S6kII Ribosomal protein S6 kinase II [Drosophila melanogaster (fruit fly)] - Gene

Summary

Official Symbol: S6kIIprovided by FlyBase
Official Full Name: Ribosomal protein S6 kinase IIprovided by FlyBase
Primary source: FLYBASE:FBgn0262866
Locus tag: Dmel_CG17596
See related: AllianceGenome:FB:FBgn0262866
Gene type: protein coding
RefSeq status: REVIEWED
Organism: Drosophila melanogaster
Lineage: Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
Also known as: CG17596; D-RSK; Dmel\CG17596; dRsk; dRSK; ign; rsk; Rsk; RSK; rsk2; S6KII
Summary: Enables mitogen-activated protein kinase binding activity and ribosomal protein S6 kinase activity. Involved in several processes, including learning; negative regulation of cell differentiation; and negative regulation of signal transduction. Located in several cellular components, including neuromuscular junction; perikaryon; and presynapse. Is expressed in adult head. Used to study Coffin-Lowry syndrome. Human ortholog(s) of this gene implicated in Coffin-Lowry syndrome; intellectual disability; and non-syndromic X-linked intellectual disability 19. Orthologous to several human genes including RPS6KA1 (ribosomal protein S6 kinase A1); RPS6KA2 (ribosomal protein S6 kinase A2); and RPS6KA3 (ribosomal protein S6 kinase A3). [provided by Alliance of Genome Resources, Jan 2025]
Orthologs: all
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Genomic context

Location:: 20C1-20C1; 1-66 cM

Exon count:: 2

Annotation release	Status	Assembly	Chr	Location
Release 6.54	current	Release 6 plus ISO1 MT (GCF_000001215.4)	X	NC_004354.4 (22529964..22536371)
Release 5.57	previous assembly	Release 5 (GCF_000001215.2)	X	NC_004354.3 (21931800..21938207)

Chromosome X - NC_004354.4 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

RSK2 is required for normal synaptic morphology and function. Loss of RSK2 function interferes with ERK signaling at different levels, interfering with synaptic function and axonal transport in Drosophila motoneurons.
Title: Loss of the Coffin-Lowry syndrome-associated gene RSK2 alters ERK activity, synaptic function and axonal transport in Drosophila motoneurons.
This study demonistrated that the visual orientation memory of Drosophila requires Foraging (PKG) upstream of Ignorant (RSK2) in ring neurons of the central complex.
Title: The visual orientation memory of Drosophila requires Foraging (PKG) upstream of Ignorant (RSK2) in ring neurons of the central complex.
the phosphorylation of S6KII residues, in vivo, does not follow a strict sequential pattern, as implied by certain cell-based studies of mammalian RSK protein.
Title: The C-terminal kinase and ERK-binding domains of Drosophila S6KII (RSK) are required for phosphorylation of the protein and modulation of circadian behavior.
In mutants with a full deletion or an N-terminal partial deletion of rsk, an increased bouton number at the neuromuscular junction is found.
Title: Drosophila RSK negatively regulates bouton number at the neuromuscular junction.
Overexpression of S6KII in wild type has a dominant-negative effect on the operant task that is rescued by the null mutant, whereas in the pavlovian task overexpression may even enhance learning performance.
Title: The S6KII (rsk) gene of Drosophila melanogaster differentially affects an operant and a classical learning task.
There is a novel regulatory mechanism of the Ras/ERK pathway by RSK, which negatively regulates ERK activity by acting as a cytoplasmic anchor in Drosophila
Title: Inhibition of ERK-MAP kinase signaling by RSK during Drosophila development.

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Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Markers

Dm0529 (e-PCR)
- UniSTS:24759

Homology

NCBI Orthologs

Orthologs from OrthoDB

Gene Ontology Provided by FlyBase

Function	Evidence Code	Pubs
enables ATP binding	IEA Inferred from Electronic Annotation more info
enables magnesium ion binding	IEA Inferred from Electronic Annotation more info
enables mitogen-activated protein kinase binding	IPI Inferred from Physical Interaction more info	PubMed
enables protein serine/threonine kinase activity	IEA Inferred from Electronic Annotation more info
enables ribosomal protein S6 kinase activity	IBA Inferred from Biological aspect of Ancestor more info
enables ribosomal protein S6 kinase activity	IDA Inferred from Direct Assay more info	PubMed
enables ribosomal protein S6 kinase activity	ISS Inferred from Sequence or Structural Similarity more info	PubMed

Process	Evidence Code	Pubs
involved_in TORC1 signaling	IBA Inferred from Biological aspect of Ancestor more info
involved_in associative learning	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in determination of adult lifespan	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in imaginal disc-derived wing vein specification	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in intracellular signal transduction	IEA Inferred from Electronic Annotation more info
involved_in locomotor rhythm	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in negative regulation of ERK1 and ERK2 cascade	IDA Inferred from Direct Assay more info	PubMed
involved_in negative regulation of compound eye cone cell fate specification	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in negative regulation of photoreceptor cell differentiation	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in negative regulation of pigment cell differentiation	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in negative regulation of protein import into nucleus	IDA Inferred from Direct Assay more info	PubMed
involved_in negative regulation of transmembrane receptor protein serine/threonine kinase signaling pathway	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in neuromuscular junction development	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in operant conditioning	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in protein phosphorylation	IEA Inferred from Electronic Annotation more info
involved_in regulation of neuromuscular junction development	IMP Inferred from Mutant Phenotype more info	PubMed

Component	Evidence Code	Pubs
is_active_in cytoplasm	IBA Inferred from Biological aspect of Ancestor more info
located_in cytosol	IDA Inferred from Direct Assay more info	PubMed
located_in neuromuscular junction	IDA Inferred from Direct Assay more info	PubMed
is_active_in nucleoplasm	IBA Inferred from Biological aspect of Ancestor more info
located_in perikaryon	IDA Inferred from Direct Assay more info	PubMed
located_in presynapse	IDA Inferred from Direct Assay more info	PubMed

General protein information

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Preferred Names: ribosomal protein S6 kinase II

Names: CG17596-PA; CG17596-PB; RPS6-protein kinase-II; Ribosomal-S6-kinase; S6 kinase II; S6kII-PA; S6kII-PB; ignorant; p90 ribosomal S6 kinase

NP_001259779.1

EC 2.7.11.1

NP_523437.2

EC 2.7.11.1

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

NC_004354.4 Reference assembly

Range

22529964..22536371

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

NM_001272850.1 → NP_001259779.1 ribosomal protein S6 kinase II, isoform B [Drosophila melanogaster]

See identical proteins and their annotated locations for NP_001259779.1

Status: REVIEWED

UniProtKB/TrEMBL

Q24496, Q9VR61

Conserved Domains (3) summary

smart00220
Location:199 → 457

S_TKc; Serine/Threonine protein kinases, catalytic domain

cd05582
Location:203 → 517

STKc_RSK_N; N-terminal catalytic domain of the Serine/Threonine Kinase, 90 kDa ribosomal protein S6 kinase

cd14091
Location:567 → 883

STKc_RSK_C; C-terminal catalytic domain of the Serine/Threonine Kinases, Ribosomal S6 kinases
NM_078713.3 → NP_523437.2 ribosomal protein S6 kinase II, isoform A [Drosophila melanogaster]

See identical proteins and their annotated locations for NP_523437.2

Status: REVIEWED

UniProtKB/TrEMBL

Q24496, Q9VR61

Related

FBpp0077052

Conserved Domains (3) summary

smart00220
Location:199 → 457

S_TKc; Serine/Threonine protein kinases, catalytic domain

cd05582
Location:203 → 517

STKc_RSK_N; N-terminal catalytic domain of the Serine/Threonine Kinase, 90 kDa ribosomal protein S6 kinase

cd14091
Location:567 → 883

STKc_RSK_C; C-terminal catalytic domain of the Serine/Threonine Kinases, Ribosomal S6 kinases