U.S. flag

An official website of the United States government

Format

Send to:

Choose Destination

Pms2 Pms2 [ Drosophila melanogaster (fruit fly) ]

Gene ID: 36705, updated on 9-Dec-2024

Summary

Go to the top of the page Help
Official Symbol
Pms2provided by FlyBase
Official Full Name
Pms2provided by FlyBase
Primary source
FLYBASE:FBgn0011660
Locus tag
Dmel_CG8169
See related
AllianceGenome:FB:FBgn0011660
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Drosophila melanogaster
Lineage
Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
Also known as
CG8169; Dmel\CG8169; dmlh-2; dmlh2; dpms2; Mlh2; pms2; PMS2
Summary
Predicted to enable ATP hydrolysis activity. Predicted to be involved in mismatch repair. Predicted to be part of MutLalpha complex. Human ortholog(s) of this gene implicated in Lynch syndrome; hereditary nonpolyposis colorectal cancer type 4; mismatch repair cancer syndrome; ovarian cancer; and urinary bladder cancer. Orthologous to several human genes including PMS2 (PMS1 homolog 2, mismatch repair system component). [provided by Alliance of Genome Resources, Dec 2024]
Orthologs
all
NEW
Try the new Gene table
Try the new Transcript table

Genomic context

Go to the top of the page Help
See Pms2 in Genome Data Viewer
Location:
51F11-51F11; 2-74 cM
Exon count:
8
Annotation release Status Assembly Chr Location
Release 6.54 current Release 6 plus ISO1 MT (GCF_000001215.4) 2R NT_033778.4 (15368074..15371520, complement)
Release 5.57 previous assembly Release 5 (GCF_000001215.2) 2R NT_033778.3 (11255579..11259025, complement)

Chromosome 2R - NT_033778.4Genomic Context describing neighboring genes Neighboring gene long non-coding RNA:CR44371 Neighboring gene Hormone receptor 51 Neighboring gene unc-5 Neighboring gene long non-coding RNA:CR44458 Neighboring gene long non-coding RNA:CR44459 Neighboring gene pseudo

Genomic regions, transcripts, and products

Go to the top of the page Help

Go to nucleotide: Graphics FASTA GenBank

Bibliography

Go to the top of the pageHelp

Related articles in PubMed

  1. DNA mismatch repair and mutation avoidance pathways. Marti TM, et al. J Cell Physiol, 2002 Apr. PMID 11920679
  2. Morphologically different hydroxyapatite nanoparticles exert differential genotoxic effects in Drosophila. Güneş M, et al. Sci Total Environ, 2023 Dec 15. PMID 37633389
  3. Uracil-containing DNA in Drosophila: stability, stage-specific accumulation, and developmental involvement. Muha V, et al. PLoS Genet, 2012. PMID 22685418, Free PMC Article
  4. DNA repair in Drosophila: insights from the Drosophila genome sequence. Sekelsky JJ, et al. J Cell Biol, 2000 Jul 24. PMID 10908583, Free PMC Article
  5. Genotoxic hazard assessment of cerium oxide and magnesium oxide nanoparticles in Drosophila. Yalçın B, et al. Nanotoxicology, 2022 Apr. PMID 35818303

See all (38) citations in PubMed

GeneRIFs: Gene References Into Functions

Interactions

Go to the top of the page Help
Products Interactant Other Gene Complex Source Pubs Description

General gene information

Go to the top of the page Help

Homology

Gene Ontology Provided by FlyBase

Function Evidence Code Pubs
enables ATP binding IEA
Inferred from Electronic Annotation
more info
  
enables ATP hydrolysis activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables ATP hydrolysis activity IEA
Inferred from Electronic Annotation
more info
  
enables ATP-dependent DNA damage sensor activity IEA
Inferred from Electronic Annotation
more info
  
enables mismatched DNA binding IEA
Inferred from Electronic Annotation
more info
  
Process Evidence Code Pubs
involved_in mismatch repair IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in mismatch repair IEA
Inferred from Electronic Annotation
more info
  
Component Evidence Code Pubs
part_of MutLalpha complex IBA
Inferred from Biological aspect of Ancestor
more info
  
part_of mismatch repair complex IEA
Inferred from Electronic Annotation
more info
  

General protein information

Go to the top of the page Help
Preferred Names
Pms2
Names
CG8169-PA
Pms2-PA

NCBI Reference Sequences (RefSeq)

Go to the top of the page Help

NEW Try the new Transcript table

Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NT_033778.4 Reference assembly

    Range
    15368074..15371520 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_057675.4 → NP_477023.1  Pms2 [Drosophila melanogaster]

    See identical proteins and their annotated locations for NP_477023.1

    Status: REVIEWED

    UniProtKB/TrEMBL
    A1ZA03, Q8T9C0
    Related
    FBpp0086520
    Conserved Domains (4) summary
    smart00853
    Location:703 → 847
    MutL_C; MutL C terminal dimerisation domain
    COG0323
    Location:26 → 880
    MutL; DNA mismatch repair ATPase MutL [Replication, recombination and repair]
    cd03484
    Location:238 → 381
    MutL_Trans_hPMS_2_like; MutL_Trans_hPMS2_like: transducer domain, having a ribosomal S5 domain 2-like fold, found in proteins similar to human PSM2 (hPSM2). hPSM2 belongs to the DNA mismatch repair (MutL/MLH1/PMS2) family. This transducer domain is homologous to the second ...
    cl00075
    Location:46 → 151
    HATPase_c; Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins
Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
A1ZA03 A1ZA03
O76417 O76417
Q8T9C0 Q8T9C0

Gene LinkOut

The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

Other Literature Sources
Molecular Biology Databases
Research Materials
Tools
Miscellaneous