U.S. flag

An official website of the United States government

Format

Send to:

Choose Destination

Cervix squamous papilloma

MedGen UID:
237038
•Concept ID:
C1336900
•
Neoplastic Process
Synonym: Cervical squamous cell papilloma
 
HPO: HP:4000153
Monarch Initiative: MONDO:0004788

Definition

A benign tumor arising from the epithelial surface of the cervix and usually caused by Human Papillomavirus infection. [from HPO]

Term Hierarchy

CClinical test,  RResearch test,  OOMIM,  GGeneReviews,  VClinVar  
  • CROGVCervix squamous papilloma

Professional guidelines

PubMed

Eliminating cervical cancer: Promising developments in primary prevention.
Ficht AL, Lapidos-Salaiz I, Phelps BR
Cancer 2020 Jan 15;126(2):242-246. Epub 2019 Sep 26 doi: 10.1002/cncr.32507. PMID: 31557324
Cervical Cancer, Version 3.2019, NCCN Clinical Practice Guidelines in Oncology.
Koh WJ, Abu-Rustum NR, Bean S, Bradley K, Campos SM, Cho KR, Chon HS, Chu C, Clark R, Cohn D, Crispens MA, Damast S, Dorigo O, Eifel PJ, Fisher CM, Frederick P, Gaffney DK, Han E, Huh WK, Lurain JR, Mariani A, Mutch D, Nagel C, Nekhlyudov L, Fader AN, Remmenga SW, Reynolds RK, Tillmanns T, Ueda S, Wyse E, Yashar CM, McMillian NR, Scavone JL
J Natl Compr Canc Netw 2019 Jan;17(1):64-84. doi: 10.6004/jnccn.2019.0001. PMID: 30659131
Cervical cancer: screening, diagnosis and staging.
Tsikouras P, Zervoudis S, Manav B, Tomara E, Iatrakis G, Romanidis C, Bothou A, Galazios G
J BUON 2016 Mar-Apr;21(2):320-5. PMID: 27273940

Recent clinical studies

Etiology

Human Papilloma Virus-Infected Cells.
Cruz-Gregorio A, Aranda-Rivera AK
Subcell Biochem 2023;106:213-226. doi: 10.1007/978-3-031-40086-5_8. PMID: 38159229
Estro-progestin Contraceptives and Risk of Cervical Cancer: A Debated Issue.
Gadducci A, Cosio S, Fruzzetti F
Anticancer Res 2020 Nov;40(11):5995-6002. doi: 10.21873/anticanres.14620. PMID: 33109537
The role of human papilloma virus test in men: First exhaustive review of literature.
Vives A, Cosentino M, Palou J
Actas Urol Esp (Engl Ed) 2020 Mar;44(2):86-93. Epub 2019 Dec 23 doi: 10.1016/j.acuro.2019.08.010. PMID: 31874781
Aerobic vaginitis: no longer a stranger.
Donders GGG, Bellen G, Grinceviciene S, Ruban K, Vieira-Baptista P
Res Microbiol 2017 Nov-Dec;168(9-10):845-858. Epub 2017 May 11 doi: 10.1016/j.resmic.2017.04.004. PMID: 28502874
Cervical cancer: screening, diagnosis and staging.
Tsikouras P, Zervoudis S, Manav B, Tomara E, Iatrakis G, Romanidis C, Bothou A, Galazios G
J BUON 2016 Mar-Apr;21(2):320-5. PMID: 27273940

Diagnosis

Interactions between microbiota and cervical epithelial, immune, and mucus barrier.
Dong M, Dong Y, Bai J, Li H, Ma X, Li B, Wang C, Li H, Qi W, Wang Y, Fan A, Han C, Xue F
Front Cell Infect Microbiol 2023;13:1124591. Epub 2023 Feb 24 doi: 10.3389/fcimb.2023.1124591. PMID: 36909729Free PMC Article
The role of human papilloma virus test in men: First exhaustive review of literature.
Vives A, Cosentino M, Palou J
Actas Urol Esp (Engl Ed) 2020 Mar;44(2):86-93. Epub 2019 Dec 23 doi: 10.1016/j.acuro.2019.08.010. PMID: 31874781
Cervical Cancer, Version 3.2019, NCCN Clinical Practice Guidelines in Oncology.
Koh WJ, Abu-Rustum NR, Bean S, Bradley K, Campos SM, Cho KR, Chon HS, Chu C, Clark R, Cohn D, Crispens MA, Damast S, Dorigo O, Eifel PJ, Fisher CM, Frederick P, Gaffney DK, Han E, Huh WK, Lurain JR, Mariani A, Mutch D, Nagel C, Nekhlyudov L, Fader AN, Remmenga SW, Reynolds RK, Tillmanns T, Ueda S, Wyse E, Yashar CM, McMillian NR, Scavone JL
J Natl Compr Canc Netw 2019 Jan;17(1):64-84. doi: 10.6004/jnccn.2019.0001. PMID: 30659131
Aerobic vaginitis: no longer a stranger.
Donders GGG, Bellen G, Grinceviciene S, Ruban K, Vieira-Baptista P
Res Microbiol 2017 Nov-Dec;168(9-10):845-858. Epub 2017 May 11 doi: 10.1016/j.resmic.2017.04.004. PMID: 28502874
Cervical cancer: screening, diagnosis and staging.
Tsikouras P, Zervoudis S, Manav B, Tomara E, Iatrakis G, Romanidis C, Bothou A, Galazios G
J BUON 2016 Mar-Apr;21(2):320-5. PMID: 27273940

Therapy

Emergency hysterectomy following iatrogenic injury to the descending branch of the uterine artery during colposcopy.
Soleymani Majd H, Yancheva S, Abdul B, Hellner K
BMJ Case Rep 2023 Dec 16;16(12) doi: 10.1136/bcr-2023-255202. PMID: 38103911Free PMC Article
Estro-progestin Contraceptives and Risk of Cervical Cancer: A Debated Issue.
Gadducci A, Cosio S, Fruzzetti F
Anticancer Res 2020 Nov;40(11):5995-6002. doi: 10.21873/anticanres.14620. PMID: 33109537
Eliminating cervical cancer: Promising developments in primary prevention.
Ficht AL, Lapidos-Salaiz I, Phelps BR
Cancer 2020 Jan 15;126(2):242-246. Epub 2019 Sep 26 doi: 10.1002/cncr.32507. PMID: 31557324
Cervical Cancer, Version 3.2019, NCCN Clinical Practice Guidelines in Oncology.
Koh WJ, Abu-Rustum NR, Bean S, Bradley K, Campos SM, Cho KR, Chon HS, Chu C, Clark R, Cohn D, Crispens MA, Damast S, Dorigo O, Eifel PJ, Fisher CM, Frederick P, Gaffney DK, Han E, Huh WK, Lurain JR, Mariani A, Mutch D, Nagel C, Nekhlyudov L, Fader AN, Remmenga SW, Reynolds RK, Tillmanns T, Ueda S, Wyse E, Yashar CM, McMillian NR, Scavone JL
J Natl Compr Canc Netw 2019 Jan;17(1):64-84. doi: 10.6004/jnccn.2019.0001. PMID: 30659131
The human papilloma vaccine: A time for NP leadership.
Hardwicke RL, Benjamins LJ, Grimes RM
Nurse Pract 2018 Jul;43(7):49-55. doi: 10.1097/01.NPR.0000534943.29252.6f. PMID: 29927817

Prognosis

Interactions between microbiota and cervical epithelial, immune, and mucus barrier.
Dong M, Dong Y, Bai J, Li H, Ma X, Li B, Wang C, Li H, Qi W, Wang Y, Fan A, Han C, Xue F
Front Cell Infect Microbiol 2023;13:1124591. Epub 2023 Feb 24 doi: 10.3389/fcimb.2023.1124591. PMID: 36909729Free PMC Article
Progesterone Receptor Is a Haploinsufficient Tumor-Suppressor Gene in Cervical Cancer.
Park Y, Baik S, Ho C, Lin CY, Chung SH
Mol Cancer Res 2021 Jan;19(1):42-47. Epub 2020 Nov 2 doi: 10.1158/1541-7786.MCR-20-0704. PMID: 33139507Free PMC Article
Potential Effects of Human Papillomavirus Type Substitution, Superinfection Exclusion and Latency on the Efficacy of the Current L1 Prophylactic Vaccines.
Hampson IN, Oliver AW, Hampson L
Viruses 2020 Dec 24;13(1) doi: 10.3390/v13010022. PMID: 33374445Free PMC Article
Cervical cancer: screening, diagnosis and staging.
Tsikouras P, Zervoudis S, Manav B, Tomara E, Iatrakis G, Romanidis C, Bothou A, Galazios G
J BUON 2016 Mar-Apr;21(2):320-5. PMID: 27273940
Squamous cell cancer of the cervix, immune senescence and HPV: is cervical cancer an age-related neoplasm?
Mandelblatt J
Adv Exp Med Biol 1993;330:13-26. doi: 10.1007/978-1-4615-2926-2_2. PMID: 8396309

Clinical prediction guides

Interactions between microbiota and cervical epithelial, immune, and mucus barrier.
Dong M, Dong Y, Bai J, Li H, Ma X, Li B, Wang C, Li H, Qi W, Wang Y, Fan A, Han C, Xue F
Front Cell Infect Microbiol 2023;13:1124591. Epub 2023 Feb 24 doi: 10.3389/fcimb.2023.1124591. PMID: 36909729Free PMC Article
Influence of human Papilloma Virus (hPV) infection on early pregnancy.
Bober L, Guzowski G, Moczulska H, Sieroszewski P
Ginekol Pol 2019;90(2):72-75. doi: 10.5603/GP.2019.0012. PMID: 30860272
Aerobic vaginitis: no longer a stranger.
Donders GGG, Bellen G, Grinceviciene S, Ruban K, Vieira-Baptista P
Res Microbiol 2017 Nov-Dec;168(9-10):845-858. Epub 2017 May 11 doi: 10.1016/j.resmic.2017.04.004. PMID: 28502874
Cervical cancer: screening, diagnosis and staging.
Tsikouras P, Zervoudis S, Manav B, Tomara E, Iatrakis G, Romanidis C, Bothou A, Galazios G
J BUON 2016 Mar-Apr;21(2):320-5. PMID: 27273940
Multiple Human Papilloma Virus Infections and Their Impact on the Development of High-Risk Cervical Lesions.
Salazar KL, Zhou HS, Xu J, Peterson LE, Schwartz MR, Mody DR, Ge Y
Acta Cytol 2015;59(5):391-8. Epub 2015 Dec 15 doi: 10.1159/000442512. PMID: 26674365

Recent systematic reviews

The significance of nonsurgical therapies for cervical infection of high-risk human papilloma virus: A systematic review and meta-analysis.
Zhuang Y, Yang H
J Obstet Gynaecol Res 2023 Sep;49(9):2213-2231. Epub 2023 Jun 26 doi: 10.1111/jog.15726. PMID: 37365015
The efficacy of vaccination to prevent human papilloma viruses infection at anal and oral: a systematic review and meta-analysis.
Zhang J, Qin Z, Lou C, Huang J, Xiong Y
Public Health 2021 Jul;196:165-171. Epub 2021 Jul 3 doi: 10.1016/j.puhe.2021.05.012. PMID: 34229128
Prevalence of Human Papilloma Virus Sub Genotypes following Head and Neck Squamous Cell Carcinomas in Asian Continent, A Systematic Review Article.
Bukhari N, Joseph JP, Hussain SS, Khan MA, Wakim MJY, Yahya EB, Arif A, Saleem A, Sharif N
Asian Pac J Cancer Prev 2019 Nov 1;20(11):3269-3277. doi: 10.31557/APJCP.2019.20.11.3269. PMID: 31759348Free PMC Article
Evidence on the prevalence, incidence, mortality and trends of human papilloma virus-associated cancers in sub-Saharan Africa: systematic scoping review.
Lekoane KMB, Kuupiel D, Mashamba-Thompson TP, Ginindza TG
BMC Cancer 2019 Jun 11;19(1):563. doi: 10.1186/s12885-019-5781-3. PMID: 31185951Free PMC Article
Combined oral contraceptives and cervical cancer.
Moodley J
Curr Opin Obstet Gynecol 2004 Feb;16(1):27-9. doi: 10.1097/00001703-200402000-00006. PMID: 15128004

Supplemental Content

Table of contents

    Clinical resources

    Practice guidelines

    • PubMed
      See practice and clinical guidelines in PubMed. The search results may include broader topics and may not capture all published guidelines. See the FAQ for details.
    • Bookshelf
      See practice and clinical guidelines in NCBI Bookshelf. The search results may include broader topics and may not capture all published guidelines. See the FAQ for details.

    Consumer resources

    Reviews

    Related information

    • PMC Articles
      Related information in PubMed Central Links
    • PubMed
      Related literature resources in PubMed

    Recent activity

    Clear Turn Off Turn On

    Your browsing activity is empty.

    Activity recording is turned off.

    Turn recording back on

    See more...