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Recurrent Aggressive T-Cell Non-Hodgkin Lymphoma

MedGen UID:
1791568
•Concept ID:
C5555127
•
Neoplastic Process

Definition

The reemergence of an aggressive T-cell non-Hodgkin lymphoma after a period of remission. [from NCI]

Professional guidelines

PubMed

Management of aggressive lymphoma after CAR T-cell therapy failure.
Nastoupil LJ, Kambhampati S
Hematology Am Soc Hematol Educ Program 2023 Dec 8;2023(1):364-369. doi: 10.1182/hematology.2023000437. PMID: 38066908Free PMC Article
Epigenetic alterations and advancement of treatment in peripheral T-cell lymphoma.
Zhang P, Zhang M
Clin Epigenetics 2020 Nov 7;12(1):169. doi: 10.1186/s13148-020-00962-x. PMID: 33160401Free PMC Article
Treatment approaches of hard-to-treat non-Hodgkin lymphomas.
Nandagopal L, Mehta A
Expert Rev Hematol 2017 Mar;10(3):259-273. Epub 2017 Feb 15 doi: 10.1080/17474086.2017.1283214. PMID: 28094575

Recent clinical studies

Etiology

Bispecific antibodies and CAR-T cells: dueling immunotherapies for large B-cell lymphomas.
Trabolsi A, Arumov A, Schatz JH
Blood Cancer J 2024 Feb 8;14(1):27. doi: 10.1038/s41408-024-00997-w. PMID: 38331870Free PMC Article
CAR T-cell therapy in aggressive lymphomas-identifying prognostic and predictive markers.
Mussetti A, Fabbri N, Sureda A
Hematology Am Soc Hematol Educ Program 2023 Dec 8;2023(1):357-363. doi: 10.1182/hematology.2023000436. PMID: 38066912Free PMC Article
How I treat secondary CNS involvement by aggressive lymphomas.
Alderuccio JP, Nayak L, Cwynarski K
Blood 2023 Nov 23;142(21):1771-1783. doi: 10.1182/blood.2023020168. PMID: 37702537Free PMC Article
CAR T-cell therapy for B-cell lymphoma.
Denlinger N, Bond D, Jaglowski S
Curr Probl Cancer 2022 Feb;46(1):100826. Epub 2021 Dec 25 doi: 10.1016/j.currproblcancer.2021.100826. PMID: 35012754Free PMC Article
Whole-genome landscape of adult T-cell leukemia/lymphoma.
Kogure Y, Kameda T, Koya J, Yoshimitsu M, Nosaka K, Yasunaga JI, Imaizumi Y, Watanabe M, Saito Y, Ito Y, McClure MB, Tabata M, Shingaki S, Yoshifuji K, Chiba K, Okada A, Kakiuchi N, Nannya Y, Kamiunten A, Tahira Y, Akizuki K, Sekine M, Shide K, Hidaka T, Kubuki Y, Kitanaka A, Hidaka M, Nakano N, Utsunomiya A, Sica RA, Acuna-Villaorduna A, Janakiram M, Shah U, Ramos JC, Shibata T, Takeuchi K, Takaori-Kondo A, Miyazaki Y, Matsuoka M, Ishitsuka K, Shiraishi Y, Miyano S, Ogawa S, Ye BH, Shimoda K, Kataoka K
Blood 2022 Feb 17;139(7):967-982. doi: 10.1182/blood.2021013568. PMID: 34695199Free PMC Article

Diagnosis

Bispecific antibodies and CAR-T cells: dueling immunotherapies for large B-cell lymphomas.
Trabolsi A, Arumov A, Schatz JH
Blood Cancer J 2024 Feb 8;14(1):27. doi: 10.1038/s41408-024-00997-w. PMID: 38331870Free PMC Article
Follicular Lymphoma: a Focus on Current and Emerging Therapies.
Cahill KE, Smith SM
Oncology (Williston Park) 2022 Feb 8;36(2):97-106. doi: 10.46883/2022.25920946. PMID: 35180337Free PMC Article
Whole-genome landscape of adult T-cell leukemia/lymphoma.
Kogure Y, Kameda T, Koya J, Yoshimitsu M, Nosaka K, Yasunaga JI, Imaizumi Y, Watanabe M, Saito Y, Ito Y, McClure MB, Tabata M, Shingaki S, Yoshifuji K, Chiba K, Okada A, Kakiuchi N, Nannya Y, Kamiunten A, Tahira Y, Akizuki K, Sekine M, Shide K, Hidaka T, Kubuki Y, Kitanaka A, Hidaka M, Nakano N, Utsunomiya A, Sica RA, Acuna-Villaorduna A, Janakiram M, Shah U, Ramos JC, Shibata T, Takeuchi K, Takaori-Kondo A, Miyazaki Y, Matsuoka M, Ishitsuka K, Shiraishi Y, Miyano S, Ogawa S, Ye BH, Shimoda K, Kataoka K
Blood 2022 Feb 17;139(7):967-982. doi: 10.1182/blood.2021013568. PMID: 34695199Free PMC Article
Epigenetic alterations and advancement of treatment in peripheral T-cell lymphoma.
Zhang P, Zhang M
Clin Epigenetics 2020 Nov 7;12(1):169. doi: 10.1186/s13148-020-00962-x. PMID: 33160401Free PMC Article
A Review of Autologous Stem Cell Transplantation in Lymphoma.
Zahid U, Akbar F, Amaraneni A, Husnain M, Chan O, Riaz IB, McBride A, Iftikhar A, Anwer F
Curr Hematol Malig Rep 2017 Jun;12(3):217-226. doi: 10.1007/s11899-017-0382-1. PMID: 28478586Free PMC Article

Therapy

Bispecific antibodies and CAR-T cells: dueling immunotherapies for large B-cell lymphomas.
Trabolsi A, Arumov A, Schatz JH
Blood Cancer J 2024 Feb 8;14(1):27. doi: 10.1038/s41408-024-00997-w. PMID: 38331870Free PMC Article
How I treat secondary CNS involvement by aggressive lymphomas.
Alderuccio JP, Nayak L, Cwynarski K
Blood 2023 Nov 23;142(21):1771-1783. doi: 10.1182/blood.2023020168. PMID: 37702537Free PMC Article
Non-viral, specifically targeted CAR-T cells achieve high safety and efficacy in B-NHL.
Zhang J, Hu Y, Yang J, Li W, Zhang M, Wang Q, Zhang L, Wei G, Tian Y, Zhao K, Chen A, Tan B, Cui J, Li D, Li Y, Qi Y, Wang D, Wu Y, Li D, Du B, Liu M, Huang H
Nature 2022 Sep;609(7926):369-374. Epub 2022 Aug 31 doi: 10.1038/s41586-022-05140-y. PMID: 36045296Free PMC Article
CAR T-cell therapy for B-cell lymphoma.
Denlinger N, Bond D, Jaglowski S
Curr Probl Cancer 2022 Feb;46(1):100826. Epub 2021 Dec 25 doi: 10.1016/j.currproblcancer.2021.100826. PMID: 35012754Free PMC Article
Chimeric antigen receptor T cells for sustained remissions in leukemia.
Maude SL, Frey N, Shaw PA, Aplenc R, Barrett DM, Bunin NJ, Chew A, Gonzalez VE, Zheng Z, Lacey SF, Mahnke YD, Melenhorst JJ, Rheingold SR, Shen A, Teachey DT, Levine BL, June CH, Porter DL, Grupp SA
N Engl J Med 2014 Oct 16;371(16):1507-17. doi: 10.1056/NEJMoa1407222. PMID: 25317870Free PMC Article

Prognosis

Bispecific antibodies and CAR-T cells: dueling immunotherapies for large B-cell lymphomas.
Trabolsi A, Arumov A, Schatz JH
Blood Cancer J 2024 Feb 8;14(1):27. doi: 10.1038/s41408-024-00997-w. PMID: 38331870Free PMC Article
CAR T-cell therapy in aggressive lymphomas-identifying prognostic and predictive markers.
Mussetti A, Fabbri N, Sureda A
Hematology Am Soc Hematol Educ Program 2023 Dec 8;2023(1):357-363. doi: 10.1182/hematology.2023000436. PMID: 38066912Free PMC Article
How I treat secondary CNS involvement by aggressive lymphomas.
Alderuccio JP, Nayak L, Cwynarski K
Blood 2023 Nov 23;142(21):1771-1783. doi: 10.1182/blood.2023020168. PMID: 37702537Free PMC Article
Whole-genome landscape of adult T-cell leukemia/lymphoma.
Kogure Y, Kameda T, Koya J, Yoshimitsu M, Nosaka K, Yasunaga JI, Imaizumi Y, Watanabe M, Saito Y, Ito Y, McClure MB, Tabata M, Shingaki S, Yoshifuji K, Chiba K, Okada A, Kakiuchi N, Nannya Y, Kamiunten A, Tahira Y, Akizuki K, Sekine M, Shide K, Hidaka T, Kubuki Y, Kitanaka A, Hidaka M, Nakano N, Utsunomiya A, Sica RA, Acuna-Villaorduna A, Janakiram M, Shah U, Ramos JC, Shibata T, Takeuchi K, Takaori-Kondo A, Miyazaki Y, Matsuoka M, Ishitsuka K, Shiraishi Y, Miyano S, Ogawa S, Ye BH, Shimoda K, Kataoka K
Blood 2022 Feb 17;139(7):967-982. doi: 10.1182/blood.2021013568. PMID: 34695199Free PMC Article
Chimeric antigen receptor T cells for sustained remissions in leukemia.
Maude SL, Frey N, Shaw PA, Aplenc R, Barrett DM, Bunin NJ, Chew A, Gonzalez VE, Zheng Z, Lacey SF, Mahnke YD, Melenhorst JJ, Rheingold SR, Shen A, Teachey DT, Levine BL, June CH, Porter DL, Grupp SA
N Engl J Med 2014 Oct 16;371(16):1507-17. doi: 10.1056/NEJMoa1407222. PMID: 25317870Free PMC Article

Clinical prediction guides

CAR T-cell therapy in aggressive lymphomas-identifying prognostic and predictive markers.
Mussetti A, Fabbri N, Sureda A
Hematology Am Soc Hematol Educ Program 2023 Dec 8;2023(1):357-363. doi: 10.1182/hematology.2023000436. PMID: 38066912Free PMC Article
How I treat secondary CNS involvement by aggressive lymphomas.
Alderuccio JP, Nayak L, Cwynarski K
Blood 2023 Nov 23;142(21):1771-1783. doi: 10.1182/blood.2023020168. PMID: 37702537Free PMC Article
Non-viral, specifically targeted CAR-T cells achieve high safety and efficacy in B-NHL.
Zhang J, Hu Y, Yang J, Li W, Zhang M, Wang Q, Zhang L, Wei G, Tian Y, Zhao K, Chen A, Tan B, Cui J, Li D, Li Y, Qi Y, Wang D, Wu Y, Li D, Du B, Liu M, Huang H
Nature 2022 Sep;609(7926):369-374. Epub 2022 Aug 31 doi: 10.1038/s41586-022-05140-y. PMID: 36045296Free PMC Article
Epigenetic alterations and advancement of treatment in peripheral T-cell lymphoma.
Zhang P, Zhang M
Clin Epigenetics 2020 Nov 7;12(1):169. doi: 10.1186/s13148-020-00962-x. PMID: 33160401Free PMC Article
Chimeric antigen receptor T cells for sustained remissions in leukemia.
Maude SL, Frey N, Shaw PA, Aplenc R, Barrett DM, Bunin NJ, Chew A, Gonzalez VE, Zheng Z, Lacey SF, Mahnke YD, Melenhorst JJ, Rheingold SR, Shen A, Teachey DT, Levine BL, June CH, Porter DL, Grupp SA
N Engl J Med 2014 Oct 16;371(16):1507-17. doi: 10.1056/NEJMoa1407222. PMID: 25317870Free PMC Article

Recent systematic reviews

Use of PD-1 blockade in refractory/relapsed natural killer T-cell lymphomas: a systematic review and synthesis of case reports.
Rivera-Francia VM, Failoc-Rojas VE, Villacorta-Carranza R, Leon Garrido-Lecca A, Calle-Villavicencio A, Torres-Mera A, Valladares-Garido MJ, Huerta-Collado Y, Motta-Guerrero R, Casanova Marquez L
Leuk Lymphoma 2024 Jan;65(1):37-47. Epub 2024 Jan 10 doi: 10.1080/10428194.2023.2264431. PMID: 37794819
Chimeric antigen receptor (CAR) T-cell therapy for people with relapsed or refractory diffuse large B-cell lymphoma.
Ernst M, Oeser A, Besiroglu B, Caro-Valenzuela J, Abd El Aziz M, Monsef I, Borchmann P, Estcourt LJ, Skoetz N, Goldkuhle M
Cochrane Database Syst Rev 2021 Sep 13;9(9):CD013365. doi: 10.1002/14651858.CD013365.pub2. PMID: 34515338Free PMC Article
Allogeneic Hematopoietic Stem Cell Transplantation in Extranodal Natural Killer/T-cell Lymphoma.
Peng YY, Xiong YY, Zhang LX, Wang J, Zhang HB, Xiao Q, Guo SL
Turk J Haematol 2021 Jun 1;38(2):126-137. Epub 2021 Feb 4 doi: 10.4274/tjh.galenos.2021.2020.0438. PMID: 33535731Free PMC Article
Efficacy of Allogeneic Hematopoietic Cell Transplantation in Cutaneous T Cell Lymphoma: Results of a Systematic Review and Meta-Analysis.
Iqbal M, Reljic T, Ayala E, Sher T, Murthy H, Roy V, Foran J, Tun H, Kumar A, Kharfan-Dabaja MA
Biol Blood Marrow Transplant 2020 Jan;26(1):76-82. Epub 2019 Sep 5 doi: 10.1016/j.bbmt.2019.08.019. PMID: 31494227
EORTC, ISCL, and USCLC consensus recommendations for the treatment of primary cutaneous CD30-positive lymphoproliferative disorders: lymphomatoid papulosis and primary cutaneous anaplastic large-cell lymphoma.
Kempf W, Pfaltz K, Vermeer MH, Cozzio A, Ortiz-Romero PL, Bagot M, Olsen E, Kim YH, Dummer R, Pimpinelli N, Whittaker S, Hodak E, Cerroni L, Berti E, Horwitz S, Prince HM, Guitart J, Estrach T, Sanches JA, Duvic M, Ranki A, Dreno B, Ostheeren-Michaelis S, Knobler R, Wood G, Willemze R
Blood 2011 Oct 13;118(15):4024-35. Epub 2011 Aug 12 doi: 10.1182/blood-2011-05-351346. PMID: 21841159Free PMC Article

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