Tsc1 Tsc1 [Drosophila melanogaster (fruit fly)] - Gene

Summary

Official Symbol: Tsc1provided by FlyBase
Official Full Name: Tsc1provided by FlyBase
Primary source: FLYBASE:FBgn0026317
Locus tag: Dmel_CG6147
See related: AllianceGenome:FB:FBgn0026317
Gene type: protein coding
RefSeq status: REVIEWED
Organism: Drosophila melanogaster
Lineage: Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
Also known as: CG6147; Dmel\CG6147; dTSC; dTSC-1; dtsc1; dTsc1; dTSC1; rocky; Tsc; TSC; tsc1; tSC1; TsC1; TSC1
Summary: Enables GTPase activator activity and protein kinase binding activity. Involved in several processes, including cellular response to chloroquine; negative regulation of developmental growth; and regulation of signal transduction. Located in cytoplasm. Part of TSC1-TSC2 complex. Is expressed in embryonic/larval salivary gland and organism. Used to study autism spectrum disorder; tuberous sclerosis; and tuberous sclerosis 1. Human ortholog(s) of this gene implicated in intellectual disability; lymphangioleiomyomatosis; tuberous sclerosis; and tuberous sclerosis 1. Orthologous to human TSC1 (TSC complex subunit 1). [provided by Alliance of Genome Resources, Jan 2025]
Orthologs: all
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Genomic context

Location:: 95E1-95E1; 3-83 cM

Exon count:: 7

Annotation release	Status	Assembly	Chr	Location
Release 6.54	current	Release 6 plus ISO1 MT (GCF_000001215.4)	3R	NT_033777.3 (24130307..24134654)
Release 5.57	previous assembly	Release 5 (GCF_000001215.2)	3R	NT_033777.2 (19956029..19960376)

Chromosome 3R - NT_033777.3 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

TSC1 is growth and size regulator, inhibit TOR-mediated amino acid availability to S6 kinase and translation initiation, its muscle and fat overactivation significantly extends lifespan.
Title: Basic mechanisms of longevity: A case study of Drosophila pro-longevity genes.
hyperactivation of TORC1 following the loss of TSC1/2 is detrimental to stem cell maintenance and multiple lineage differentiation in the Drosophila intestinal stem cell lineage, a mechanism that could be conserved in other stem cell lineages
Title: TSC1/2 regulates intestinal stem cell maintenance and lineage differentiation through Rheb-TORC1-S6K but independently of nutritional status or Notch regulation.
Data indicate that TORC1 activation by PVR involves Tsc1/Tsc2.
Title: Platelet-derived growth factor/vascular endothelial growth factor receptor inactivation by sunitinib results in Tsc1/Tsc2-dependent inhibition of TORC1.
deregulation of TORC1 induces activation of JNK, indicate that multiple cellular stresses are induced and contribute to the synthetic-lethal interactions between RB and TSC1/TSC2 inactivation.
Title: Deregulated G1-S control and energy stress contribute to the synthetic-lethal interactions between inactivation of RB and TSC1 or TSC2.
study demonstrates that in the Drosophila lymph gland the tumor suppressors TSC and PTEN control blood progenitor proliferation through a common TOR- and 4EBP-dependent pathway
Title: Multifaceted roles of PTEN and TSC orchestrate growth and differentiation of Drosophila blood progenitors.
TSC1/2 and Myc coordinate the growth and division of Drosophila intestinal stem cells.
Title: Tuberous sclerosis complex and Myc coordinate the growth and division of Drosophila intestinal stem cells.
TSC1 regulates E2F1 expression during development and cooperates with RBF1 to control proliferation and survival.
Title: Tuberous sclerosis complex 1 regulates dE2F1 expression during development and cooperates with RBF1 to control proliferation and survival.
TSC1/2 prevents precocious GSC differentiation by inhibiting TORC1 activity and subsequently differentiation-promoting programs
Title: TSC1/2 tumour suppressor complex maintains Drosophila germline stem cells by preventing differentiation.
Tsc-mediated control of axon guidance and synapse assembly occurs via growth-independent signaling mechanisms, and suggest that Tor complex 2, a regulator of actin organization, is critical in these aspects of neuronal development
Title: Mechanisms of TSC-mediated control of synapse assembly and axon guidance.
shows that phosphorylation of the Tsc1/2 complex by Akt is not required for Akt to activate TORC1 and to promote tissue growth in Drosophila
Title: Akt phosphorylates both Tsc1 and Tsc2 in Drosophila, but neither phosphorylation is required for normal animal growth.

Submit: New GeneRIF Correction See all GeneRIFs (15)

Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Homology

NCBI Orthologs

Orthologs from OrthoDB

Gene Ontology Provided by FlyBase

Function	Evidence Code	Pubs
enables GTPase activator activity	IDA Inferred from Direct Assay more info	PubMed
enables kinase binding	IPI Inferred from Physical Interaction more info	PubMed
enables protein binding	IPI Inferred from Physical Interaction more info	PubMed
enables protein kinase binding	IPI Inferred from Physical Interaction more info	PubMed

Process	Evidence Code	Pubs
involved_in cellular response to chloroquine	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in cellular response to hypoxia	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in cholesterol homeostasis	IGI Inferred from Genetic Interaction more info	PubMed
involved_in determination of adult lifespan	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in enteroendocrine cell differentiation	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in intestinal stem cell homeostasis	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in larval midgut histolysis	IGI Inferred from Genetic Interaction more info	PubMed
involved_in lipid homeostasis	IGI Inferred from Genetic Interaction more info	PubMed
involved_in lymph gland development	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in negative regulation of TOR signaling	IBA Inferred from Biological aspect of Ancestor more info
involved_in negative regulation of TOR signaling	IGI Inferred from Genetic Interaction more info	PubMed
involved_in negative regulation of TORC1 signaling	IGI Inferred from Genetic Interaction more info	PubMed
involved_in negative regulation of TORC1 signaling	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in negative regulation of cell growth	IGI Inferred from Genetic Interaction more info	PubMed
involved_in negative regulation of cell growth	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in negative regulation of cell population proliferation	IBA Inferred from Biological aspect of Ancestor more info
involved_in negative regulation of cell population proliferation	IGI Inferred from Genetic Interaction more info	PubMed
involved_in negative regulation of cell population proliferation	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in negative regulation of cell size	IGI Inferred from Genetic Interaction more info	PubMed
involved_in negative regulation of cell size	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in negative regulation of developmental growth	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in negative regulation of imaginal disc growth	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in negative regulation of insulin receptor signaling pathway	IGI Inferred from Genetic Interaction more info	PubMed
involved_in negative regulation of insulin receptor signaling pathway	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in negative regulation of organ growth	IGI Inferred from Genetic Interaction more info	PubMed
involved_in negative regulation of organ growth	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in negative regulation of vascular endothelial growth factor receptor signaling pathway	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in oogenesis	IGI Inferred from Genetic Interaction more info	PubMed
involved_in open tracheal system development	HMP more info	PubMed
involved_in positive regulation of TORC2 signaling	IGI Inferred from Genetic Interaction more info	PubMed
involved_in positive regulation of TORC2 signaling	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in positive regulation of hippo signaling	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in positive regulation of macroautophagy	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in regulation of cell cycle	IBA Inferred from Biological aspect of Ancestor more info
involved_in regulation of cell cycle	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in regulation of cell population proliferation	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in regulation of terminal button organization	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in regulation of timing of cell differentiation	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in response to nutrient	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in signal transduction	IGI Inferred from Genetic Interaction more info	PubMed

Component	Evidence Code	Pubs
part_of TSC1-TSC2 complex	IBA Inferred from Biological aspect of Ancestor more info
part_of TSC1-TSC2 complex	IDA Inferred from Direct Assay more info	PubMed
part_of TSC1-TSC2 complex	IPI Inferred from Physical Interaction more info	PubMed
located_in cytoplasm	IDA Inferred from Direct Assay more info	PubMed

General protein information

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Preferred Names: Tsc1

Names: CG6147-PA; TTuberous sclerosis complex 1; Tsc1-PA; hamartin; jolly green giant; rocky; tuberous sclerosis 1; tuberous sclerosis complex 1; tuberous sclerosis complex protein 1

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

NT_033777.3 Reference assembly

Range

24130307..24134654

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

NM_058067.3 → NP_477415.1 Tsc1 [Drosophila melanogaster]

See identical proteins and their annotated locations for NP_477415.1

Status: REVIEWED

UniProtKB/TrEMBL

H1ZYA3, Q9U9A9, Q9VCC9

Related

FBpp0083931

Conserved Domains (2) summary

pfam04388
Location:3 → 715

Hamartin; Hamartin protein

pfam14662
Location:736 → 915

KASH_CCD; Coiled-coil region of CCDC155 or KASH