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Cervical Squamous Neoplasm

MedGen UID:
275712
•Concept ID:
C1516434
•
Neoplastic Process
Synonym: Cervical Squamous Tumor

Definition

A benign, precancerous, or malignant neoplasm that arises from the squamous epithelium of the cervix. Representative examples include condyloma acuminatum, cervical intraepithelial neoplasia, and squamous cell carcinoma. [from NCI]

Term Hierarchy

CClinical test,  RResearch test,  OOMIM,  GGeneReviews,  VClinVar  
  • CROGVCervical Squamous Neoplasm

Professional guidelines

PubMed

International Consensus Statement on Allergy and Rhinology: Sinonasal Tumors.
Kuan EC, Wang EW, Adappa ND, Beswick DM, London NR Jr, Su SY, Wang MB, Abuzeid WM, Alexiev B, Alt JA, Antognoni P, Alonso-Basanta M, Batra PS, Bhayani M, Bell D, Bernal-Sprekelsen M, Betz CS, Blay JY, Bleier BS, Bonilla-Velez J, Callejas C, Carrau RL, Casiano RR, Castelnuovo P, Chandra RK, Chatzinakis V, Chen SB, Chiu AG, Choby G, Chowdhury NI, Citardi MJ, Cohen MA, Dagan R, Dalfino G, Dallan I, Dassi CS, de Almeida J, Dei Tos AP, DelGaudio JM, Ebert CS, El-Sayed IH, Eloy JA, Evans JJ, Fang CH, Farrell NF, Ferrari M, Fischbein N, Folbe A, Fokkens WJ, Fox MG, Lund VJ, Gallia GL, Gardner PA, Geltzeiler M, Georgalas C, Getz AE, Govindaraj S, Gray ST, Grayson JW, Gross BA, Grube JG, Guo R, Ha PK, Halderman AA, Hanna EY, Harvey RJ, Hernandez SC, Holtzman AL, Hopkins C, Huang Z, Huang Z, Humphreys IM, Hwang PH, Iloreta AM, Ishii M, Ivan ME, Jafari A, Kennedy DW, Khan M, Kimple AJ, Kingdom TT, Knisely A, Kuo YJ, Lal D, Lamarre ED, Lan MY, Le H, Lechner M, Lee NY, Lee JK, Lee VH, Levine CG, Lin JC, Lin DT, Lobo BC, Locke T, Luong AU, Magliocca KR, Markovic SN, Matnjani G, McKean EL, Meço C, Mendenhall WM, Michel L, Na'ara S, Nicolai P, Nuss DW, Nyquist GG, Oakley GM, Omura K, Orlandi RR, Otori N, Papagiannopoulos P, Patel ZM, Pfister DG, Phan J, Psaltis AJ, Rabinowitz MR, Ramanathan M Jr, Rimmer R, Rosen MR, Sanusi O, Sargi ZB, Schafhausen P, Schlosser RJ, Sedaghat AR, Senior BA, Shrivastava R, Sindwani R, Smith TL, Smith KA, Snyderman CH, Solares CA, Sreenath SB, Stamm A, Stölzel K, Sumer B, Surda P, Tajudeen BA, Thompson LDR, Thorp BD, Tong CCL, Tsang RK, Turner JH, Turri-Zanoni M, Udager AM, van Zele T, VanKoevering K, Welch KC, Wise SK, Witterick IJ, Won TB, Wong SN, Woodworth BA, Wormald PJ, Yao WC, Yeh CF, Zhou B, Palmer JN
Int Forum Allergy Rhinol 2024 Feb;14(2):149-608. Epub 2024 Jan 2 doi: 10.1002/alr.23262. PMID: 37658764
HPV-associated oropharyngeal cancer: epidemiology, molecular biology and clinical management.
Lechner M, Liu J, Masterson L, Fenton TR
Nat Rev Clin Oncol 2022 May;19(5):306-327. Epub 2022 Feb 1 doi: 10.1038/s41571-022-00603-7. PMID: 35105976Free PMC Article
Delineation of the primary tumour Clinical Target Volumes (CTV-P) in laryngeal, hypopharyngeal, oropharyngeal and oral cavity squamous cell carcinoma: AIRO, CACA, DAHANCA, EORTC, GEORCC, GORTEC, HKNPCSG, HNCIG, IAG-KHT, LPRHHT, NCIC CTG, NCRI, NRG Oncology, PHNS, SBRT, SOMERA, SRO, SSHNO, TROG consensus guidelines.
Grégoire V, Evans M, Le QT, Bourhis J, Budach V, Chen A, Eisbruch A, Feng M, Giralt J, Gupta T, Hamoir M, Helito JK, Hu C, Hunter K, Johansen J, Kaanders J, Laskar SG, Lee A, Maingon P, Mäkitie A, Micciche' F, Nicolai P, O'Sullivan B, Poitevin A, Porceddu S, Składowski K, Tribius S, Waldron J, Wee J, Yao M, Yom SS, Zimmermann F, Grau C
Radiother Oncol 2018 Jan;126(1):3-24. Epub 2017 Nov 24 doi: 10.1016/j.radonc.2017.10.016. PMID: 29180076

Recent clinical studies

Etiology

MRI-based deep learning and radiomics for prediction of occult cervical lymph node metastasis and prognosis in early-stage oral and oropharyngeal squamous cell carcinoma: a diagnostic study.
Lan T, Kuang S, Liang P, Ning C, Li Q, Wang L, Wang Y, Lin Z, Hu H, Yang L, Li J, Liu J, Li Y, Wu F, Chai H, Song X, Huang Y, Duan X, Zeng D, Li J, Cao H
Int J Surg 2024 Aug 1;110(8):4648-4659. doi: 10.1097/JS9.0000000000001578. PMID: 38729119Free PMC Article
PET-MR Imaging in Head and Neck.
Lee YZ, Ramalho J, Kessler B
Magn Reson Imaging Clin N Am 2017 May;25(2):315-324. Epub 2017 Feb 14 doi: 10.1016/j.mric.2016.12.008. PMID: 28390531
A meta-analysis on selective versus comprehensive neck dissection in oral squamous cell carcinoma patients with clinically node-positive neck.
Liang L, Zhang T, Kong Q, Liang J, Liao G
Oral Oncol 2015 Dec;51(12):1076-81. Epub 2015 Oct 23 doi: 10.1016/j.oraloncology.2015.10.005. PMID: 26500065
Evaluation and staging of the neck in patients with malignant disease.
Shum JW, Dierks EJ
Oral Maxillofac Surg Clin North Am 2014 May;26(2):209-21. Epub 2014 Mar 20 doi: 10.1016/j.coms.2014.01.007. PMID: 24656885
Branchiogenic carcinoma.
Black B, Maran AG
Clin Otolaryngol Allied Sci 1978 Feb;3(1):27-36. doi: 10.1111/j.1365-2273.1978.tb00662.x. PMID: 648005

Diagnosis

PET-MR Imaging in Head and Neck.
Lee YZ, Ramalho J, Kessler B
Magn Reson Imaging Clin N Am 2017 May;25(2):315-324. Epub 2017 Feb 14 doi: 10.1016/j.mric.2016.12.008. PMID: 28390531
(18)F-Fluorodeoxyglucose PET/MR Imaging in Head and Neck Cancer.
Platzek I
PET Clin 2016 Oct;11(4):375-86. Epub 2016 Jul 7 doi: 10.1016/j.cpet.2016.05.002. PMID: 27593244
Cervical lymph node evaluation and diagnosis.
Bryson TC, Shah GV, Srinivasan A, Mukherji SK
Otolaryngol Clin North Am 2012 Dec;45(6):1363-83. doi: 10.1016/j.otc.2012.08.007. PMID: 23153753
Submandibular and sublingual spaces: diagnostic imaging and evaluation.
Agarwal AK, Kanekar SG
Otolaryngol Clin North Am 2012 Dec;45(6):1311-23. doi: 10.1016/j.otc.2012.08.005. PMID: 23153751
Retropharyngeal and prevertebral spaces: anatomic imaging and diagnosis.
Debnam JM, Guha-Thakurta N
Otolaryngol Clin North Am 2012 Dec;45(6):1293-310. doi: 10.1016/j.otc.2012.08.004. PMID: 23153750Free PMC Article

Therapy

Iatrogenic Cervical Epidermoid Cyst Following Tracheostomy.
Kim MS, Lee M, Lee JC, Sung ES
Ear Nose Throat J 2024 May;103(5):NP256-NP258. Epub 2021 Oct 20 doi: 10.1177/01455613211053423. PMID: 34670428
Comparison of second-line treatments of recurrent and/or metastatic squamous cell carcinoma of the head and neck.
El Rassy E, Assi T, Bakouny Z, El Karak F, Pavlidis N, Ghosn M
Future Oncol 2019 Mar;15(8):909-923. Epub 2019 Jan 23 doi: 10.2217/fon-2018-0663. PMID: 30669875
Prognostic factors, predictive markers and cancer biology: the triad for successful oral cancer chemoprevention.
Monteiro de Oliveira Novaes JA, William WN Jr
Future Oncol 2016 Oct;12(20):2379-86. Epub 2016 Jun 22 doi: 10.2217/fon-2016-0168. PMID: 27329013Free PMC Article
The current role of systemic chemotherapy in the primary treatment of head and neck cancer.
Busch CJ, Tribius S, Schafhausen P, Knecht R
Cancer Treat Rev 2015 Mar;41(3):217-21. Epub 2015 Feb 7 doi: 10.1016/j.ctrv.2015.02.002. PMID: 25687982
Neck dissection: past and present.
Ducic Y, Young L, McIntyre J
Minerva Chir 2010 Feb;65(1):45-58. PMID: 20212417

Prognosis

Management of Subglottic Cancer.
Mann H, Seligman K, Colwell N, Burr A, Glazer TA
Otolaryngol Clin North Am 2023 Apr;56(2):305-312. doi: 10.1016/j.otc.2022.11.001. PMID: 37030943
Survival outcomes after treatment of cancer of the oral cavity (1985-2015).
Zanoni DK, Montero PH, Migliacci JC, Shah JP, Wong RJ, Ganly I, Patel SG
Oral Oncol 2019 Mar;90:115-121. Epub 2019 Feb 15 doi: 10.1016/j.oraloncology.2019.02.001. PMID: 30846169Free PMC Article
Dynamic Contrast-Enhanced MR Imaging in Head and Neck Cancer.
Kabadi SJ, Fatterpekar GM, Anzai Y, Mogen J, Hagiwara M, Patel SH
Magn Reson Imaging Clin N Am 2018 Feb;26(1):135-149. Epub 2017 Oct 21 doi: 10.1016/j.mric.2017.08.008. PMID: 29128001
Diffusion-Weighted Imaging in Head and Neck Cancer: Technique, Limitations, and Applications.
Connolly M, Srinivasan A
Magn Reson Imaging Clin N Am 2018 Feb;26(1):121-133. Epub 2017 Oct 14 doi: 10.1016/j.mric.2017.08.011. PMID: 29128000
Neck dissection: past and present.
Ducic Y, Young L, McIntyre J
Minerva Chir 2010 Feb;65(1):45-58. PMID: 20212417

Clinical prediction guides

MRI-based deep learning and radiomics for prediction of occult cervical lymph node metastasis and prognosis in early-stage oral and oropharyngeal squamous cell carcinoma: a diagnostic study.
Lan T, Kuang S, Liang P, Ning C, Li Q, Wang L, Wang Y, Lin Z, Hu H, Yang L, Li J, Liu J, Li Y, Wu F, Chai H, Song X, Huang Y, Duan X, Zeng D, Li J, Cao H
Int J Surg 2024 Aug 1;110(8):4648-4659. doi: 10.1097/JS9.0000000000001578. PMID: 38729119Free PMC Article
Surgical Management of the Neck in Oral Cavity Squamous Cell Carcinoma.
Mihulka O, Nisenbaum E, Nicolli E
Crit Rev Oncog 2024;29(3):25-31. doi: 10.1615/CritRevOncog.2023050817. PMID: 38683152
Update from the 5th Edition of the World Health Organization Classification of Head and Neck Tumors: Hypopharynx, Larynx, Trachea and Parapharyngeal Space.
Zidar N, Gale N
Head Neck Pathol 2022 Mar;16(1):31-39. Epub 2022 Mar 21 doi: 10.1007/s12105-021-01405-6. PMID: 35312977Free PMC Article
Dynamic Contrast-Enhanced MR Imaging in Head and Neck Cancer.
Kabadi SJ, Fatterpekar GM, Anzai Y, Mogen J, Hagiwara M, Patel SH
Magn Reson Imaging Clin N Am 2018 Feb;26(1):135-149. Epub 2017 Oct 21 doi: 10.1016/j.mric.2017.08.008. PMID: 29128001
Diffusion-Weighted Imaging in Head and Neck Cancer: Technique, Limitations, and Applications.
Connolly M, Srinivasan A
Magn Reson Imaging Clin N Am 2018 Feb;26(1):121-133. Epub 2017 Oct 14 doi: 10.1016/j.mric.2017.08.011. PMID: 29128000

Recent systematic reviews

Accuracy of artificial intelligence-assisted detection of Oral Squamous Cell Carcinoma: A systematic review and meta-analysis.
Elmakaty I, Elmarasi M, Amarah A, Abdo R, Malki MI
Crit Rev Oncol Hematol 2022 Oct;178:103777. Epub 2022 Aug 2 doi: 10.1016/j.critrevonc.2022.103777. PMID: 35931404
Elective neck dissection in salivary gland malignancies: Systematic review and meta-analysis.
Yan F, Lao WP, Nguyen SA, Sharma AK, Day TA
Head Neck 2022 Feb;44(2):505-517. Epub 2021 Dec 4 doi: 10.1002/hed.26923. PMID: 34862810
Human Papillomavirus-Related Multiphenotypic Sinonasal Carcinoma-An Even Broader Tumor Entity?
Zupancic M, Näsman A
Viruses 2021 Sep 17;13(9) doi: 10.3390/v13091861. PMID: 34578442Free PMC Article
Human papillomavirus infection and oral squamous cell carcinoma - a systematic review.
Melo BAC, Vilar LG, Oliveira NR, Lima PO, Pinheiro MB, Domingueti CP, Pereira MC
Braz J Otorhinolaryngol 2021 May-Jun;87(3):346-352. Epub 2020 Nov 29 doi: 10.1016/j.bjorl.2020.10.017. PMID: 33339760Free PMC Article
Elective neck treatment in sinonasal undifferentiated carcinoma: Systematic review and meta-analysis.
Faisal M, Seemann R, Lill C, Hamzavi S, Wutzl A, Erovic BM, Janik S
Head Neck 2020 May;42(5):1057-1066. Epub 2020 Jan 10 doi: 10.1002/hed.26077. PMID: 31922316Free PMC Article

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