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ALK-negative anaplastic large cell lymphoma

MedGen UID:
272266
•Concept ID:
C1332078
•
Neoplastic Process
Synonyms: ALCL, ALK-; ALK negative anaplastic large cell lymphoma; ALK- ALCL; ALK- anaplastic large cell lymphoma; ALK-Negative Anaplastic Large Cell Lymphoma; Anaplastic large cell lymphoma, ALK (anaplastic lymphoma kinase) negative; Anaplastic large cell lymphoma, ALK negative; Anaplastic Large Cell Lymphoma, ALK-Negative; anaplastic large cell lymphoma, ALK-negative; Anaplastic lymphoma kinase negative anaplastic large cell lymphoma
SNOMED CT: Anaplastic large cell lymphoma, ALK negative (448212009); Anaplastic lymphoma kinase negative anaplastic large cell lymphoma (448212009); ALK negative anaplastic large cell lymphoma (1172729004); Anaplastic lymphoma kinase negative anaplastic large cell lymphoma (1172729004); Anaplastic large cell lymphoma, ALK (anaplastic lymphoma kinase) negative (1172729004)
Modes of inheritance:
Not genetically inherited
MedGen UID:
988794
•Concept ID:
CN307044
•
Finding
Source: Orphanet
clinical entity without genetic inheritance.
See: This record
Not genetically inherited (Orphanet)
 
Monarch Initiative: MONDO:0017603
Orphanet: ORPHA300903

Definition

A type of ALCL, a rare and aggressive peripheral T-cell non-Hodgkin lymphoma affecting lymph nodes and extranodal sites, which is characterized by the lack of expression of a protein called anaplastic lymphoma kinase (ALK). [from ORDO]

Professional guidelines

PubMed

Treatment strategies and outcome in relapsed peripheral T-cell lymphoma: results from the Netherlands Cancer Registry.
Brink M, Huisman F, Meeuwes FO, van der Poel MWM, Kersten MJ, Wondergem M, Böhmer L, Woei-A-Jin FJSH, Visser O, Oostvogels R, Jansen PM, Diepstra A, Snijders TJF, Huls G, Vermaat JSP, Plattel WJ, Nijland M
Blood Adv 2024 Jul 23;8(14):3619-3628. doi: 10.1182/bloodadvances.2023012531. PMID: 38739705Free PMC Article
Advances in the treatment and prognosis of anaplastic lymphoma kinase negative anaplastic large cell lymphoma.
Wang X, Wu J, Zhang M
Hematology 2019 Dec;24(1):440-445. doi: 10.1080/16078454.2019.1613290. PMID: 31072226
Treatment of Peripheral T-Cell Lymphoma: Many Shades of Gray.
Lunning MA
Oncology (Williston Park) 2015 Aug;29(8):545-50. PMID: 26281838

Recent clinical studies

Etiology

Update on T-Cell Lymphoma Epidemiology.
Chen JJ, Tokumori FC, Del Guzzo C, Kim J, Ruan J
Curr Hematol Malig Rep 2024 Jun;19(3):93-103. Epub 2024 Mar 7 doi: 10.1007/s11899-024-00727-w. PMID: 38451372
ALK-negative anaplastic large cell lymphoma: features and outcomes of 235 patients from the International T-Cell Project.
Shustov A, Cabrera ME, Civallero M, Bellei M, Ko YH, Manni M, Skrypets T, Horwitz SM, De Souza CA, Radford JA, Bobillo S, Prates MV, Ferreri AJM, Chiattone C, Spina M, Vose JM, Chiappella A, Laszlo D, Marino D, Stelitano C, Federico M
Blood Adv 2021 Feb 9;5(3):640-648. doi: 10.1182/bloodadvances.2020001581. PMID: 33560375Free PMC Article
Clinical and prognostic differences between ALK-negative anaplastic large cell lymphoma and peripheral T cell lymphoma, not otherwise specified: a single institution experience.
Deng XW, Zhang XM, Wang WH, Wang SL, Jin J, Fang H, Ren H, Liu YP, He XH, Dong M, Song YW, Li YX
Ann Hematol 2016 Aug;95(8):1271-80. Epub 2016 May 21 doi: 10.1007/s00277-016-2696-9. PMID: 27209536
ALK-negative anaplastic large cell lymphoma is a genetically heterogeneous disease with widely disparate clinical outcomes.
Parrilla Castellar ER, Jaffe ES, Said JW, Swerdlow SH, Ketterling RP, Knudson RA, Sidhu JS, Hsi ED, Karikehalli S, Jiang L, Vasmatzis G, Gibson SE, Ondrejka S, Nicolae A, Grogg KL, Allmer C, Ristow KM, Wilson WH, Macon WR, Law ME, Cerhan JR, Habermann TM, Ansell SM, Dogan A, Maurer MJ, Feldman AL
Blood 2014 Aug 28;124(9):1473-80. Epub 2014 Jun 3 doi: 10.1182/blood-2014-04-571091. PMID: 24894770Free PMC Article
Gene expression signatures delineate biological and prognostic subgroups in peripheral T-cell lymphoma.
Iqbal J, Wright G, Wang C, Rosenwald A, Gascoyne RD, Weisenburger DD, Greiner TC, Smith L, Guo S, Wilcox RA, Teh BT, Lim ST, Tan SY, Rimsza LM, Jaffe ES, Campo E, Martinez A, Delabie J, Braziel RM, Cook JR, Tubbs RR, Ott G, Geissinger E, Gaulard P, Piccaluga PP, Pileri SA, Au WY, Nakamura S, Seto M, Berger F, de Leval L, Connors JM, Armitage J, Vose J, Chan WC, Staudt LM; Lymphoma Leukemia Molecular Profiling Project and the International Peripheral T-cell Lymphoma Project
Blood 2014 May 8;123(19):2915-23. Epub 2014 Mar 14 doi: 10.1182/blood-2013-11-536359. PMID: 24632715Free PMC Article

Diagnosis

Update on T-Cell Lymphoma Epidemiology.
Chen JJ, Tokumori FC, Del Guzzo C, Kim J, Ruan J
Curr Hematol Malig Rep 2024 Jun;19(3):93-103. Epub 2024 Mar 7 doi: 10.1007/s11899-024-00727-w. PMID: 38451372
Diagnosis of anaplastic lymphoma kinase-negative anaplastic large cell lymphoma on pleural fluid cytology.
Greenland NY, Lu CM, Cook S, Peng Y
Diagn Cytopathol 2021 Dec;49(12):E458-E461. Epub 2021 Aug 18 doi: 10.1002/dc.24855. PMID: 34406711
Breast Implant-associated Anaplastic Large Cell Lymphoma: Review and Multiparametric Imaging Paradigms.
Sharma B, Jurgensen-Rauch A, Pace E, Attygalle AD, Sharma R, Bommier C, Wotherspoon AC, Sharma S, Iyengar S, El-Sharkawi D
Radiographics 2020 May-Jun;40(3):609-628. Epub 2020 Apr 17 doi: 10.1148/rg.2020190198. PMID: 32302264
Molecular Genetics in the Diagnosis and Biology of Lymphoid Neoplasms.
Lim MS, Bailey NG, King RL, Piris M
Am J Clin Pathol 2019 Aug 1;152(3):277-301. doi: 10.1093/ajcp/aqz078. PMID: 31278738
Gene expression signatures delineate biological and prognostic subgroups in peripheral T-cell lymphoma.
Iqbal J, Wright G, Wang C, Rosenwald A, Gascoyne RD, Weisenburger DD, Greiner TC, Smith L, Guo S, Wilcox RA, Teh BT, Lim ST, Tan SY, Rimsza LM, Jaffe ES, Campo E, Martinez A, Delabie J, Braziel RM, Cook JR, Tubbs RR, Ott G, Geissinger E, Gaulard P, Piccaluga PP, Pileri SA, Au WY, Nakamura S, Seto M, Berger F, de Leval L, Connors JM, Armitage J, Vose J, Chan WC, Staudt LM; Lymphoma Leukemia Molecular Profiling Project and the International Peripheral T-cell Lymphoma Project
Blood 2014 May 8;123(19):2915-23. Epub 2014 Mar 14 doi: 10.1182/blood-2013-11-536359. PMID: 24632715Free PMC Article

Therapy

Diagnosis of anaplastic lymphoma kinase-negative anaplastic large cell lymphoma on pleural fluid cytology.
Greenland NY, Lu CM, Cook S, Peng Y
Diagn Cytopathol 2021 Dec;49(12):E458-E461. Epub 2021 Aug 18 doi: 10.1002/dc.24855. PMID: 34406711
ALK-negative anaplastic large cell lymphoma: features and outcomes of 235 patients from the International T-Cell Project.
Shustov A, Cabrera ME, Civallero M, Bellei M, Ko YH, Manni M, Skrypets T, Horwitz SM, De Souza CA, Radford JA, Bobillo S, Prates MV, Ferreri AJM, Chiattone C, Spina M, Vose JM, Chiappella A, Laszlo D, Marino D, Stelitano C, Federico M
Blood Adv 2021 Feb 9;5(3):640-648. doi: 10.1182/bloodadvances.2020001581. PMID: 33560375Free PMC Article
Breast Implant-associated Anaplastic Large Cell Lymphoma: Review and Multiparametric Imaging Paradigms.
Sharma B, Jurgensen-Rauch A, Pace E, Attygalle AD, Sharma R, Bommier C, Wotherspoon AC, Sharma S, Iyengar S, El-Sharkawi D
Radiographics 2020 May-Jun;40(3):609-628. Epub 2020 Apr 17 doi: 10.1148/rg.2020190198. PMID: 32302264
Cytological features of breast implant-associated anaplastic large cell lymphoma in pleural effusion.
D'Alessandris N, Lucatelli P, Tripodi D, Amabile MI, Ascoli V
Diagn Cytopathol 2019 Nov;47(11):1213-1217. Epub 2019 Jul 26 doi: 10.1002/dc.24287. PMID: 31348611
Clinical and prognostic differences between ALK-negative anaplastic large cell lymphoma and peripheral T cell lymphoma, not otherwise specified: a single institution experience.
Deng XW, Zhang XM, Wang WH, Wang SL, Jin J, Fang H, Ren H, Liu YP, He XH, Dong M, Song YW, Li YX
Ann Hematol 2016 Aug;95(8):1271-80. Epub 2016 May 21 doi: 10.1007/s00277-016-2696-9. PMID: 27209536

Prognosis

Update on T-Cell Lymphoma Epidemiology.
Chen JJ, Tokumori FC, Del Guzzo C, Kim J, Ruan J
Curr Hematol Malig Rep 2024 Jun;19(3):93-103. Epub 2024 Mar 7 doi: 10.1007/s11899-024-00727-w. PMID: 38451372
Diagnosis of anaplastic lymphoma kinase-negative anaplastic large cell lymphoma on pleural fluid cytology.
Greenland NY, Lu CM, Cook S, Peng Y
Diagn Cytopathol 2021 Dec;49(12):E458-E461. Epub 2021 Aug 18 doi: 10.1002/dc.24855. PMID: 34406711
ALK-Negative Anaplastic Large Cell Lymphoma (ALCL): Prognostic Implications of Molecular Subtyping and JAK-STAT Pathway.
Parkhi M, Bal A, Das A, Kashyap D, Bhardwaj S, Prakash G, Malhotra P
Appl Immunohistochem Mol Morphol 2021 Oct 1;29(9):648-656. doi: 10.1097/PAI.0000000000000936. PMID: 33901030
Breast Implant-associated Anaplastic Large Cell Lymphoma: Review and Multiparametric Imaging Paradigms.
Sharma B, Jurgensen-Rauch A, Pace E, Attygalle AD, Sharma R, Bommier C, Wotherspoon AC, Sharma S, Iyengar S, El-Sharkawi D
Radiographics 2020 May-Jun;40(3):609-628. Epub 2020 Apr 17 doi: 10.1148/rg.2020190198. PMID: 32302264
Gene expression signatures delineate biological and prognostic subgroups in peripheral T-cell lymphoma.
Iqbal J, Wright G, Wang C, Rosenwald A, Gascoyne RD, Weisenburger DD, Greiner TC, Smith L, Guo S, Wilcox RA, Teh BT, Lim ST, Tan SY, Rimsza LM, Jaffe ES, Campo E, Martinez A, Delabie J, Braziel RM, Cook JR, Tubbs RR, Ott G, Geissinger E, Gaulard P, Piccaluga PP, Pileri SA, Au WY, Nakamura S, Seto M, Berger F, de Leval L, Connors JM, Armitage J, Vose J, Chan WC, Staudt LM; Lymphoma Leukemia Molecular Profiling Project and the International Peripheral T-cell Lymphoma Project
Blood 2014 May 8;123(19):2915-23. Epub 2014 Mar 14 doi: 10.1182/blood-2013-11-536359. PMID: 24632715Free PMC Article

Clinical prediction guides

ALK-negative anaplastic large cell lymphoma: features and outcomes of 235 patients from the International T-Cell Project.
Shustov A, Cabrera ME, Civallero M, Bellei M, Ko YH, Manni M, Skrypets T, Horwitz SM, De Souza CA, Radford JA, Bobillo S, Prates MV, Ferreri AJM, Chiattone C, Spina M, Vose JM, Chiappella A, Laszlo D, Marino D, Stelitano C, Federico M
Blood Adv 2021 Feb 9;5(3):640-648. doi: 10.1182/bloodadvances.2020001581. PMID: 33560375Free PMC Article
Breast Implant-associated Anaplastic Large Cell Lymphoma: Review and Multiparametric Imaging Paradigms.
Sharma B, Jurgensen-Rauch A, Pace E, Attygalle AD, Sharma R, Bommier C, Wotherspoon AC, Sharma S, Iyengar S, El-Sharkawi D
Radiographics 2020 May-Jun;40(3):609-628. Epub 2020 Apr 17 doi: 10.1148/rg.2020190198. PMID: 32302264
ALK-negative anaplastic large cell lymphoma is a genetically heterogeneous disease with widely disparate clinical outcomes.
Parrilla Castellar ER, Jaffe ES, Said JW, Swerdlow SH, Ketterling RP, Knudson RA, Sidhu JS, Hsi ED, Karikehalli S, Jiang L, Vasmatzis G, Gibson SE, Ondrejka S, Nicolae A, Grogg KL, Allmer C, Ristow KM, Wilson WH, Macon WR, Law ME, Cerhan JR, Habermann TM, Ansell SM, Dogan A, Maurer MJ, Feldman AL
Blood 2014 Aug 28;124(9):1473-80. Epub 2014 Jun 3 doi: 10.1182/blood-2014-04-571091. PMID: 24894770Free PMC Article
Gene expression signatures delineate biological and prognostic subgroups in peripheral T-cell lymphoma.
Iqbal J, Wright G, Wang C, Rosenwald A, Gascoyne RD, Weisenburger DD, Greiner TC, Smith L, Guo S, Wilcox RA, Teh BT, Lim ST, Tan SY, Rimsza LM, Jaffe ES, Campo E, Martinez A, Delabie J, Braziel RM, Cook JR, Tubbs RR, Ott G, Geissinger E, Gaulard P, Piccaluga PP, Pileri SA, Au WY, Nakamura S, Seto M, Berger F, de Leval L, Connors JM, Armitage J, Vose J, Chan WC, Staudt LM; Lymphoma Leukemia Molecular Profiling Project and the International Peripheral T-cell Lymphoma Project
Blood 2014 May 8;123(19):2915-23. Epub 2014 Mar 14 doi: 10.1182/blood-2013-11-536359. PMID: 24632715Free PMC Article
Cytogenetic abnormalities and clinical correlations in peripheral T-cell lymphoma.
Nelson M, Horsman DE, Weisenburger DD, Gascoyne RD, Dave BJ, Loberiza FR, Ludkovski O, Savage KJ, Armitage JO, Sanger WG
Br J Haematol 2008 May;141(4):461-9. Epub 2008 Mar 12 doi: 10.1111/j.1365-2141.2008.07042.x. PMID: 18341637

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