U.S. flag

An official website of the United States government

Format

Send to:

Choose Destination

kel kelch [ Drosophila melanogaster (fruit fly) ]

Gene ID: 35084, updated on 4-Jan-2025

Summary

Go to the top of the page Help
Official Symbol
kelprovided by FlyBase
Official Full Name
kelchprovided by FlyBase
Primary source
FLYBASE:FBgn0001301
Locus tag
Dmel_CG7210
See related
AllianceGenome:FB:FBgn0001301
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Drosophila melanogaster
Lineage
Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
Also known as
CG7210; Dm.Ring_canal/KELC_DROME; Dmel\CG7210; Kel; Kelch
Summary
Enables actin binding activity. Involved in actin cytoskeleton organization; cellularization; and oogenesis. Located in female germline ring canal. Is expressed in several structures, including anlage in statu nascendi; central brain anlage in statu nascendi; dorsal ectoderm anlage; gonad; and ring canal. Human ortholog(s) of this gene implicated in pseudohypoaldosteronism. Orthologous to human KLHL2 (kelch like family member 2) and KLHL3 (kelch like family member 3). [provided by Alliance of Genome Resources, Jan 2025]
Orthologs
all
NEW
Try the new Gene table
Try the new Transcript table

Genomic context

Go to the top of the page Help
See kel in Genome Data Viewer
Location:
36E5-36E6; 2-53 cM
Exon count:
6
Annotation release Status Assembly Chr Location
Release 6.54 current Release 6 plus ISO1 MT (GCF_000001215.4) 2L NT_033779.5 (18129884..18138083, complement)
Release 5.57 previous assembly Release 5 (GCF_000001215.2) 2L NT_033779.4 (18129884..18138083, complement)

Chromosome 2L - NT_033779.5Genomic Context describing neighboring genes Neighboring gene uncharacterized protein Neighboring gene uncharacterized protein Neighboring gene Gustatory receptor-like 36b Neighboring gene Suppressor of cytokine signaling at 36E Neighboring gene long non-coding RNA:CR44478 Neighboring gene uncharacterized protein

Genomic regions, transcripts, and products

Go to the top of the page Help

Go to nucleotide: Graphics FASTA GenBank

Bibliography

Go to the top of the pageHelp

Related articles in PubMed

  1. Drosophila kelch motif is derived from a common enzyme fold. Bork P, et al. J Mol Biol, 1994 Mar 11. PMID 8126718
  2. kelch encodes a component of intercellular bridges in Drosophila egg chambers. Xue F, et al. Cell, 1993 Mar 12. PMID 8453663
  3. Formation of actin filament bundles in the ring canals of developing Drosophila follicles. Tilney LG, et al. J Cell Biol, 1996 Apr. PMID 8601614, Free PMC Article
  4. Stimulation of stop codon readthrough: frequent presence of an extended 3' RNA structural element. Firth AE, et al. Nucleic Acids Res, 2011 Aug. PMID 21525127, Free PMC Article
  5. Domains of Importin-alpha2 required for ring canal assembly during Drosophila oogenesis. Gorjánácz M, et al. J Struct Biol, 2006 Apr. PMID 16458020

See all (126) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. present genetic evidence consistent with HtsRC being the CRL3(Kelch) substrate, as well as biochemical evidence indicating that HtsRC is ubiquitylated and degraded by the proteasome.
    Title: Targeted substrate degradation by Kelch controls the actin cytoskeleton during ring canal expansion.
  2. results demonstrate that Kelch promotes ring canal cytoskeleton growth primarily through its activity as cullin-RING E3 ubiquitin ligase component
    Title: Actin Cytoskeletal Organization in Drosophila Germline Ring Canals Depends on Kelch Function in a Cullin-RING E3 Ligase.
  3. COP9 limits dendritic branching via Cullin3-dependent degradation of the actin-crosslinking BTB-domain protein Kelch
    Title: COP9 limits dendritic branching via Cullin3-dependent degradation of the actin-crosslinking BTB-domain protein Kelch.
  4. demonstrate that association of Drosophila KEL with Cullin-3, likely in a cullin-RING ligase, is essential for the growth of Drosophila female germline ring canals.
    Title: Drosophila Kelch functions with Cullin-3 to organize the ring canal actin cytoskeleton.
Submit: New GeneRIF Correction

Interactions

Go to the top of the page Help
Products Interactant Other Gene Complex Source Pubs Description

General gene information

Go to the top of the page Help

Homology

Gene Ontology Provided by FlyBase

Function Evidence Code Pubs
enables actin binding IDA
Inferred from Direct Assay
more info
 PubMed 
enables ubiquitin-like ligase-substrate adaptor activity IBA
Inferred from Biological aspect of Ancestor
more info
  
Process Evidence Code Pubs
involved_in actin cytoskeleton organization IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in cellularization IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in female germline ring canal formation IDA
Inferred from Direct Assay
more info
 PubMed 
involved_in female germline ring canal formation IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in follicle cell of egg chamber migration HMP PubMed 
involved_in oocyte karyosome formation IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in oogenesis HMP PubMed 
involved_in oogenesis IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in ovarian fusome organization IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in ovarian nurse cell to oocyte transport IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in proteasome-mediated ubiquitin-dependent protein catabolic process IBA
Inferred from Biological aspect of Ancestor
more info
  
Component Evidence Code Pubs
part_of Cul3-RING ubiquitin ligase complex IBA
Inferred from Biological aspect of Ancestor
more info
  
is_active_in cytoplasm IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in female germline ring canal IDA
Inferred from Direct Assay
more info
 PubMed 
located_in female germline ring canal inner rim TAS
Traceable Author Statement
more info
 PubMed 
located_in germline ring canal IDA
Inferred from Direct Assay
more info
 PubMed 
located_in germline ring canal TAS
Traceable Author Statement
more info
 PubMed 

General protein information

Go to the top of the page Help
Preferred Names
kelch
Names
CG7210-PA
CG7210-PB
kel-PA
kel-PB

NCBI Reference Sequences (RefSeq)

Go to the top of the page Help

NEW Try the new Transcript table

Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NT_033779.5 Reference assembly

    Range
    18129884..18138083 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_165242.2 → NP_724095.1  kelch, isoform A [Drosophila melanogaster]

    See identical proteins and their annotated locations for NP_724095.1

    Status: REVIEWED

    UniProtKB/Swiss-Prot
    Q04652
    Related
    FBpp0080595
    Conserved Domains (5) summary
    smart00612
    Location:497 → 543
    Kelch; Kelch domain
    PHA03098
    Location:150 → 675
    PHA03098; kelch-like protein; Provisional
    sd00038
    Location:439 → 482
    Kelch; KELCH repeat [structural motif]
    pfam00651
    Location:147 → 250
    BTB; BTB/POZ domain
    pfam07707
    Location:258 → 359
    BACK; BTB And C-terminal Kelch

  2. NM_057241.3 → NP_476589.4  kelch, isoform B [Drosophila melanogaster]

    See identical proteins and their annotated locations for NP_476589.4

    Status: REVIEWED

    UniProtKB/Swiss-Prot
    F0JAF0, Q04652, Q04653, Q86PA7, Q9VJA2
    Related
    FBpp0080596
    Conserved Domains (5) summary
    smart00612
    Location:497 → 543
    Kelch; Kelch domain
    PHA03098
    Location:150 → 675
    PHA03098; kelch-like protein; Provisional
    sd00038
    Location:439 → 482
    Kelch; KELCH repeat [structural motif]
    pfam00651
    Location:147 → 250
    BTB; BTB/POZ domain
    pfam07707
    Location:258 → 359
    BACK; BTB And C-terminal Kelch
Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q04652.4 Q04652

Gene LinkOut

The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

Other Literature Sources
Molecular Biology Databases
Research Materials
Tools
Miscellaneous