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CG10638 uncharacterized protein [ Drosophila melanogaster (fruit fly) ]

Gene ID: 39424, updated on 9-Dec-2024

Summary

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Official Symbol
CG10638provided by FlyBase
Official Full Name
uncharacterized proteinprovided by FlyBase
Primary source
FLYBASE:FBgn0036290
Locus tag
Dmel_CG10638
See related
AllianceGenome:FB:FBgn0036290
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Drosophila melanogaster
Lineage
Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
Also known as
AKR; anon-WO0172774.89; AR; CG32101; Dmel\CG10638
Summary
Predicted to enable aldose reductase (NADPH) activity. Involved in fructose biosynthetic process and sorbitol biosynthetic process. Predicted to be active in cytosol. Is expressed in several structures, including Malpighian tubule primordium; adult head; embryonic/larval midgut primordium; ganglia; and gut section. Human ortholog(s) of this gene implicated in 46,XY sex reversal 8. Orthologous to human AKR1B10 (aldo-keto reductase family 1 member B10); AKR1B15 (aldo-keto reductase family 1 member B15); and AKR1C4 (aldo-keto reductase family 1 member C4). [provided by Alliance of Genome Resources, Dec 2024]
Orthologs
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Genomic context

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See CG10638 in Genome Data Viewer
Location:
69C3-69C4; 3-38 cM
Exon count:
8
Annotation release Status Assembly Chr Location
Release 6.54 current Release 6 plus ISO1 MT (GCF_000001215.4) 3L NT_037436.4 (12498106..12501311, complement)
Release 5.57 previous assembly Release 5 (GCF_000001215.2) 3L NT_037436.3 (12491206..12494411, complement)

Chromosome 3L - NT_037436.4Genomic Context describing neighboring genes Neighboring gene uncharacterized protein Neighboring gene long non-coding RNA:CR45681 Neighboring gene antisense RNA:CR45682 Neighboring gene uncharacterized protein Neighboring gene antisense RNA:CR43868 Neighboring gene uncharacterized protein Neighboring gene uncharacterized protein Neighboring gene uncharacterized protein Neighboring gene vihar

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. Integrating protein-protein interaction networks with phenotypes reveals signs of interactions. Vinayagam A, et al. Nat Methods, 2014 Jan. PMID 24240319, Free PMC Article
  2. The polyol pathway is an evolutionarily conserved system for sensing glucose uptake. Sano H, et al. PLoS Biol, 2022 Jun. PMID 35687590, Free PMC Article
  3. Gene Expression as a Dosimeter in Irradiated Drosophila melanogaster. Shrestha S, et al. J Comput Biol, 2017 Dec. PMID 29035581, Free PMC Article
  4. SWI/SNF regulates the alternative processing of a specific subset of pre-mRNAs in Drosophila melanogaster. Waldholm J, et al. BMC Mol Biol, 2011 Nov 2. PMID 22047075, Free PMC Article
  5. Circulating fructose regulates a germline stem cell increase via gustatory receptor-mediated gut hormone secretion in mated Drosophila. Hoshino R, et al. Sci Adv, 2023 Feb 24. PMID 36827377, Free PMC Article

See all (46) citations in PubMed

GeneRIFs: Gene References Into Functions

Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Homology

Gene Ontology Provided by FlyBase

Function Evidence Code Pubs
enables aldose reductase (NADPH) activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables aldose reductase (NADPH) activity ISS
Inferred from Sequence or Structural Similarity
more info
  
enables aldose reductase (NADPH) activity TAS
Traceable Author Statement
more info
 PubMed 
enables oxidoreductase activity IEA
Inferred from Electronic Annotation
more info
  
Process Evidence Code Pubs
involved_in fructose biosynthetic process IGI
Inferred from Genetic Interaction
more info
 PubMed 
involved_in sorbitol biosynthetic process IGI
Inferred from Genetic Interaction
more info
 PubMed 
Component Evidence Code Pubs
is_active_in cytosol IBA
Inferred from Biological aspect of Ancestor
more info
  

General protein information

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Preferred Names
uncharacterized protein
Names
CG10638-PA
CG10638-PB
CG10638-PD
aldo-keto reductase
aldose reductase
NP_001287050.1
NP_729808.1
NP_996068.1

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NT_037436.4 Reference assembly

    Range
    12498106..12501311 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_001300121.1 → NP_001287050.1  uncharacterized protein Dmel_CG10638, isoform D [Drosophila melanogaster]

    See identical proteins and their annotated locations for NP_001287050.1

    Status: REVIEWED

    UniProtKB/TrEMBL
    Q8SXE8, Q9VTY2, Q9VTY3
    Conserved Domains (2) summary
    COG0656
    Location:5 → 302
    ARA1; Aldo/keto reductase, related to diketogulonate reductase [Secondary metabolites biosynthesis, transport and catabolism]
    COG0667
    Location:5 → 297
    Tas; Predicted oxidoreductase (related to aryl-alcohol dehydrogenase) [General function prediction only]

  2. NM_168501.2 → NP_729808.1  uncharacterized protein Dmel_CG10638, isoform A [Drosophila melanogaster]

    See identical proteins and their annotated locations for NP_729808.1

    Status: REVIEWED

    UniProtKB/TrEMBL
    Q8SXE8, Q9VTY2, Q9VTY3
    Related
    FBpp0088362
    Conserved Domains (2) summary
    COG0656
    Location:5 → 302
    ARA1; Aldo/keto reductase, related to diketogulonate reductase [Secondary metabolites biosynthesis, transport and catabolism]
    COG0667
    Location:5 → 297
    Tas; Predicted oxidoreductase (related to aryl-alcohol dehydrogenase) [General function prediction only]

  3. NM_206346.3 → NP_996068.1  uncharacterized protein Dmel_CG10638, isoform B [Drosophila melanogaster]

    See identical proteins and their annotated locations for NP_996068.1

    Status: REVIEWED

    UniProtKB/TrEMBL
    Q4V4R8, Q8IQH2
    Conserved Domains (2) summary
    COG0656
    Location:5 → 299
    ARA1; Aldo/keto reductase, related to diketogulonate reductase [Secondary metabolites biosynthesis, transport and catabolism]
    COG0667
    Location:5 → 284
    Tas; Predicted oxidoreductase (related to aryl-alcohol dehydrogenase) [General function prediction only]
Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q8IQH2 Q8IQH2
Q8SXE8 Q8SXE8
Q9VTY2 Q9VTY2

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