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Lymphomatous Adult T-Cell Leukemia/Lymphoma

MedGen UID:
233634
Concept ID:
C1334466
Neoplastic Process
Synonym: Lymphomatous Adult T-Cell Lymphoma/Leukemia

Definition

An adult T-cell leukemia/lymphoma characterized by generalized lymphadenopathy without peripheral blood involvement. Most patients have advanced disease, however hypercalcemia is not frequently present. [from NCI]

Term Hierarchy

CClinical test,  RResearch test,  OOMIM,  GGeneReviews,  VClinVar  
  • CROGVLymphomatous Adult T-Cell Leukemia/Lymphoma

Professional guidelines

PubMed

Temple WC, Mueller S, Hermiston ML, Burkhardt B
Best Pract Res Clin Haematol 2023 Mar;36(1):101449. Epub 2023 Feb 16 doi: 10.1016/j.beha.2023.101449. PMID: 36907639
Gregory S
Semin Oncol Nurs 2019 Dec;35(6):150951. Epub 2019 Nov 20 doi: 10.1016/j.soncn.2019.150951. PMID: 31759820
Cook LB, Fuji S, Hermine O, Bazarbachi A, Ramos JC, Ratner L, Horwitz S, Fields P, Tanase A, Bumbea H, Cwynarski K, Taylor G, Waldmann TA, Bittencourt A, Marcais A, Suarez F, Sibon D, Phillips A, Lunning M, Farid R, Imaizumi Y, Choi I, Ishida T, Ishitsuka K, Fukushima T, Uchimaru K, Takaori-Kondo A, Tokura Y, Utsunomiya A, Matsuoka M, Tsukasaki K, Watanabe T
J Clin Oncol 2019 Mar 10;37(8):677-687. Epub 2019 Jan 18 doi: 10.1200/JCO.18.00501. PMID: 30657736Free PMC Article

Recent clinical studies

Etiology

Stuver R, Horwitz SM, Epstein-Peterson ZD
Curr Treat Options Oncol 2023 Aug;24(8):948-964. Epub 2023 Jun 10 doi: 10.1007/s11864-023-01111-1. PMID: 37300656Free PMC Article
Kameda T, Kataoka K, Kamiunten A, Hidaka M, Miyoshi H, Nakano N, Nosaka K, Yoshimitsu M, Yasunaga JI, Kogure Y, Shide K, Miyahara M, Sakamoto T, Akizuki K, Hidaka T, Kubuki Y, Koya J, Kawano N, Yamashita K, Kawano H, Toyama T, Maeda K, Marutsuka K, Imaizumi Y, Kato K, Sugio T, Tokunaga M, Tashiro Y, Takaori-Kondo A, Miyazaki Y, Akashi K, Ishitsuka K, Matsuoka M, Ohshima K, Watanabe T, Kitanaka A, Utsunomiya A, Ogawa S, Shimoda K
Haematologica 2023 Aug 1;108(8):2178-2191. doi: 10.3324/haematol.2022.281510. PMID: 36794502Free PMC Article
Miyashiro D, Sanches JA
Semin Diagn Pathol 2020 Mar;37(2):81-91. Epub 2019 Jul 30 doi: 10.1053/j.semdp.2019.07.010. PMID: 31387753
Cook LB, Fuji S, Hermine O, Bazarbachi A, Ramos JC, Ratner L, Horwitz S, Fields P, Tanase A, Bumbea H, Cwynarski K, Taylor G, Waldmann TA, Bittencourt A, Marcais A, Suarez F, Sibon D, Phillips A, Lunning M, Farid R, Imaizumi Y, Choi I, Ishida T, Ishitsuka K, Fukushima T, Uchimaru K, Takaori-Kondo A, Tokura Y, Utsunomiya A, Matsuoka M, Tsukasaki K, Watanabe T
J Clin Oncol 2019 Mar 10;37(8):677-687. Epub 2019 Jan 18 doi: 10.1200/JCO.18.00501. PMID: 30657736Free PMC Article
Mehta-Shah N, Ratner L, Horwitz SM
J Oncol Pract 2017 Aug;13(8):487-492. doi: 10.1200/JOP.2017.021907. PMID: 28796966Free PMC Article

Diagnosis

Stuver R, Horwitz SM, Epstein-Peterson ZD
Curr Treat Options Oncol 2023 Aug;24(8):948-964. Epub 2023 Jun 10 doi: 10.1007/s11864-023-01111-1. PMID: 37300656Free PMC Article
Katayama S, Hiraishi T, Ota M
Br J Haematol 2022 Aug;198(4):618. Epub 2022 Jun 27 doi: 10.1111/bjh.18318. PMID: 35759250
Makita S, Tobinai K
Hematol Oncol 2017 Jun;35 Suppl 1:54-59. doi: 10.1002/hon.2401. PMID: 28591416
Mercadal S, Sureda A, González-Barca E
Med Clin (Barc) 2017 Feb 23;148(4):176-180. Epub 2016 Nov 30 doi: 10.1016/j.medcli.2016.10.005. PMID: 27914673
Oliveira PD, Farre L, Bittencourt AL
Rev Assoc Med Bras (1992) 2016 Oct;62(7):691-700. doi: 10.1590/1806-9282.62.07.691. PMID: 27925051

Therapy

Izutsu K, Makita S, Nosaka K, Yoshimitsu M, Utsunomiya A, Kusumoto S, Morishima S, Tsukasaki K, Kawamata T, Ono T, Rai S, Katsuya H, Ishikawa J, Yamada H, Kato K, Tachibana M, Kakurai Y, Adachi N, Tobinai K, Yonekura K, Ishitsuka K
Blood 2023 Mar 9;141(10):1159-1168. doi: 10.1182/blood.2022016862. PMID: 36150143Free PMC Article
Kamoi K, Ohno-Matsui K
Am J Trop Med Hyg 2020 Jan;102(1):7-8. doi: 10.4269/ajtmh.19-0539. PMID: 31971149Free PMC Article
Cook LB, Fuji S, Hermine O, Bazarbachi A, Ramos JC, Ratner L, Horwitz S, Fields P, Tanase A, Bumbea H, Cwynarski K, Taylor G, Waldmann TA, Bittencourt A, Marcais A, Suarez F, Sibon D, Phillips A, Lunning M, Farid R, Imaizumi Y, Choi I, Ishida T, Ishitsuka K, Fukushima T, Uchimaru K, Takaori-Kondo A, Tokura Y, Utsunomiya A, Matsuoka M, Tsukasaki K, Watanabe T
J Clin Oncol 2019 Mar 10;37(8):677-687. Epub 2019 Jan 18 doi: 10.1200/JCO.18.00501. PMID: 30657736Free PMC Article
Mehta-Shah N, Ratner L, Horwitz SM
J Oncol Pract 2017 Aug;13(8):487-492. doi: 10.1200/JOP.2017.021907. PMID: 28796966Free PMC Article
Yoshie O, Matsushima K
Int Immunol 2015 Jan;27(1):11-20. Epub 2014 Aug 2 doi: 10.1093/intimm/dxu079. PMID: 25087232

Prognosis

Izutsu K, Makita S, Nosaka K, Yoshimitsu M, Utsunomiya A, Kusumoto S, Morishima S, Tsukasaki K, Kawamata T, Ono T, Rai S, Katsuya H, Ishikawa J, Yamada H, Kato K, Tachibana M, Kakurai Y, Adachi N, Tobinai K, Yonekura K, Ishitsuka K
Blood 2023 Mar 9;141(10):1159-1168. doi: 10.1182/blood.2022016862. PMID: 36150143Free PMC Article
Mehta-Shah N, Ratner L, Horwitz SM
J Oncol Pract 2017 Aug;13(8):487-492. doi: 10.1200/JOP.2017.021907. PMID: 28796966Free PMC Article
Makita S, Tobinai K
Hematol Oncol 2017 Jun;35 Suppl 1:54-59. doi: 10.1002/hon.2401. PMID: 28591416
Oliveira PD, Farre L, Bittencourt AL
Rev Assoc Med Bras (1992) 2016 Oct;62(7):691-700. doi: 10.1590/1806-9282.62.07.691. PMID: 27925051
Qayyum S, Choi JK
Arch Pathol Lab Med 2014 Feb;138(2):282-6. doi: 10.5858/arpa.2012-0379-RS. PMID: 24476526

Clinical prediction guides

Nakashima M, Uchimaru K
Int J Mol Sci 2023 May 13;24(10) doi: 10.3390/ijms24108731. PMID: 37240076Free PMC Article
Ohmoto A, Fuji S
Expert Rev Hematol 2023 Jul-Dec;16(7):535-541. Epub 2023 May 18 doi: 10.1080/17474086.2023.2215424. PMID: 37191476
Tamaki T, Karube K, Sakihama S, Tsuruta Y, Awazawa R, Hayashi M, Nakada N, Matsumoto H, Yagi N, Ohshiro K, Nakazato I, Kitamura S, Nishi Y, Miyagi T, Yamaguchi S, Nakachi S, Morishima S, Masuzaki H, Takahashi K, Fukushima T, Wada N
Mod Pathol 2023 Aug;36(8):100169. Epub 2023 Mar 29 doi: 10.1016/j.modpat.2023.100169. PMID: 36997002
Shichijo T, Nosaka K, Tatetsu H, Higuchi Y, Endo S, Inoue Y, Toyoda K, Kikukawa Y, Kawakita T, Yasunaga JI, Matsuoka M
Br J Haematol 2022 Sep;198(6):983-987. Epub 2022 May 24 doi: 10.1111/bjh.18281. PMID: 35607839
Miyashiro D, Sanches JA
Semin Diagn Pathol 2020 Mar;37(2):81-91. Epub 2019 Jul 30 doi: 10.1053/j.semdp.2019.07.010. PMID: 31387753

Recent systematic reviews

Ohmoto A, Fuji S
Expert Rev Anti Infect Ther 2024 May;22(5):307-316. Epub 2024 Apr 1 doi: 10.1080/14787210.2024.2336547. PMID: 38536666
Nosaka K, Crawford B, Yi J, Kuan W, Matsumoto T, Takahashi T
Eur J Haematol 2022 Mar;108(3):212-222. Epub 2021 Dec 8 doi: 10.1111/ejh.13728. PMID: 34862665Free PMC Article
Grover P, Veilleux O, Tian L, Sun R, Previtera M, Curran E, Muffly L
Blood Adv 2022 Mar 8;6(5):1608-1618. doi: 10.1182/bloodadvances.2020003482. PMID: 34610109Free PMC Article
Aamir S, Anwar MY, Khalid F, Khan SI, Ali MA, Khattak ZE
Clin Lymphoma Myeloma Leuk 2021 Apr;21(4):e334-e347. Epub 2020 Dec 17 doi: 10.1016/j.clml.2020.12.010. PMID: 33573914
Oliveira PD, de Carvalho RF, Bittencourt AL
Int J STD AIDS 2017 Mar;28(3):217-228. Epub 2016 Dec 14 doi: 10.1177/0956462416684461. PMID: 28178905

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