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rictor rapamycin-insensitive companion of Tor [ Drosophila melanogaster (fruit fly) ]

Gene ID: 32919, updated on 9-Dec-2024

Summary

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Official Symbol
rictorprovided by FlyBase
Official Full Name
rapamycin-insensitive companion of Torprovided by FlyBase
Primary source
FLYBASE:FBgn0031006
Locus tag
Dmel_CG8002
See related
AllianceGenome:FB:FBgn0031006
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Drosophila melanogaster
Lineage
Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
Also known as
8002; CG8002; Dmel\CG8002; dRic; dRictor; dRICTOR; Rictor; RICTOR
Summary
Enables protein serine/threonine kinase activator activity. Involved in several processes, including TORC2 signaling; positive regulation of cell size; and positive regulation of signal transduction. Part of TORC2 complex. Human ortholog(s) of this gene implicated in breast ductal carcinoma; gastrointestinal system cancer (multiple); and lung cancer (multiple). Orthologous to human RICTOR (RPTOR independent companion of MTOR complex 2). [provided by Alliance of Genome Resources, Dec 2024]
Orthologs
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Genomic context

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See rictor in Genome Data Viewer
Location:
18B6-18B6; 1-62 cM
Exon count:
13
Annotation release Status Assembly Chr Location
Release 6.54 current Release 6 plus ISO1 MT (GCF_000001215.4) X NC_004354.4 (19252111..19261240, complement)
Release 5.57 previous assembly Release 5 (GCF_000001215.2) X NC_004354.3 (19146144..19155273, complement)

Chromosome X - NC_004354.4Genomic Context describing neighboring genes Neighboring gene uncharacterized protein Neighboring gene uncharacterized protein Neighboring gene Heparan sulfate 3-O sulfotransferase-B Neighboring gene Vav guanine nucleotide exchange factor Neighboring gene uncharacterized protein Neighboring gene uncharacterized protein Neighboring gene uncharacterized protein

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. Heat tolerance in Drosophila melanogaster is influenced by oxygen conditions and mutations in cell size control pathways. Privalova V, et al. Philos Trans R Soc Lond B Biol Sci, 2024 Feb 26. PMID 38186282,
  2. Systemic changes in cell size throughout the body of Drosophila melanogaster associated with mutations in molecular cell cycle regulators. Privalova V, et al. Sci Rep, 2023 May 9. PMID 37160985, Free PMC Article
  3. An evolutionarily conserved protein CHORD regulates scaling of dendritic arbors with body size. Shimono K, et al. Sci Rep, 2014 Mar 19. PMID 24643112, Free PMC Article
  4. The mTORC2/AKT/VCP axis is associated with quality control of the stalled translation of poly(GR) dipeptide repeats in C9-ALS/FTD. Li Y, et al. J Biol Chem, 2023 Mar. PMID 36764521, Free PMC Article
  5. TORC2: a novel target for treating age-associated memory impairment. Johnson JL, et al. Sci Rep, 2015 Oct 22. PMID 26489398, Free PMC Article

See all (96) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. Sin1, Rictor, Trc and target of rapamycin (TOR), components of the TOR complex 2 (TORC2), are required for dendritic tiling of class IV da neurons
    Title: The target of rapamycin complex 2 controls dendritic tiling of Drosophila sensory neurons through the Tricornered kinase signalling pathway.
  2. We found that neither S6K-dependent cell growth nor S6K-Thr-398 phosphorylation was affected in rictor-null mutants.
    Title: Discrete functions of rictor and raptor in cell growth regulation in Drosophila.
  3. Sin1 together with Rictor are key components of mTORC2 and play an essential role in Akt phosphorylation and signaling
    Title: Identification of Sin1 as an essential TORC2 component required for complex formation and kinase activity.
  4. results suggest that dTOR and dRictor have a shared positive role in the phosphorylation of the hydrophobic motif site of dAkt/dPKB.
    Title: Phosphorylation and regulation of Akt/PKB by the rictor-mTOR complex.
Submit: New GeneRIF Correction

Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Homology

Gene Ontology Provided by FlyBase

Function Evidence Code Pubs
enables protein serine/threonine kinase activator activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables protein serine/threonine kinase activator activity IMP
Inferred from Mutant Phenotype
more info
 PubMed 
Process Evidence Code Pubs
involved_in TOR signaling IEA
Inferred from Electronic Annotation
more info
  
involved_in TORC2 signaling IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in TORC2 signaling IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in cellular response to insulin stimulus IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in cellular response to starvation IDA
Inferred from Direct Assay
more info
 PubMed 
involved_in dendrite morphogenesis IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in positive regulation of cell size IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in positive regulation of insulin receptor signaling pathway IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in positive regulation of phosphatidylinositol 3-kinase/protein kinase B signal transduction IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in positive regulation of phosphatidylinositol 3-kinase/protein kinase B signal transduction IGI
Inferred from Genetic Interaction
more info
 PubMed 
involved_in positive regulation of phosphatidylinositol 3-kinase/protein kinase B signal transduction IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in positive regulation of synaptic assembly at neuromuscular junction IGI
Inferred from Genetic Interaction
more info
 PubMed 
involved_in positive regulation of transcription by transcription factor localization IPI
Inferred from Physical Interaction
more info
 PubMed 
involved_in protein localization to nucleus IPI
Inferred from Physical Interaction
more info
 PubMed 
involved_in regulation of cell size IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in regulation of dendrite development IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in stress granule assembly IMP
Inferred from Mutant Phenotype
more info
 PubMed 
Component Evidence Code Pubs
part_of TORC2 complex IBA
Inferred from Biological aspect of Ancestor
more info
  
part_of TORC2 complex IEA
Inferred from Electronic Annotation
more info
  
part_of TORC2 complex IMP
Inferred from Mutant Phenotype
more info
 PubMed 

General protein information

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Preferred Names
rapamycin-insensitive companion of Tor
Names
CG8002-PA
CG8002-PB
CG8002-PC
dRictor
rictor
rictor-PA
rictor-PB
rictor-PC

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NC_004354.4 Reference assembly

    Range
    19252111..19261240 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_001298503.1 → NP_001285432.1  rapamycin-insensitive companion of Tor, isoform B [Drosophila melanogaster]

    See identical proteins and their annotated locations for NP_001285432.1

    Status: REVIEWED

    UniProtKB/TrEMBL
    Q7YU91, X2JL73
    Conserved Domains (4) summary
    pfam14663
    Location:785 → 888
    RasGEF_N_2; Rapamycin-insensitive companion of mTOR RasGEF_N domain
    pfam14664
    Location:63 → 440
    RICTOR_N; Rapamycin-insensitive companion of mTOR, N-term
    pfam14666
    Location:567 → 778
    RICTOR_M; Rapamycin-insensitive companion of mTOR, middle domain
    pfam14668
    Location:957 → 1027
    RICTOR_V; Rapamycin-insensitive companion of mTOR, domain 5

  2. NM_133143.2 → NP_573371.1  rapamycin-insensitive companion of Tor, isoform A [Drosophila melanogaster]

    See identical proteins and their annotated locations for NP_573371.1

    Status: REVIEWED

    UniProtKB/TrEMBL
    Q7YU91, Q9VWJ6
    Related
    FBpp0074458
    Conserved Domains (4) summary
    pfam14663
    Location:805 → 908
    RasGEF_N_2; Rapamycin-insensitive companion of mTOR RasGEF_N domain
    pfam14664
    Location:63 → 440
    RICTOR_N; Rapamycin-insensitive companion of mTOR, N-term
    pfam14666
    Location:583 → 798
    RICTOR_M; Rapamycin-insensitive companion of mTOR, middle domain
    pfam14668
    Location:977 → 1047
    RICTOR_V; Rapamycin-insensitive companion of mTOR, domain 5

  3. NM_001298504.1 → NP_001285433.1  rapamycin-insensitive companion of Tor, isoform C [Drosophila melanogaster]

    See identical proteins and their annotated locations for NP_001285433.1

    Status: REVIEWED

    UniProtKB/TrEMBL
    Q7YU91, X2JFR5
    Conserved Domains (4) summary
    pfam14663
    Location:793 → 896
    RasGEF_N_2; Rapamycin-insensitive companion of mTOR RasGEF_N domain
    pfam14664
    Location:51 → 428
    RICTOR_N; Rapamycin-insensitive companion of mTOR, N-term
    pfam14666
    Location:571 → 786
    RICTOR_M; Rapamycin-insensitive companion of mTOR, middle domain
    pfam14668
    Location:965 → 1035
    RICTOR_V; Rapamycin-insensitive companion of mTOR, domain 5
Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q7YU91 Q7YU91
Q9VWJ6 Q9VWJ6
X2JFR5 X2JFR5
X2JL73 X2JL73

Gene LinkOut

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