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Benign Cervical Mixed Epithelial and Mesenchymal Neoplasm

MedGen UID:
267346
•Concept ID:
C1511086
•
Neoplastic Process

Definition

A neoplasm that arises from the cervix and is characterized by the presence of benign epithelial and benign mesenchymal elements. This category includes adenofibroma and adenomyoma. [from NCI]

Recent clinical studies

Etiology

Primordial Odontogenic Tumor; Archival Review of 19380 Cases in a 55-Year Retrospective Study.
Ranjbar M, Moradzadeh Khiavi M, Ghazi M, Derakhshan S
Asian Pac J Cancer Prev 2023 Aug 1;24(8):2845-2853. doi: 10.31557/APJCP.2023.24.8.2845. PMID: 37642073Free PMC Article
Frequency of Odontogenic Tumors: A Single Center Study of 1089 Cases in Japan and Literature Review.
Kokubun K, Yamamoto K, Nakajima K, Akashi Y, Chujo T, Takano M, Katakura A, Matsuzaka K
Head Neck Pathol 2022 Jun;16(2):494-502. Epub 2021 Oct 30 doi: 10.1007/s12105-021-01390-w. PMID: 34716904Free PMC Article
Incidence of occult uterine sarcoma and other unexpected pathologies in patients having surgery for presumed myomas: A retrospective observational study.
Mühlenbrock MV, Navarrete-Rey P, Kovoor E, Guzman-Rojas R, Troncoso F, Miranda-Mendoza I
J Gynecol Obstet Hum Reprod 2021 Sep;50(7):101992. Epub 2020 Nov 17 doi: 10.1016/j.jogoh.2020.101992. PMID: 33217603
Targeted Next-Generation Sequencing and Allele-Specific Quantitative PCR of Laser Capture Microdissected Samples Uncover Molecular Differences in Mixed Odontogenic Tumors.
Coura BP, Bernardes VF, de Sousa SF, Diniz MG, Moreira RG, de Andrade BAB, Romañach MJ, Pontes HAR, Gomez RS, Odell EW, Gomes CC
J Mol Diagn 2020 Dec;22(12):1393-1399. Epub 2020 Sep 20 doi: 10.1016/j.jmoldx.2020.08.005. PMID: 32966885
Papillary adenofibroma of the cervix: a case report.
Haberal A, Cil AP, Gunes M, Cavusoglu D
Ultrasound Obstet Gynecol 2005 Aug;26(2):186-7. doi: 10.1002/uog.1948. PMID: 16041681

Diagnosis

Frequency of Odontogenic Tumors: A Single Center Study of 1089 Cases in Japan and Literature Review.
Kokubun K, Yamamoto K, Nakajima K, Akashi Y, Chujo T, Takano M, Katakura A, Matsuzaka K
Head Neck Pathol 2022 Jun;16(2):494-502. Epub 2021 Oct 30 doi: 10.1007/s12105-021-01390-w. PMID: 34716904Free PMC Article
Ameloblastic Fibroodontoma of Mandible Causing Tumor Induced Osteomalacia: A Case Report with Review of 88 Phosphaturic Oral Neoplasms.
Mishra D, Kaur H, Bhalla AS, Manchanda S, Sasikumar J, Agarwal B, Roychoudhury A
Head Neck Pathol 2021 Sep;15(3):975-988. Epub 2021 Jan 4 doi: 10.1007/s12105-020-01267-4. PMID: 33394371Free PMC Article
Incidence of occult uterine sarcoma and other unexpected pathologies in patients having surgery for presumed myomas: A retrospective observational study.
Mühlenbrock MV, Navarrete-Rey P, Kovoor E, Guzman-Rojas R, Troncoso F, Miranda-Mendoza I
J Gynecol Obstet Hum Reprod 2021 Sep;50(7):101992. Epub 2020 Nov 17 doi: 10.1016/j.jogoh.2020.101992. PMID: 33217603
Case for diagnosis. Chondroid syringoma.
Franco JP, Zacaron LH, Lima RB, D'Acri AM, Martins CJ
An Bras Dermatol 2013 Nov-Dec;88(6):997-9. doi: 10.1590/abd1806-4841.20132515. PMID: 24474117Free PMC Article
Pleomorphic adenoma (benign mixed tumour) of the salivary glands: its diverse clinical, radiological, and histopathological presentation.
Lingam RK, Daghir AA, Nigar E, Abbas SA, Kumar M
Br J Oral Maxillofac Surg 2011 Jan;49(1):14-20. doi: 10.1016/j.bjoms.2009.09.014. PMID: 19926180

Therapy

Metastasizing uterine mullerian adenosarcoma in a young female: Diagnostic enigma.
Patnayak R, Rukmangadha N, Architha P, Reddy GS, Lakshmi AY, Kannan T, Jena A
Indian J Pathol Microbiol 2018 Jul-Sep;61(3):440-442. doi: 10.4103/IJPM.IJPM_1_18. PMID: 30004077
Colony-forming assay of human salivary gland tumors. Applications for chemosensitivity and histogenetic studies.
Johns ME, Mills SE, Thompson KK
Arch Otolaryngol 1983 Nov;109(11):709-14. doi: 10.1001/archotol.1983.00800250003001. PMID: 6314953

Prognosis

Imaging findings of uterine adenosarcoma with sarcomatous overgrowth: two case reports, emphasizing restricted diffusion on diffusion weighted imaging.
Nakai G, Matsutani H, Yamada T, Ohmichi M, Yamamoto K, Osuga K
BMC Womens Health 2021 Dec 16;21(1):416. doi: 10.1186/s12905-021-01567-z. PMID: 34915866Free PMC Article
Incidence of occult uterine sarcoma and other unexpected pathologies in patients having surgery for presumed myomas: A retrospective observational study.
Mühlenbrock MV, Navarrete-Rey P, Kovoor E, Guzman-Rojas R, Troncoso F, Miranda-Mendoza I
J Gynecol Obstet Hum Reprod 2021 Sep;50(7):101992. Epub 2020 Nov 17 doi: 10.1016/j.jogoh.2020.101992. PMID: 33217603

Clinical prediction guides

Imaging findings of uterine adenosarcoma with sarcomatous overgrowth: two case reports, emphasizing restricted diffusion on diffusion weighted imaging.
Nakai G, Matsutani H, Yamada T, Ohmichi M, Yamamoto K, Osuga K
BMC Womens Health 2021 Dec 16;21(1):416. doi: 10.1186/s12905-021-01567-z. PMID: 34915866Free PMC Article
Incidence of occult uterine sarcoma and other unexpected pathologies in patients having surgery for presumed myomas: A retrospective observational study.
Mühlenbrock MV, Navarrete-Rey P, Kovoor E, Guzman-Rojas R, Troncoso F, Miranda-Mendoza I
J Gynecol Obstet Hum Reprod 2021 Sep;50(7):101992. Epub 2020 Nov 17 doi: 10.1016/j.jogoh.2020.101992. PMID: 33217603
Targeted Next-Generation Sequencing and Allele-Specific Quantitative PCR of Laser Capture Microdissected Samples Uncover Molecular Differences in Mixed Odontogenic Tumors.
Coura BP, Bernardes VF, de Sousa SF, Diniz MG, Moreira RG, de Andrade BAB, Romañach MJ, Pontes HAR, Gomez RS, Odell EW, Gomes CC
J Mol Diagn 2020 Dec;22(12):1393-1399. Epub 2020 Sep 20 doi: 10.1016/j.jmoldx.2020.08.005. PMID: 32966885

Recent systematic reviews

Prevalence of BRAF p.V600E and Detection Methods in Benign Mixed and Malignant Odontogenic Tumors: A Systematic Review.
Severino-Lazo RJG, de Vasconcelos Carvalho M, Campello CP, Moraes SLD, do Egito Vasconcelos BC, Pellizzer EP
Head Neck Pathol 2023 Dec;17(4):1000-1010. Epub 2023 Dec 6 doi: 10.1007/s12105-023-01601-6. PMID: 38057461Free PMC Article

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