9 doi: 10.1002/cam4.2631. PMID: 31705618 Free PMC Article

Pretransplant FDG-PET in aggressive non-Hodgkin lymphoma: systematic review and meta-analysis.

Adams HJ, Kwee TC
Eur J Haematol 2017 Apr;98(4):337-347. Epub 2017 Jan 23 doi: 10.1111/ejh.12837. PMID: 27943422

Structural genomic alterations in primary mediastinal large B-cell lymphoma.

Twa DD, Steidl C
Leuk Lymphoma 2015;56(8):2239-50. Epub 2015 Jan 21 doi: 10.3109/10428194.2014.985673. PMID: 25393674

An enhanced International Prognostic Index (NCCN-IPI) for patients with diffuse large B-cell lymphoma treated in the rituximab era.

Zhou Z, Sehn LH, Rademaker AW, Gordon LI, Lacasce AS, Crosby-Thompson A, Vanderplas A, Zelenetz AD, Abel GA, Rodriguez MA, Nademanee A, Kaminski MS, Czuczman MS, Millenson M, Niland J, Gascoyne RD, Connors JM, Friedberg JW, Winter JN
Blood 2014 Feb 6;123(6):837-42. Epub 2013 Nov 21 doi: 10.1182/blood-2013-09-524108. PMID: 24264230 Free PMC Article

See all (128)

Recent systematic reviews

Long non-coding RNA as a novel biomarker and therapeutic target in aggressive B-cell non-Hodgkin lymphoma: A systematic review.

Khanmohammadi S, Fallahtafti P
J Cell Mol Med 2023 Jul;27(14):1928-1946. Epub 2023 May 29 doi: 10.1111/jcmm.17795. PMID: 37246627 Free PMC Article

Systematic literature review of health-related quality of life among aggressive non-Hodgkin lymphoma survivors.

Lin VW, Blaylock B, Epstein J, Purdum A
Curr Med Res Opin 2018 Aug;34(8):1529-1535. Epub 2018 May 18 doi: 10.1080/03007995.2018.1474091. PMID: 29741105

Pretransplant FDG-PET in aggressive non-Hodgkin lymphoma: systematic review and meta-analysis.

Adams HJ, Kwee TC
Eur J Haematol 2017 Apr;98(4):337-347. Epub 2017 Jan 23 doi: 10.1111/ejh.12837. PMID: 27943422

CHOP-like-14 compared to CHOP-like-21 for patients with aggressive lymphoma--a meta-analysis of randomized controlled trials.

Vidal L, Shpilberg O, Gurion R, Monsef I, Raanani P, Ram R, Gafter-Gvili A
Acta Oncol 2016;55(1):77-84. Epub 2015 May 21 doi: 10.3109/0284186X.2015.1043025. PMID: 25997705

Changes in the influence of lymphoma- and HIV-specific factors on outcomes in AIDS-related non-Hodgkin lymphoma.

Barta SK, Samuel MS, Xue X, Wang D, Lee JY, Mounier N, Ribera JM, Spina M, Tirelli U, Weiss R, Galicier L, Boue F, Little RF, Dunleavy K, Wilson WH, Wyen C, Remick SC, Kaplan LD, Ratner L, Noy A, Sparano JA
Ann Oncol 2015 May;26(5):958-966. Epub 2015 Jan 28 doi: 10.1093/annonc/mdv036. PMID: 25632071 Free PMC Article

See all (9)

MedGen

National Center for Biotechnology Information

Send to:

Aggressive Non-Hodgkin Lymphoma

Definition

Term Hierarchy

Professional guidelines

PubMed

Recent clinical studies

Etiology

Diagnosis

Therapy

Prognosis

Clinical prediction guides

Recent systematic reviews

Supplemental Content

Table of contents

Practice guidelines

Recent activity