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    cora coracle [ Drosophila melanogaster (fruit fly) ]

    Gene ID: 37205, updated on 17-Dec-2024

    Summary

    Official Symbol
    coraprovided by FlyBase
    Official Full Name
    coracleprovided by FlyBase
    Primary source
    FLYBASE:FBgn0010434
    Locus tag
    Dmel_CG11949
    See related
    AllianceGenome:FB:FBgn0010434
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Drosophila melanogaster
    Lineage
    Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
    Also known as
    CG11949; cor; Cor; COR; Cora; Coracle; D4.1; Dmel\CG11949; l(2)k08713; mdcds_14526
    Summary
    Predicted to enable actin binding activity and structural molecule activity. Involved in several processes, including adult somatic muscle development; cell adhesion involved in heart morphogenesis; and neurogenesis. Located in plasma membrane and smooth septate junction. Is expressed in several structures, including epidermis; epithelial cell; gut section; imaginal disc; and internal sense organ. Used to study inflammatory bowel disease. Human ortholog(s) of this gene implicated in autosomal dominant intellectual developmental disorder 11; esophagus squamous cell carcinoma; and hereditary elliptocytosis. Orthologous to several human genes including EPB41 (erythrocyte membrane protein band 4.1) and EPB41L1 (erythrocyte membrane protein band 4.1 like 1). [provided by Alliance of Genome Resources, Dec 2024]
    Orthologs
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    Genomic context

    See cora in Genome Data Viewer
    Location:
    56C4-56C4; 2-88 cM
    Exon count:
    18
    Annotation release Status Assembly Chr Location
    Release 6.54 current Release 6 plus ISO1 MT (GCF_000001215.4) 2R NT_033778.4 (19229063..19243751)
    Release 5.57 previous assembly Release 5 (GCF_000001215.2) 2R NT_033778.3 (15116568..15131256)

    Chromosome 2R - NT_033778.4Genomic Context describing neighboring genes Neighboring gene happyhour Neighboring gene uncharacterized protein Neighboring gene uncharacterized protein Neighboring gene windbeutel

    Genomic regions, transcripts, and products

    Bibliography

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?

    Interactions

    General gene information

    Gene Ontology Provided by FlyBase

    Function Evidence Code Pubs
    enables actin binding  
    enables structural molecule activity  
    Component Evidence Code Pubs
    is_active_in cytoskeleton  
    located_in cytoskeleton  
    is_active_in plasma membrane  
    located_in plasma membrane PubMed 
    located_in septate junction PubMed 
    located_in smooth septate junction PubMed 

    General protein information

    Preferred Names
    coracle
    Names
    CG11949-PA
    CG11949-PB
    CG11949-PC
    CG11949-PE
    CG11949-PF
    CG11949-PG
    D4.1-Coracle
    cora-PA
    cora-PB
    cora-PC
    cora-PE
    cora-PF
    cora-PG

    NCBI Reference Sequences (RefSeq)

    NEW Try the new Transcript table

    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NT_033778.4 Reference assembly

      Range
      19229063..19243751
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_166336.2 → NP_725864.1  coracle, isoform C [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_725864.1

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      Q9V8R9
      Related
      FBpp0085694
      Conserved Domains (6) summary
      smart00295
      Location:34 → 224
      B41; Band 4.1 homologues
      cd13184
      Location:219 → 312
      FERM_C_4_1_family; FERM domain C-lobe of Protein 4.1 family
      pfam00373
      Location:116 → 224
      FERM_M; FERM central domain
      pfam05902
      Location:617 → 703
      4_1_CTD; 4.1 protein C-terminal domain (CTD)
      pfam08736
      Location:323 → 363
      FA; FERM adjacent (FA)
      pfam09379
      Location:36 → 98
      FERM_N; FERM N-terminal domain
    2. NM_166337.2 → NP_725865.1  coracle, isoform B [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_725865.1

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      Q9V8R9
      Related
      FBpp0085696
      Conserved Domains (6) summary
      smart00295
      Location:34 → 224
      B41; Band 4.1 homologues
      cd13184
      Location:219 → 312
      FERM_C_4_1_family; FERM domain C-lobe of Protein 4.1 family
      pfam00373
      Location:116 → 224
      FERM_M; FERM central domain
      pfam05902
      Location:803 → 889
      4_1_CTD; 4.1 protein C-terminal domain (CTD)
      pfam08736
      Location:323 → 363
      FA; FERM adjacent (FA)
      pfam09379
      Location:36 → 98
      FERM_N; FERM N-terminal domain
    3. NM_001299678.1 → NP_001286607.1  coracle, isoform F [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_001286607.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      A0A0B4LFX4
      Conserved Domains (7) summary
      smart00295
      Location:34 → 224
      B41; Band 4.1 homologues
      cd13184
      Location:219 → 312
      FERM_C_4_1_family; FERM domain C-lobe of Protein 4.1 family
      pfam00373
      Location:116 → 224
      FERM_M; FERM central domain
      pfam05902
      Location:1514 → 1600
      4_1_CTD; 4.1 protein C-terminal domain (CTD)
      pfam08736
      Location:323 → 363
      FA; FERM adjacent (FA)
      pfam09379
      Location:36 → 98
      FERM_N; FERM N-terminal domain
      pfam13360
      Location:839 → 982
      PQQ_2; PQQ-like domain
    4. NM_079067.4 → NP_523791.2  coracle, isoform A [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_523791.2

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      A1ZBI0, Q1WWD0, Q24440, Q24441, Q24442, Q9V8R8, Q9V8R9, Q9V8S0
      Related
      FBpp0085697
      Conserved Domains (7) summary
      smart00295
      Location:34 → 224
      B41; Band 4.1 homologues
      cd13184
      Location:219 → 312
      FERM_C_4_1_family; FERM domain C-lobe of Protein 4.1 family
      pfam00373
      Location:116 → 224
      FERM_M; FERM central domain
      pfam05902
      Location:1612 → 1698
      4_1_CTD; 4.1 protein C-terminal domain (CTD)
      pfam08736
      Location:323 → 363
      FA; FERM adjacent (FA)
      pfam09379
      Location:36 → 98
      FERM_N; FERM N-terminal domain
      pfam13360
      Location:829 → 972
      PQQ_2; PQQ-like domain
    5. NM_001299679.1 → NP_001286608.1  coracle, isoform G [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_001286608.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      A0A0B4LG23
      Conserved Domains (7) summary
      smart00295
      Location:34 → 224
      B41; Band 4.1 homologues
      cd13184
      Location:219 → 312
      FERM_C_4_1_family; FERM domain C-lobe of Protein 4.1 family
      pfam00373
      Location:116 → 224
      FERM_M; FERM central domain
      pfam05902
      Location:1610 → 1696
      4_1_CTD; 4.1 protein C-terminal domain (CTD)
      pfam08736
      Location:323 → 363
      FA; FERM adjacent (FA)
      pfam09379
      Location:36 → 98
      FERM_N; FERM N-terminal domain
      pfam13360
      Location:829 → 972
      PQQ_2; PQQ-like domain
    6. NM_166338.3 → NP_725866.1  coracle, isoform E [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_725866.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      H5V8A7
      Related
      FBpp0290494
      Conserved Domains (6) summary
      smart00295
      Location:34 → 224
      B41; Band 4.1 homologues
      cd13184
      Location:219 → 312
      FERM_C_4_1_family; FERM domain C-lobe of Protein 4.1 family
      pfam00373
      Location:116 → 224
      FERM_M; FERM central domain
      pfam05902
      Location:613 → 699
      4_1_CTD; 4.1 protein C-terminal domain (CTD)
      pfam08736
      Location:323 → 363
      FA; FERM adjacent (FA)
      pfam09379
      Location:36 → 98
      FERM_N; FERM N-terminal domain
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