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Cervical cancer

MedGen UID:
890252
•Concept ID:
C4048328
•
Neoplastic Process
Synonyms: Cancer of cervix; Cervical cancer, somatic; Cervix cancer
SNOMED CT: Cancer of cervix (363354003)
 
Gene (location): FGFR3 (4p16.3)
 
HPO: HP:0030079
Monarch Initiative: MONDO:0002974
OMIM®: 603956

Definition

A tumor of the uterine cervix. [from HPO]

Clinical features

From HPO
Neoplasm
MedGen UID:
10294
•Concept ID:
C0027651
•
Neoplastic Process
An organ or organ-system abnormality that consists of uncontrolled autonomous cell-proliferation which can occur in any part of the body as a benign or malignant neoplasm (tumor).
See: Feature record | Search on this feature
Cervical cancer
MedGen UID:
890252
•Concept ID:
C4048328
•
Neoplastic Process
A tumor of the uterine cervix.
See: Feature record | Search on this feature
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Term Hierarchy

CClinical test,  RResearch test,  OOMIM,  GGeneReviews,  VClinVar  
  • CROGVCervical cancer

Conditions with this feature

Cervical cancer
MedGen UID:
890252
•Concept ID:
C4048328
•
Neoplastic Process
A tumor of the uterine cervix.
See: Condition Record
Mosaic variegated aneuploidy syndrome 7 with inflammation and tumor predisposition
MedGen UID:
1824057
•Concept ID:
C5774284
•
Disease or Syndrome
Mosaic variegated aneuploidy syndrome-7 with inflammation and tumor predisposition (MVA7) is an autosomal recessive disorder characterized by increased susceptibility to benign and malignant neoplasms beginning in early childhood. Affected individuals show dysmorphic facies and may have early developmental delay. Patient cells show a high level of aneuploidy due to defects in cell division (Villarroya-Beltri et al., 2022). For a discussion of genetic heterogeneity of MVA, see MVA1 (257300).
See: Condition Record
Cervical cancer
Mosaic variegated aneuploidy syndrome 7 with inflammation and tumor predisposition

Professional guidelines

PubMed

NRG Oncology/RTOG Consensus Guidelines for Delineation of Clinical Target Volume for Intensity Modulated Pelvic Radiation Therapy in Postoperative Treatment of Endometrial and Cervical Cancer: An Update.
Small W Jr, Bosch WR, Harkenrider MM, Strauss JB, Abu-Rustum N, Albuquerque KV, Beriwal S, Creutzberg CL, Eifel PJ, Erickson BA, Fyles AW, Hentz CL, Jhingran A, Klopp AH, Kunos CA, Mell LK, Portelance L, Powell ME, Viswanathan AN, Yacoub JH, Yashar CM, Winter KA, Gaffney DK
Int J Radiat Oncol Biol Phys 2021 Feb 1;109(2):413-424. Epub 2020 Sep 6 doi: 10.1016/j.ijrobp.2020.08.061. PMID: 32905846Free PMC Article
2019 ASCCP Risk-Based Management Consensus Guidelines for Abnormal Cervical Cancer Screening Tests and Cancer Precursors.
Perkins RB, Guido RS, Castle PE, Chelmow D, Einstein MH, Garcia F, Huh WK, Kim JJ, Moscicki AB, Nayar R, Saraiya M, Sawaya GF, Wentzensen N, Schiffman M; 2019 ASCCP Risk-Based Management Consensus Guidelines Committee
J Low Genit Tract Dis 2020 Apr;24(2):102-131. doi: 10.1097/LGT.0000000000000525. PMID: 32243307Free PMC Article
Cervical cancer: screening, diagnosis and staging.
Tsikouras P, Zervoudis S, Manav B, Tomara E, Iatrakis G, Romanidis C, Bothou A, Galazios G
J BUON 2016 Mar-Apr;21(2):320-5. PMID: 27273940

Curated

NCCN Clinical Practice Guidelines in Oncology (NCCN Guidelines®) Cervical Cancer, 2024

Technology Assessment on Genetic Testing or Molecular Pathology Testing of Cancers with Unknown Primary Site to Determine Origin (ARCHIVED)

Recent clinical studies

Etiology

Carcinogenesis and management of human papillomavirus-associated cervical cancer.
Kusakabe M, Taguchi A, Sone K, Mori M, Osuga Y
Int J Clin Oncol 2023 Aug;28(8):965-974. Epub 2023 Jun 9 doi: 10.1007/s10147-023-02337-7. PMID: 37294390Free PMC Article
Cervical Cancer Screening.
Gavinski K, DiNardo D
Med Clin North Am 2023 Mar;107(2):259-269. Epub 2022 Dec 26 doi: 10.1016/j.mcna.2022.10.006. PMID: 36759096
Cervical Cancer Immunotherapy: Facts and Hopes.
Ferrall L, Lin KY, Roden RBS, Hung CF, Wu TC
Clin Cancer Res 2021 Sep 15;27(18):4953-4973. Epub 2021 Apr 22 doi: 10.1158/1078-0432.CCR-20-2833. PMID: 33888488Free PMC Article
Cervical Cancer Screening: Past, Present, and Future.
Bedell SL, Goldstein LS, Goldstein AR, Goldstein AT
Sex Med Rev 2020 Jan;8(1):28-37. Epub 2019 Nov 30 doi: 10.1016/j.sxmr.2019.09.005. PMID: 31791846
Cervical Cancer: An Overview of Pathophysiology and Management.
Johnson CA, James D, Marzan A, Armaos M
Semin Oncol Nurs 2019 Apr;35(2):166-174. Epub 2019 Mar 14 doi: 10.1016/j.soncn.2019.02.003. PMID: 30878194

Diagnosis

Global challenges of radiotherapy for the treatment of locally advanced cervical cancer.
Mayadev JS, Ke G, Mahantshetty U, Pereira MD, Tarnawski R, Toita T
Int J Gynecol Cancer 2022 Mar;32(3):436-445. doi: 10.1136/ijgc-2021-003001. PMID: 35256434Free PMC Article
Estimates of incidence and mortality of cervical cancer in 2018: a worldwide analysis.
Arbyn M, Weiderpass E, Bruni L, de Sanjosé S, Saraiya M, Ferlay J, Bray F
Lancet Glob Health 2020 Feb;8(2):e191-e203. Epub 2019 Dec 4 doi: 10.1016/S2214-109X(19)30482-6. PMID: 31812369Free PMC Article
Cervical Cancer Screening: Past, Present, and Future.
Bedell SL, Goldstein LS, Goldstein AR, Goldstein AT
Sex Med Rev 2020 Jan;8(1):28-37. Epub 2019 Nov 30 doi: 10.1016/j.sxmr.2019.09.005. PMID: 31791846
Cervical Cancer: An Overview of Pathophysiology and Management.
Johnson CA, James D, Marzan A, Armaos M
Semin Oncol Nurs 2019 Apr;35(2):166-174. Epub 2019 Mar 14 doi: 10.1016/j.soncn.2019.02.003. PMID: 30878194
Cervical cancer worldwide.
Vu M, Yu J, Awolude OA, Chuang L
Curr Probl Cancer 2018 Sep;42(5):457-465. Epub 2018 Jun 25 doi: 10.1016/j.currproblcancer.2018.06.003. PMID: 30064936

Therapy

First-Line Pembrolizumab + Chemotherapy Versus Placebo + Chemotherapy for Persistent, Recurrent, or Metastatic Cervical Cancer: Final Overall Survival Results of KEYNOTE-826.
Monk BJ, Colombo N, Tewari KS, Dubot C, Caceres MV, Hasegawa K, Shapira-Frommer R, Salman P, Yañez E, Gümüş M, Olivera Hurtado de Mendoza M, Samouëlian V, Castonguay V, Arkhipov A, Tekin C, Li K, Keefe SM, Lorusso D; KEYNOTE-826 Investigators
J Clin Oncol 2023 Dec 20;41(36):5505-5511. Epub 2023 Nov 1 doi: 10.1200/JCO.23.00914. PMID: 37910822
Bevacizumab (Avastin®) in cancer treatment: A review of 15 years of clinical experience and future outlook.
Garcia J, Hurwitz HI, Sandler AB, Miles D, Coleman RL, Deurloo R, Chinot OL
Cancer Treat Rev 2020 Jun;86:102017. Epub 2020 Mar 26 doi: 10.1016/j.ctrv.2020.102017. PMID: 32335505
Human papillomavirus vaccine against cervical cancer: Opportunity and challenge.
Wang R, Pan W, Jin L, Huang W, Li Y, Wu D, Gao C, Ma D, Liao S
Cancer Lett 2020 Feb 28;471:88-102. Epub 2019 Dec 5 doi: 10.1016/j.canlet.2019.11.039. PMID: 31812696
Systemic therapy in cervical cancer: 30 years in review.
Liontos M, Kyriazoglou A, Dimitriadis I, Dimopoulos MA, Bamias A
Crit Rev Oncol Hematol 2019 May;137:9-17. Epub 2019 Feb 28 doi: 10.1016/j.critrevonc.2019.02.009. PMID: 31014518
HPV vaccine MedImmune/GlaxoSmithKline.
Billich A
Curr Opin Investig Drugs 2003 Feb;4(2):210-3. PMID: 12669384

Prognosis

A Review of Cervical Cancer: Incidence and Disparities.
Buskwofie A, David-West G, Clare CA
J Natl Med Assoc 2020 Apr;112(2):229-232. Epub 2020 Apr 8 doi: 10.1016/j.jnma.2020.03.002. PMID: 32278478
Estimates of incidence and mortality of cervical cancer in 2018: a worldwide analysis.
Arbyn M, Weiderpass E, Bruni L, de Sanjosé S, Saraiya M, Ferlay J, Bray F
Lancet Glob Health 2020 Feb;8(2):e191-e203. Epub 2019 Dec 4 doi: 10.1016/S2214-109X(19)30482-6. PMID: 31812369Free PMC Article
Cancer statistics, 2019.
Siegel RL, Miller KD, Jemal A
CA Cancer J Clin 2019 Jan;69(1):7-34. Epub 2019 Jan 8 doi: 10.3322/caac.21551. PMID: 30620402
Global cancer statistics 2018: GLOBOCAN estimates of incidence and mortality worldwide for 36 cancers in 185 countries.
Bray F, Ferlay J, Soerjomataram I, Siegel RL, Torre LA, Jemal A
CA Cancer J Clin 2018 Nov;68(6):394-424. Epub 2018 Sep 12 doi: 10.3322/caac.21492. PMID: 30207593
Global Cancer Incidence and Mortality Rates and Trends--An Update.
Torre LA, Siegel RL, Ward EM, Jemal A
Cancer Epidemiol Biomarkers Prev 2016 Jan;25(1):16-27. Epub 2015 Dec 14 doi: 10.1158/1055-9965.EPI-15-0578. PMID: 26667886

Clinical prediction guides

Systematic review and meta-analysis of prediction models used in cervical cancer.
Jha AK, Mithun S, Sherkhane UB, Jaiswar V, Osong B, Purandare N, Kannan S, Prabhash K, Gupta S, Vanneste B, Rangarajan V, Dekker A, Wee L
Artif Intell Med 2023 May;139:102549. Epub 2023 Apr 11 doi: 10.1016/j.artmed.2023.102549. PMID: 37100501
Assessing the risk of cervical neoplasia in the post-HPV vaccination era.
Lehtinen M, Pimenoff VN, Nedjai B, Louvanto K, Verhoef L, Heideman DAM, El-Zein M, Widschwendter M, Dillner J
Int J Cancer 2023 Mar 15;152(6):1060-1068. Epub 2022 Oct 10 doi: 10.1002/ijc.34286. PMID: 36093582Free PMC Article
The role of sentinel lymph nodes in endometrial and cervical cancer.
Smith B, Backes F
J Surg Oncol 2015 Dec;112(7):753-60. Epub 2015 Sep 9 doi: 10.1002/jso.24022. PMID: 26351988
Reaching women who do not participate in the regular cervical cancer screening programme by offering self-sampling kits: a systematic review and meta-analysis of randomised trials.
Verdoodt F, Jentschke M, Hillemanns P, Racey CS, Snijders PJ, Arbyn M
Eur J Cancer 2015 Nov;51(16):2375-85. Epub 2015 Aug 18 doi: 10.1016/j.ejca.2015.07.006. PMID: 26296294
Role of 18F-FDG PET/CT in the carcinoma of the uterus: a review of literature.
Musto A, Grassetto G, Marzola MC, Chondrogiannis S, Maffione AM, Rampin L, Fuster D, Giammarile F, Colletti PM, Rubello D
Yonsei Med J 2014 Nov;55(6):1467-72. doi: 10.3349/ymj.2014.55.6.1467. PMID: 25323881Free PMC Article

Recent systematic reviews

Risk factors for human papillomavirus infection, cervical intraepithelial neoplasia and cervical cancer: an umbrella review and follow-up Mendelian randomisation studies.
Bowden SJ, Doulgeraki T, Bouras E, Markozannes G, Athanasiou A, Grout-Smith H, Kechagias KS, Ellis LB, Zuber V, Chadeau-Hyam M, Flanagan JM, Tsilidis KK, Kalliala I, Kyrgiou M
BMC Med 2023 Jul 27;21(1):274. doi: 10.1186/s12916-023-02965-w. PMID: 37501128Free PMC Article
Systematic review and meta-analysis of prediction models used in cervical cancer.
Jha AK, Mithun S, Sherkhane UB, Jaiswar V, Osong B, Purandare N, Kannan S, Prabhash K, Gupta S, Vanneste B, Rangarajan V, Dekker A, Wee L
Artif Intell Med 2023 May;139:102549. Epub 2023 Apr 11 doi: 10.1016/j.artmed.2023.102549. PMID: 37100501
Cervical cancer screening uptake in Sub-Saharan Africa: a systematic review and meta-analysis.
Yimer NB, Mohammed MA, Solomon K, Tadese M, Grutzmacher S, Meikena HK, Alemnew B, Sharew NT, Habtewold TD
Public Health 2021 Jun;195:105-111. Epub 2021 May 31 doi: 10.1016/j.puhe.2021.04.014. PMID: 34082174
Educational Interventions for Cervical Cancer Screening Behavior of Women: A Systematic Review.
Saei Ghare Naz M, Kariman N, Ebadi A, Ozgoli G, Ghasemi V, Rashidi Fakari F
Asian Pac J Cancer Prev 2018 Apr 25;19(4):875-884. doi: 10.22034/APJCP.2018.19.4.875. PMID: 29693331Free PMC Article
Cervical Cancer Prevalence, Incidence and Mortality in Low and Middle Income Countries: A Systematic Review.
Shrestha AD, Neupane D, Vedsted P, Kallestrup P
Asian Pac J Cancer Prev 2018 Feb 26;19(2):319-324. doi: 10.22034/APJCP.2018.19.2.319. PMID: 29479954Free PMC Article

Supplemental Content

Table of contents

    Clinical resources

    Practice guidelines

    • PubMed
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      See practice and clinical guidelines in NCBI Bookshelf. The search results may include broader topics and may not capture all published guidelines. See the FAQ for details.

    Curated

    • NCCN, 2024
      NCCN Clinical Practice Guidelines in Oncology (NCCN Guidelines®) Cervical Cancer, 2024
    • AHRQ, 2013
      Technology Assessment on Genetic Testing or Molecular Pathology Testing of Cancers with Unknown Primary Site to Determine Origin (ARCHIVED)

    Consumer resources

    Reviews

    Related information

    • ClinVar
      Related medical variations
    • Gene
      Related information in NCBI Gene
    • GTR
      Related information in GTR
    • GTR(Clinical)
      Clinical tests in GTR
    • MeSH
      Related Medical Subject Headings
    • OMIM
      Related records in OMIM
    • OMIM(Genes)
      OMIM records containing genes associated with phenotypes registered in MedGen
    • PMC Articles
      Related information in PubMed Central Links
    • PubMed
      Related literature resources in PubMed
    • PubMed (OMIM)
      Related literature resources in PubMed

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