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Splenic T Lymphoblastic Lymphoma

MedGen UID:
233461
•Concept ID:
C1336074
•
Neoplastic Process
Synonyms: Splenic Precursor T-Lymphoblastic Lymphoma; Splenic T-Lymphoblastic Lymphoma

Definition

T-lymphoblastic lymphoma that affects the spleen. [from NCI]

Term Hierarchy

CClinical test,  RResearch test,  OOMIM,  GGeneReviews,  VClinVar  
  • CROGVSplenic T Lymphoblastic Lymphoma

Professional guidelines

PubMed

Valrubicin-loaded immunoliposomes for specific vesicle-mediated cell death in the treatment of hematological cancers.
Georgievski A, Bellaye PS, Tournier B, Choubley H, Pais de Barros JP, Herbst M, Béduneau A, Callier P, Collin B, Végran F, Ballerini P, Garrido C, Quéré R
Cell Death Dis 2024 May 11;15(5):328. doi: 10.1038/s41419-024-06715-5. PMID: 38734740Free PMC Article
Apoptosis-mediated inhibition of human T-cell acute lymphoblastic leukemia upon treatment with Staphylococus Aureus enterotoxin-superantigen.
Duarte A, Montagna DR, Pastorini M, Alemán M
Front Immunol 2023;14:1176432. Epub 2023 Jun 12 doi: 10.3389/fimmu.2023.1176432. PMID: 37377961Free PMC Article
Characteristic clinicopathologic features of adult B-cell lymphoblastic lymphoma with special emphasis on differential diagnosis with an atypical form probably of blastic lymphocytic lymphoma of intermediate differentiation origin.
Cheng AL, Su IJ, Tien HF, Wang CC, Chen YC, Wang CH
Cancer 1994 Feb 1;73(3):706-10. doi: 10.1002/1097-0142(19940201)73:3<706::aid-cncr2820730334>3.0.co;2-u. PMID: 7507799

Recent clinical studies

Etiology

Valrubicin-loaded immunoliposomes for specific vesicle-mediated cell death in the treatment of hematological cancers.
Georgievski A, Bellaye PS, Tournier B, Choubley H, Pais de Barros JP, Herbst M, Béduneau A, Callier P, Collin B, Végran F, Ballerini P, Garrido C, Quéré R
Cell Death Dis 2024 May 11;15(5):328. doi: 10.1038/s41419-024-06715-5. PMID: 38734740Free PMC Article
Shared genetic architecture between autoimmune disorders and B-cell acute lymphoblastic leukemia: insights from large-scale genome-wide cross-trait analysis.
Yu X, Chen Y, Chen J, Fan Y, Lu H, Wu D, Xu Y
BMC Med 2024 Apr 15;22(1):161. doi: 10.1186/s12916-024-03385-0. PMID: 38616254Free PMC Article
LINC00853 restrains T cell acute lymphoblastic leukemia invasion and infiltration by regulating CCR9/CCL25.
Li J, Muhammad J, Xie T, Sun J, Lei Y, Wei Z, Pan S, Qin H, Shao L, Jiang D, Zhang Q
Mol Immunol 2021 Dec;140:267-275. Epub 2021 Nov 20 doi: 10.1016/j.molimm.2021.10.016. PMID: 34808497
Targeting the B-cell receptor signaling pathway in B lymphoid malignancies.
Buchner M, Müschen M
Curr Opin Hematol 2014 Jul;21(4):341-9. doi: 10.1097/MOH.0000000000000048. PMID: 24811161Free PMC Article
Lymphoblastic lymphoma.
Cortelazzo S, Ponzoni M, Ferreri AJ, Hoelzer D
Crit Rev Oncol Hematol 2011 Sep;79(3):330-43. Epub 2011 Jan 26 doi: 10.1016/j.critrevonc.2010.12.003. PMID: 21273093

Diagnosis

Nuclear PFKP promotes CXCR4-dependent infiltration by T cell acute lymphoblastic leukemia.
Gao X, Qin S, Wu Y, Chu C, Jiang B, Johnson RH, Kuang D, Zhang J, Wang X, Mehta A, Tew KD, Leone GW, Yu XZ, Wang H
J Clin Invest 2021 Aug 16;131(16) doi: 10.1172/JCI143119. PMID: 34255748Free PMC Article
Overexpression of wild-type IL-7Rα promotes T-cell acute lymphoblastic leukemia/lymphoma.
Silva A, Almeida ARM, Cachucho A, Neto JL, Demeyer S, de Matos M, Hogan T, Li Y, Meijerink J, Cools J, Grosso AR, Seddon B, Barata JT
Blood 2021 Sep 23;138(12):1040-1052. doi: 10.1182/blood.2019000553. PMID: 33970999Free PMC Article
Hepatosplenic T-Cell Lymphoma: A Clinicopathologic Review With an Emphasis on Diagnostic Differentiation From Other T-Cell/Natural Killer-Cell Neoplasms.
Shi Y, Wang E
Arch Pathol Lab Med 2015 Sep;139(9):1173-80. doi: 10.5858/arpa.2014-0079-RS. PMID: 26317456
Lymphoblastic lymphoma.
Cortelazzo S, Ponzoni M, Ferreri AJ, Hoelzer D
Crit Rev Oncol Hematol 2011 Sep;79(3):330-43. Epub 2011 Jan 26 doi: 10.1016/j.critrevonc.2010.12.003. PMID: 21273093
Lymphoma--emerging realities in sub-Saharan Africa.
Sissolak G, Juritz J, Sissolak D, Wood L, Jacobs P
Transfus Apher Sci 2010 Apr;42(2):141-50. Epub 2010 Feb 10 doi: 10.1016/j.transci.2010.01.009. PMID: 20149748

Therapy

Shared genetic architecture between autoimmune disorders and B-cell acute lymphoblastic leukemia: insights from large-scale genome-wide cross-trait analysis.
Yu X, Chen Y, Chen J, Fan Y, Lu H, Wu D, Xu Y
BMC Med 2024 Apr 15;22(1):161. doi: 10.1186/s12916-024-03385-0. PMID: 38616254Free PMC Article
An Anti-CD7 Antibody-Drug Conjugate Target Showing Potent Antitumor Activity for T-Lymphoblastic Leukemia (T-ALL).
Wang S, Zhang R, Zhong K, Guo W, Tong A
Biomolecules 2024 Jan 15;14(1) doi: 10.3390/biom14010106. PMID: 38254706Free PMC Article
Antileukemic properties of the kinase inhibitor OTSSP167 in T-cell acute lymphoblastic leukemia.
Bridges CS, Chen TJ, Puppi M, Rabin KR, Lacorazza HD
Blood Adv 2023 Feb 14;7(3):422-435. doi: 10.1182/bloodadvances.2022008548. PMID: 36399528Free PMC Article
CD22ΔE12 as a molecular target for RNAi therapy.
Uckun FM, Ma H, Cheng J, Myers DE, Qazi S
Br J Haematol 2015 May;169(3):401-14. Epub 2015 Feb 6 doi: 10.1111/bjh.13306. PMID: 25659406Free PMC Article
Lymphoblastic lymphoma.
Cortelazzo S, Ponzoni M, Ferreri AJ, Hoelzer D
Crit Rev Oncol Hematol 2011 Sep;79(3):330-43. Epub 2011 Jan 26 doi: 10.1016/j.critrevonc.2010.12.003. PMID: 21273093

Prognosis

LINC00853 restrains T cell acute lymphoblastic leukemia invasion and infiltration by regulating CCR9/CCL25.
Li J, Muhammad J, Xie T, Sun J, Lei Y, Wei Z, Pan S, Qin H, Shao L, Jiang D, Zhang Q
Mol Immunol 2021 Dec;140:267-275. Epub 2021 Nov 20 doi: 10.1016/j.molimm.2021.10.016. PMID: 34808497
Nuclear PFKP promotes CXCR4-dependent infiltration by T cell acute lymphoblastic leukemia.
Gao X, Qin S, Wu Y, Chu C, Jiang B, Johnson RH, Kuang D, Zhang J, Wang X, Mehta A, Tew KD, Leone GW, Yu XZ, Wang H
J Clin Invest 2021 Aug 16;131(16) doi: 10.1172/JCI143119. PMID: 34255748Free PMC Article
Hepatosplenic T-Cell Lymphoma: A Clinicopathologic Review With an Emphasis on Diagnostic Differentiation From Other T-Cell/Natural Killer-Cell Neoplasms.
Shi Y, Wang E
Arch Pathol Lab Med 2015 Sep;139(9):1173-80. doi: 10.5858/arpa.2014-0079-RS. PMID: 26317456
Targeting the B-cell receptor signaling pathway in B lymphoid malignancies.
Buchner M, Müschen M
Curr Opin Hematol 2014 Jul;21(4):341-9. doi: 10.1097/MOH.0000000000000048. PMID: 24811161Free PMC Article
Lymphoblastic lymphoma.
Cortelazzo S, Ponzoni M, Ferreri AJ, Hoelzer D
Crit Rev Oncol Hematol 2011 Sep;79(3):330-43. Epub 2011 Jan 26 doi: 10.1016/j.critrevonc.2010.12.003. PMID: 21273093

Clinical prediction guides

Shared genetic architecture between autoimmune disorders and B-cell acute lymphoblastic leukemia: insights from large-scale genome-wide cross-trait analysis.
Yu X, Chen Y, Chen J, Fan Y, Lu H, Wu D, Xu Y
BMC Med 2024 Apr 15;22(1):161. doi: 10.1186/s12916-024-03385-0. PMID: 38616254Free PMC Article
An Anti-CD7 Antibody-Drug Conjugate Target Showing Potent Antitumor Activity for T-Lymphoblastic Leukemia (T-ALL).
Wang S, Zhang R, Zhong K, Guo W, Tong A
Biomolecules 2024 Jan 15;14(1) doi: 10.3390/biom14010106. PMID: 38254706Free PMC Article
Constitutively active CaMKII Drives B lineage acute lymphoblastic leukemia/lymphoma in tp53 mutant zebrafish.
Rothschild SC, Lai G, Tombes RM, Clements WK
PLoS Genet 2023 Dec;19(12):e1011102. Epub 2023 Dec 20 doi: 10.1371/journal.pgen.1011102. PMID: 38117861Free PMC Article
LINC00853 restrains T cell acute lymphoblastic leukemia invasion and infiltration by regulating CCR9/CCL25.
Li J, Muhammad J, Xie T, Sun J, Lei Y, Wei Z, Pan S, Qin H, Shao L, Jiang D, Zhang Q
Mol Immunol 2021 Dec;140:267-275. Epub 2021 Nov 20 doi: 10.1016/j.molimm.2021.10.016. PMID: 34808497
Targeting the B-cell receptor signaling pathway in B lymphoid malignancies.
Buchner M, Müschen M
Curr Opin Hematol 2014 Jul;21(4):341-9. doi: 10.1097/MOH.0000000000000048. PMID: 24811161Free PMC Article

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