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Recurrent Peripheral T-Cell Lymphoma, Not Otherwise Specified

MedGen UID:
1651768
•Concept ID:
C4727586
•
Neoplastic Process

Definition

The reemergence of peripheral T-cell lymphoma, not otherwise specified after a period of remission. [from NCI]

Term Hierarchy

CClinical test,  RResearch test,  OOMIM,  GGeneReviews,  VClinVar  
  • CROGVRecurrent Peripheral T-Cell Lymphoma, Not Otherwise Specified

Professional guidelines

PubMed

Nelarabine: when and how to use in the treatment of T-cell acute lymphoblastic leukemia.
Shimony S, DeAngelo DJ, Luskin MR
Blood Adv 2024 Jan 9;8(1):23-36. doi: 10.1182/bloodadvances.2023010303. PMID: 37389830Free PMC Article
Epigenetic alterations and advancement of treatment in peripheral T-cell lymphoma.
Zhang P, Zhang M
Clin Epigenetics 2020 Nov 7;12(1):169. doi: 10.1186/s13148-020-00962-x. PMID: 33160401Free PMC Article
Extranodal NK/T-cell lymphoma: Updates in biology and management strategies.
Yamaguchi M, Oguchi M, Suzuki R
Best Pract Res Clin Haematol 2018 Sep;31(3):315-321. Epub 2018 Jul 3 doi: 10.1016/j.beha.2018.07.002. PMID: 30213402

Recent clinical studies

Etiology

Pathobiology of nodal peripheral T-cell lymphomas: current understanding and future directions.
Bisig B, Savage KJ, De Leval L
Haematologica 2023 Dec 1;108(12):3227-3243. doi: 10.3324/haematol.2023.282716. PMID: 38037800Free PMC Article
Peripheral T-Cell Lymphoma, not Otherwise Specified (PTCL-NOS).
Oluwasanjo A, Kartan S, Johnson W, Alpdogan O, Gru A, Mishra A, Haverkos BM, Gong J, Porcu P
Cancer Treat Res 2019;176:83-98. doi: 10.1007/978-3-319-99716-2_4. PMID: 30596214
Molecular Insights Into Pathogenesis of Peripheral T Cell Lymphoma: a Review.
Lone W, Alkhiniji A, Manikkam Umakanthan J, Iqbal J
Curr Hematol Malig Rep 2018 Aug;13(4):318-328. doi: 10.1007/s11899-018-0460-z. PMID: 29951889
Genetic Landscape and Classification of Peripheral T Cell Lymphomas.
Sandell RF, Boddicker RL, Feldman AL
Curr Oncol Rep 2017 Apr;19(4):28. doi: 10.1007/s11912-017-0582-9. PMID: 28303495Free PMC Article
Allogeneic transplantation in T-cell lymphomas.
Schmitz N, Wu HS, Glass B
Semin Hematol 2014 Jan;51(1):67-72. Epub 2013 Nov 28 doi: 10.1053/j.seminhematol.2013.11.010. PMID: 24468318

Diagnosis

Molecular heterogeneity in peripheral T-cell lymphoma, not otherwise specified revealed by comprehensive genetic profiling.
Watatani Y, Sato Y, Miyoshi H, Sakamoto K, Nishida K, Gion Y, Nagata Y, Shiraishi Y, Chiba K, Tanaka H, Zhao L, Ochi Y, Takeuchi Y, Takeda J, Ueno H, Kogure Y, Shiozawa Y, Kakiuchi N, Yoshizato T, Nakagawa MM, Nanya Y, Yoshida K, Makishima H, Sanada M, Sakata-Yanagimoto M, Chiba S, Matsuoka R, Noguchi M, Hiramoto N, Ishikawa T, Kitagawa J, Nakamura N, Tsurumi H, Miyazaki T, Kito Y, Miyano S, Shimoda K, Takeuchi K, Ohshima K, Yoshino T, Ogawa S, Kataoka K
Leukemia 2019 Dec;33(12):2867-2883. Epub 2019 May 15 doi: 10.1038/s41375-019-0473-1. PMID: 31092896
Peripheral T-Cell Lymphoma, not Otherwise Specified (PTCL-NOS).
Oluwasanjo A, Kartan S, Johnson W, Alpdogan O, Gru A, Mishra A, Haverkos BM, Gong J, Porcu P
Cancer Treat Res 2019;176:83-98. doi: 10.1007/978-3-319-99716-2_4. PMID: 30596214
Molecular Insights Into Pathogenesis of Peripheral T Cell Lymphoma: a Review.
Lone W, Alkhiniji A, Manikkam Umakanthan J, Iqbal J
Curr Hematol Malig Rep 2018 Aug;13(4):318-328. doi: 10.1007/s11899-018-0460-z. PMID: 29951889
Genetic Landscape and Classification of Peripheral T Cell Lymphomas.
Sandell RF, Boddicker RL, Feldman AL
Curr Oncol Rep 2017 Apr;19(4):28. doi: 10.1007/s11912-017-0582-9. PMID: 28303495Free PMC Article
How I manage peripheral T-cell lymphoma, not otherwise specified and angioimmunoblastic T-cell lymphoma: current practice and a glimpse into the future.
Schmitz N, de Leval L
Br J Haematol 2017 Mar;176(6):851-866. Epub 2016 Dec 16 doi: 10.1111/bjh.14473. PMID: 27982416

Therapy

Peripheral T-Cell Lymphoma, not Otherwise Specified (PTCL-NOS).
Oluwasanjo A, Kartan S, Johnson W, Alpdogan O, Gru A, Mishra A, Haverkos BM, Gong J, Porcu P
Cancer Treat Res 2019;176:83-98. doi: 10.1007/978-3-319-99716-2_4. PMID: 30596214
Allogeneic hematopoietic stem cell transplantation for T-cell lymphomas.
Schmitz N, Lenz G, Stelljes M
Blood 2018 Jul 19;132(3):245-253. Epub 2018 Apr 26 doi: 10.1182/blood-2018-01-791335. PMID: 29699989
How I manage peripheral T-cell lymphoma, not otherwise specified and angioimmunoblastic T-cell lymphoma: current practice and a glimpse into the future.
Schmitz N, de Leval L
Br J Haematol 2017 Mar;176(6):851-866. Epub 2016 Dec 16 doi: 10.1111/bjh.14473. PMID: 27982416
Objective responses in relapsed T-cell lymphomas with single-agent brentuximab vedotin.
Horwitz SM, Advani RH, Bartlett NL, Jacobsen ED, Sharman JP, O'Connor OA, Siddiqi T, Kennedy DA, Oki Y
Blood 2014 May 15;123(20):3095-100. Epub 2014 Mar 20 doi: 10.1182/blood-2013-12-542142. PMID: 24652992Free PMC Article
Peripheral T-cell lymphoma in children and adolescents: a single-institution experience.
Al Mahmoud R, Weitzman S, Schechter T, Ngan B, Abdelhaleem M, Alexander S
J Pediatr Hematol Oncol 2012 Nov;34(8):611-6. doi: 10.1097/MPH.0b013e3182707592. PMID: 23042011

Prognosis

Pathobiology of nodal peripheral T-cell lymphomas: current understanding and future directions.
Bisig B, Savage KJ, De Leval L
Haematologica 2023 Dec 1;108(12):3227-3243. doi: 10.3324/haematol.2023.282716. PMID: 38037800Free PMC Article
Peripheral T-Cell Lymphoma, not Otherwise Specified (PTCL-NOS).
Oluwasanjo A, Kartan S, Johnson W, Alpdogan O, Gru A, Mishra A, Haverkos BM, Gong J, Porcu P
Cancer Treat Res 2019;176:83-98. doi: 10.1007/978-3-319-99716-2_4. PMID: 30596214
Genetic Landscape and Classification of Peripheral T Cell Lymphomas.
Sandell RF, Boddicker RL, Feldman AL
Curr Oncol Rep 2017 Apr;19(4):28. doi: 10.1007/s11912-017-0582-9. PMID: 28303495Free PMC Article
How I manage peripheral T-cell lymphoma, not otherwise specified and angioimmunoblastic T-cell lymphoma: current practice and a glimpse into the future.
Schmitz N, de Leval L
Br J Haematol 2017 Mar;176(6):851-866. Epub 2016 Dec 16 doi: 10.1111/bjh.14473. PMID: 27982416
Allogeneic transplantation in T-cell lymphomas.
Schmitz N, Wu HS, Glass B
Semin Hematol 2014 Jan;51(1):67-72. Epub 2013 Nov 28 doi: 10.1053/j.seminhematol.2013.11.010. PMID: 24468318

Clinical prediction guides

Treatment strategies and outcome in relapsed peripheral T-cell lymphoma: results from the Netherlands Cancer Registry.
Brink M, Huisman F, Meeuwes FO, van der Poel MWM, Kersten MJ, Wondergem M, Böhmer L, Woei-A-Jin FJSH, Visser O, Oostvogels R, Jansen PM, Diepstra A, Snijders TJF, Huls G, Vermaat JSP, Plattel WJ, Nijland M
Blood Adv 2024 Jul 23;8(14):3619-3628. doi: 10.1182/bloodadvances.2023012531. PMID: 38739705Free PMC Article
T follicular helper phenotype predicts response to histone deacetylase inhibitors in relapsed/refractory peripheral T-cell lymphoma.
Ghione P, Faruque P, Mehta-Shah N, Seshan V, Ozkaya N, Bhaskar S, Yeung J, Spinner MA, Lunning M, Inghirami G, Moskowitz A, Galasso N, Ganesan N, van der Weyden C, Ruan J, Prince HM, Trotman J, Advani R, Dogan A, Horwitz S
Blood Adv 2020 Oct 13;4(19):4640-4647. doi: 10.1182/bloodadvances.2020002396. PMID: 33002132Free PMC Article
Recurrent activating mutations of CD28 in peripheral T-cell lymphomas.
Rohr J, Guo S, Huo J, Bouska A, Lachel C, Li Y, Simone PD, Zhang W, Gong Q, Wang C, Cannon A, Heavican T, Mottok A, Hung S, Rosenwald A, Gascoyne R, Fu K, Greiner TC, Weisenburger DD, Vose JM, Staudt LM, Xiao W, Borgstahl GE, Davis S, Steidl C, McKeithan T, Iqbal J, Chan WC
Leukemia 2016 May;30(5):1062-70. Epub 2015 Dec 31 doi: 10.1038/leu.2015.357. PMID: 26719098Free PMC Article
Objective responses in relapsed T-cell lymphomas with single-agent brentuximab vedotin.
Horwitz SM, Advani RH, Bartlett NL, Jacobsen ED, Sharman JP, O'Connor OA, Siddiqi T, Kennedy DA, Oki Y
Blood 2014 May 15;123(20):3095-100. Epub 2014 Mar 20 doi: 10.1182/blood-2013-12-542142. PMID: 24652992Free PMC Article
Molecular classification of T-cell lymphomas.
de Leval L, Bisig B, Thielen C, Boniver J, Gaulard P
Crit Rev Oncol Hematol 2009 Nov;72(2):125-43. Epub 2009 Feb 23 doi: 10.1016/j.critrevonc.2009.01.002. PMID: 19233683

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