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D2hgdh D-2-hydroxyglutaric acid dehydrogenase [ Drosophila melanogaster (fruit fly) ]

Gene ID: 31184, updated on 9-Dec-2024

Summary

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Official Symbol
D2hgdhprovided by FlyBase
Official Full Name
D-2-hydroxyglutaric acid dehydrogenaseprovided by FlyBase
Primary source
FLYBASE:FBgn0023507
Locus tag
Dmel_CG3835
See related
AllianceGenome:FB:FBgn0023507
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Drosophila melanogaster
Lineage
Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
Also known as
CG3835; D2HGDH; Dmel\CG3835; EG87B1; EG:87B1.3
Summary
Enables (R)-2-hydroxyglutarate dehydrogenase activity. Involved in organic acid metabolic process. Predicted to be active in mitochondrion. Is expressed in several structures, including adult head; adult heart; anlage in statu nascendi; germline cell; and main body follicle cell. Human ortholog(s) of this gene implicated in D-2-hydroxyglutaric aciduria 1. Orthologous to human D2HGDH (D-2-hydroxyglutarate dehydrogenase). [provided by Alliance of Genome Resources, Dec 2024]
Orthologs
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Genomic context

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See D2hgdh in Genome Data Viewer
Location:
2D4-2D4; 1-0.6 cM
Exon count:
7
Annotation release Status Assembly Chr Location
Release 6.54 current Release 6 plus ISO1 MT (GCF_000001215.4) X NC_004354.4 (2141489..2144937)
Release 5.57 previous assembly Release 5 (GCF_000001215.2) X NC_004354.3 (2035522..2038970)

Chromosome X - NC_004354.4Genomic Context describing neighboring genes Neighboring gene polyhomeotic distal Neighboring gene polyhomeotic proximal Neighboring gene Phosphogluconate dehydrogenase Neighboring gene bcn92 Neighboring gene wings apart-like

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. Positive Selection at the Polyhomeotic Locus Led to Decreased Thermosensitivity of Gene Expression in Temperate Drosophila melanogaster. Voigt S, et al. Genetics, 2015 Jun. PMID 25855066, Free PMC Article
  2. Evidence that strong positive selection drives neofunctionalization in the tandemly duplicated polyhomeotic genes in Drosophila. Beisswanger S, et al. Proc Natl Acad Sci U S A, 2008 Apr 8. PMID 18381818, Free PMC Article
  3. Linking global histone acetylation to the transcription enhancement of X-chromosomal genes in Drosophila males. Smith ER, et al. J Biol Chem, 2001 Aug 24. PMID 11445559
  4. GAL4 enhancer trap patterns during Drosophila development. Ward EJ, et al. Genesis, 2002 Sep-Oct. PMID 12324946
  5. Loss of the Polycomb group gene polyhomeotic induces non-autonomous cell overproliferation. Feng S, et al. EMBO Rep, 2011 Feb. PMID 21164514, Free PMC Article

See all (50) citations in PubMed

GeneRIFs: Gene References Into Functions

Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Homology

Gene Ontology Provided by FlyBase

Function Evidence Code Pubs
enables (R)-2-hydroxyglutarate dehydrogenase activity IMP
Inferred from Mutant Phenotype
more info
 PubMed 
enables FAD binding IEA
Inferred from Electronic Annotation
more info
  
enables catalytic activity IEA
Inferred from Electronic Annotation
more info
  
Process Evidence Code Pubs
involved_in organic acid metabolic process IMP
Inferred from Mutant Phenotype
more info
 PubMed 
Component Evidence Code Pubs
is_active_in mitochondrion IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in mitochondrion ISS
Inferred from Sequence or Structural Similarity
more info
  

General protein information

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Preferred Names
D-2-hydroxyglutaric acid dehydrogenase
Names
CG3835-PA
CG3835-PB
CG3835-PC
D2hgdh-PA
D2hgdh-PB
D2hgdh-PC
NP_569982.1
NP_726794.1
NP_726795.1

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NC_004354.4 Reference assembly

    Range
    2141489..2144937
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_166930.2 → NP_726795.1  D-2-hydroxyglutaric acid dehydrogenase, isoform C [Drosophila melanogaster]

    See identical proteins and their annotated locations for NP_726795.1

    Status: REVIEWED

    UniProtKB/TrEMBL
    O46096, Q7K511
    Related
    FBpp0070366
    Conserved Domains (3) summary
    COG0277
    Location:85 → 532
    GlcD; FAD/FMN-containing dehydrogenase [Energy production and conversion]
    pfam01565
    Location:115 → 252
    FAD_binding_4; FAD binding domain
    pfam02913
    Location:291 → 531
    FAD-oxidase_C; FAD linked oxidases, C-terminal domain

  2. NM_166929.2 → NP_726794.1  D-2-hydroxyglutaric acid dehydrogenase, isoform B [Drosophila melanogaster]

    See identical proteins and their annotated locations for NP_726794.1

    Status: REVIEWED

    UniProtKB/TrEMBL
    O46096, Q7K511
    Related
    FBpp0070365
    Conserved Domains (3) summary
    COG0277
    Location:85 → 532
    GlcD; FAD/FMN-containing dehydrogenase [Energy production and conversion]
    pfam01565
    Location:115 → 252
    FAD_binding_4; FAD binding domain
    pfam02913
    Location:291 → 531
    FAD-oxidase_C; FAD linked oxidases, C-terminal domain

  3. NM_130626.3 → NP_569982.1  D-2-hydroxyglutaric acid dehydrogenase, isoform A [Drosophila melanogaster]

    See identical proteins and their annotated locations for NP_569982.1

    Status: REVIEWED

    UniProtKB/TrEMBL
    O46096, Q7K511
    Related
    FBpp0070367
    Conserved Domains (3) summary
    COG0277
    Location:85 → 532
    GlcD; FAD/FMN-containing dehydrogenase [Energy production and conversion]
    pfam01565
    Location:115 → 252
    FAD_binding_4; FAD binding domain
    pfam02913
    Location:291 → 531
    FAD-oxidase_C; FAD linked oxidases, C-terminal domain
Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
O46096 O46096
Q7K511 Q7K511

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