Atg4a Autophagy-related 4a [Drosophila melanogaster (fruit fly)] - Gene

Summary

Official Symbol: Atg4aprovided by FlyBase
Official Full Name: Autophagy-related 4aprovided by FlyBase
Primary source: FLYBASE:FBgn0031298
Locus tag: Dmel_CG4428
See related: AllianceGenome:FB:FBgn0031298
Gene type: protein coding
RefSeq status: REVIEWED
Organism: Drosophila melanogaster
Lineage: Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
Also known as: APG4; atg4; Atg4; ATG4; AUT2; CG4428; Dmel\CG4428
Summary: Predicted to enable cysteine-type endopeptidase activity and protein-phosphatidylethanolamide deconjugating activity. Involved in macroautophagy. Predicted to be located in cytosol. Predicted to be active in cytoplasm. Is expressed in organism. Orthologous to several human genes including ATG4A (autophagy related 4A cysteine peptidase). [provided by Alliance of Genome Resources, Jan 2025]
Orthologs: all
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Annotation release	Status	Assembly	Chr	Location
Release 6.54	current	Release 6 plus ISO1 MT (GCF_000001215.4)	2L	NT_033779.5 (1080911..1085380)
Release 5.57	previous assembly	Release 5 (GCF_000001215.2)	2L	NT_033779.4 (1080911..1085380)

Chromosome 2L - NT_033779.5 Genomic Context describing neighboring genes

Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Submit: New GeneRIF Correction

Products	Interactant	Other Gene	Complex	Source	Pubs	Description

Function	Evidence Code	Pubs
enables cysteine-type endopeptidase activity	IBA Inferred from Biological aspect of Ancestor more info
enables cysteine-type endopeptidase activity	ISS Inferred from Sequence or Structural Similarity more info
enables cysteine-type peptidase activity	IEA Inferred from Electronic Annotation more info
enables protein-phosphatidylethanolamide deconjugating activity	IBA Inferred from Biological aspect of Ancestor more info
enables protein-phosphatidylethanolamide deconjugating activity	IEA Inferred from Electronic Annotation more info
enables protein-phosphatidylethanolamide deconjugating activity	ISS Inferred from Sequence or Structural Similarity more info	PubMed

Process	Evidence Code	Pubs
involved_in aggrephagy	IBA Inferred from Biological aspect of Ancestor more info
involved_in autophagosome assembly	IBA Inferred from Biological aspect of Ancestor more info
involved_in autophagosome assembly	ISS Inferred from Sequence or Structural Similarity more info
NOT involved_in larval midgut cell programmed cell death	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in macroautophagy	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in mitophagy	IBA Inferred from Biological aspect of Ancestor more info
involved_in mitophagy	ISS Inferred from Sequence or Structural Similarity more info
involved_in piecemeal microautophagy of the nucleus	IBA Inferred from Biological aspect of Ancestor more info
involved_in protein processing	IBA Inferred from Biological aspect of Ancestor more info

Component	Evidence Code	Pubs
is_active_in cytoplasm	IBA Inferred from Biological aspect of Ancestor more info
located_in cytosol	ISS Inferred from Sequence or Structural Similarity more info

Names: Atg4a-PA; Atg4a-PB; Autophagy-specific gene 4; Autophagy-specific gene 4a; CG4428-PA; CG4428-PB

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