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Cervical Microglandular Polyp

MedGen UID:
232047
•Concept ID:
C1332918
•
Neoplastic Process
Synonyms: Microglandular Polyp of Cervix; Microglandular Polyp of the Cervix; Microglandular Polyp of the Uterine Cervix; Microglandular Polyp of Uterine Cervix; Uterine Cervix Microglandular Polyp

Definition

A benign endocervical polypoid epithelial hyperplasia characterized by the presence of tightly packed glandular structures. It is usually seen in women on oral contraceptive therapy and during pregnancy. [from NCI]

Term Hierarchy

CClinical test,  RResearch test,  OOMIM,  GGeneReviews,  VClinVar  
  • CROGVCervical Microglandular Polyp

Professional guidelines

PubMed

Mitotically active microglandular hyperplasia of the cervix: a case series with implications for the differential diagnosis.
Abi-Raad R, Alomari A, Hui P, Buza N
Int J Gynecol Pathol 2014 Sep;33(5):524-30. doi: 10.1097/PGP.0000000000000086. PMID: 25083971

Recent clinical studies

Etiology

KRAS Mutations in Mucinous Lesions of the Uterus.
He M, Jackson CL, Gubrod RB, Breese V, Steinhoff M, Lawrence WD, Xiong J
Am J Clin Pathol 2015 Jun;143(6):778-84. doi: 10.1309/AJCP69RBNUHHOJRI. PMID: 25972319
Mitotically active microglandular hyperplasia of the cervix: a case series with implications for the differential diagnosis.
Abi-Raad R, Alomari A, Hui P, Buza N
Int J Gynecol Pathol 2014 Sep;33(5):524-30. doi: 10.1097/PGP.0000000000000086. PMID: 25083971
Dysplasia and malignancy in endocervical polyps.
Berzolla CE, Schnatz PF, O'Sullivan DM, Bansal R, Mandavilli S, Sorosky JI
J Womens Health (Larchmt) 2007 Nov;16(9):1317-21. doi: 10.1089/jwh.2007.0408. PMID: 18001188
Clinical significance of a cytologic diagnosis of atypical glandular cells, favor endometrial origin, in Pap smears.
Saad RS, Takei H, Liu YL, Silverman JE, Lipscomb JT, Ruiz B
Acta Cytol 2006 Jan-Feb;50(1):48-54. doi: 10.1159/000325894. PMID: 16514840
Atypical glandular cells of undetermined significance on cervical smears. A study with cytohistologic correlation.
Burja IT, Thompson SK, Sawyer WL Jr, Shurbaji MS
Acta Cytol 1999 May-Jun;43(3):351-6. doi: 10.1159/000331080. PMID: 10349361

Diagnosis

KRAS Mutations in Mucinous Lesions of the Uterus.
He M, Jackson CL, Gubrod RB, Breese V, Steinhoff M, Lawrence WD, Xiong J
Am J Clin Pathol 2015 Jun;143(6):778-84. doi: 10.1309/AJCP69RBNUHHOJRI. PMID: 25972319
The expression and diagnostic utility of p63 in the female genital tract.
Houghton O, McCluggage WG
Adv Anat Pathol 2009 Sep;16(5):316-21. doi: 10.1097/PAP.0b013e3181b507c6. PMID: 19700941
Dysplasia and malignancy in endocervical polyps.
Berzolla CE, Schnatz PF, O'Sullivan DM, Bansal R, Mandavilli S, Sorosky JI
J Womens Health (Larchmt) 2007 Nov;16(9):1317-21. doi: 10.1089/jwh.2007.0408. PMID: 18001188
Endometrioid carcinoma of the uterine corpus: a review of its pathology with emphasis on recent advances and problematic aspects.
Clement PB, Young RH
Adv Anat Pathol 2002 May;9(3):145-84. doi: 10.1097/00125480-200205000-00001. PMID: 11981113
Atypical forms of microglandular hyperplasia of the cervix simulating carcinoma. A report of five cases and review of the literature.
Young RH, Scully RE
Am J Surg Pathol 1989 Jan;13(1):50-6. doi: 10.1097/00000478-198901000-00007. PMID: 2535775

Therapy

Do High Rates of Atypical Glandular Cells Correlate With Higher Incidence of Disease in a Large Safety Net Hospital.
Kuhn T, Finneran C, Kohut A, Wang E, Birdsong G, Krishnamurti U, Mosunjac M, Tadros T, Oprea G, Avadhani V, Boguslawski S, Karlow S, Schnatz P, Khanna N, Flowers L
J Low Genit Tract Dis 2020 Oct;24(4):353-357. doi: 10.1097/LGT.0000000000000556. PMID: 32569024

Prognosis

Do High Rates of Atypical Glandular Cells Correlate With Higher Incidence of Disease in a Large Safety Net Hospital.
Kuhn T, Finneran C, Kohut A, Wang E, Birdsong G, Krishnamurti U, Mosunjac M, Tadros T, Oprea G, Avadhani V, Boguslawski S, Karlow S, Schnatz P, Khanna N, Flowers L
J Low Genit Tract Dis 2020 Oct;24(4):353-357. doi: 10.1097/LGT.0000000000000556. PMID: 32569024
Mitotically active microglandular hyperplasia of the cervix: a case series with implications for the differential diagnosis.
Abi-Raad R, Alomari A, Hui P, Buza N
Int J Gynecol Pathol 2014 Sep;33(5):524-30. doi: 10.1097/PGP.0000000000000086. PMID: 25083971
Clinical implications of atypical glandular cells of undetermined significance, favor endometrial origin.
Chhieng DC, Elgert P, Cohen JM, Cangiarella JF
Cancer 2001 Dec 25;93(6):351-6. doi: 10.1002/cncr.10139. PMID: 11748574
Significance of AGUS Pap smears in pregnant and postpartum women.
Chhieng DC, Elgert P, Cangiarella JF, Cohen JM
Acta Cytol 2001 May-Jun;45(3):294-9. doi: 10.1159/000327621. PMID: 11393057
Clinical evaluation of follow-up methods and results of atypical glandular cells of undetermined significance (AGUS) detected on cervicovaginal Pap smears.
Kim TJ, Kim HS, Park CT, Park IS, Hong SR, Park JS, Shim JU
Gynecol Oncol 1999 May;73(2):292-8. doi: 10.1006/gyno.1999.5360. PMID: 10329049

Clinical prediction guides

Clinical implications of atypical glandular cells of undetermined significance, favor endometrial origin.
Chhieng DC, Elgert P, Cohen JM, Cangiarella JF
Cancer 2001 Dec 25;93(6):351-6. doi: 10.1002/cncr.10139. PMID: 11748574

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