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Grade III lymphomatoid granulomatosis

MedGen UID:
78928
•Concept ID:
C0279067
•
Neoplastic Process
Synonyms: Angiocentric Immunoproliferative Lesion Grade III; Grade III Angiocentric Immunoproliferative Lesion; Grade III Angiocentric Immunoproliferative Lesions; Grade III Lymphomatoid Granulomatosis; grade III lymphomatoid granulomatosis
 
Monarch Initiative: MONDO:0859749

Definition

Lymphomatoid granulomatosis characterized by the presence of aggregates of neoplastic large B-lymphocytes, usually admixed with pleomorphic and Hodgkin-like cells, in a background of chronic inflammation. Necrotic changes are present and are usually extensive. Grade III lymphomatoid granulomatosis should be approached clinically as a subtype of diffuse large B-cell lymphoma. [from NCI]

Recent clinical studies

Diagnosis

Use of rituximab in lymphomatoid granulomatosis with isolated central nervous system involvement.
Mooneyham J, Gentille C, Barbieri A, Shah S
BMJ Case Rep 2020 Sep 7;13(9) doi: 10.1136/bcr-2020-235412. PMID: 32900727Free PMC Article
Rare case of pulmonary lymphomatoid granulomatosis in conjunction with tuberculosis: A case report.
Ha YW, Kim CH, Park Y, Sohn JW, Kim MJ, Yoon YK
Medicine (Baltimore) 2017 Oct;96(42):e8323. doi: 10.1097/MD.0000000000008323. PMID: 29049243Free PMC Article
Oral lymphomatoid granulomatosis, the first sign of a 'rare disease': a case report.
Cargini P, Civica M, Sollima L, Di Cola E, Pontecorvi E, Cutilli T
J Med Case Rep 2014 May 15;8:152. doi: 10.1186/1752-1947-8-152. PMID: 24886196Free PMC Article

Therapy

Epstein-Barr virus-positive CD30+ B-cell lymphoproliferative disease with histologic features resembling grade III lymphomatoid granulomatosis induced by methotrexate.
Quaye EH, D'Angelis C, Powell J
Dermatol Online J 2023 Feb 15;29(1) doi: 10.5070/D329160212. PMID: 37040909
Use of rituximab in lymphomatoid granulomatosis with isolated central nervous system involvement.
Mooneyham J, Gentille C, Barbieri A, Shah S
BMJ Case Rep 2020 Sep 7;13(9) doi: 10.1136/bcr-2020-235412. PMID: 32900727Free PMC Article
Oral lymphomatoid granulomatosis, the first sign of a 'rare disease': a case report.
Cargini P, Civica M, Sollima L, Di Cola E, Pontecorvi E, Cutilli T
J Med Case Rep 2014 May 15;8:152. doi: 10.1186/1752-1947-8-152. PMID: 24886196Free PMC Article

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