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Flad1 Flavin adenine dinucleotide synthetase 1 [ Drosophila melanogaster (fruit fly) ]

Gene ID: 32240, updated on 14-Nov-2024

Summary

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Official Symbol
Flad1provided by FlyBase
Official Full Name
Flavin adenine dinucleotide synthetase 1provided by FlyBase
Primary source
FLYBASE:FBgn0030431
Locus tag
Dmel_CG4407
See related
AllianceGenome:FB:FBgn0030431
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Drosophila melanogaster
Lineage
Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
Also known as
CG4407; Dmel\CG4407; Fad1
Summary
Predicted to enable FMN adenylyltransferase activity. Predicted to be involved in FAD biosynthetic process. Predicted to be active in cytosol. Is expressed in adult head. Orthologous to human FLAD1 (flavin adenine dinucleotide synthetase 1). [provided by Alliance of Genome Resources, Nov 2024]
Orthologs
all
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Genomic context

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See Flad1 in Genome Data Viewer
Location:
11D1-11D1; 1-41 cM
Exon count:
4
Annotation release Status Assembly Chr Location
Release 6.54 current Release 6 plus ISO1 MT (GCF_000001215.4) X NC_004354.4 (12901353..12903516, complement)
Release 5.57 previous assembly Release 5 (GCF_000001215.2) X NC_004354.3 (12795386..12797549, complement)

Chromosome X - NC_004354.4Genomic Context describing neighboring genes Neighboring gene uncharacterized protein Neighboring gene Coenzyme Q8 Neighboring gene uncharacterized protein Neighboring gene mitochondrial ribosomal protein L49

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. The Drosophila radish gene encodes a protein required for anesthesia-resistant memory. Folkers E, et al. Proc Natl Acad Sci U S A, 2006 Nov 14. PMID 17088531, Free PMC Article
  2. Evolutionary rate covariation analysis of E-cadherin identifies Raskol as a regulator of cell adhesion and actin dynamics in Drosophila. Raza Q, et al. PLoS Genet, 2019 Feb. PMID 30763317, Free PMC Article
  3. An in vivo RNA interference screen identifies gene networks controlling Drosophila melanogaster blood cell homeostasis. Avet-Rochex A, et al. BMC Dev Biol, 2010 Jun 11. PMID 20540764, Free PMC Article
  4. Collagen secretion screening in Drosophila supports a common secretory machinery and multiple Rab requirements. Ke H, et al. J Genet Genomics, 2018 Jun 1. PMID 29935791
  5. A Genetic Screen for Genes That Impact Peroxisomes in Drosophila Identifies Candidate Genes for Human Disease. Graves HK, et al. G3 (Bethesda), 2020 Jan 7. PMID 31767637, Free PMC Article

See all (32) citations in PubMed

GeneRIFs: Gene References Into Functions

Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Homology

Gene Ontology Provided by FlyBase

Function Evidence Code Pubs
enables FMN adenylyltransferase activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables FMN adenylyltransferase activity ISS
Inferred from Sequence or Structural Similarity
more info
  
enables catalytic activity IEA
Inferred from Electronic Annotation
more info
  
Process Evidence Code Pubs
involved_in FAD biosynthetic process IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in FAD biosynthetic process ISS
Inferred from Sequence or Structural Similarity
more info
  
Component Evidence Code Pubs
is_active_in cytosol ISS
Inferred from Sequence or Structural Similarity
more info
  
is_active_in mitochondrial matrix ISS
Inferred from Sequence or Structural Similarity
more info
  

General protein information

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Preferred Names
flavin adenine dinucleotide synthetase 1
Names
CG4407-PA
CG4407-PB
Flad1-PA
Flad1-PB
NP_572837.1
NP_727648.1

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NC_004354.4 Reference assembly

    Range
    12901353..12903516 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_132609.4 → NP_572837.1  flavin adenine dinucleotide synthetase 1, isoform A [Drosophila melanogaster]

    See identical proteins and their annotated locations for NP_572837.1

    Status: REVIEWED

    UniProtKB/TrEMBL
    Q961A2, Q9VYI5
    Related
    FBpp0073528
    Conserved Domains (1) summary
    cd01713
    Location:118 → 267
    PAPS_reductase; This domain is found in phosphoadenosine phosphosulphate (PAPS) reductase enzymes or PAPS sulphotransferase. PAPS reductase is part of the adenine nucleotide alpha hydrolases superfamily also including N type ATP PPases and ATP sulphurylases. A highly ...

  2. NM_167342.2 → NP_727648.1  flavin adenine dinucleotide synthetase 1, isoform B [Drosophila melanogaster]

    See identical proteins and their annotated locations for NP_727648.1

    Status: REVIEWED

    UniProtKB/TrEMBL
    Q8IR76
    Related
    FBpp0073529
    Conserved Domains (1) summary
    cd01713
    Location:90 → 239
    PAPS_reductase; This domain is found in phosphoadenosine phosphosulphate (PAPS) reductase enzymes or PAPS sulphotransferase. PAPS reductase is part of the adenine nucleotide alpha hydrolases superfamily also including N type ATP PPases and ATP sulphurylases. A highly ...
Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q8IR76 Q8IR76
Q9VYI5 Q9VYI5

Gene LinkOut

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