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Splenic B Lymphoblastic Lymphoma

MedGen UID:
236844
•Concept ID:
C1336072
•
Neoplastic Process
Synonyms: Splenic B-Lymphoblastic Lymphoma; Splenic Precursor B-Lymphoblastic Lymphoma

Definition

B-lymphoblastic lymphoma that involves the spleen. [from NCI]

Term Hierarchy

CClinical test,  RResearch test,  OOMIM,  GGeneReviews,  VClinVar  
  • CROGVSplenic B Lymphoblastic Lymphoma

Professional guidelines

PubMed

Valrubicin-loaded immunoliposomes for specific vesicle-mediated cell death in the treatment of hematological cancers.
Georgievski A, Bellaye PS, Tournier B, Choubley H, Pais de Barros JP, Herbst M, Béduneau A, Callier P, Collin B, Végran F, Ballerini P, Garrido C, Quéré R
Cell Death Dis 2024 May 11;15(5):328. doi: 10.1038/s41419-024-06715-5. PMID: 38734740Free PMC Article
Comparison of Myocyte Enhancer Factor 2B Versus Other Germinal Center-associated Antigens in the Differential Diagnosis of B-Cell Non-Hodgkin Lymphomas.
Moore EM, Swerdlow SH, Gibson SE
Am J Surg Pathol 2018 Mar;42(3):342-350. doi: 10.1097/PAS.0000000000001015. PMID: 29309299
Amphotericin B lipid complex for the treatment of patients with acute leukemia and hepatosplenic candidiasis.
Sallah S, Semelka RC, Sallah W, Vainright JR, Philips DL
Leuk Res 1999 Nov;23(11):995-9. doi: 10.1016/s0145-2126(99)00129-0. PMID: 10576503

Recent clinical studies

Etiology

Valrubicin-loaded immunoliposomes for specific vesicle-mediated cell death in the treatment of hematological cancers.
Georgievski A, Bellaye PS, Tournier B, Choubley H, Pais de Barros JP, Herbst M, Béduneau A, Callier P, Collin B, Végran F, Ballerini P, Garrido C, Quéré R
Cell Death Dis 2024 May 11;15(5):328. doi: 10.1038/s41419-024-06715-5. PMID: 38734740Free PMC Article
Shared genetic architecture between autoimmune disorders and B-cell acute lymphoblastic leukemia: insights from large-scale genome-wide cross-trait analysis.
Yu X, Chen Y, Chen J, Fan Y, Lu H, Wu D, Xu Y
BMC Med 2024 Apr 15;22(1):161. doi: 10.1186/s12916-024-03385-0. PMID: 38616254Free PMC Article
B-cell Non-Hodgkin Lymphomas with Plasmacytic Differentiation.
Harmon CM, Smith LB
Surg Pathol Clin 2016 Mar;9(1):11-28. doi: 10.1016/j.path.2015.09.007. PMID: 26940265
Targeting the B-cell receptor signaling pathway in B lymphoid malignancies.
Buchner M, Müschen M
Curr Opin Hematol 2014 Jul;21(4):341-9. doi: 10.1097/MOH.0000000000000048. PMID: 24811161Free PMC Article
Lymphoblastic lymphoma.
Cortelazzo S, Ponzoni M, Ferreri AJ, Hoelzer D
Crit Rev Oncol Hematol 2011 Sep;79(3):330-43. Epub 2011 Jan 26 doi: 10.1016/j.critrevonc.2010.12.003. PMID: 21273093

Diagnosis

Precursor B-ALL Cell Lines Differentially Respond to SYK Inhibition by Entospletinib.
Sender S, Sekora A, Villa Perez S, Chabanovska O, Becker A, Ngezahayo A, Junghanss C, Murua Escobar H
Int J Mol Sci 2021 Jan 8;22(2) doi: 10.3390/ijms22020592. PMID: 33435587Free PMC Article
Aggressive B-cell lymphomas with a primary bone marrow presentation.
Zamò A, Johnston P, Attygalle AD, Laurent C, Arber DA, Fend F
Histopathology 2020 Sep;77(3):369-379. Epub 2020 Jul 14 doi: 10.1111/his.14124. PMID: 32324290
B-cell Non-Hodgkin Lymphomas with Plasmacytic Differentiation.
Harmon CM, Smith LB
Surg Pathol Clin 2016 Mar;9(1):11-28. doi: 10.1016/j.path.2015.09.007. PMID: 26940265
Lymphoblastic lymphoma.
Cortelazzo S, Ponzoni M, Ferreri AJ, Hoelzer D
Crit Rev Oncol Hematol 2011 Sep;79(3):330-43. Epub 2011 Jan 26 doi: 10.1016/j.critrevonc.2010.12.003. PMID: 21273093
Lymphoma--emerging realities in sub-Saharan Africa.
Sissolak G, Juritz J, Sissolak D, Wood L, Jacobs P
Transfus Apher Sci 2010 Apr;42(2):141-50. Epub 2010 Feb 10 doi: 10.1016/j.transci.2010.01.009. PMID: 20149748

Therapy

Shared genetic architecture between autoimmune disorders and B-cell acute lymphoblastic leukemia: insights from large-scale genome-wide cross-trait analysis.
Yu X, Chen Y, Chen J, Fan Y, Lu H, Wu D, Xu Y
BMC Med 2024 Apr 15;22(1):161. doi: 10.1186/s12916-024-03385-0. PMID: 38616254Free PMC Article
An Anti-CD7 Antibody-Drug Conjugate Target Showing Potent Antitumor Activity for T-Lymphoblastic Leukemia (T-ALL).
Wang S, Zhang R, Zhong K, Guo W, Tong A
Biomolecules 2024 Jan 15;14(1) doi: 10.3390/biom14010106. PMID: 38254706Free PMC Article
CD22ΔE12 as a molecular target for RNAi therapy.
Uckun FM, Ma H, Cheng J, Myers DE, Qazi S
Br J Haematol 2015 May;169(3):401-14. Epub 2015 Feb 6 doi: 10.1111/bjh.13306. PMID: 25659406Free PMC Article
Interleukin-27 inhibits pediatric B-acute lymphoblastic leukemia cell spreading in a preclinical model.
Canale S, Cocco C, Frasson C, Seganfreddo E, Di Carlo E, Ognio E, Sorrentino C, Ribatti D, Zorzoli A, Basso G, Dufour C, Airoldi I
Leukemia 2011 Dec;25(12):1815-24. Epub 2011 Jun 24 doi: 10.1038/leu.2011.158. PMID: 21701492
Lymphoblastic lymphoma.
Cortelazzo S, Ponzoni M, Ferreri AJ, Hoelzer D
Crit Rev Oncol Hematol 2011 Sep;79(3):330-43. Epub 2011 Jan 26 doi: 10.1016/j.critrevonc.2010.12.003. PMID: 21273093

Prognosis

B-cell Non-Hodgkin Lymphomas with Plasmacytic Differentiation.
Harmon CM, Smith LB
Surg Pathol Clin 2016 Mar;9(1):11-28. doi: 10.1016/j.path.2015.09.007. PMID: 26940265
Targeting the B-cell receptor signaling pathway in B lymphoid malignancies.
Buchner M, Müschen M
Curr Opin Hematol 2014 Jul;21(4):341-9. doi: 10.1097/MOH.0000000000000048. PMID: 24811161Free PMC Article
Lymphoblastic lymphoma.
Cortelazzo S, Ponzoni M, Ferreri AJ, Hoelzer D
Crit Rev Oncol Hematol 2011 Sep;79(3):330-43. Epub 2011 Jan 26 doi: 10.1016/j.critrevonc.2010.12.003. PMID: 21273093
Lymphoma--emerging realities in sub-Saharan Africa.
Sissolak G, Juritz J, Sissolak D, Wood L, Jacobs P
Transfus Apher Sci 2010 Apr;42(2):141-50. Epub 2010 Feb 10 doi: 10.1016/j.transci.2010.01.009. PMID: 20149748
Nonnasal lymphoma expressing the natural killer cell marker CD56: a clinicopathologic study of 49 cases of an uncommon aggressive neoplasm.
Chan JK, Sin VC, Wong KF, Ng CS, Tsang WY, Chan CH, Cheung MM, Lau WH
Blood 1997 Jun 15;89(12):4501-13. PMID: 9192774

Clinical prediction guides

Shared genetic architecture between autoimmune disorders and B-cell acute lymphoblastic leukemia: insights from large-scale genome-wide cross-trait analysis.
Yu X, Chen Y, Chen J, Fan Y, Lu H, Wu D, Xu Y
BMC Med 2024 Apr 15;22(1):161. doi: 10.1186/s12916-024-03385-0. PMID: 38616254Free PMC Article
Constitutively active CaMKII Drives B lineage acute lymphoblastic leukemia/lymphoma in tp53 mutant zebrafish.
Rothschild SC, Lai G, Tombes RM, Clements WK
PLoS Genet 2023 Dec;19(12):e1011102. Epub 2023 Dec 20 doi: 10.1371/journal.pgen.1011102. PMID: 38117861Free PMC Article
Combined Casein Kinase II inhibition and epigenetic modulation in acute B-lymphoblastic leukemia.
Richter A, Roolf C, Hamed M, Gladbach YS, Sender S, Konkolefski C, Knübel G, Sekora A, Fuellen G, Vollmar B, Murua Escobar H, Junghanss C
BMC Cancer 2019 Mar 6;19(1):202. doi: 10.1186/s12885-019-5411-0. PMID: 30841886Free PMC Article
Targeting the B-cell receptor signaling pathway in B lymphoid malignancies.
Buchner M, Müschen M
Curr Opin Hematol 2014 Jul;21(4):341-9. doi: 10.1097/MOH.0000000000000048. PMID: 24811161Free PMC Article
Lymphoma--emerging realities in sub-Saharan Africa.
Sissolak G, Juritz J, Sissolak D, Wood L, Jacobs P
Transfus Apher Sci 2010 Apr;42(2):141-50. Epub 2010 Feb 10 doi: 10.1016/j.transci.2010.01.009. PMID: 20149748

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