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Nrx-IV Neurexin IV [ Drosophila melanogaster (fruit fly) ]

Gene ID: 39387, updated on 4-Jan-2025

Summary

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Official Symbol
Nrx-IVprovided by FlyBase
Official Full Name
Neurexin IVprovided by FlyBase
Primary source
FLYBASE:FBgn0013997
Locus tag
Dmel_CG6827
See related
AllianceGenome:FB:FBgn0013997
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Drosophila melanogaster
Lineage
Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
Also known as
CG682; CG6827; CNTNAP2; CT21123; Dmel\CG6827; Dnrx; l(3)68Ff; l(3)rsg23; neurexin; nrx; Nrx; NRX; nrx IV; Nrx IV; NRX IV; nrx-iv; nrx-IV; nrx4; Nrx4; nrxIV; NrxIV; Nx IV; rsg23
Summary
Involved in several processes, including cell adhesion involved in heart morphogenesis; nervous system development; and terminal button organization. Located in plasma membrane; pleated septate junction; and presynaptic active zone. Is expressed in several structures, including glial cell; gut section; internal sense organ; peripheral nervous system; and sensory organ cell. Used to study autism spectrum disorder and autosomal recessive intellectual developmental disorder. Human ortholog(s) of this gene implicated in several diseases, including autism spectrum disorder (multiple); communication disorder (multiple); cortical dysplasia-focal epilepsy syndrome; major depressive disorder; and social phobia. Orthologous to several human genes including CNTNAP2 (contactin associated protein 2). [provided by Alliance of Genome Resources, Jan 2025]
Orthologs
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Genomic context

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See Nrx-IV in Genome Data Viewer
Location:
68F6-68F7; 3-38 cM
Exon count:
13
Annotation release Status Assembly Chr Location
Release 6.54 current Release 6 plus ISO1 MT (GCF_000001215.4) 3L NT_037436.4 (12146519..12156990)
Release 5.57 previous assembly Release 5 (GCF_000001215.2) 3L NT_037436.3 (12139619..12150090)

Chromosome 3L - NT_037436.4Genomic Context describing neighboring genes Neighboring gene Rho GTPase activating protein at 68F Neighboring gene eukaryotic translation initiation factor 3 subunit l Neighboring gene uncharacterized protein Neighboring gene uncharacterized protein Neighboring gene Rhodopsin 7

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. Close similarity between Drosophila neurexin IV and mammalian Caspr protein suggests a conserved mechanism for cellular interactions. Peles E, et al. Cell, 1997 Mar 21. PMID 9118217
  2. A Laminin G-EGF-Laminin G module in Neurexin IV is essential for the apico-lateral localization of Contactin and organization of septate junctions. Banerjee S, et al. PLoS One, 2011. PMID 22022470, Free PMC Article
  3. Drosophila neurexin IV interacts with Roundabout and is required for repulsive midline axon guidance. Banerjee S, et al. J Neurosci, 2010 Apr 21. PMID 20410118, Free PMC Article
  4. Axoglial junctions: separate the channels or scramble the message. Brophy PJ. Curr Biol, 2001 Jul 24. PMID 11509252
  5. The making of neurexins. Missler M, et al. J Neurochem, 1998 Oct. PMID 9751164

See all (258) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. Screen for novel regulators of synapse morphogenesis at the larval neuromuscular junction in Drosophila identified miR-34 as conserved synapse-regulatory miRNA and junctional receptor CNTNAP4/Neurexin-IV (Nrx-IV) and the membrane cytoskeletal effector Adducin/Hu-li tai shao (Hts) as proteins whose synaptic expression is restricted by miR-34.
    Title: The conserved microRNA miR-34 regulates synaptogenesis via coordination of distinct mechanisms in presynaptic and postsynaptic cells.
  2. DNrx promotes ephrin clustering and reveals that ephrin/Eph signaling from adjacent L4 neurons restricts axonal branches of L4 neurons in columns.
    Title: Neurexin Restricts Axonal Branching in Columns by Promoting Ephrin Clustering.
  3. Daughterless and Tcf4 are expressed in postmitotic neurons in Drosophila melanogaster and mice, respectively, where they function to restrict neurite branching and synapse formation in part by restricting the expression of the cell adhesion molecule Neurexin.[Tcf4]
    Title: Type I bHLH Proteins Daughterless and Tcf4 Restrict Neurite Branching and Synapse Formation by Repressing Neurexin in Postmitotic Neurons.
  4. Neurexin mediates retinoid transport and subsequent rhodopsin maturation in visual function; the Drosophila homolog of alpha-neurexin is critical for fly visual function.
    Title: Neurexin regulates visual function via mediating retinoid transport to promote rhodopsin maturation.
  5. The regulation of glial-specific splicing of Neurexin IV requires HOW and Cdk12 activity.
    Title: The regulation of glial-specific splicing of Neurexin IV requires HOW and Cdk12 activity.
  6. The first Laminin G-EGF-Laminin G module in the extracellular region of Neurexin IV is necessary for the localization of and association with Contactin.
    Title: A Laminin G-EGF-Laminin G module in Neurexin IV is essential for the apico-lateral localization of Contactin and organization of septate junctions.
  7. Cno function as a novel regulator of neuron-glia interactions, forming a complex with Shg, Wrapper and Neurexin IV.
    Title: Canoe functions at the CNS midline glia in a complex with Shotgun and Wrapper-Nrx-IV during neuron-glia interactions.
  8. The possibility that neurexin is present postsynaptically raises new hypotheses regarding neurexin function in synapses, and our results provide new insights into the role of neurexin in synapse development
    Title: Neurexin in embryonic Drosophila neuromuscular junctions.
  9. Nrx IV is essential for proper Robo localization and repulsive axon guidance, and is a novel interacting partner of the Slit/Robo signaling pathway.
    Title: Drosophila neurexin IV interacts with Roundabout and is required for repulsive midline axon guidance.
  10. Although both Neurexin IV isoforms are able to bind Wrapper, the neuronal isoform has a higher affinity for Wrapper
    Title: Drosophila Neurexin IV stabilizes neuron-glia interactions at the CNS midline by binding to Wrapper.
Submit: New GeneRIF Correction See all GeneRIFs (14)

Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Homology

Gene Ontology Provided by FlyBase

Process Evidence Code Pubs
involved_in axon ensheathment IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in cell adhesion involved in heart morphogenesis IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in cell-cell junction organization TAS
Traceable Author Statement
more info
 PubMed 
involved_in dorsal closure IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in establishment of glial blood-brain barrier IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in heart process IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in nerve maturation IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in presynaptic membrane assembly IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in protein localization TAS
Traceable Author Statement
more info
 PubMed 
involved_in regulation of tube size, open tracheal system IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in septate junction assembly IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in synaptic target recognition IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in terminal button organization IMP
Inferred from Mutant Phenotype
more info
 PubMed 
Component Evidence Code Pubs
located_in plasma membrane HDA PubMed 
located_in plasma membrane IDA
Inferred from Direct Assay
more info
 PubMed 
located_in pleated septate junction IDA
Inferred from Direct Assay
more info
 PubMed 
located_in presynaptic active zone IDA
Inferred from Direct Assay
more info
 PubMed 
located_in synapse IDA
Inferred from Direct Assay
more info
 PubMed 

General protein information

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Preferred Names
neurexin IV
Names
CG6827-PA
CG6827-PB
Neurexin-4
Neurexin-IV
Nrx-IV-PA
Nrx-IV-PB
neurexin
neurexin 4
neurexinIV
rose-gespleten region interval 23

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NT_037436.4 Reference assembly

    Range
    12146519..12156990
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_168491.3 → NP_729787.2  neurexin IV, isoform B [Drosophila melanogaster]

    See identical proteins and their annotated locations for NP_729787.2

    Status: REVIEWED

    UniProtKB/TrEMBL
    Q6NN26, Q8IQH0
    Conserved Domains (7) summary
    smart00294
    Location:1239 → 1255
    4.1m; putative band 4.1 homologues' binding motif
    smart00231
    Location:46 → 185
    FA58C; Coagulation factor 5/8 C-terminal domain, discoidin domain
    cd00054
    Location:966 → 998
    EGF_CA; Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular (mostly animal) proteins. Many of these proteins require calcium for their biological function and calcium-binding sites have been found to be located at the ...
    cd00057
    Location:57 → 184
    FA58C; Coagulation factor 5/8 C-terminal domain, discoidin domain; Cell surface-attached carbohydrate-binding domain, present in eukaryotes and assumed to have horizontally transferred to eubacterial genomes.
    cd00110
    Location:192 → 340
    LamG; Laminin G domain; Laminin G-like domains are usually Ca++ mediated receptors that can have binding sites for steroids, beta1 integrins, heparin, sulfatides, fibulin-1, and alpha-dystroglycans. Proteins that contain LamG domains serve a variety of ...
    pfam00008
    Location:546 → 575
    EGF; EGF-like domain
    pfam02210
    Location:824 → 943
    Laminin_G_2; Laminin G domain

  2. NM_079310.3 → NP_524034.2  neurexin IV, isoform A [Drosophila melanogaster]

    See identical proteins and their annotated locations for NP_524034.2

    Status: REVIEWED

    UniProtKB/Swiss-Prot
    Q94887, Q9VTU5
    UniProtKB/TrEMBL
    Q6NN26
    Related
    FBpp0075730
    Conserved Domains (7) summary
    smart00294
    Location:1239 → 1255
    4.1m; putative band 4.1 homologues' binding motif
    smart00231
    Location:46 → 185
    FA58C; Coagulation factor 5/8 C-terminal domain, discoidin domain
    cd00054
    Location:966 → 998
    EGF_CA; Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular (mostly animal) proteins. Many of these proteins require calcium for their biological function and calcium-binding sites have been found to be located at the ...
    cd00057
    Location:57 → 184
    FA58C; Coagulation factor 5/8 C-terminal domain, discoidin domain; Cell surface-attached carbohydrate-binding domain, present in eukaryotes and assumed to have horizontally transferred to eubacterial genomes.
    cd00110
    Location:192 → 340
    LamG; Laminin G domain; Laminin G-like domains are usually Ca++ mediated receptors that can have binding sites for steroids, beta1 integrins, heparin, sulfatides, fibulin-1, and alpha-dystroglycans. Proteins that contain LamG domains serve a variety of ...
    pfam00008
    Location:546 → 575
    EGF; EGF-like domain
    pfam02210
    Location:824 → 943
    Laminin_G_2; Laminin G domain
Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q8IQH0 Q8IQH0
Q94887.2 Q94887

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