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Recurrent Aggressive Adult Non-Hodgkin Lymphoma

MedGen UID:
146179
•Concept ID:
C0677726
•
Neoplastic Process
Synonyms: Aggressive Recurrent Adult Non-Hodgkin's Lymphoma; Recurrent Adult Aggressive Non-Hodgkin's Lymphoma; Recurrent Aggressive Adult Non-Hodgkin's Lymphoma

Definition

The reemergence of an aggressive adult non-Hodgkin lymphoma after a period of remission. [from NCI]

Professional guidelines

PubMed

Diagnosis, prevention and treatment of central nervous system involvement in peripheral t-cell lymphomas.
Zing N, Fischer T, Federico M, Chiattone C, Ferreri AJM
Crit Rev Oncol Hematol 2021 Nov;167:103496. Epub 2021 Oct 12 doi: 10.1016/j.critrevonc.2021.103496. PMID: 34653598
Treatment of relapsed/refractory paediatric aggressive B-cell non-Hodgkin lymphoma.
Moleti ML, Testi AM, Foà R
Br J Haematol 2020 Jun;189(5):826-843. Epub 2020 Mar 6 doi: 10.1111/bjh.16461. PMID: 32141616
Treatment for patients with relapsed/refractory mantle cell lymphoma: European-based recommendations.
Dreyling M, Aurer I, Cortelazzo S, Hermine O, Hess G, Jerkeman M, Le Gouill S, Ribrag V, Trněný M, Visco C, Walewski J, Zaja F, Zinzani PL
Leuk Lymphoma 2018 Aug;59(8):1814-1828. Epub 2017 Nov 27 doi: 10.1080/10428194.2017.1403602. PMID: 29172868

Recent clinical studies

Etiology

How I treat secondary CNS involvement by aggressive lymphomas.
Alderuccio JP, Nayak L, Cwynarski K
Blood 2023 Nov 23;142(21):1771-1783. doi: 10.1182/blood.2023020168. PMID: 37702537Free PMC Article
CAR T-cell therapy for B-cell lymphoma.
Denlinger N, Bond D, Jaglowski S
Curr Probl Cancer 2022 Feb;46(1):100826. Epub 2021 Dec 25 doi: 10.1016/j.currproblcancer.2021.100826. PMID: 35012754Free PMC Article
Long-term clinical outcomes of tisagenlecleucel in patients with relapsed or refractory aggressive B-cell lymphomas (JULIET): a multicentre, open-label, single-arm, phase 2 study.
Schuster SJ, Tam CS, Borchmann P, Worel N, McGuirk JP, Holte H, Waller EK, Jaglowski S, Bishop MR, Damon LE, Foley SR, Westin JR, Fleury I, Ho PJ, Mielke S, Teshima T, Janakiram M, Hsu JM, Izutsu K, Kersten MJ, Ghosh M, Wagner-Johnston N, Kato K, Corradini P, Martinez-Prieto M, Han X, Tiwari R, Salles G, Maziarz RT
Lancet Oncol 2021 Oct;22(10):1403-1415. Epub 2021 Sep 10 doi: 10.1016/S1470-2045(21)00375-2. PMID: 34516954
Treatment of relapsed/refractory paediatric aggressive B-cell non-Hodgkin lymphoma.
Moleti ML, Testi AM, Foà R
Br J Haematol 2020 Jun;189(5):826-843. Epub 2020 Mar 6 doi: 10.1111/bjh.16461. PMID: 32141616
Non-Hodgkin's lymphoma.
Shad A, Magrath I
Pediatr Clin North Am 1997 Aug;44(4):863-90. doi: 10.1016/s0031-3955(05)70534-4. PMID: 9286289

Diagnosis

Burkitt lymphoma.
López C, Burkhardt B, Chan JKC, Leoncini L, Mbulaiteye SM, Ogwang MD, Orem J, Rochford R, Roschewski M, Siebert R
Nat Rev Dis Primers 2022 Dec 15;8(1):78. doi: 10.1038/s41572-022-00404-3. PMID: 36522349
Long-term clinical outcomes of tisagenlecleucel in patients with relapsed or refractory aggressive B-cell lymphomas (JULIET): a multicentre, open-label, single-arm, phase 2 study.
Schuster SJ, Tam CS, Borchmann P, Worel N, McGuirk JP, Holte H, Waller EK, Jaglowski S, Bishop MR, Damon LE, Foley SR, Westin JR, Fleury I, Ho PJ, Mielke S, Teshima T, Janakiram M, Hsu JM, Izutsu K, Kersten MJ, Ghosh M, Wagner-Johnston N, Kato K, Corradini P, Martinez-Prieto M, Han X, Tiwari R, Salles G, Maziarz RT
Lancet Oncol 2021 Oct;22(10):1403-1415. Epub 2021 Sep 10 doi: 10.1016/S1470-2045(21)00375-2. PMID: 34516954
Treatment of relapsed/refractory paediatric aggressive B-cell non-Hodgkin lymphoma.
Moleti ML, Testi AM, Foà R
Br J Haematol 2020 Jun;189(5):826-843. Epub 2020 Mar 6 doi: 10.1111/bjh.16461. PMID: 32141616
Follicular non-Hodgkin's lymphoma.
Hayashi D, Lee JC, Devenney-Cakir B, Zaim S, Ounadjela S, Solal-Céligny P, Juweid M, Guermazi A
Clin Radiol 2010 May;65(5):408-20. Epub 2010 Mar 15 doi: 10.1016/j.crad.2010.01.010. PMID: 20380942
Non-Hodgkin's lymphoma.
Shad A, Magrath I
Pediatr Clin North Am 1997 Aug;44(4):863-90. doi: 10.1016/s0031-3955(05)70534-4. PMID: 9286289

Therapy

An open-label, single-arm phase 2 trial of valemetostat for relapsed or refractory adult T-cell leukemia/lymphoma.
Izutsu K, Makita S, Nosaka K, Yoshimitsu M, Utsunomiya A, Kusumoto S, Morishima S, Tsukasaki K, Kawamata T, Ono T, Rai S, Katsuya H, Ishikawa J, Yamada H, Kato K, Tachibana M, Kakurai Y, Adachi N, Tobinai K, Yonekura K, Ishitsuka K
Blood 2023 Mar 9;141(10):1159-1168. doi: 10.1182/blood.2022016862. PMID: 36150143Free PMC Article
CAR T-cell therapy for B-cell lymphoma.
Denlinger N, Bond D, Jaglowski S
Curr Probl Cancer 2022 Feb;46(1):100826. Epub 2021 Dec 25 doi: 10.1016/j.currproblcancer.2021.100826. PMID: 35012754Free PMC Article
Long-term clinical outcomes of tisagenlecleucel in patients with relapsed or refractory aggressive B-cell lymphomas (JULIET): a multicentre, open-label, single-arm, phase 2 study.
Schuster SJ, Tam CS, Borchmann P, Worel N, McGuirk JP, Holte H, Waller EK, Jaglowski S, Bishop MR, Damon LE, Foley SR, Westin JR, Fleury I, Ho PJ, Mielke S, Teshima T, Janakiram M, Hsu JM, Izutsu K, Kersten MJ, Ghosh M, Wagner-Johnston N, Kato K, Corradini P, Martinez-Prieto M, Han X, Tiwari R, Salles G, Maziarz RT
Lancet Oncol 2021 Oct;22(10):1403-1415. Epub 2021 Sep 10 doi: 10.1016/S1470-2045(21)00375-2. PMID: 34516954
Mantle cell lymphoma.
Cortelazzo S, Ponzoni M, Ferreri AJM, Dreyling M
Crit Rev Oncol Hematol 2020 Sep;153:103038. Epub 2020 Jul 4 doi: 10.1016/j.critrevonc.2020.103038. PMID: 32739830
Treatment of relapsed/refractory paediatric aggressive B-cell non-Hodgkin lymphoma.
Moleti ML, Testi AM, Foà R
Br J Haematol 2020 Jun;189(5):826-843. Epub 2020 Mar 6 doi: 10.1111/bjh.16461. PMID: 32141616

Prognosis

An open-label, single-arm phase 2 trial of valemetostat for relapsed or refractory adult T-cell leukemia/lymphoma.
Izutsu K, Makita S, Nosaka K, Yoshimitsu M, Utsunomiya A, Kusumoto S, Morishima S, Tsukasaki K, Kawamata T, Ono T, Rai S, Katsuya H, Ishikawa J, Yamada H, Kato K, Tachibana M, Kakurai Y, Adachi N, Tobinai K, Yonekura K, Ishitsuka K
Blood 2023 Mar 9;141(10):1159-1168. doi: 10.1182/blood.2022016862. PMID: 36150143Free PMC Article
Mantle cell lymphoma.
Cortelazzo S, Ponzoni M, Ferreri AJM, Dreyling M
Crit Rev Oncol Hematol 2020 Sep;153:103038. Epub 2020 Jul 4 doi: 10.1016/j.critrevonc.2020.103038. PMID: 32739830
Treatment of relapsed/refractory paediatric aggressive B-cell non-Hodgkin lymphoma.
Moleti ML, Testi AM, Foà R
Br J Haematol 2020 Jun;189(5):826-843. Epub 2020 Mar 6 doi: 10.1111/bjh.16461. PMID: 32141616
CNS International Prognostic Index: A Risk Model for CNS Relapse in Patients With Diffuse Large B-Cell Lymphoma Treated With R-CHOP.
Schmitz N, Zeynalova S, Nickelsen M, Kansara R, Villa D, Sehn LH, Glass B, Scott DW, Gascoyne RD, Connors JM, Ziepert M, Pfreundschuh M, Loeffler M, Savage KJ
J Clin Oncol 2016 Sep 10;34(26):3150-6. Epub 2016 Jul 5 doi: 10.1200/JCO.2015.65.6520. PMID: 27382100
Follicular non-Hodgkin's lymphoma.
Hayashi D, Lee JC, Devenney-Cakir B, Zaim S, Ounadjela S, Solal-Céligny P, Juweid M, Guermazi A
Clin Radiol 2010 May;65(5):408-20. Epub 2010 Mar 15 doi: 10.1016/j.crad.2010.01.010. PMID: 20380942

Clinical prediction guides

How I treat secondary CNS involvement by aggressive lymphomas.
Alderuccio JP, Nayak L, Cwynarski K
Blood 2023 Nov 23;142(21):1771-1783. doi: 10.1182/blood.2023020168. PMID: 37702537Free PMC Article
A Phase III study of zanubrutinib plus rituximab versus bendamustine plus rituximab in transplant-ineligible, untreated mantle cell lymphoma.
Dreyling M, Tam CS, Wang M, Smith SD, Ladetto M, Huang H, Novotny W, Co M, Romano A, Holmgren E, Huang J, Gouill SL
Future Oncol 2021 Jan;17(3):255-262. Epub 2020 Sep 28 doi: 10.2217/fon-2020-0794. PMID: 32985902
CNS International Prognostic Index: A Risk Model for CNS Relapse in Patients With Diffuse Large B-Cell Lymphoma Treated With R-CHOP.
Schmitz N, Zeynalova S, Nickelsen M, Kansara R, Villa D, Sehn LH, Glass B, Scott DW, Gascoyne RD, Connors JM, Ziepert M, Pfreundschuh M, Loeffler M, Savage KJ
J Clin Oncol 2016 Sep 10;34(26):3150-6. Epub 2016 Jul 5 doi: 10.1200/JCO.2015.65.6520. PMID: 27382100
Ibrutinib versus temsirolimus in patients with relapsed or refractory mantle-cell lymphoma: an international, randomised, open-label, phase 3 study.
Dreyling M, Jurczak W, Jerkeman M, Silva RS, Rusconi C, Trneny M, Offner F, Caballero D, Joao C, Witzens-Harig M, Hess G, Bence-Bruckler I, Cho SG, Bothos J, Goldberg JD, Enny C, Traina S, Balasubramanian S, Bandyopadhyay N, Sun S, Vermeulen J, Rizo A, Rule S
Lancet 2016 Feb 20;387(10020):770-8. Epub 2015 Dec 7 doi: 10.1016/S0140-6736(15)00667-4. PMID: 26673811
Follicular non-Hodgkin's lymphoma.
Hayashi D, Lee JC, Devenney-Cakir B, Zaim S, Ounadjela S, Solal-Céligny P, Juweid M, Guermazi A
Clin Radiol 2010 May;65(5):408-20. Epub 2010 Mar 15 doi: 10.1016/j.crad.2010.01.010. PMID: 20380942

Recent systematic reviews

A systematic overview of radiation therapy effects in non-Hodgkin's lymphoma.
Gustavsson A, Osterman B, Cavallin-Ståhl E
Acta Oncol 2003;42(5-6):605-19. doi: 10.1080/02841860310014435. PMID: 14596518
A systematic overview of chemotherapy effects in aggressive non-Hodgkin's lymphoma.
Kimby E, Brandt L, Nygren P, Glimelius B; SBU-group. Swedish Council of Technology Assessment in Health Care
Acta Oncol 2001;40(2-3):198-212. doi: 10.1080/02841860151116268. PMID: 11441932

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