Gli Gliotactin [Drosophila melanogaster (fruit fly)] - Gene

Summary

Official Symbol: Gliprovided by FlyBase
Official Full Name: Gliotactinprovided by FlyBase
Primary source: FLYBASE:FBgn0001987
Locus tag: Dmel_CG3903
See related: AllianceGenome:FB:FBgn0001987
Gene type: protein coding
RefSeq status: REVIEWED
Organism: Drosophila melanogaster
Lineage: Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
Also known as: BG:DS09217.3; CG3903; Dmel\CG3903; gli; GLI; l(2)35Dg; l(2)br45; n(2)k09033
Summary: Involved in several processes, including nervous system development; positive regulation of BMP signaling pathway; and positive regulation of border follicle cell migration. Located in lateral plasma membrane; septate junction; and tricellular tight junction. Is expressed in several structures, including epidermis; ganglia; glial cell; head epidermis primordium; and imaginal disc. Orthologous to human NLGN2 (neuroligin 2). [provided by Alliance of Genome Resources, Dec 2024]
Orthologs: all
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Genomic context

Location:: 35D4-35D4; 2-51 cM

Exon count:: 9

Annotation release	Status	Assembly	Chr	Location
Release 6.54	current	Release 6 plus ISO1 MT (GCF_000001215.4)	2L	NT_033779.5 (15756002..15762758, complement)
Release 5.57	previous assembly	Release 5 (GCF_000001215.2)	2L	NT_033779.4 (15756002..15762758, complement)

Chromosome 2L - NT_033779.5 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Overexpressed Gliotactin activates BMP signaling through interfering with the Tkv-Dad association.
Title: Overexpressed Gliotactin activates BMP signaling through interfering with the Tkv-Dad association.
Interplay between Anakonda, Gliotactin, and M6 for Tricellular Junction Assembly and Anchoring of Septate Junctions in Drosophila Epithelium.
Title: Interplay between Anakonda, Gliotactin, and M6 for Tricellular Junction Assembly and Anchoring of Septate Junctions in Drosophila Epithelium.
Disentanglement of the neighbour cells from the midbody, and the midbody movement, are impaired in the absence of the Gliotactin (Gli) and Anakonda (Aka) TCJ proteins.
Title: Tricellular junction proteins promote disentanglement of daughter and neighbour cells during epithelial cytokinesis.
Gliotactin leads to a feedback loop to control Gliotactin mRNA levels thorough Tkv protein signalling and induction of miR-184.
Title: The Drosophila tricellular junction protein Gliotactin regulates its own mRNA levels through BMP-mediated induction of miR-184.
A Comparison of Ci/Gli Activity as Regulated by Sufu in Drosophila and Mammalian Hedgehog Response
Title: A Comparison of Ci/Gli Activity as Regulated by Sufu in Drosophila and Mammalian Hedgehog Response.
Gliotactin and Discs large are co-regulated to maintain epithelial integrity.
Title: Gliotactin and Discs large are co-regulated to maintain epithelial integrity.
Gliotactin levels within the cell membrane are regulated to ensure correct protein localization and cell survival.
Title: Control of Gliotactin localization and levels by tyrosine phosphorylation and endocytosis is necessary for survival of polarized epithelia.
These results suggest a target gene-selective involvement of the PAF1 complex in Hh signaling via the Parafibromin/Hyx-mediated recruitment to Gli/Ci.
Title: The role of Parafibromin/Hyrax as a nuclear Gli/Ci-interacting protein in Hedgehog target gene control.
The intracellular domain of gliotactin is natively unfolded.
Title: The intracellular domain of the Drosophila cholinesterase-like neural adhesion protein, gliotactin, is natively unfolded.
The apical polarization of Gli and Cora functions to stabilize and align prehairs relative to anterior-posterior cell boundaries during pupal wing development.
Title: Transient apical polarization of Gliotactin and Coracle is required for parallel alignment of wing hairs in Drosophila.

Submit: New GeneRIF Correction See all GeneRIFs (11)

Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Homology

NCBI Orthologs

Orthologs from OrthoDB

Gene Ontology Provided by FlyBase

Function	Evidence Code	Pubs
NOT enables peptidase activity	IKR Inferred from Key Residues more info

Process	Evidence Code	Pubs
involved_in cell adhesion involved in heart morphogenesis	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in establishment of blood-nerve barrier	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in maintenance of imaginal disc-derived wing hair orientation	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in positive regulation of BMP signaling pathway	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in positive regulation of border follicle cell migration	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in regulation of tube size, open tracheal system	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in septate junction assembly	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in spermatid differentiation	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in synaptic target recognition	IMP Inferred from Mutant Phenotype more info	PubMed

Component	Evidence Code	Pubs
located_in lateral plasma membrane	IDA Inferred from Direct Assay more info	PubMed
located_in plasma membrane	IDA Inferred from Direct Assay more info	PubMed
is_active_in septate junction	IBA Inferred from Biological aspect of Ancestor more info
located_in septate junction	IDA Inferred from Direct Assay more info	PubMed
is_active_in tricellular tight junction	IBA Inferred from Biological aspect of Ancestor more info
located_in tricellular tight junction	IDA Inferred from Direct Assay more info	PubMed
located_in tricellular tight junction	IMP Inferred from Mutant Phenotype more info	PubMed