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Cervix disorder

MedGen UID:
2970
•Concept ID:
C0007867
•
Disease or Syndrome
Synonym: Cervix disease
SNOMED CT: Disease of cervix (63339007); Disorder of uterine cervix (63339007); Disorder of cervix (63339007)
 
Monarch Initiative: MONDO:0002256

Definition

A non-neoplastic or neoplastic disorder that affects the cervix. Representative examples include cervicitis, endocervical polyp, and carcinoma. [from NCI]

Term Hierarchy

CClinical test,  RResearch test,  OOMIM,  GGeneReviews,  VClinVar  
  • CROGVCervix disorder

Professional guidelines

PubMed

NRG Oncology/RTOG Consensus Guidelines for Delineation of Clinical Target Volume for Intensity Modulated Pelvic Radiation Therapy in Postoperative Treatment of Endometrial and Cervical Cancer: An Update.
Small W Jr, Bosch WR, Harkenrider MM, Strauss JB, Abu-Rustum N, Albuquerque KV, Beriwal S, Creutzberg CL, Eifel PJ, Erickson BA, Fyles AW, Hentz CL, Jhingran A, Klopp AH, Kunos CA, Mell LK, Portelance L, Powell ME, Viswanathan AN, Yacoub JH, Yashar CM, Winter KA, Gaffney DK
Int J Radiat Oncol Biol Phys 2021 Feb 1;109(2):413-424. Epub 2020 Sep 6 doi: 10.1016/j.ijrobp.2020.08.061. PMID: 32905846Free PMC Article
2019 ASCCP Risk-Based Management Consensus Guidelines for Abnormal Cervical Cancer Screening Tests and Cancer Precursors.
Perkins RB, Guido RS, Castle PE, Chelmow D, Einstein MH, Garcia F, Huh WK, Kim JJ, Moscicki AB, Nayar R, Saraiya M, Sawaya GF, Wentzensen N, Schiffman M; 2019 ASCCP Risk-Based Management Consensus Guidelines Committee
J Low Genit Tract Dis 2020 Apr;24(2):102-131. doi: 10.1097/LGT.0000000000000525. PMID: 32243307Free PMC Article
ACOG Practice Bulletin No.142: Cerclage for the management of cervical insufficiency.
Obstet Gynecol 2014 Feb;123(2 Pt 1):372-379. doi: 10.1097/01.AOG.0000443276.68274.cc. PMID: 24451674

Recent clinical studies

Etiology

Cervical Pessary for Prevention of Preterm Birth in Individuals With a Short Cervix: The TOPS Randomized Clinical Trial.
Hoffman MK, Clifton RG, Biggio JR, Saade GR, Ugwu LG, Longo M, Bousleiman SZ, Clark K, Grobman WA, Frey HA, Chauhan SP, Dugoff L, Manuck TA, Chien EK, Rouse DJ, Simhan HN, Esplin MS, Macones GA; National Institute of Child Health and Human Development Maternal-Fetal Medicine Units (MFMU) Network
JAMA 2023 Jul 25;330(4):340-348. doi: 10.1001/jama.2023.10812. PMID: 37490086Free PMC Article
The developing spectrum of gastric-type cervical glandular lesions.
Talia KL, McCluggage WG
Pathology 2018 Feb;50(2):122-133. Epub 2017 Dec 9 doi: 10.1016/j.pathol.2017.09.009. PMID: 29233547
Short cervix syndrome: current knowledge from etiology to the control.
Guimarães Filho HA, Araujo Júnior E, Pires CR, Nardozza LM, Moron AF
Arch Gynecol Obstet 2013 Apr;287(4):621-8. Epub 2013 Feb 7 doi: 10.1007/s00404-013-2740-0. PMID: 23389247
Clinical management of the short cervix.
Mateus J
Obstet Gynecol Clin North Am 2011 Jun;38(2):367-85, xi-xii. doi: 10.1016/j.ogc.2011.02.020. PMID: 21575806
Understanding cervical cytology.
Beal MW
Nurse Pract 1987 Mar;12(3):8-10, 15, 18-22. PMID: 3561907

Diagnosis

Short cervix syndrome: current knowledge from etiology to the control.
Guimarães Filho HA, Araujo Júnior E, Pires CR, Nardozza LM, Moron AF
Arch Gynecol Obstet 2013 Apr;287(4):621-8. Epub 2013 Feb 7 doi: 10.1007/s00404-013-2740-0. PMID: 23389247
2011 colposcopic terminology of the International Federation for Cervical Pathology and Colposcopy.
Bornstein J, Bentley J, Bösze P, Girardi F, Haefner H, Menton M, Perrotta M, Prendiville W, Russell P, Sideri M, Strander B, Tatti S, Torne A, Walker P
Obstet Gynecol 2012 Jul;120(1):166-72. doi: 10.1097/AOG.0b013e318254f90c. PMID: 22914406
Special considerations for women with IBD.
Moleski SM, Choudhary C
Gastroenterol Clin North Am 2011 Jun;40(2):387-98, viii-ix. doi: 10.1016/j.gtc.2011.03.003. PMID: 21601786
Imaging of cervical pathology.
Rezvani M, Shaaban A
Clin Obstet Gynecol 2009 Mar;52(1):94-111. doi: 10.1097/GRF.0b013e31819617f1. PMID: 19179863
Cervical insufficiency.
Bengtsson LP
Acta Obstet Gynecol Scand 1968;47(S1):7-35. doi: 10.3109/00016346809156843. PMID: 4875705

Therapy

Cervical Pessary for Prevention of Preterm Birth in Individuals With a Short Cervix: The TOPS Randomized Clinical Trial.
Hoffman MK, Clifton RG, Biggio JR, Saade GR, Ugwu LG, Longo M, Bousleiman SZ, Clark K, Grobman WA, Frey HA, Chauhan SP, Dugoff L, Manuck TA, Chien EK, Rouse DJ, Simhan HN, Esplin MS, Macones GA; National Institute of Child Health and Human Development Maternal-Fetal Medicine Units (MFMU) Network
JAMA 2023 Jul 25;330(4):340-348. doi: 10.1001/jama.2023.10812. PMID: 37490086Free PMC Article
Vaginal progesterone for preventing preterm birth and adverse perinatal outcomes in singleton gestations with a short cervix: a meta-analysis of individual patient data.
Romero R, Conde-Agudelo A, Da Fonseca E, O'Brien JM, Cetingoz E, Creasy GW, Hassan SS, Nicolaides KH
Am J Obstet Gynecol 2018 Feb;218(2):161-180. Epub 2017 Nov 17 doi: 10.1016/j.ajog.2017.11.576. PMID: 29157866Free PMC Article
Overview of the benefits and potential issues of the nonavalent HPV vaccine.
Mariani L, Preti M, Cristoforoni P, Stigliano CM, Perino A
Int J Gynaecol Obstet 2017 Mar;136(3):258-265. Epub 2017 Jan 14 doi: 10.1002/ijgo.12075. PMID: 28087890
Human papillomavirus vaccination: where are we now?
Brotherton JM
J Paediatr Child Health 2014 Dec;50(12):959-65. Epub 2014 Jun 9 doi: 10.1111/jpc.12627. PMID: 24909919
Cervical insufficiency.
Bengtsson LP
Acta Obstet Gynecol Scand 1968;47(S1):7-35. doi: 10.3109/00016346809156843. PMID: 4875705

Prognosis

Late Toxicity After Adjuvant Conventional Radiation Versus Image-Guided Intensity-Modulated Radiotherapy for Cervical Cancer (PARCER): A Randomized Controlled Trial.
Chopra S, Gupta S, Kannan S, Dora T, Engineer R, Mangaj A, Maheshwari A, Shylasree TS, Ghosh J, Paul SN, Phurailatpam R, Charnalia M, Alone M, Swamidas J, Mahantshetty U, Deodhar K, Kerkar R, Shrivastava SK
J Clin Oncol 2021 Nov 20;39(33):3682-3692. Epub 2021 Sep 10 doi: 10.1200/JCO.20.02530. PMID: 34506246
Worldwide trends in cervical cancer incidence and mortality, with predictions for the next 15 years.
Lin S, Gao K, Gu S, You L, Qian S, Tang M, Wang J, Chen K, Jin M
Cancer 2021 Nov 1;127(21):4030-4039. Epub 2021 Aug 9 doi: 10.1002/cncr.33795. PMID: 34368955
A Review of Cervical Cancer: Incidence and Disparities.
Buskwofie A, David-West G, Clare CA
J Natl Med Assoc 2020 Apr;112(2):229-232. Epub 2020 Apr 8 doi: 10.1016/j.jnma.2020.03.002. PMID: 32278478
Estimates of incidence and mortality of cervical cancer in 2018: a worldwide analysis.
Arbyn M, Weiderpass E, Bruni L, de Sanjosé S, Saraiya M, Ferlay J, Bray F
Lancet Glob Health 2020 Feb;8(2):e191-e203. Epub 2019 Dec 4 doi: 10.1016/S2214-109X(19)30482-6. PMID: 31812369Free PMC Article
Cervical Cancer Prevalence, Incidence and Mortality in Low and Middle Income Countries: A Systematic Review.
Shrestha AD, Neupane D, Vedsted P, Kallestrup P
Asian Pac J Cancer Prev 2018 Feb 26;19(2):319-324. doi: 10.22034/APJCP.2018.19.2.319. PMID: 29479954Free PMC Article

Clinical prediction guides

Advancements in the Application of Ultrasound Elastography in the Cervix.
Shao J, Shi G, Qi Z, Zheng J, Chen S
Ultrasound Med Biol 2021 Aug;47(8):2048-2063. Epub 2021 May 26 doi: 10.1016/j.ultrasmedbio.2021.04.009. PMID: 34049726
Short cervix syndrome: current knowledge from etiology to the control.
Guimarães Filho HA, Araujo Júnior E, Pires CR, Nardozza LM, Moron AF
Arch Gynecol Obstet 2013 Apr;287(4):621-8. Epub 2013 Feb 7 doi: 10.1007/s00404-013-2740-0. PMID: 23389247
Screening for cervical cancer.
Guidozzi F
Obstet Gynecol Surv 1996 Apr;51(4):247-52. doi: 10.1097/00006254-199604000-00021. PMID: 8657401
Spontaneously changing gravid cervix: clinical implications and prognostic features.
Hertzberg BS, Kliewer MA, Farrell TA, DeLong DM
Radiology 1995 Sep;196(3):721-4. doi: 10.1148/radiology.196.3.7644635. PMID: 7644635
Nurse-midwifery evaluation and management of cervical pathology and the colposcopic examination.
Worthington S, Rubin M
J Nurse Midwifery 1993 Mar-Apr;38(2 Suppl):36S-41S. doi: 10.1016/0091-2182(93)90095-x. PMID: 8387104

Recent systematic reviews

Global and regional estimates of genital human papillomavirus prevalence among men: a systematic review and meta-analysis.
Bruni L, Albero G, Rowley J, Alemany L, Arbyn M, Giuliano AR, Markowitz LE, Broutet N, Taylor M
Lancet Glob Health 2023 Sep;11(9):e1345-e1362. doi: 10.1016/S2214-109X(23)00305-4. PMID: 37591583Free PMC Article
Human papillomavirus vaccine effectiveness by age at vaccination: A systematic review.
Ellingson MK, Sheikha H, Nyhan K, Oliveira CR, Niccolai LM
Hum Vaccin Immunother 2023 Aug 1;19(2):2239085. doi: 10.1080/21645515.2023.2239085. PMID: 37529935Free PMC Article
Systematic review and meta-analysis of prediction models used in cervical cancer.
Jha AK, Mithun S, Sherkhane UB, Jaiswar V, Osong B, Purandare N, Kannan S, Prabhash K, Gupta S, Vanneste B, Rangarajan V, Dekker A, Wee L
Artif Intell Med 2023 May;139:102549. Epub 2023 Apr 11 doi: 10.1016/j.artmed.2023.102549. PMID: 37100501
Role of human papillomavirus (HPV) vaccination on HPV infection and recurrence of HPV related disease after local surgical treatment: systematic review and meta-analysis.
Kechagias KS, Kalliala I, Bowden SJ, Athanasiou A, Paraskevaidi M, Paraskevaidis E, Dillner J, Nieminen P, Strander B, Sasieni P, Veroniki AA, Kyrgiou M
BMJ 2022 Aug 3;378:e070135. doi: 10.1136/bmj-2022-070135. PMID: 35922074Free PMC Article
Cervical Cancer Prevalence, Incidence and Mortality in Low and Middle Income Countries: A Systematic Review.
Shrestha AD, Neupane D, Vedsted P, Kallestrup P
Asian Pac J Cancer Prev 2018 Feb 26;19(2):319-324. doi: 10.22034/APJCP.2018.19.2.319. PMID: 29479954Free PMC Article

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