Nrg Neuroglian [Drosophila melanogaster (fruit fly)] - Gene

Summary

Official Symbol: Nrgprovided by FlyBase
Official Full Name: Neuroglianprovided by FlyBase
Primary source: FLYBASE:FBgn0264975
Locus tag: Dmel_CG1634
See related: AllianceGenome:FB:FBgn0264975
Gene type: protein coding
RefSeq status: REVIEWED
Organism: Drosophila melanogaster
Lineage: Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
Also known as: ceb; CG1634; CT4318; Dmel\CG1634; fs(1)M72; ibx; l(1)7Fa; l(1)G0099; l(1)G0413; l(1)G0488; NFASC; Ngl; nrg; NRG; Nrg167; Nrg180; RA35
Summary: Enables calcium ion binding activity and cell adhesion molecule binding activity. Involved in several processes, including female mating behavior; melanotic encapsulation of foreign target; and nervous system development. Located in several cellular components, including filopodium; lateral plasma membrane; and pleated septate junction. Colocalizes with cytoneme. Is expressed in several structures, including brain; glial cell; hindgut; mushroom body; and synaptic neuropil subdomain. Used to study MASA syndrome and epilepsy. Human ortholog(s) of this gene implicated in MASA syndrome; hydrocephalus; ovarian carcinoma; pancreatic cancer; and schizophrenia. Orthologous to several human genes including CHL1 (cell adhesion molecule L1 like); NFASC (neurofascin); and NRCAM (neuronal cell adhesion molecule). [provided by Alliance of Genome Resources, Jan 2025]
Orthologs: all
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Genomic context

Location:: 7F2-7F4; 1-23 cM

Exon count:: 12

Annotation release	Status	Assembly	Chr	Location
Release 6.54	current	Release 6 plus ISO1 MT (GCF_000001215.4)	X	NC_004354.4 (8517373..8555170)
Release 5.57	previous assembly	Release 5 (GCF_000001215.2)	X	NC_004354.3 (8411406..8449203)

Chromosome X - NC_004354.4 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Neuroglian regulates Drosophila intestinal stem cell proliferation through enhanced signaling via the epidermal growth factor receptor.
Title: Neuroglian regulates Drosophila intestinal stem cell proliferation through enhanced signaling via the epidermal growth factor receptor.
Differential Neuroglian signaling in commissural pioneer interneurons not only prepatterns the olfactory contralateral tracts but also prevents the targeting of ingrowing sensory axons to their ipsilateral synaptic partners.
Title: Pioneer interneurons instruct bilaterality in the Drosophila olfactory sensory map.
In Drosophila, the L1CAM homolog Neuroglian (Nrg) is expressed as two isoforms. Epidermal Nrg167 encircles dendrites by interactions with dendritic Nrg180 to support dendrite growth, stabilization, and enclosure inside epidermis. Nrg180 forms homophilic interactions to facilitate axonal bundling.
Title: Epidermis-Derived L1CAM Homolog Neuroglian Mediates Dendrite Enclosure and Blocks Heteroneuronal Dendrite Bundling.
Dendrite pruning requires the developmentally regulated degradation of the cell adhesion molecule Neuroglian, and loss of Rab11 causes defects in the developmental degradation of Neuroglian and another target, the ion channel Ppk26.
Title: Rab11 is required for neurite pruning and developmental membrane protein degradation in Drosophila sensory neurons.
Prd1, alpha-Adaptin, and Unc-104 act in a common pathway to promote dendrite pruning by down-regulating Neuroglian protein.
Title: Prd1 associates with the clathrin adaptor α-Adaptin and the kinesin-3 Imac/Unc-104 to govern dendrite pruning in Drosophila.
An ankyrin-binding motif regulates nuclear levels of L1-type neuroglian and expression of the oncogene Myc in Drosophila neurons.
Title: An ankyrin-binding motif regulates nuclear levels of L1-type neuroglian and expression of the oncogene Myc in Drosophila neurons.
Neuroglian mediates adhesion between functionally distinct mushroom body axon populations to enforce and control appropriate projections into distinct axonal layers and lobes essential for olfactory learning and memory.
Title: L1CAM/Neuroglian controls the axon-axon interactions establishing layered and lobular mushroom body architecture.
Nrg plays a critical inhibitory role in dendrite pruning in dendritic arborization neurons.
Title: Endocytic pathways downregulate the L1-type cell adhesion molecule neuroglian to promote dendrite pruning in Drosophila.
Regulation of the interaction between Neuroglian and Ankyrin is an important novel module enabling local control of synaptic connectivity and function.
Title: Transsynaptic coordination of synaptic growth, function, and stability by the L1-type CAM Neuroglian.
Data describe the role of the L1-type CAM Neuroglian protein (NRG) in different steps of Drosophila mushroom body (MB) neuron axonogenesis.
Title: The Drosophila L1CAM homolog Neuroglian signals through distinct pathways to control different aspects of mushroom body axon development.

Submit: New GeneRIF Correction See all GeneRIFs (18)

Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Homology

NCBI Orthologs

Orthologs from OrthoDB

Gene Ontology Provided by FlyBase

Function	Evidence Code	Pubs
enables calcium ion binding	IDA Inferred from Direct Assay more info	PubMed
enables cell adhesion molecule binding	IPI Inferred from Physical Interaction more info	PubMed

Process	Evidence Code	Pubs
involved_in axon ensheathment	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in axon extension	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in axonogenesis	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in cell adhesion involved in heart morphogenesis	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in cell-cell adhesion	IDA Inferred from Direct Assay more info	PubMed
involved_in central complex development	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in dendrite morphogenesis	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in establishment of glial blood-brain barrier	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in female courtship behavior	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in imaginal disc morphogenesis	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in male courtship behavior	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in melanotic encapsulation of foreign target	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in motor neuron axon guidance	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in mushroom body development	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in nerve maturation	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in neuron cell-cell adhesion	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in photoreceptor cell axon guidance	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in regulation of female receptivity	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in regulation of tube size, open tracheal system	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in septate junction assembly	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in synapse organization	IMP Inferred from Mutant Phenotype more info	PubMed

Component	Evidence Code	Pubs
located_in axon	IDA Inferred from Direct Assay more info	PubMed
colocalizes_with cytoneme	IDA Inferred from Direct Assay more info	PubMed
located_in dendrite	IDA Inferred from Direct Assay more info	PubMed
located_in filopodium	IDA Inferred from Direct Assay more info	PubMed
located_in lateral plasma membrane	IDA Inferred from Direct Assay more info	PubMed
located_in membrane	IMP Inferred from Mutant Phenotype more info	PubMed
is_active_in neuron projection	IBA Inferred from Biological aspect of Ancestor more info
located_in neuronal cell body	IDA Inferred from Direct Assay more info	PubMed
located_in plasma membrane	HDA more info	PubMed
located_in plasma membrane	IDA Inferred from Direct Assay more info	PubMed
located_in pleated septate junction	IDA Inferred from Direct Assay more info	PubMed
located_in septate junction	IDA Inferred from Direct Assay more info	PubMed

General protein information

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Preferred Names: neuroglian

Names: CG1634-PA; CG1634-PB; CG1634-PC; CG1634-PD; CG1634-PE; CG1634-PF; CG1634-PG; CG1634-PH; CG1634-PI; Nrg-PA; Nrg-PB; Nrg-PC; Nrg-PD; Nrg-PE; Nrg-PF; Nrg-PG; Nrg-PH; Nrg-PI; central brain deranged; female sterile(1)M72; icebox; lethal (1) G0488

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

NC_004354.4 Reference assembly

Range

8517373..8555170

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

NM_001169234.3 → NP_001162705.1 neuroglian, isoform E [Drosophila melanogaster]

See identical proteins and their annotated locations for NP_001162705.1

Status: REVIEWED

UniProtKB/Swiss-Prot

A4V452, E1JJF8, E1JJF9, O61541, O61542, P20241, Q1WWD5, Q24414, Q24415, Q95U64, Q9V3X0

UniProtKB/TrEMBL

C0PTX6

Conserved Domains (7) summary

smart00410
Location:57 → 127

IG_like; Immunoglobulin like

cd00063
Location:917 → 1004

FN3; Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all ...

pfam07679
Location:339 → 427

I-set; Immunoglobulin I-set domain

pfam00041
Location:817 → 905

fn3; Fibronectin type III domain

pfam00047
Location:525 → 609

ig; Immunoglobulin domain

pfam13882
Location:1155 → 1235

Bravo_FIGEY; Bravo-like intracellular region

cl11960
Location:55 → 128

Ig; Immunoglobulin domain
NM_001272408.1 → NP_001259337.1 neuroglian, isoform I [Drosophila melanogaster]

See identical proteins and their annotated locations for NP_001259337.1

Status: REVIEWED

UniProtKB/Swiss-Prot

A4V452, E1JJF8, E1JJF9, O61541, O61542, P20241, Q1WWD5, Q24414, Q24415, Q95U64, Q9V3X0

UniProtKB/TrEMBL

C0PTX6

Conserved Domains (7) summary

smart00410
Location:57 → 127

IG_like; Immunoglobulin like

cd00063
Location:917 → 1004

FN3; Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all ...

pfam07679
Location:339 → 427

I-set; Immunoglobulin I-set domain

pfam00041
Location:817 → 905

fn3; Fibronectin type III domain

pfam00047
Location:525 → 609

ig; Immunoglobulin domain

pfam13882
Location:1155 → 1235

Bravo_FIGEY; Bravo-like intracellular region

cl11960
Location:55 → 128

Ig; Immunoglobulin domain
NM_206657.4 → NP_996380.1 neuroglian, isoform C [Drosophila melanogaster]

See identical proteins and their annotated locations for NP_996380.1

Status: REVIEWED

UniProtKB/TrEMBL

C0PTX6

Conserved Domains (7) summary

smart00410
Location:57 → 127

IG_like; Immunoglobulin like

cd00063
Location:917 → 1004

FN3; Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all ...

pfam07679
Location:339 → 427

I-set; Immunoglobulin I-set domain

pfam00041
Location:817 → 905

fn3; Fibronectin type III domain

pfam00047
Location:525 → 609

ig; Immunoglobulin domain

pfam13882
Location:1155 → 1237

Bravo_FIGEY; Bravo-like intracellular region

cl11960
Location:55 → 128

Ig; Immunoglobulin domain
NM_167160.2 → NP_727274.1 neuroglian, isoform B [Drosophila melanogaster]

See identical proteins and their annotated locations for NP_727274.1

Status: REVIEWED

UniProtKB/Swiss-Prot

A4V452, E1JJF8, E1JJF9, O61541, O61542, P20241, Q1WWD5, Q24414, Q24415, Q95U64, Q9V3X0

UniProtKB/TrEMBL

C0PTX6

Related

FBpp0071155

Conserved Domains (7) summary

smart00410
Location:57 → 127

IG_like; Immunoglobulin like

cd00063
Location:917 → 1004

FN3; Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all ...

pfam07679
Location:339 → 427

I-set; Immunoglobulin I-set domain

pfam00041
Location:817 → 905

fn3; Fibronectin type III domain

pfam00047
Location:525 → 609

ig; Immunoglobulin domain

pfam13882
Location:1155 → 1235

Bravo_FIGEY; Bravo-like intracellular region

cl11960
Location:55 → 128

Ig; Immunoglobulin domain
NM_078535.3 → NP_511090.1 neuroglian, isoform A [Drosophila melanogaster]

See identical proteins and their annotated locations for NP_511090.1

Status: REVIEWED

UniProtKB/TrEMBL

C0PTX6

Related

FBpp0071154

Conserved Domains (7) summary

smart00410
Location:57 → 127

IG_like; Immunoglobulin like

cd00063
Location:917 → 1004

FN3; Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all ...

pfam07679
Location:339 → 427

I-set; Immunoglobulin I-set domain

pfam00041
Location:817 → 905

fn3; Fibronectin type III domain

pfam00047
Location:525 → 609

ig; Immunoglobulin domain

pfam13882
Location:1155 → 1237

Bravo_FIGEY; Bravo-like intracellular region

cl11960
Location:55 → 128

Ig; Immunoglobulin domain
NM_001258652.1 → NP_001245581.1 neuroglian, isoform G [Drosophila melanogaster]

See identical proteins and their annotated locations for NP_001245581.1

Status: REVIEWED

UniProtKB/TrEMBL

C0PTX6, M9NEZ5

Conserved Domains (7) summary

smart00410
Location:57 → 127

IG_like; Immunoglobulin like

cd00063
Location:917 → 1004

FN3; Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all ...

pfam07679
Location:339 → 427

I-set; Immunoglobulin I-set domain

pfam00041
Location:817 → 905

fn3; Fibronectin type III domain

pfam00047
Location:525 → 609

ig; Immunoglobulin domain

pfam13882
Location:1155 → 1221

Bravo_FIGEY; Bravo-like intracellular region

cl11960
Location:55 → 128

Ig; Immunoglobulin domain
NM_001169235.1 → NP_001162706.1 neuroglian, isoform F [Drosophila melanogaster]

See identical proteins and their annotated locations for NP_001162706.1

Status: REVIEWED

UniProtKB/TrEMBL

C0PTX6

Conserved Domains (7) summary

smart00410
Location:57 → 127

IG_like; Immunoglobulin like

cd00063
Location:917 → 1004

FN3; Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all ...

pfam07679
Location:339 → 427

I-set; Immunoglobulin I-set domain

pfam00041
Location:817 → 905

fn3; Fibronectin type III domain

pfam00047
Location:525 → 609

ig; Immunoglobulin domain

pfam13882
Location:1155 → 1237

Bravo_FIGEY; Bravo-like intracellular region

cl11960
Location:55 → 128

Ig; Immunoglobulin domain
NM_001272407.2 → NP_001259336.1 neuroglian, isoform H [Drosophila melanogaster]

See identical proteins and their annotated locations for NP_001259336.1

Status: REVIEWED

UniProtKB/TrEMBL

C0PTX6

Conserved Domains (7) summary

smart00410
Location:57 → 127

IG_like; Immunoglobulin like

cd00063
Location:917 → 1004

FN3; Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all ...

pfam07679
Location:339 → 427

I-set; Immunoglobulin I-set domain

pfam00041
Location:817 → 905

fn3; Fibronectin type III domain

pfam00047
Location:525 → 609

ig; Immunoglobulin domain

pfam13882
Location:1155 → 1237

Bravo_FIGEY; Bravo-like intracellular region

cl11960
Location:55 → 128

Ig; Immunoglobulin domain
NM_001169233.2 → NP_001162704.1 neuroglian, isoform D [Drosophila melanogaster]

See identical proteins and their annotated locations for NP_001162704.1

Status: REVIEWED

UniProtKB/TrEMBL

C0PTX6

Conserved Domains (7) summary

smart00410
Location:57 → 127

IG_like; Immunoglobulin like

cd00063
Location:917 → 1004

FN3; Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all ...

pfam07679
Location:339 → 427

I-set; Immunoglobulin I-set domain

pfam00041
Location:817 → 905

fn3; Fibronectin type III domain

pfam00047
Location:525 → 609

ig; Immunoglobulin domain

pfam13882
Location:1155 → 1237

Bravo_FIGEY; Bravo-like intracellular region

cl11960
Location:55 → 128

Ig; Immunoglobulin domain