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Classical Burkitt Lymphoma

MedGen UID:
234153
•Concept ID:
C1333063
•
Neoplastic Process
Synonym: Classical Burkitt's Lymphoma

Definition

A Burkitt lymphoma characterized by the presence of a uniform malignant lymphocytic infiltrate that is composed of medium-sized cells with round nuclei and multiple basophilic nucleoli, abundant mitotic figures, and a starry-sky pattern due to the presence of multiple tangible body macrophages. [from NCI]

Term Hierarchy

CClinical test,  RResearch test,  OOMIM,  GGeneReviews,  VClinVar  
  • CROGVClassical Burkitt Lymphoma

Professional guidelines

PubMed

Burkitt leukaemia/lymphoma: R-CODOX-M/R-IVAC remains gold standard treatment in BL.
Smyth L, Browne PV, Conneally E, Flynn C, Hayden P, Jeffers M, O'Brien D, Quinn F, Kelly J, Perera M, Crotty GM, Leahy M, Hennessy B, Jackson F, Ryan M, Vandenberghe E
Ir J Med Sci 2016 Nov;185(4):773-777. Epub 2015 Apr 7 doi: 10.1007/s11845-015-1288-3. PMID: 25843016
Post-transplant lymphoproliferative diseases in Asian solid organ transplant recipients: late onset and favorable response to treatment.
Chan TS, Hwang YY, Gill H, Au WY, Leung AY, Tse E, Chim CS, Loong F, Kwong YL
Clin Transplant 2012 Sep-Oct;26(5):679-83. Epub 2012 Feb 10 doi: 10.1111/j.1399-0012.2011.01593.x. PMID: 22324300
Treatment of high-grade lymphoid malignancies in adults.
Schiffer CA
Semin Hematol 2001 Oct;38(4 Suppl 10):22-6. doi: 10.1016/s0037-1963(01)90040-x. PMID: 11694948

Recent clinical studies

Etiology

Broadening the horizon: potential applications of CAR-T cells beyond current indications.
Karsten H, Matrisch L, Cichutek S, Fiedler W, Alsdorf W, Block A
Front Immunol 2023;14:1285406. Epub 2023 Nov 27 doi: 10.3389/fimmu.2023.1285406. PMID: 38090582Free PMC Article
Primary Mediastinal B-Cell Lymphoma in Children and Young Adults.
Forlenza CJ, Chadburn A, Giulino-Roth L
J Natl Compr Canc Netw 2023 Mar;21(3):323-330. doi: 10.6004/jnccn.2023.7004. PMID: 36898366
An etiological role for the Epstein-Barr virus in the pathogenesis of classical Hodgkin lymphoma.
Murray PG, Young LS
Blood 2019 Aug 15;134(7):591-596. Epub 2019 Jun 11 doi: 10.1182/blood.2019000568. PMID: 31186275
Pediatric lymphoma diagnosis: role of FNAC, biopsy, immunohistochemistry and molecular diagnostics.
Iyer VK
Indian J Pediatr 2013 Sep;80(9):756-63. Epub 2013 Aug 8 doi: 10.1007/s12098-013-1128-2. PMID: 23925793
The gray zone between Burkitt's lymphoma and diffuse large B-cell lymphoma from a genetics perspective.
Salaverria I, Siebert R
J Clin Oncol 2011 May 10;29(14):1835-43. Epub 2011 Apr 11 doi: 10.1200/JCO.2010.32.8385. PMID: 21482997

Diagnosis

Hepatic Lymphoma Diagnosis.
Choi WT, Gill RM
Surg Pathol Clin 2018 Jun;11(2):389-402. Epub 2018 Mar 21 doi: 10.1016/j.path.2018.02.003. PMID: 29751882
Diagnosis and classification of hematologic malignancies on the basis of genetics.
Taylor J, Xiao W, Abdel-Wahab O
Blood 2017 Jul 27;130(4):410-423. Epub 2017 Jun 9 doi: 10.1182/blood-2017-02-734541. PMID: 28600336Free PMC Article
Pediatric lymphoma diagnosis: role of FNAC, biopsy, immunohistochemistry and molecular diagnostics.
Iyer VK
Indian J Pediatr 2013 Sep;80(9):756-63. Epub 2013 Aug 8 doi: 10.1007/s12098-013-1128-2. PMID: 23925793
EBV-associated lymphoproliferative disorders: classification and treatment.
Carbone A, Gloghini A, Dotti G
Oncologist 2008 May;13(5):577-85. doi: 10.1634/theoncologist.2008-0036. PMID: 18515742
Chronic Epstein-Barr virus infection.
Jones JF, Straus SE
Annu Rev Med 1987;38:195-209. doi: 10.1146/annurev.me.38.020187.001211. PMID: 3034134

Therapy

Primary Mediastinal B-Cell Lymphoma in Children and Young Adults.
Forlenza CJ, Chadburn A, Giulino-Roth L
J Natl Compr Canc Netw 2023 Mar;21(3):323-330. doi: 10.6004/jnccn.2023.7004. PMID: 36898366
Inhibition of SUMOylation enhances DNA hypomethylating drug efficacy to reduce outgrowth of hematopoietic malignancies.
Kroonen JS, de Graaf IJ, Kumar S, Remst DFG, Wouters AK, Heemskerk MHM, Vertegaal ACO
Leukemia 2023 Apr;37(4):864-876. Epub 2023 Feb 15 doi: 10.1038/s41375-023-01838-8. PMID: 36792656Free PMC Article
HIV-Related Lymphoproliferative Diseases in the Era of Combination Antiretroviral Therapy.
Castelli R, Schiavon R, Preti C, Ferraris L
Cardiovasc Hematol Disord Drug Targets 2020;20(3):175-180. doi: 10.2174/1871529X20666200415121009. PMID: 32294049Free PMC Article
Burkitt leukaemia/lymphoma: R-CODOX-M/R-IVAC remains gold standard treatment in BL.
Smyth L, Browne PV, Conneally E, Flynn C, Hayden P, Jeffers M, O'Brien D, Quinn F, Kelly J, Perera M, Crotty GM, Leahy M, Hennessy B, Jackson F, Ryan M, Vandenberghe E
Ir J Med Sci 2016 Nov;185(4):773-777. Epub 2015 Apr 7 doi: 10.1007/s11845-015-1288-3. PMID: 25843016
Burkitt lymphoma in adults.
Perkins AS, Friedberg JW
Hematology Am Soc Hematol Educ Program 2008:341-8. doi: 10.1182/asheducation-2008.1.341. PMID: 19074108

Prognosis

Broadening the horizon: potential applications of CAR-T cells beyond current indications.
Karsten H, Matrisch L, Cichutek S, Fiedler W, Alsdorf W, Block A
Front Immunol 2023;14:1285406. Epub 2023 Nov 27 doi: 10.3389/fimmu.2023.1285406. PMID: 38090582Free PMC Article
EBV-positive B-cell lymphomas and lymphoproliferative disorders: Review from the perspective of immune escape and immunodeficiency.
Satou A, Nakamura S
Cancer Med 2021 Oct;10(19):6777-6785. Epub 2021 Aug 13 doi: 10.1002/cam4.4198. PMID: 34387382Free PMC Article
Diagnosis and classification of hematologic malignancies on the basis of genetics.
Taylor J, Xiao W, Abdel-Wahab O
Blood 2017 Jul 27;130(4):410-423. Epub 2017 Jun 9 doi: 10.1182/blood-2017-02-734541. PMID: 28600336Free PMC Article
Diffuse large B-cell lymphomas and burkitt lymphoma.
de Leval L, Hasserjian RP
Hematol Oncol Clin North Am 2009 Aug;23(4):791-827. doi: 10.1016/j.hoc.2009.04.004. PMID: 19577170
Burkitt lymphoma in adults.
Perkins AS, Friedberg JW
Hematology Am Soc Hematol Educ Program 2008:341-8. doi: 10.1182/asheducation-2008.1.341. PMID: 19074108

Clinical prediction guides

Inhibition of SUMOylation enhances DNA hypomethylating drug efficacy to reduce outgrowth of hematopoietic malignancies.
Kroonen JS, de Graaf IJ, Kumar S, Remst DFG, Wouters AK, Heemskerk MHM, Vertegaal ACO
Leukemia 2023 Apr;37(4):864-876. Epub 2023 Feb 15 doi: 10.1038/s41375-023-01838-8. PMID: 36792656Free PMC Article
EBV-positive B-cell lymphomas and lymphoproliferative disorders: Review from the perspective of immune escape and immunodeficiency.
Satou A, Nakamura S
Cancer Med 2021 Oct;10(19):6777-6785. Epub 2021 Aug 13 doi: 10.1002/cam4.4198. PMID: 34387382Free PMC Article
HIV-Related Lymphoproliferative Diseases in the Era of Combination Antiretroviral Therapy.
Castelli R, Schiavon R, Preti C, Ferraris L
Cardiovasc Hematol Disord Drug Targets 2020;20(3):175-180. doi: 10.2174/1871529X20666200415121009. PMID: 32294049Free PMC Article
Human immunodeficiency virus (HIV) and Epstein-Barr virus (EBV) related lymphomas, pathology view point.
Linke-Serinsöz E, Fend F, Quintanilla-Martinez L
Semin Diagn Pathol 2017 Jul;34(4):352-363. Epub 2017 Apr 7 doi: 10.1053/j.semdp.2017.04.003. PMID: 28506687
Centric and pericentric chromosome rearrangements in hematopoietic malignancies.
Berger R, Busson-Le Coniat M
Leukemia 1999 May;13(5):671-8. doi: 10.1038/sj.leu.2401365. PMID: 10374869

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