Mer Merlin [Drosophila melanogaster (fruit fly)] - Gene

Summary

Official Symbol: Merprovided by FlyBase
Official Full Name: Merlinprovided by FlyBase
Primary source: FLYBASE:FBgn0086384
Locus tag: Dmel_CG14228
See related: AllianceGenome:FB:FBgn0086384
Gene type: protein coding
RefSeq status: REVIEWED
Organism: Drosophila melanogaster
Lineage: Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
Also known as: BG01543; CG14228; D-Mer; Dmel\CG14228; Dmerlin; Emr2; EMR2; mer; MER; NF2
Summary: Enables protein-membrane adaptor activity. Involved in several processes, including R8 cell differentiation; germ cell development; and meiotic nuclear division. Located in several cellular components, including Nebenkern; apicomedial cortex; and subapical part of cell. Part of Kibra-Ex-Mer complex. Is active in cytoplasmic side of apical plasma membrane. Colocalizes with cell-cell junction. Human ortholog(s) of this gene implicated in gastrointestinal system cancer (multiple); malignant pleural mesothelioma; meningioma (multiple); neurilemmoma; and vestibular schwannomatosis. Orthologous to human NF2 (NF2, moesin-ezrin-radixin like (MERLIN) tumor suppressor). [provided by Alliance of Genome Resources, Jan 2025]
Orthologs: all
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Genomic context

Location:: 18E1-18E1; 1-64 cM

Exon count:: 5

Annotation release	Status	Assembly	Chr	Location
Release 6.54	current	Release 6 plus ISO1 MT (GCF_000001215.4)	X	NC_004354.4 (19689697..19693500, complement)
Release 5.57	previous assembly	Release 5 (GCF_000001215.2)	X	NC_004354.3 (19583730..19587533, complement)

Chromosome X - NC_004354.4 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

PI4P-mediated solid-like Merlin condensates orchestrate Hippo pathway regulation.
Title: PI4P-mediated solid-like Merlin condensates orchestrate Hippo pathway regulation.
Merlin and expanded integrate cell signaling that regulates cyst stem cell proliferation in the Drosophila testis niche.
Title: Merlin and expanded integrate cell signaling that regulates cyst stem cell proliferation in the Drosophila testis niche.
The crystal structure of the FERM and C-terminal domain complex of Drosophila Merlin.
Title: The crystal structure of the FERM and C-terminal domain complex of Drosophila Merlin.
Here, we show that Merlin (Mer), a homolog of the human tumor suppressor neurofibromatosis 2, is required to coordinate proliferation of germline stem cells (GSCs) and somatic cyst stem cells (CySCs) in the Drosophila testis.
Title: Merlin is required for coordinating proliferation of two stem cell lineages in the Drosophila testis.
Merlin and Kibra activate Hippo signaling in parallel to Expanded at a spatially distinct cellular domain, the medial apical cortex.
Title: Kibra and Merlin Activate the Hippo Pathway Spatially Distinct from and Independent of Expanded.
Rae1 increases activation of the core kinases Hippo and Warts and plays a post-transcriptional role to increase the protein levels of the Merlin, Hippo, and Warts components of the pathway; therefore, in addition to Rae1 coordinating organ size regulation with proliferative control, we propose that Rae1 also acts in a feedback circuit to regulate pathway homeostas
Title: The Hippo Pathway Targets Rae1 to Regulate Mitosis and Organ Size and to Feed Back to Regulate Upstream Components Merlin, Hippo, and Warts.
Sip1 facilitates the activation of Merlin as a tumor suppressor protein.
Title: Regulation of cell proliferation and adhesion by means of a novel region of drosophila merlin interacting with Sip1.
These results indicate that in both Drosophila and mammals, Merlin activates Wts/Lats phosphorylation without stimulating the intrinsic kinase activity of Hpo/Mst.
Title: Spatial organization of Hippo signaling at the plasma membrane mediated by the tumor suppressor Merlin/NF2.
Drosophila melanogaster protein phosphatase type 1 beta (flapwing) co-regulates dephosphorylation and altered activity of both Merlin and Moesin.
Title: The PP1 phosphatase flapwing regulates the activity of Merlin and Moesin in Drosophila.
The result reveals role for merlin in neuronal specification and maintenance and show that the Hippo pathway is reimplemented for sensory neuron fate by combining canonical and noncanonical regulatory steps.
Title: Binary regulation of Hippo pathway by Merlin/NF2, Kibra, Lgl, and Melted specifies and maintains postmitotic neuronal fate.

Submit: New GeneRIF Correction See all GeneRIFs (25)

Pathways from PubChem

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Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Homology

NCBI Orthologs

Orthologs from OrthoDB

Gene Ontology Provided by FlyBase

Function	Evidence Code	Pubs
enables actin binding	IBA Inferred from Biological aspect of Ancestor more info
enables actin binding	IEA Inferred from Electronic Annotation more info
enables integrin binding	IBA Inferred from Biological aspect of Ancestor more info
enables protein binding	IPI Inferred from Physical Interaction more info	PubMed
enables protein-membrane adaptor activity	IDA Inferred from Direct Assay more info	PubMed

Process	Evidence Code	Pubs
involved_in R8 cell development	IGI Inferred from Genetic Interaction more info	PubMed
involved_in R8 cell fate specification	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in axis specification	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in cell-cell signaling	IEP Inferred from Expression Pattern more info	PubMed
involved_in compound eye morphogenesis	IGI Inferred from Genetic Interaction more info	PubMed
involved_in compound eye photoreceptor cell differentiation	IGI Inferred from Genetic Interaction more info	PubMed
involved_in endocytic recycling	IGI Inferred from Genetic Interaction more info	PubMed
involved_in endocytosis	IEP Inferred from Expression Pattern more info	PubMed
involved_in epithelial structure maintenance	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in hippo signaling	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in male meiosis cytokinesis	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in meiotic chromosome separation	IMP Inferred from Mutant Phenotype more info
involved_in negative regulation of cell population proliferation	IBA Inferred from Biological aspect of Ancestor more info
involved_in negative regulation of cell population proliferation	IGI Inferred from Genetic Interaction more info	PubMed
involved_in negative regulation of cell population proliferation	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in negative regulation of glial cell proliferation	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in negative regulation of organ growth	IGI Inferred from Genetic Interaction more info	PubMed
involved_in negative regulation of organ growth	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in pole plasm mRNA localization	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in positive regulation of apoptotic process	IGI Inferred from Genetic Interaction more info	PubMed
involved_in positive regulation of cell-cell adhesion	IGI Inferred from Genetic Interaction more info	PubMed
involved_in positive regulation of early endosome to late endosome transport	IBA Inferred from Biological aspect of Ancestor more info
involved_in positive regulation of hippo signaling	IDA Inferred from Direct Assay more info	PubMed
involved_in positive regulation of hippo signaling	IGI Inferred from Genetic Interaction more info	PubMed
involved_in positive regulation of hippo signaling	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in positive regulation of protein localization to early endosome	IBA Inferred from Biological aspect of Ancestor more info
involved_in protein localization to plasma membrane	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in regulation of cell differentiation	IGI Inferred from Genetic Interaction more info	PubMed
involved_in regulation of cell growth	IEP Inferred from Expression Pattern more info	PubMed
involved_in regulation of cell population proliferation	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in regulation of cell shape	IBA Inferred from Biological aspect of Ancestor more info
involved_in regulation of compound eye retinal cell programmed cell death	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in regulation of gliogenesis	IBA Inferred from Biological aspect of Ancestor more info
involved_in regulation of hippo signaling	IBA Inferred from Biological aspect of Ancestor more info
involved_in regulation of organelle assembly	IBA Inferred from Biological aspect of Ancestor more info
involved_in regulation of signal transduction	IGI Inferred from Genetic Interaction more info	PubMed
involved_in sperm individualization	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in spermatogenesis	IMP Inferred from Mutant Phenotype more info	PubMed

Component	Evidence Code	Pubs
part_of Kibra-Ex-Mer complex	IDA Inferred from Direct Assay more info	PubMed
part_of Kibra-Ex-Mer complex	IPI Inferred from Physical Interaction more info	PubMed
located_in Nebenkern	IDA Inferred from Direct Assay more info	PubMed
is_active_in adherens junction	IBA Inferred from Biological aspect of Ancestor more info
located_in adherens junction	IDA Inferred from Direct Assay more info	PubMed
is_active_in apical part of cell	IBA Inferred from Biological aspect of Ancestor more info
located_in apical part of cell	IDA Inferred from Direct Assay more info	PubMed
located_in apical plasma membrane	IDA Inferred from Direct Assay more info	PubMed
located_in apicomedial cortex	IDA Inferred from Direct Assay more info	PubMed
located_in cell cortex	IDA Inferred from Direct Assay more info	PubMed
colocalizes_with cell-cell junction	IDA Inferred from Direct Assay more info	PubMed
located_in cytoplasm	IDA Inferred from Direct Assay more info	PubMed
is_active_in cytoplasmic side of apical plasma membrane	IDA Inferred from Direct Assay more info	PubMed
located_in cytoskeleton	IEA Inferred from Electronic Annotation more info
is_active_in filopodium	IBA Inferred from Biological aspect of Ancestor more info
located_in membrane	IDA Inferred from Direct Assay more info	PubMed
is_active_in plasma membrane	IBA Inferred from Biological aspect of Ancestor more info
located_in plasma membrane	IDA Inferred from Direct Assay more info	PubMed
located_in subapical part of cell	IDA Inferred from Direct Assay more info	PubMed

General protein information

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Preferred Names: merlin

Names: BG01543; CG14228-PA; CG14228-PB; D merlin; Ezrin-moesin-radixin-2; Mer-PA; Mer-PB; Merlin/Neurofibromin 2; dmerlin

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

NC_004354.4 Reference assembly

Range

19689697..19693500 complement

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GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

NM_001298529.1 → NP_001285458.1 merlin, isoform B [Drosophila melanogaster]

See identical proteins and their annotated locations for NP_001285458.1

Status: REVIEWED

UniProtKB/Swiss-Prot

Q24054, Q24564, Q8SWY3

UniProtKB/TrEMBL

C6TP59, X2JFU0

Conserved Domains (3) summary

smart00295
Location:14 → 216

B41; Band 4.1 homologues

cd13194
Location:210 → 306

FERM_C_ERM; FERM domain C-lobe/F3 of the ERM family

pfam00769
Location:341 → 635

ERM; Ezrin/radixin/moesin family
NM_078689.4 → NP_523413.1 merlin, isoform A [Drosophila melanogaster]

See identical proteins and their annotated locations for NP_523413.1

Status: REVIEWED

UniProtKB/Swiss-Prot

Q24054, Q24564, Q8SWY3

UniProtKB/TrEMBL

C6TP59, X2JFU0

Related

FBpp0074523

Conserved Domains (3) summary

smart00295
Location:14 → 216

B41; Band 4.1 homologues

cd13194
Location:210 → 306

FERM_C_ERM; FERM domain C-lobe/F3 of the ERM family

pfam00769
Location:341 → 635

ERM; Ezrin/radixin/moesin family