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Hsp60A Heat shock protein 60A [ Drosophila melanogaster (fruit fly) ]

Gene ID: 32045, updated on 4-Jan-2025

Summary

Official Symbol
Hsp60Aprovided by FlyBase
Official Full Name
Heat shock protein 60Aprovided by FlyBase
Primary source
FLYBASE:FBgn0015245
Locus tag
Dmel_CG12101
See related
AllianceGenome:FB:FBgn0015245
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Drosophila melanogaster
Lineage
Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
Also known as
12; BP5; CG12101; cpn60; Cpn60; d-hsp60; Dm10A; Dmel\CG12101; Dmhsp60; DmHsp60; G62; Hsp 60; hsp60; Hsp60; HSP60; hsp60A; HSP60A; Hsp64; IEF16; l(1)10Ac; l(1)BP5; l(1)dp025; l(1)G8; l(1)HM21; l(1)L12; Mmp-P1; SSP 7506
Summary
Predicted to enable ATP hydrolysis activity and protein-folding chaperone binding activity. Involved in cellular response to heat and mitochondrion organization. Located in mitochondrial inner membrane. Is expressed in several structures, including adult head; adult heart; dorsal pharyngeal muscle cell; embryonic/larval midgut primordium; and gut section. Human ortholog(s) of this gene implicated in several diseases, including artery disease (multiple); autistic disorder; glucose intolerance; hereditary spastic paraplegia (multiple); and hypomyelinating leukodystrophy 4. Orthologous to human HSPD1 (heat shock protein family D (Hsp60) member 1). [provided by Alliance of Genome Resources, Jan 2025]
Orthologs
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Genomic context

See Hsp60A in Genome Data Viewer
Location:
10A4-10A4; 1-33 cM
Exon count:
4
Annotation release Status Assembly Chr Location
Release 6.54 current Release 6 plus ISO1 MT (GCF_000001215.4) X NC_004354.4 (11108482..11112308)
Release 5.57 previous assembly Release 5 (GCF_000001215.2) X NC_004354.3 (11002515..11006341)

Chromosome X - NC_004354.4Genomic Context describing neighboring genes Neighboring gene antisense RNA:CR45604 Neighboring gene uncharacterized protein Neighboring gene uncharacterized protein Neighboring gene uncharacterized protein Neighboring gene Regulatory particle triple-A ATPase 3

Genomic regions, transcripts, and products

Bibliography

Interactions

General gene information

Gene Ontology Provided by FlyBase

Function Evidence Code Pubs
enables ATP binding  
enables ATP hydrolysis activity  
enables ATP-dependent protein folding chaperone  
enables protein-folding chaperone binding  
Process Evidence Code Pubs
involved_in apoptotic mitochondrial changes  
involved_in cellular response to heat PubMed 
involved_in mitochondrial unfolded protein response  
involved_in mitochondrion organization PubMed 
involved_in protein folding  
involved_in protein import into mitochondrial intermembrane space  
involved_in protein refolding  
NOT involved_in response to heat PubMed 
Component Evidence Code Pubs
is_active_in mitochondrial inner membrane  
located_in mitochondrial inner membrane PubMed 
is_active_in mitochondrial matrix  
located_in mitochondrion PubMed 
located_in mitochondrion PubMed 

General protein information

Preferred Names
heat shock protein 60A
Names
60-kDa heat shock protein, mitochondrial
CG12101-PA
CG12101-PB
Hsp 60
Hsp60A-PA
Hsp60A-PB
heat shock protein 60
heat shock protein 60 kDa
lethal(1)10Ac
mitochondrial matrix protein P1

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NC_004354.4 Reference assembly

    Range
    11108482..11112308
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_078560.3 → NP_511115.2  heat shock protein 60A, isoform A [Drosophila melanogaster]

    See identical proteins and their annotated locations for NP_511115.2

    Status: REVIEWED

    UniProtKB/Swiss-Prot
    A4V4A0, O02649, P35380, Q6NR71, Q95026, Q9VZ31
    UniProtKB/TrEMBL
    C7LA94
    Related
    FBpp0073290
    Conserved Domains (2) summary
    PTZ00114
    Location:12 → 549
    PTZ00114; Heat shock protein 60; Provisional
    cd03344
    Location:24 → 544
    GroEL; GroEL_like type I chaperonin. Chaperonins are involved in productive folding of proteins. They share a common general morphology, a double toroid of 2 stacked rings, each composed of 7-9 subunits. The symmetry of type I is seven-fold and they are found ...
  2. NM_167266.1 → NP_727489.1  heat shock protein 60A, isoform B [Drosophila melanogaster]

    See identical proteins and their annotated locations for NP_727489.1

    Status: REVIEWED

    UniProtKB/Swiss-Prot
    A4V4A0, O02649, P35380, Q6NR71, Q95026, Q9VZ31
    UniProtKB/TrEMBL
    C7LA94
    Related
    FBpp0073291, FBtr0073435
    Conserved Domains (2) summary
    PTZ00114
    Location:12 → 549
    PTZ00114; Heat shock protein 60; Provisional
    cd03344
    Location:24 → 544
    GroEL; GroEL_like type I chaperonin. Chaperonins are involved in productive folding of proteins. They share a common general morphology, a double toroid of 2 stacked rings, each composed of 7-9 subunits. The symmetry of type I is seven-fold and they are found ...
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