Full Report

Format

Full Report
Summary (Text)
Summary (XML)

Send to:

Choose Destination

File
Clipboard
Collections

Low Grade Cervical Squamous Intraepithelial Neoplasia

MedGen UID:: 309333
•Concept ID:: C1518005
•: Neoplastic Process

Synonyms:

Cervical Squamous Intraepithelial Neoplasia 1; Low Grade Cervical Squamous Intraepithelial Lesion; Low-Grade Cervical SIL; Low-Grade Cervical Squamous Intraepithelial Lesion; Low-Grade CIN; Mild Squamous Dysplasia of the Cervix

Definition

A precancerous neoplastic process that affects the cervical squamous epithelium without evidence of invasion. It is usually associated with human papillomavirus infection. It is characterized by the presence of mild atypia in the superficial epithelial layer that may be associated with koilocytosis. Maturation is present in the upper two thirds of the epithelium. Mitotic figures are not numerous and are present in the basal third of the epithelium. [from NCI]

Term Hierarchy

GTR
MeSH

CClinical test, RResearch test, OOMIM, GGeneReviews, VClinVar

CROGVLow Grade Cervical Squamous Intraepithelial Neoplasia

Disorder of the genitourinary system
- Reproductive system disorder
  - Female reproductive system disorder
    - Female Reproductive System Precancerous Condition
      - Cervical intraepithelial neoplasia
        Cervical squamous intraepithelial neoplasia
        Low Grade Cervical Squamous Intraepithelial Neoplasia
        Cervical Squamous Intraepithelial Neoplasia 1

Professional guidelines

PubMed

Prevalence of human papillomavirus genotypes and precancerous cervical lesions in a screening population in the Republic of Korea, 2014-2016.

Ouh YT, Min KJ, Cho HW, Ki M, Oh JK, Shin SY, Hong JH, Lee JK
J Gynecol Oncol 2018 Jan;29(1):e14. doi: 10.3802/jgo.2018.29.e14. PMID: 29185272 Free PMC Article

See all (1)

Recent clinical studies

Etiology

The recent natural history of human papillomavirus cervical infection in women living with HIV: A scoping review of meta-analyses and systematic reviews and the construction of a hypothetical model.

Gilles C, Konopnicki D, Rozenberg S
HIV Med 2023 Aug;24(8):877-892. Epub 2023 Apr 16 doi: 10.1111/hiv.13490. PMID: 37062862

The European Society of Gynaecological Oncology (ESGO), the International Society for the Study of Vulvovaginal Disease (ISSVD), the European College for the Study of Vulval Disease (ECSVD), and the European Federation for Colposcopy (EFC) consensus statement on the management of vaginal intraepithelial neoplasia.

Kesic V, Carcopino X, Preti M, Vieira-Baptista P, Bevilacqua F, Bornstein J, Chargari C, Cruickshank M, Erzeneoglu E, Gallio N, Gultekin M, Heller D, Joura E, Kyrgiou M, Madić T, Planchamp F, Regauer S, Reich O, Esat Temiz B, Woelber L, Zodzika J, Stockdale C
Int J Gynecol Cancer 2023 Apr 3;33(4):446-461. doi: 10.1136/ijgc-2022-004213. PMID: 36958755 Free PMC Article

Severe cervical inflammation and high-grade squamous intraepithelial lesions: a cross-sectional study.

Long T, Long L, Chen Y, Li Y, Tuo Y, Hu Y, Xie L, He G, Zhao W, Lu X, Lin Z
Arch Gynecol Obstet 2021 Feb;303(2):547-556. Epub 2020 Sep 26 doi: 10.1007/s00404-020-05804-y. PMID: 32980959

Differences Between Squamous Intraepithelial Lesions of the Vulva and the Cervix.

Maclean AB, Jones RW
J Low Genit Tract Dis 2020 Jul;24(3):330-331. doi: 10.1097/LGT.0000000000000545. PMID: 32501869

Cervical intraepithelial neoplasia.

Crum CP, McLachlin CM
J Cell Biochem Suppl 1995;23:71-9. doi: 10.1002/jcb.240590910. PMID: 8747380

See all (1124)

Diagnosis

Update from the 5th Edition of the World Health Organization Classification of Head and Neck Tumors: Hypopharynx, Larynx, Trachea and Parapharyngeal Space.

Zidar N, Gale N
Head Neck Pathol 2022 Mar;16(1):31-39. Epub 2022 Mar 21 doi: 10.1007/s12105-021-01405-6. PMID: 35312977 Free PMC Article

A Unique Lesion of the Esophageal Mucosal Epithelium: Low-grade Intraepithelial Neoplasia or Basal-layer-type Squamous Cell Carcinoma?

Zhao Y, Fu YW, Sun Q
Chin Med J (Engl) 2017 Jul 5;130(13):1619-1620. doi: 10.4103/0366-6999.208230. PMID: 28639581 Free PMC Article

Raman spectroscopy for screening and diagnosis of cervical cancer.

Lyng FM, Traynor D, Ramos IR, Bonnier F, Byrne HJ
Anal Bioanal Chem 2015 Nov;407(27):8279-89. Epub 2015 Aug 16 doi: 10.1007/s00216-015-8946-1. PMID: 26277185

Histology of cervical intraepithelial neoplasia and the role of biomarkers.

Martin CM, O'Leary JJ
Best Pract Res Clin Obstet Gynaecol 2011 Oct;25(5):605-15. Epub 2011 Jun 1 doi: 10.1016/j.bpobgyn.2011.04.005. PMID: 21636328

Cervical intraepithelial neoplasia.

Crum CP, McLachlin CM
J Cell Biochem Suppl 1995;23:71-9. doi: 10.1002/jcb.240590910. PMID: 8747380

See all (1082)

Therapy

Cervical Screening and Colposcopy Management of Women Age 24 and Under.

Buick C, Jembere N, Wang L, Kupets R
J Obstet Gynaecol Can 2020 Dec;42(12):1518-1524. Epub 2020 Jul 1 doi: 10.1016/j.jogc.2020.06.013. PMID: 32988802

HPV testing and vaccination in Europe.

Leeson SC, Alibegashvili T, Arbyn M, Bergeron C, Carriero C, Mergui JL, Nieminen P, Prendiville W, Redman CW, Rieck GC, Quaas J, Petry KU
J Low Genit Tract Dis 2014 Jan;18(1):61-9. doi: 10.1097/LGT.0b013e318286b8d3. PMID: 23774078

LUMA cervical imaging system.

Kendrick JE, Huh WK, Alvarez RD
Expert Rev Med Devices 2007 Mar;4(2):121-9. doi: 10.1586/17434440.4.2.121. PMID: 17359219

Cervical intraepithelial neoplasia.

Crum CP, McLachlin CM
J Cell Biochem Suppl 1995;23:71-9. doi: 10.1002/jcb.240590910. PMID: 8747380

See all (224)

Prognosis

Clinical Regression of High-Grade Cervical Intraepithelial Neoplasia Is Associated With Absence of FAM19A4/miR124-2 DNA Methylation (CONCERVE Study).

Kremer WW, Dick S, Heideman DAM, Steenbergen RDM, Bleeker MCG, Verhoeve HR, van Baal WM, van Trommel N, Kenter GG, Meijer CJLM, Berkhof J
J Clin Oncol 2022 Sep 10;40(26):3037-3046. Epub 2022 May 5 doi: 10.1200/JCO.21.02433. PMID: 35512257 Free PMC Article

Update from the 5th Edition of the World Health Organization Classification of Head and Neck Tumors: Hypopharynx, Larynx, Trachea and Parapharyngeal Space.

Zidar N, Gale N
Head Neck Pathol 2022 Mar;16(1):31-39. Epub 2022 Mar 21 doi: 10.1007/s12105-021-01405-6. PMID: 35312977 Free PMC Article

Can We Reduce Overtreatment of Cervical High-Grade Squamous Intraepithelial Lesions?

Bradbury M, Rabasa J, Murcia MT, Dinarès MC, Sainz A, Castellet C, Pérez-Benavente A, Gil-Moreno A, Centeno C
J Low Genit Tract Dis 2022 Jan 1;26(1):20-26. doi: 10.1097/LGT.0000000000000635. PMID: 34928250

The role of endocervicoscopy in women with cervical intraepithelial neoplasia: a systematic review of the literature.

Della Corte L, Mercorio A, Giampaolino P, Vitale SG, Vizzielli G, Bifulco G, Lavitola G
Updates Surg 2022 Aug;74(4):1239-1245. Epub 2021 Nov 5 doi: 10.1007/s13304-021-01193-2. PMID: 34739708

Histology of cervical intraepithelial neoplasia and the role of biomarkers.

Martin CM, O'Leary JJ
Best Pract Res Clin Obstet Gynaecol 2011 Oct;25(5):605-15. Epub 2011 Jun 1 doi: 10.1016/j.bpobgyn.2011.04.005. PMID: 21636328

See all (614)

Clinical prediction guides

Cervical Cancer Screening: A Review.

Perkins RB, Wentzensen N, Guido RS, Schiffman M
JAMA 2023 Aug 8;330(6):547-558. doi: 10.1001/jama.2023.13174. PMID: 37552298

Colposcopy Standards: Guidelines for Endocervical Curettage at Colposcopy.

Massad LS, Perkins RB, Naresh A, Nelson EL, Spiryda L, Gecsi KS, Mulhem E, Kostas-Polston E, Zou T, Giles TL, Wentzensen N
J Low Genit Tract Dis 2023 Jan 1;27(1):97-101. Epub 2022 Oct 12 doi: 10.1097/LGT.0000000000000710. PMID: 36222824 Free PMC Article

Update from the 5th Edition of the World Health Organization Classification of Head and Neck Tumors: Hypopharynx, Larynx, Trachea and Parapharyngeal Space.

Zidar N, Gale N
Head Neck Pathol 2022 Mar;16(1):31-39. Epub 2022 Mar 21 doi: 10.1007/s12105-021-01405-6. PMID: 35312977 Free PMC Article

Can We Reduce Overtreatment of Cervical High-Grade Squamous Intraepithelial Lesions?

Histology of cervical intraepithelial neoplasia and the role of biomarkers.

Martin CM, O'Leary JJ
Best Pract Res Clin Obstet Gynaecol 2011 Oct;25(5):605-15. Epub 2011 Jun 1 doi: 10.1016/j.bpobgyn.2011.04.005. PMID: 21636328

See all (649)

Recent systematic reviews

The role of endocervicoscopy in women with cervical intraepithelial neoplasia: a systematic review of the literature.

Della Corte L, Mercorio A, Giampaolino P, Vitale SG, Vizzielli G, Bifulco G, Lavitola G
Updates Surg 2022 Aug;74(4):1239-1245. Epub 2021 Nov 5 doi: 10.1007/s13304-021-01193-2. PMID: 34739708

Cervical Stratified Mucin-Producing Intraepithelial Lesion: A Systematic Review of Diagnosis and Management.

Wolf JL, Billingsley CC, Kendler A, Jackson AL
J Low Genit Tract Dis 2020 Jul;24(3):259-264. doi: 10.1097/LGT.0000000000000536. PMID: 32332219

The use of human papillomavirus DNA methylation in cervical intraepithelial neoplasia: A systematic review and meta-analysis.

Bowden SJ, Kalliala I, Veroniki AA, Arbyn M, Mitra A, Lathouras K, Mirabello L, Chadeau-Hyam M, Paraskevaidis E, Flanagan JM, Kyrgiou M
EBioMedicine 2019 Dec;50:246-259. Epub 2019 Nov 12 doi: 10.1016/j.ebiom.2019.10.053. PMID: 31732479 Free PMC Article

Guidelines for Cervical Cancer Screening in Immunosuppressed Women Without HIV Infection.

Moscicki AB, Flowers L, Huchko MJ, Long ME, MacLaughlin KL, Murphy J, Spiryda LB, Gold MA
J Low Genit Tract Dis 2019 Apr;23(2):87-101. doi: 10.1097/LGT.0000000000000468. PMID: 30907775

Colposcopic triage methods for detecting cervical intraepithelial neoplasia grade 3 after cytopathological diagnosis of low-grade squamous intraepithelial lesion: a systematic review on diagnostic tests.

Corrêa Fde M, Russomano FB, Oliveira CA
Sao Paulo Med J 2012;130(1):44-52. doi: 10.1590/s1516-31802012000100008. PMID: 22344359 Free PMC Article

See all (31)

MedGen

National Center for Biotechnology Information

Send to:

Low Grade Cervical Squamous Intraepithelial Neoplasia

Definition

Term Hierarchy

Professional guidelines

PubMed

Recent clinical studies

Etiology

Diagnosis

Therapy

Prognosis

Clinical prediction guides

Recent systematic reviews

Supplemental Content

Table of contents

Practice guidelines

Related information

Recent activity